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Search Results: 1 - 10 of 557 matches for " Sudha vidyasagar "
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Retracted: "highly active antiretroviral therapy induced adverse drug reactions in Indian human immunodeficiency virus positive patients"
Rajesh,Radhakrishnan; Vidyasagar,Sudha; Nandakumar,Krishnadas;
Pharmacy Practice (Internet) , 2011, DOI: 10.4321/S1886-36552011000100008
Abstract: [retracted]objective: to assess the incidence, severity pattern, causality, predictability and preventability of adverse drug reactions (adrs) and to identify risk factors for adverse drug reactions in highly active antiretroviral therapy. methods: enrolled patients were intensively monitored for adrs to highly active antiretroviral therapy. predictability was assessed based on history of previous exposure to the drug or literature incidence of adrs. preventability was assessed using schumock and thornton criteria and severity was assessed using modified hartwig and siegel scale. multivariate logistic regressions were used to identify the risk factors for adrs. results: monitoring of 130 retropositive patients by active pharmacovigilance identified 74 adrs from 57 patients. anemia and hepatotoxicity were the most commonly observed adrs. the organ system commonly affected by adr was red blood cell (21.4%).the adrs were moderate in 77% of cases. type a reactions (77%) were more common. a total of 10.8% adrs were definitely preventable. the incidence rate of adrs (65.9%) was highest with zidovudine + lamivudine + nevirapine combination. a total of 84% interruptions to highly active antiretroviral therapy were due to toxicity. cd4 less than 200 cells/μl, female gender and tuberculosis were observed as risk factors for adrs. conclusion: incidence of adrs in intensively monitored patients was found to be 43.8%. anemia in hiv patients is an influential risk factor for occurrence of adrs. with the increasing access to antiretroviral in india, clinicians must focus on early detection and prevention of adrs to highly active antiretroviral therapy.
Clinical Profile of Type 2 Diabetes Mellitus and Body Mass Index - Is there any correlation ?
Prabhu Mukhyaprana M,Sudha Vidyasagar,Shashikiran U
Calicut Medical Journal , 2004,
Abstract: BACKGROUND: Obesity in Type 2 Diabetes is uncommon in Indian population, compared to western population. Markers of obesity are Body mass index (BMI) & waist Hip ratio (WHR). Does BMI by current definition will correlate well with diabetes related complications in Indian Diabetic population? AIM: To study clinical profile and complications among four groups of cases of type 2 diabetes classified based on BMI Lean, Normal weight, Over-weight, and Obese Diabetics.SETTING & DESIGN: Diabetes clinic Dr TMA Pay Hospital, Udupi attached to K M C Manipal. Descriptive case series analysis of 500 serial type 2 diabeticsMATERIALS & METHODS: 500 Type 2 diabetic patients from Diabetic clinic between July 2000 to January 2001 divided into 4 groups based on body mass index (BMI) were our study subjects. Detailed clinical examination and screening for micro/macro vascular complications was done in all patientsRESULTS: Lean diabetics were 7.4%. Majority of diabetics had normal weight (65%). 24% belonged to overweight group; only2.6% of diabetics were obese. Incidence of hypertension in lean diabetic was 16.2%, whereas it was 38.8% in normal weight diabetics 42% in over weight diabetics and 61.5% in obese diabetics. The incidence of ischemic heart disease (I.H.D) was very low in lean diabetics (2.7%); it was 13.88% in normal weight diabetics, 12% in over weight diabetics and 23% in obese diabetics. As body mass increases, the prevalence of macro vascular complications was increasing. But micro vascular complications prevalence was similar in all groups. Fasting and postprandial sugar levels were significantly higher in lean diabetics. Lean diabetics had significantly favorable lipid profile compared to other groups.CONCLUSIONS: Obesity as defined body mass index is uncommon in Indian context. However subtle signs of obesity like waist hip ratio are abnormal even in diabetics with normal and lean BMI. Lean diabetics like all other groups are prone for micro vascular complications, whereas over-weight and obese diabetics are prone for macro vascular complications like I.H.D. and hypertension. Lean diabetics have more severe hyperglycemia and favorable lipid profile compared to other groups.
Aniridia-Wilms′ tumour syndrome-A case report
Vidyasagar M,Sagar Sudha,Kumar Girija,Rao PLNG
Indian Journal of Ophthalmology , 1992,
Abstract: Wilms′ tumour is rarely associated with sporadic non-familial congenital aniridia. A child with sporadic aniridia has a 25% chance of subsequently developing Wilms′ tumour. Unawareness of this association can lead to a delayed diagnosis of Wilms′ tumour. One such case in a 2 year old is reported. Wilms′ tumour, one of the common childhood malignancies, is associated with other congenital anomalies in about 15% of cases. These include hemihypertrophy, genitourinary abnormalities, mental retardation, aniridia etc. Sporadic non-familial aniridia was noted in only 1.1% of 547 children with Wilms′ tumours evaluated by the National Wilms′ Tumour study group. Unawareness on the part of a clinician about these associated anomalies can lead to an avoidable delay in diagnosing Wilms′ tumour. One such case in a two year old girl is being reported.
Sodium Glucose Co transporter 2 (SGLT2) Inhibitors: A New Sword for the Treatment of Type 2 Diabetes Mellitus
R.Rajesh,,Patel Naren,Sudha vidyasagar,,Unnikrishnan
International Journal of Pharma Sciences and Research , 2010,
Abstract: The low affinity sodium glucose cotransporter (SGLT2) plays a major role in physiology of glucose reabsorption from proximal part of kidney. Almost all glucose excreted through glomerular filtration, isreabsorbed via SGLT2 until blood glucose level reaches to its hreshold value for glucose excretion i.e. ~180mg/dl. Increasing the glucose excretion by inhibiting the SGLT2 is the novel approach for the treatment of diabetes. Safe and normal life of patients having familial renal glucosuria due to SLC5A2 gene mutation is accelerating the development of SGLT2 inhibitors. Weight loss and very low risk of hypoglycemia are the potential benefits of these inhibitors. There are number of molecules in this class under the stage of development.
Safety Aspects of Antiretroviral Therapy for Management of HIV Infection
R.Rajesh,Sudha vidyasagar,Patel Naren,ManjuVarghese
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: There are four classes of antiretroviral agents used in the treatment of HIV/AIDS. Adverse effects to Highly Active Antiretroviral Therapy (HAART) are common and often difficult to avoid. In many cases, research is not able to identify the exact cause of an adverse event. The severity of adverse reactions varies greatly and difficult to manage; typically prevention is more desirable than treatment. However, this is not always true. This paper will review safety aspect of class-wide Highly Active Antiretroviral Therapy, mechanism of action. A class-wide adverse effect for Reverse transcriptase inhibitors includes lactic acidosis, peripheral neuropathy and lipoatrophy. Class wide adverse effects to non-nucleoside reverse transcriptase inhibitors include rash and hepatotoxicity, while efavirenz has its own unique CNS reactions. Protease inhibitor side effects include hyperglycemia, lipoaccumulation, dyslipidemia, and gastrointestinal (GI) intolerance. Coreceptor CCR5 antagonists, which provide a novel mechanism of action, are a recent addition to the armamentarium of antiretroviral agents. Antiretroviral are an important break-through in the treatment of HIV/AIDS. However, adverse reactions from these drugs can range from mild to life-threatening, and determining which agent is the cause is frequently difficult to discern. Fortunately, side effects can be monitored, treated and in many cases, prevented.
Unusual Neurological Complication of Typhoid Fever
Sudha Vidyasagar,Srinivas Nalloor**,,Shashikiran U***,,Mukhyaprana Prabhu M
Calicut Medical Journal , 2004,
Abstract: 36-year-old male with typhoid fever presented with conduction aphasia and parietal lobe dysfunction (Gerstmann Syndrome) due to an infarct in the left inferior parietal/superior temporal cortex documented by CT Scan. This case highlights an unusual neurological complication of typhoid fever hitherto not reported in the literature.
An unusual presentation of tropical pyomyositis
Sudha Vidyasagar,Annappa Kudva,Abhishek Malhotra,M. Mukhyaprana Prabhu
Calicut Medical Journal , 2004,
Abstract: Tropical pyomyositis is a primary pyogenic infection of skeletal muscle, often caused by Staphylococcus aureus. The most common presentation of tropical pyomyositis is that of multiple acute abscesses with fever. Hepatitis is a rare manifestation of this disease. We report a case of tropical pyomyositis, presented with hepatic encephalopathy leading to initial diagnostic dilemma.
Effect of different concentrations of metal ions on alpha amylase production by Bacillus amyloliquefaciens
Sudha
Research in Biotechnology , 2012,
Abstract: Bacillus amyloliquefaciens is obtained from soil which produces extracellular alphaamylase enzyme. The present study is concerned with effect of metal ions on alpha amylaseproduction. Metal ions are Ca2+, Cu2+, Mg2+, Fe2+ and Mn2+ at different concentrations 2g/l,5g/l and 7g/l. Supplementations of salts of certain ions provide good growth ofmicroorganism and production of alpha amylase. Ca2+and Mg2+exhibit positive influence onalpha-amylase production. Our results show that the amylase production is higher in thepresence of Ca2+ (0.439) IU/ml/min at 7g/l concentration in comparison of other metal ions.The enzyme activity of Mg2+(0.321) IU/ml/min at 2g/l concentration. The study focuses onsupplementation of metal ions increase the production of amylase.
THERMAL DIFFUSION EFFECT ON MHD FREE CONVECTION HEAT AND MASS TRANSFER FLOW PAST A UNIFORMLY VERTICAL PLATE WITH HEAT SINK
G. Vidyasagar
Journal of Global Research in Mathematical Archives , 2013,
Abstract: This paper deals with the combined effect of thermal diffusion and heat absorption on the MHD free convection heat and mass transfer flow of a viscous incompressible fluid past a continuously moving infinite plate. Closed form of solution for the velocity, temperature and concentration field are obtained and discussed graphically for various values of the physical parameters present. In addition, expressions for the skin friction is also derived and finally discussed with the help of table and graphs. Keywords: Free convection, Heat and Mass transfer, Heat Sink, Thermal radiation, Magnetic Field.
HEAT AND MASS TRANSFER EFFECTS ON MHD BOUNDARY LAYER FLOW OVER A MOVING VERTICAL POROUS PLATE
G. Vidyasagar
Journal of Global Research in Mathematical Archives , 2013,
Abstract: We study a two-dimensional free convection effects on the steady incompressible laminar MHD heat and mass transfer characteristics of a linearly started porous vertical plate, the velocity of the fluid far away from the plate surface is assumed zero for a quiescent state fluid. The variations of surface temperature and concentration are linear. All the fluid properties are assumed to be constant except for the density variations in the buoyancy force term of the linear momentum equation. The magnetic Reynolds number is assumed to be small, so that the induced magnetic field is neglected. No electrical field is assumed to exist and both viscous and magnetic dissipations are neglected. The Hall effects, the viscous dissipation and the joule heating terms are also neglected. The governing equations are solved numerically by using shooting method. Dimensionless velocity, temperature and concentration profiles are displayed graphically for different values of suction parameter (fw), magnetic parameter ( ), permeability parameter (K), local temperature Grashof number (Gr), local concentration Grashof number (Gc), Prandtl number ( ) and Schmidt number (Sc). The values of skin-friction, Nusselt number and Sherwood number for different physical parameters are also presented through tables. Keywords: Porous medium, MHD, Heat transfer and Mass transfer, Vertical plate.
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