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Search Results: 1 - 10 of 412 matches for " Subal Debnath "
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FORMULATION AND EVALUATION OF LACTIC ACID BACILLUS AND ZINC SULPHATE FAST DISPERSIBLE TABLETS
Srikanth CH,Subal Debnath,Shireesh Kiran R,Raja shekhar S
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: The aim of the present work is to formulate fast dispersible tablets of lactic acid bacillus & Zinc sulphate. In this study, different formulations of fast dispersible tablets were prepared using various excipients & super disintegrants. Different concentrations of crospovidone, cross carmellose sodium & sodium starch glycolate were used as super disintegrants in the formulation of fast dissolution tablet. The powder mass was evaluated for flow properties. All these formulations were prepared by wet granulation method. The tablets were evaluated for hardness, thickness, weight variation, friability, wetting time, disintegration time, and water absorption ratio. Tablets containing crospovidone showed shorter disintegration time i.e. less than 30 sec, comparaed to cross carmellose sodium & sodium starch glycolate hence better patient compliance & effective therapy.
A REVIEW: HERBS USED AS ANTICANCER AGENTS
Badri Nagarani,Subal debnath,Santhosh Kumar C,Chiranjib Bhattacharjee
International Research Journal of Pharmacy , 2011,
Abstract: Herbs are the plants which will have desirable odour, taste and other medical uses. Anti-cancer agents are effective in cancer treatment. Here an attempt has been made to review some herbs used for the prevention and treatment of cancer. These herbs were found for posses anticancer, cytotoxic or antioxidant activity in various pre-clinical or clinical studies. Cancer is a disease in which body cells become abnormal and divide without control. Cancer cell may invade nearby tissues and they may spread through the blood stream & lymphatic system to other parts of the body. The search for anticancer agents from the plant sources alkaloids in earnest in the 1950s such as Vincristine, Vinblastine and the isolation of cytotoxic Podophyllotoxins will reduce white blood cell count and caused bone marrow depression in rats. Roots, leaves, stem, root, bark and fruity of the plant herbs are used in the treatment of cancer. The dietary antioxidants having anti carcinogenic property are in demand. Identification and characterization of these anti-carcinogens in the diet can be used for reducing the risk of human cancer. Tea (Camellia thea) an evergreen plant contains antioxidants which prevent and repair cellular damage caused by reactive free radicals. Supervitamin drinks containing a combination of Hordeum vulgare, Medicago sativa and Spirulina enhances the activity of immune cells against cancer. Mentha species containing antioxidants prevent reocurrence of cancer.
FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF NIFEDIPINE HYDROCHLORIDE USING MULTI-UNIT CHITOSAN TREATED ALGINATE
Soumik Ghosh,,Nansri Saha Ghosh,,Subal Debnath,,G. Ganesh kumar
International Journal of Pharmaceutical and Biological Research , 2010,
Abstract: The main objective of the present work was to develop sustained release matrix tablets of water soluble Nifedipine hydrochloride using multi-unit chitosan treated alginate. Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by contineously releasing medication over an extended period of time after administration of single dose. Here the release of orally administered drug depends on the residence time of dosage form in the GIT. In the sustained release formulation of Nifedipine as the dose administration is reduced, increases patient compliance. This formulation exhibit neither very slow nor very fast rates of absorption and excretion. The sustained release formulation of nifedipine is absorbed uniformly from the entire gastro-intestinal tract. It is administrated orally in relatively small dose of 20 mg. The addition of chitosan increased the swelling of multiple unit systems (MUS) in acidic conditions and reduced the drug release from MUS. The MUS retained in gastrointestinal tract (GIT) for more than 12 h and distributed throughout the GIT. This study demonstrates that the matrix type chitosan treated alginate MUS can be a good addition to sustained release tablets to deliver Nifedipine hydrochloride and expected to be less of an irritant to gastric and intestinal mucosa.
Nephroprotective Evaluation of Ethanolic Extract of the Seeds of Papaya and Pumpkin Fruit in Cisplatin-induced Nephrotoxicity
Subal Debnath,Nilesh Babre,,Y.S.Manjunath,V.Mallareddy
Journal of Pharmaceutical Science and Technology , 2010,
Abstract: The present study is focused on the Nephroprotective evaluation of ethanolic extract of the papaya seed, PaSE ( Biological name- Carica papaya, family – Caricaceae) and pumpkin seed, PuSE (Biological name - Curcubita pepo, family – Curcurbitaceae). Cisplatin (10mg/kg, i.p.)used for the nephrotoxicity, which is the dose limiting side effect of the Cisplatin (Cis-diamine dichloro platinum-II). The ethanolic extract of PaSE & PuSE exhibited protection against cisplatin-induced nephrotoxicity, which were proved by the gross behavioural studies,histopathological, renal function and biochemical studies. Antioxidant studies like nitric oxide scavenging activity, lipid peroxidation in kidney also supporting the nephroprotective activity of these seeds. This nephroprotective study also compared with chloroform extract of the dried Zinger roots, ZE (Zingiber officinale Rosc, Family- Zingiberaceae) and methimazole (MZL) which is already evaluated. Histopathological investigation of the kidney like glomerularcongestion, blood vessel congestion, intestinal edema, inflammatory cells, necrosis, tubular casts were also observed for control, test and reference groups.
Hypolipidemic Effect of Hydro-Alcoholic Extract of Barringtonia acutangula Linn Root Extract on Streptozotocin-induced Diabetic Rats
Nilesh P Babre,Subal Debnath,Y.S.Manjunath,Gajanan Deshmaukh
Journal of Pharmaceutical Science and Technology , 2010,
Abstract: Our present study was to find out the hypolipidemic activity of an hydro-alcoholic extract of Barringtonia acutangula Linn root (EBA) on streptozotocin (STZ)-induced rats. Normal as well as diabetic albino rats was divided into groups (n=6) receiving different treatments i.e. vehicle (control), ethanolic extract, EBA (1g and 2g/kg b.w), STZ and glibenclamide. Blood samples was collected by cardiac puncture and wasanalyzed for lipid profile on days 0,7,14 and 21. STZ-treated diabetic rats has abnormal lipid profile, whereas the Barringtonia acutangula Linn root extract (EBA) treated groups showed significant improvement in the lipid profile comparable to glibenclamide treated group. However, improvement in lipid profile was less than that achieved with the standard drug glibenclamide. We conclude that administration of EBA improves lipid profile on euglycemic as well as diabetic rats. The probable mechanism of this action is delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity by saponin which is present in EBA.
Prevalence of Thinness among Santal Preschool Children Using New Body Mass Index Cut-Off Points
Subal Das,Kaushik Bose
Journal of Anthropology , 2011, DOI: 10.1155/2011/602782
Abstract: A community-based cross-sectional study was undertaken to determine the prevalence of undernutrition using body mass index (BMI) among 2–6-year Santal preschool children of Purulia District, West Bengal, India. A total of 251 (116 boys and 135 girls) children from 12 villages were measured. Commonly used indicators, that is, weight, height, and BMI, were used to evaluate the nutritional status. More boys (59.5%) than girls (53.3%), based on BMI, were undernourished. Significant age differences in weight (=44.29???;=3), height (=58.48???;=3), and BMI (=3.52???;=3) among boys were observed. Similarly, significant differences between ages in mean weight (=56.27???;=3), height (=64.76???;=3), and BMI (=2.62???;=3) were observed among the girls. The present study revealed that the nutritional status of the preschool children of Santal tribal community of these villages was poor with very high rate of thinness in boys and girls (59.5% and 53.3%, resp.).
Body Mass Index and Chronic Energy Deficiency among Adult Santals of Purulia District, West Bengal, India.
Subal Das,Kaushik Bose
International Journal of Human Sciences , 2010,
Abstract: The present community based cross-sectional study was undertaken to determine the overall prevalence of undernutrition using BMI (kg/m2) among adult Santal tribals of Purulia District, West Bengal, India. Our study is measured data on height and weight of adults aged 18 years and above from 10 villages of Purulia District. A total of 513 (196 males and 317 females) adults aged 18 years and above were measured. One commonly used indicator i.e., BMI was used to evaluate the nutritional status of the subjects. Based on BMI, chronic energy deficiency (CED) was used as a measure of undernutrition. Females were found to be more undernourished than their male counterparts (30.6%) & (63.4%). This sex difference was statistically highly significant (x2 = 55.96; df = 4; p < 0.001). Our study demonstrated that Santals of Purulia, both males as well as females, were under nutritional stress. In general, tribes of West Bengal were experiencing serious to critical nutritional deficit. Urgent government attention is required to rectify this nutritional problem.
Comparison of body composition among rural preschool children of Purulia, West Bengal, using two different equations
Subal Das,Kaushik Bose
Human Biology Review , 2012,
Abstract: Body composition is an important factor in identifying populations at risk of metabolic disease including type-2 diabetes in South Asian children. Many equations for calculating body-fat percentage (BF %) from anthropometric methods have been developed among South-Asian children. The objective of this study was to compare the BF % derived from two different methods obtained from skinfold equations in Santal tribal and Bauri caste preschool children. In Purulia, 1012 (480 girls, 532 boys) rural children aged 2-6 years underwent anthropometric measurements. We conducted anthropometry, including biceps, triceps, sub-scapular, suprailiac and medial-calf skinfold thicknesses. Two previously published equations (Shaikh and Mahalanabis and Slaughter et al.,) were used to calculate BF % from anthropometric data. There was poor agreement between the two BF % values. The former equation over estimated the BF (%) while the latter equation tended to under-estimate BF (%). Thus, currently available skinfold equations do not accurately predict BF % in rural preschool children of Purulia, West Bengal, India. Further studies are needed using direct methods of determining body fat. Subsequently, validation studies using skinfolds should be undertaken to determine the sex and ethnic specific equations.
Prevalence of Thinness among Santal Preschool Children Using New Body Mass Index Cut-Off Points
Subal Das,Kaushik Bose
Journal of Anthropology , 2011, DOI: 10.1155/2011/602782
Abstract: A community-based cross-sectional study was undertaken to determine the prevalence of undernutrition using body mass index (BMI) among 2–6-year Santal preschool children of Purulia District, West Bengal, India. A total of 251 (116 boys and 135 girls) children from 12 villages were measured. Commonly used indicators, that is, weight, height, and BMI, were used to evaluate the nutritional status. More boys (59.5%) than girls (53.3%), based on BMI, were undernourished. Significant age differences in weight ( ), height ( ), and BMI ( ) among boys were observed. Similarly, significant differences between ages in mean weight ( ), height ( ), and BMI ( ) were observed among the girls. The present study revealed that the nutritional status of the preschool children of Santal tribal community of these villages was poor with very high rate of thinness in boys and girls (59.5% and 53.3%, resp.). 1. Introduction Health and nutritional status are two crucial and interlinked aspects of human development, which in turn interact with demographic variables in important ways. Malnutrition (a condition that occurs due to the intake of inadequate amount of nutrients leading to insufficient nourishment) continues to be a problem of considerable magnitude in most of the developing countries of the world. Preschool children are one of the most nutritionally vulnerable segments of the population. Nutrition during the first five years has not only an impact on growth and morbidity during childhood, but also acts as a determinant of nutritional status in adolescent and adult life. Global comparative data indicate that contrary to common perception, prevalence of undernutrition (a deficiency of calories or of one or more essential nutrients) is highest in South Asian children [1]. India has the highest occurrence of childhood malnutrition in the world [2]. Malnutrition underlies 55 percent of all deaths of children younger than five years of age globally [3]. Malnutrition makes a child susceptible to infections and delays recovery, thus increasing mortality and morbidity [4]. It is therefore logical to direct increasing attention to the quality of life of the survivors [5]. According to the 2001 census, the Purulia District of West Bengal, India has a total population of 25, 36, 516, out of which 89.93% are residing in rural areas, and 10.07% are in urban areas. Out of this total population, 19.22% belongs to Scheduled Tribes. In West Bengal, Purulia District has the second highest percentage of tribal population (18.3%) after Jalpaiguri (18.9%). Santals belong to the
Importance of Surface Preparation for Corrosion Protection of Automobiles  [PDF]
Narayan Chandra Debnath
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2013, DOI: 10.4236/jsemat.2013.31A014
Abstract:

An overview of science and technology of pretreatment process suitable for automotive finishing with cathodic electrodeposition primer is presented in details in this paper. Both the theoretical principles and practical aspects of tricationic phosphating process that are used in automotive industry are discussed in details. The characteristic features of phosphate coatings of both conventional high zinc phosphating formulations and modern tricationic phosphating formulations on steel surface are compared in details by SEM, EDX and XRD techniques. The corrosion protection of the phosphated and painted steel panels were evaluated by both salt spray test and electrochemical impedance spectroscopy (EIS). The analysis of impedance data in terms of pore resistance (Rpo), coating capacitance (Cc) and breakpoint frequency (fb) as a function of salt spray exposure time provides a clear insight into the mechanism of superior corrosion resistance provided by the modern tricationic phosphating formulations compared with conventional high zinc phosphating formulations.

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