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Search Results: 1 - 10 of 10089 matches for " Steven Tucker "
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Integrating RFID Technology with Intelligent Classifiers for Meaningful Prediction Knowledge  [PDF]
Peter Darcy, Steven Tucker, Bela Stantic
Advances in Internet of Things (AIT) , 2013, DOI: 10.4236/ait.2013.32004
Abstract: Radio Frequency Identification (RFID) is wireless technology that has been designed to automatically identify tagged objects using a reader. Several applications of this technology have been introduced in past literature such as pet identification and luggage tracking which have increased the efficiency and effectiveness of each environment into which it was integrated. However, due to the ambiguous nature of the captured information with the existence of missing, wrong and duplicate readings, the wide-scale adoption of the architecture is limited to commercial sectors where the integrity of the observations can tolerate ambiguity. In this work, we propose an application of RFID to take the reporting of class attendance and to integrate a predictive classifier to extract high level meaningful information that can be used in diverse areas such as scheduling and low student retention. We conclude by providing an analysis of the core strengths and opportunities that exist for this concept and how we might extend it in future research.
Building Trust—One Gift at a Time
Maro? Servátka,Steven Tucker,Radovan Vadovi?
Games , 2011, DOI: 10.3390/g2040412
Abstract: This paper reports an experiment evaluating the effect of gift giving on building trust. We have nested our explorations in the standard version of the investment game. Our gift treatment includes a dictator stage in which the trustee decides whether to give a gift to the trustor before both of them proceed to play the investment game. We observe that in such case the majority of trustees offer their endowment to trustors. Consequently, receiving a gift significantly increases the amounts sent by trustors when controlling for the differences in payoffs created by it. Trustees are, however, not better off by giving a gift as the increase in the amount sent by trustors is not large enough to offset the trustees’ loss associated with the cost of giving a gift.
Systems Biology: The take, input, vision, concerns and hopes  [PDF]
Graeme Tucker
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.22014
Abstract: Systems Biology is a relatively new branch of biology that brings together an interdisciplinary team of scientist, computer engineers and mathematicians. Biomedicine can gain much from the input of Systems Biology. The object and aims of this article centre on clarification and direction for Systems Biology, notably in regard to human health and disease.
Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination
Xiaoli Tang, Sicheng Wen, Dong Zheng, Lynne Tucker, Lulu Cao, Dennis Pantazatos, Steven F. Moss, Bharat Ramratnam
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072503
Abstract: The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expression of Drosha, the molecular mechanisms that regulate its protein levels are largely unknown. Here, we report that ubiquitination and acetylation regulate Drosha protein levels oppositely. Deacetylase inhibitors trichostatin A (TSA) and nicotinamide (NIA) increase Drosha protein level as measured by western blot but have no effects on its mRNA level in HEK293T cells. TSA increases miRNA-143 production in a miRNA sensor assay and in a qPCR analysis in HEK293T cells. Treatment of AGS and HEK293T cells with proteasome inhibitors MG132 or Omuralide increases Drosha protein levels. Furthermore, the N-terminal, but not the C-terminal Drosha can be acetylated by multiple acetyl transferases including p300, CBP and GCN5. Acetylation of Drosha competes with its ubquitination, inhibiting the degradation induced by the ubiquitin-proteasome pathway, thereby increasing Drosha protein levels. Infection of the gastric mucosa AGS cells by H. pylori, the gastric cancer associated carcinogen, leads to the ubiquitination and reduction of Drosha protein levels. H. pylori infection of AGS cells has no significant effects on Drosha mRNA levels. Our findings establish a central mechanism of protein homeostasis as playing a critical role in miRNA biogenesis.
Ergocalciferol and Microcirculatory Function in Chronic Kidney Disease and Concomitant Vitamin D Deficiency: An Exploratory, Double Blind, Randomised Controlled Trial
Gavin Dreyer, Arthur T. Tucker, Steven M. Harwood, Rupert M. Pearse, Martin J. Raftery, Muhammad M. Yaqoob
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099461
Abstract: Background and Objectives Vitamin D deficiency and endothelial dysfunction are non-traditional risk factors for cardiovascular events in chronic kidney disease. Previous studies in chronic kidney disease have failed to demonstrate a beneficial effect of vitamin D on arterial stiffness, left ventricular mass and inflammation but none have assessed the effect of vitamin D on microcirculatory endothelial function. Study Design We conducted a randomised controlled trial of 38 patients with non diabetic chronic kidney disease stage 3–4 and concomitant vitamin D deficiency (<16 ng/dl) who received oral ergocalciferol (50,000 IU weekly for one month followed by 50,000 IU monthly) or placebo over 6 months. The primary outcome was change in microcirculatory function measured by laser Doppler flowmetry after iontophoresis of acetylcholine. Secondary endpoints were tissue advanced glycation end products, sublingual functional capillary density and flow index as well as macrovascular parameters. Parallel in vitro experiments were conducted to determine the effect of ergocalciferol on cultured human endothelial cells. Results Twenty patients received ergocalciferol and 18 patients received placebo. After 6 months, there was a significant improvement in the ergocalciferol group in both endothelium dependent microcirculatory vasodilatation after iontophoresis of acetylcholine (p = 0.03) and a reduction in tissue advanced glycation end products (p = 0.03). There were no changes in sublingual microcirculatory parameters. Pulse pressure (p = 0.01) but not aortic pulse wave velocity was reduced. There were no significant changes in bone mineral parameters, blood pressure or left ventricular mass index suggesting that ergocalciferol improved endothelial function independently of these parameters. In parallel experiments, expression of endothelial nitric oxide synthase and activity were increased in human endothelial cells in a dose dependent manner. Conclusions Ergocalciferol improved microcirculatory endothelial function in patients with chronic kidney disease and concomitant vitamin D deficiency. This process may be mediated through enhanced expression and activity of endothelial nitric oxide synthase. Trial Registration Clinical trials.gov NCT00882401
Original Research: Pupillary Constriction Velocity and Latency to Predict Excessive Daytime Sleepiness  [PDF]
Vyas Umesh, Woodson B. Tucker
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.611106
Abstract: Background: Excessive daytime sleepiness (EDS) is common in adults. A need exists for an easier and faster objective clinical measures of EDS. The autonomic nervous system controls pupil size and prior pupillometry studies have demonstrated associations with sleepiness. We used a novel portable device to assess pupillometry and prospectively evaluated a sleep clinic cohort. Methods: Following IRB approval Pupillometry (The ForSiteTM, NeurOptics, Irvine, CA), was performed on 113 sleep clinic patients. Constriction and dilation velocity and latencies, minimum and maximum aperture were obtained along with Epworth Sleepiness Score (ESS), 10 point Visual Analog Scale (VAS), BMI, gender, age and AHI. Three sets of measures were obtained and analyzed with ANOVA, t-test, Linear Regression and Pearson correlation coefficients (SAS, Cary, NC). Results: Both constriction velocity and latency correlated with VAS (n = 88, r = 0.28, p = 0.007 and r = 0.31, p = 0.004). Only constriction velocity correlated with AHI (n = 78, r = -0.27, p = 0.016). Multivariate linear regression which includes VAS and age predicted constriction velocity (r = 0.36, p = 0.002) and latency (r = 0.38, p = 0.001). Using Pearson correlation, AHI and VAS combined were associated with constriction velocity (-0.273 (0.016), and 0.284 (0.007), respectively). Using a maximum constriction velocity threshold value (age adjusted) of 2.8, VAS ≥ 6 was predicted with a sensitivity of 83% and specificity of 84%. Conclusions: Pupillary constriction velocity and latency predict self-reported VAS state of sleepiness. While both are affected by age, only constriction velocity is affected by apnea severity. These data suggest that a portable pupillometer may provide a method to identify individuals with abnormal sleepiness.
An assessment of the Myers Briggs Type Indicator from a theological perspective
AR Tucker
Acta Theologica , 2011,
Abstract: The aim of this article is to assess the Myers Briggs Type Indicator (MBTI ) from a Reformed perspective of a Trinitarian biblical hermeneutic of hope. It examines and assesses the compatibility of its assumptions with a theory of personhood derived from a Reformed perspective. It then suggests why it has made such an impact among Christian counsellors, what its popularity means to the church, and makes recommendations to practitioners. It is not intended to be a formal psychological assessment.
Practical theology: Can it really help the local congregation?
AR Tucker
HTS Theological Studies/Teologiese Studies , 2011,
Abstract: This article sought to demonstrate that a synthesis of various church growth methods used within the framework of Heitink’s (1999:124ff.) three theory of action perspectives, namely the ‘hermeneutical’, ‘empirical’ and ‘strategic’, has successfully enabled the building up of one congregation both structurally and spiritually. The ‘building up’ concept was drawn from the practical theological subdiscipline of ‘building up the local church’. This subdiscipline judges the success of God’s work in a local congregation by how effective it is in mobilising its members, facilitating growth towards holistic maturity, making disciples and serving others in mission. Since 2006, St John’s has moved towards this goal by mobilising its members into four new ministry teams (with 13 subsidiary teams), which appear to have achieved growth in these areas.
An ‘inclusive’ model of integrated care
Helen Tucker
International Journal of Integrated Care , 2010,
Abstract:
"Esto es para toda la vida": Un análisis discursivo de los dilemas de la construcción de identidades en un diagnóstico "Das ist für's Leben": Eine Diskursanalyse der Dilemmata bei der Konstruktion diagnostischer Identit ten "This is for Life": A Discursive Analysis of the Dilemmas of Constructing Diagnostic Identities
Ian Tucker
Forum : Qualitative Social Research , 2009,
Abstract: Este artículo incluye una aproximación de análisis discursivo a la construcción de identidades a partir de la recepción de un diagnóstico psiquiátrico (me referiré globalmente a todas ellas como "las identidades de diagnóstico") dilemático, y las subsiguientes negociaciones de las identidades a la luz de ese dilema. Más concretamente, el interés se centra en el diagnóstico de la esquizofrenia, y en cómo construyen sus identidades las personas que reciben el diagnóstico. Una característica fundamental del recibir un diagnóstico de esquizofrenia, es la posibilidad de ver amenazada la propia identidad por las muchas ideas negativas y estereotipadas que persisten con relación a la esquizofrenia. Basándose en la literatura reciente en el campo de la investigación sobre usuarios de servicios de salud mental, el trabajo intenta ir más allá de los límites de una perspectiva psiquiátrica biomédica del diagnóstico, con el fin de aclarar cómo tales clasificaciones impactan en los que las reciben. En este artículo, el re-funcionamiento discursivo de las identidades de diagnóstico individual incluye estrategias de resistencia al diagnóstico, intentos de distanciarse del diagnóstico, diagnósticos existencialistas, y el reconocimiento aunque reticente a las sugerencias que consideran un "riesgo" social a las personas con diagnóstico de esquizofrenia. URN: urn:nbn:de:0114-fqs0903240 In diesem Beitrag nutze ich einen diskursanalytischen Ansatz zum Verst ndnis von Identit ten, die durch den Erhalt psychiatrischer Diagnosen als Dilemmata konstruiert werden (ich werde diese im Weiteren als "diagnostische Identit ten" bezeichnen), und zum Nachvollzug der folgenden Aushandlungen von Identit t im Lichte dieser Dilemmata. Konkreter interessiert mich die Diagnose Schizophrenie und wie Menschen, die als schizophren diagnostiziert wurden, ihre Identit ten konstruieren. Ein wesentlicher Aspekt der Schizophrenie-Diagnose ist, dass die eigene Identit t m glicherweise als bedroht (und bedrohlich) erlebt wird mit Blick auf die zahlreichen negativen und ganz überwiegend stereotypisierten Vorstellungen, die über Schizophrenie existieren. Indem ich auf Literatur aus dem Bereich der Gesundheitsversorgungsforschung zurückgreife, versuche ich über die Begrenzungen einer psychiatrisch-biomedizinischen Perspektive hinauszukommen um verstehen zu k nnen, welchen Einfluss derartige Klassifikationen und Zuschreibungen auf diejenigen haben, die sie erfahren. Ich zeige auch die diskursiven überarbeitungen individueller diagnostischer Identit ten und deren Strategien wie z.B. Widerstand gegen die Dia
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