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Search Results: 1 - 10 of 231132 matches for " Steven R. Blumen "
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Benefits of ACE Inhibitors in Diabetes
Maria E. Ramos-Nino,Steven R. Blumen
Clinical Medicine : Therapeutics , 2009,
Abstract: Angiotensin-converting enzyme (ACE) inhibitors have been FDA-approved for treating refractory hypertension since 1981. Since then, clinical investigations support the benefits of ACE inhibition (ACE I) in pathologies like congestive heart failure, myocardial infarction, diabetes mellitus, chronic renal insufficiency, and atherosclerotic cardiovascular disease. Both, clinical trials and animal models of type I and type II diabetes have shown that hyperactivity of the angiotensin II signaling pathway contributes to the development of diabetes and its complications, and that blockade of the renin angiotensin system prevents new onset diabetes and reduces the risk of diabetic complications. Furthermore, ACE inhibitors are generally well tolerated and have few contraindications. This article describes ACE as a target molecule and gives an overview on the clinical evidence that supports the use of ACE inhibitors in diabetes.
Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas
Maria E Ramos-Nino, Steven R Blumen, Harvey Pass, Brooke T Mossman
Molecular Cancer , 2007, DOI: 10.1186/1476-4598-6-81
Abstract: Malignant mesothelioma (MM) is an insidious tumor associated historically with occupational exposure to asbestos [1,2]. Recently, infection by simian virus 40 (SV40) has been implicated as a contributory factor in the development of MMs [3,4] but these findings are controversial [5-7]. The average survival of patients is less than 1 year after initial diagnosis of MM, and no successful treatment options exist for the majority of patients [1,3]. These pleomorphic tumors are unique in that they have a long latency period (average of 30+ years) and various pathologies (epithelial, sarcomatous and mixed) that complicate their diagnosis and may govern their prognosis [1,3].Although the mechanisms of development of MM are obscure, the initiation of signaling events after interaction of mesothelial cells with asbestos fibers or infection by SV40 may result in transactivation of genes governing cell proliferation and other properties of neoplastic cells [2,8,9]. The transcription factor, activator protein-1 (AP-1) consists of members of the Jun (c-Jun, JunD, JunB) and Fos (c-Fos, FosB, Fra-1, Fra-2) family of early response protooncogenes [10,11] and is a major target of asbestos-induced cell signaling via activation of mitogen activated protein kinases (MAPK) [12,13].In comparison to other Jun and Fos family members, increases in Fra-1 expression by asbestos are protracted in rodent lung epithelial [14] and pleural mesothelial cells and are critical in maintenance of the malignant phenotype of rat MMs [15]. Moreover, cd44, which encodes the principal hyaluronic acid receptor in a variety of cell types, is a fra-1 regulated gene in rat MMs [16].CD44 is a type I transmembrane glycoprotein (85–200 kDa) and functions as the major cellular adhesion molecule for hyaluronic acid (HA), a component of the extracellular matrix (ECM). CD44 is expressed in most human cell types and is implicated in a wide variety of physiological and pathological processes, including lymphocyte homing
Probing the local structure: macromolecular combs in external fields
R. Burioni,D. Cassi,A. Blumen
Physics , 2002, DOI: 10.1016/S0301-0104(02)00725-5
Abstract: Recent experimental methods allow to monitor the response of macromolecules to locally applied fields, complementing usual, mesoscopic techniques. Based on the Rouse-model and its extension to generalized Gaussian structures (GGS), we follow here the stretching of comb macromolecules under local fields. This leads to a wealth of informations about the structure: Namely, given the inhomogeneous architecture of combs, the dynamics and amount of stretching depend strongly on the position of the monomer on which the external fields act. We discuss both the theoretical and the experimental implications of our findings, given that micromanipulations can be supplemented by fluorescence measurements, which are very sensitive to changes in the intramolecular distances.
Training Cognitive Control in Older Adults with the Space Fortress Game: The Role of Training Instructions and Basic Motor Ability
Helena M. Blumen,Daniel Gopher,Joshua R. Steinerman,Yaakov Stern
Frontiers in Aging Neuroscience , 2010, DOI: 10.3389/fnagi.2010.00145
Abstract: This study examined if and how cognitively healthy older adults can learn to play a complex computer-based action game called the Space Fortress (SF) as a function of training instructions [Standard vs. Emphasis Change (EC); e.g., Gopher et al., 1989] and basic motor ability. A total of 35 cognitively healthy older adults completed a 3-month SF training program with three SF sessions weekly. Twelve 3-min games were played during each session. Basic motor ability was assessed with an aiming task, which required rapidly rotating a spaceship to shoot targets. Older adults showed improved performance on the SF task over time, but did not perform at the same level as younger adults. Unlike studies of younger adults, overall SF performance in older adults was greater following standard instructions than following EC instructions. However, this advantage was primarily due to collecting more bonus points and not – the primary goal of the game – shooting and destroying the fortress, which in contrast benefited from EC instructions. Basic motor ability was low and influenced many different aspects of SF game learning, often interacted with learning rate, and influenced overall SF performance. These findings show that older adults can be trained to deal with the complexity of the SF task but that overall SF performance, and the ability to capitalize on EC instructions, differs when a basic ability such as motor control is low. Hence, the development of this training program as a cognitive intervention that can potentially compensate for age-related cognitive decline should consider that basic motor ability can interact with the efficiency of training instructions that promote the use of cognitive control (e.g., EC instructions) – and the confluence between such basic abilities and higher-level cognitive control abilities should be further examined.
Publication Patterns in 3 Prominent Educational Psychology Journals: The Geography of Editors, Advisors, Authors, and Participants  [PDF]
Steven R. Yussen
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.211009
Abstract:

This article considers the publication practices of 3 leading journals in Educational Psychology, for the 6-year period 2008-2013, to determine their representation of countries throughout the world among the editors, editorial board members, authors, and the participants in the samples (the samples of participants based on a random subset of the articles published). The journals considered are: 1) Journal of Educational Psychology (JEP); 2) Contemporary Educational Psychology (CEP); and 3) The British Journal of Educational Psychology (BJEP). The journals published in the United States (JEP and CEP) have a 50 - 60 percent focus on individuals and participants in the United States. For BJEP, the United Kingdom accounts for about a third of authors and participants. Significantly more non-English speaking European countries are represented in the BJEP than in the two American journals. In all three countries, Asia, Africa, and Central and South America are significantly under-represented in the authors and participants of studies.

Motivation, giftedness and talent: A challenge to success Motivación, sobredotación y talento: un desafío para el éxito
Sheyla Blumen
Revista de Psicología , 2008,
Abstract: Definitions about giftedness and talent involving motivation as a significant variable either in the genesis of giftedness or in the development of intellectual talent are analyzed. An analysis on the influence of motivation in successful achievers, underachievers, as well as in the socialemotional development of the gifted is presented. An update view of the goals achieved by Peru as a country, as well as the actual challenges that faces Peru in the development of giftedness and talent in multicultural and poverty conditions, at the conceptualization, identification, and program levels are presented. Moreover, an economic and viable project of advocacy on the development of giftedness in Peru within the regular educational system along Elementary, Secondary and College level is presented. Finally, conclusions and recommendations for the development of state policies in order to promote giftedness in Peru are presented. Se analizan las definiciones actuales sobre el talento y la sobredotación, con énfasis en la variable motivación, presentándose diferentes posturas sobre la influencia de la motivación en la génesis de la sobredotación y en el desarrollo del talento. Posteriormente se analiza la influencia de la motivación en el desempe o sobresaliente, en el bajo rendimiento, así como en el desarrollo socioemocional del sobredotado. Se presenta una visión panorámica de los logros y desafíos del Perú en el desarrollo del talento y la sobredotación, a nivel de conceptualización, identificación e intervención en contextos multiculturales y de pobreza. Se propone un proyecto económico y viable de fomento al desarrollo del talento en el Perú dentro del sistema educativo regular, a lo largo de los tres niveles educativos: primaria, secundaria y terciaria. Finalmente, se incluyen conclusiones y recomendaciones para el desarrollo de políticas de estado de fomento al talento en el Perú.
El desarrollo de las habilidades cognitivas según los avances en las teorías psicológicas
Sheyla Blumen
Revista de Psicología , 1997,
Abstract: Se presentan los modelos más representativos del desarrollo cognitivo según los avances en las teorías psicológicas. Luego se realiza un breve análisis de los modelos en función a seis factores relacionados con diferentes áreas de la psicología y las ciencias sociales (importancia de cada etapa, procesos, conocimiento, diferencias individuales, contexto y limitaciones en el desarrollo cognitivo). Finalmente se presenta una propuesta de integración de los modelos actuales del desarrollo cognitivo desarrollado por Sincoff y Sternberg (1989)
Reiter, S. (2008). Disability from a humanistic perspective: Towards a better quality of life. Nueva York: Nova Biomedical Books. 237 p. (ISBN 978-1-60456-412-9).
Sheyla Blumen
Revista de Psicología , 2009,
Abstract: La rese a no contiene resumen.
Introducción al número especial en creatividad, talento y sobredotación
Sheyla Blumen
Revista de Psicología , 2008,
Abstract: La introducción no presenta resumen.
Topological invariants of three-manifolds from U_q(osp(1|2n))
Sacha Blumen
Mathematics , 2002,
Abstract: We create Resthetikhin-Turaev topological invariants of closed orientable three-manifolds from the quantum supergroup U_q(osp(1|2n)) at certain even roots of unity. To construct the invariants we develop tensor product theorems for finite dimensional modules of U_q(osp(1|2n)) at roots of unity.
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