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Search Results: 1 - 10 of 155581 matches for " Stephen F. Garczynski "
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Sex Pheromone Receptor Specificity in the European Corn Borer Moth, Ostrinia nubilalis
Kevin W. Wanner,Andrew S. Nichols,Jean E. Allen,Peggy L. Bunger,Stephen F. Garczynski,Charles E. Linn Jr.,Hugh M. Robertson,Charles W. Luetje
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008685
Abstract: The European corn borer (ECB), Ostrinia nubilalis (Hubner), exists as two separate sex pheromone races. ECB(Z) females produce a 97:3 blend of Z11- and E11-tetradecenyl acetate whereas ECB(E) females produce an opposite 1:99 ratio of the Z and E isomers. Males of each race respond specifically to their conspecific female's blend. A closely related species, the Asian corn borer (ACB), O. furnacalis, uses a 3:2 blend of Z12- and E12-tetradecenyl acetate, and is believed to have evolved from an ECB-like ancestor. To further knowledge of the molecular mechanisms of pheromone detection and its evolution among closely related species we identified and characterized sex pheromone receptors from ECB(Z).
Moth Sex Pheromone Receptors and Deceitful Parapheromones
Pingxi Xu, Stephen F. Garczynski, Elizabeth Atungulu, Zainulabeuddin Syed, Young-Moo Choo, Diogo M. Vidal, Caio H. L. Zitelli, Walter S. Leal
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041653
Abstract: The insect's olfactory system is so selective that male moths, for example, can discriminate female-produced sex pheromones from compounds with minimal structural modifications. Yet, there is an exception for this “lock-and-key” tight selectivity. Formate analogs can be used as replacement for less chemically stable, long-chain aldehyde pheromones, because male moths respond physiologically and behaviorally to these parapheromones. However, it remained hitherto unknown how formate analogs interact with aldehyde-sensitive odorant receptors (ORs). Neuronal responses to semiochemicals were investigated with single sensillum recordings. Odorant receptors (ORs) were cloned using degenerate primers, and tested with the Xenopus oocyte expression system. Quality, relative quantity, and purity of samples were evaluated by gas chromatography and gas chromatography-mass spectrometry. We identified olfactory receptor neurons (ORNs) housed in trichoid sensilla on the antennae of male navel orangeworm that responded equally to the main constituent of the sex pheromone, (11Z,13Z)-hexadecadienal (Z11Z13-16Ald), and its formate analog, (9Z,11Z)-tetradecen-1-yl formate (Z9Z11-14OFor). We cloned an odorant receptor co-receptor (Orco) and aldehyde-sensitive ORs from the navel orangeworm, one of which (AtraOR1) was expressed specifically in male antennae. AtraOR1?AtraOrco-expressing oocytes responded mainly to Z11Z13-16Ald, with moderate sensitivity to another component of the sex pheromone, (11Z,13Z)-hexadecadien-1-ol. Surprisingly, this receptor was more sensitive to the related formate than to the natural sex pheromone. A pheromone receptor from Heliothis virescens, HR13 ( = HvirOR13) showed a similar profile, with stronger responses elicited by a formate analog than to the natural sex pheromone, (11Z)-hexadecenal thus suggesting this might be a common feature of moth pheromone receptors.
Navigating the Updated Anaphylaxis Parameters
Stephen F Kemp
Allergy, Asthma & Clinical Immunology , 2007, DOI: 10.1186/1710-1492-3-2-40
Abstract: With the clear objective of improving the quality of patient care through the provision of evidencebased and consensus guidelines for anaphylaxis, "The Diagnosis and Management of Anaphylaxis: An Updated Practice Parameter" was developed by the Joint Task Force on Practice Parameters [1], which represents the American Academy of Allergy, Asthma and Immunology (AAAAI); the American College of Allergy, Asthma and Immunology (ACAAI); and the Joint Council of Allergy, Asthma and Immunology. This document updates and expands on its 1998 predecessor [2]. Because this effort involved many contributors, no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. The diagnosis and management of anaphylactic reactions must be individualized on the basis of unique features in particular patients.In keeping with this spirit, the following discussion focuses on material deemed to be substantively updated or changed from the 1998 parameters. Any discussion that may depart from consensus or reflect personal opinion is clearly designated.Anaphylaxis is not a reportable disease, and both its morbidity and mortality are probably underestimated. A variety of statistics on the epidemiology of anaphylaxis have been published, but the lifetime risk per person in the United States and Canada is presumed to be 1 to 3%, with a mortality rate of 1% [3-7].There is no universally accepted definition of anaphylaxis. Three proposed consensus definitions are presented. The World Allergy Organization, composed of 39 countries, proposed that older, traditional terminology, anaphylactic and anaphylactoid, be discarded in favour of immunologic and nonimmunologic anaphylaxis [8]. The Joint Task Force on Practice Parameters states, "Anaphylaxis is an acute lifethreatening reaction that results from the sudden systemic release of mast cells and basophil mediators. It has varied clinical present
A New Journal and a New Model for Structured Data Dissemination for an Era of Genomic Medicine
Stephen F. Kingsmore
Journal of Genomes and Exomes , 2012, DOI: 10.4137/JGE.S10090
Abstract: The Journal of Genomes and Exomes is a new, international, peer-reviewed, open-access, online publication. The Journal of Genomes and Exomes welcomes all structured reports of high quality genome, exome and gene panel sequences with attendant, detailed phenotypes. It also welcomes structured genotype-phenotype reports that confirm prior preliminary associations. It provides: – Open-access—freely accessible online, authors retain copyright – Fast publication times – Peer review by expert, practicing researchers – Post-publication tools to facilitate community-based meta-analysis for confirmation of genotype-phenotype relationships.
Minimal predictive see-saw model with normal neutrino mass hierarchy
King, Stephen F.
High Energy Physics - Phenomenology , 2013,
Abstract: We consider the type I see-saw model with two right-handed neutrinos and a normal neutrino mass hierarchy and impose a zero coupling between the right-handed neutrino mainly responsible for the atmospheric neutrino mass and the electron neutrino. We derive a master formula which relates see-saw input parameters in a one to one correspondence with physical neutrino observables. Using the master formula we search for simple ratios of couplings consistent with current data on neutrino mass and lepton mixing. We discover a minimal predictive example in which the right-handed neutrino mainly responsible for the atmospheric neutrino mass has couplings to (nu_e, nu_mu, nu_tau) proportional to (0,1,1) and the right-handed neutrino mainly responsible for the solar neutrino mass has couplings to (nu_e, nu_mu, nu_tau) proportional to (1,1,3) or (1,3,1), with a relative phase eta = -/+ pi/3, providing the link between leptogenesis and CP violation in neutrino oscillation experiments. We show how these patterns of couplings could arise from an A_4 family symmetry model of leptons which predicts all the PMNS parameters in terms of the neutrino mass ratio m_2/m_3, corresponding to approximate Tri-bimaximal-Cabibbo mixing, accurate to one degree, with the prediction delta = +/- pi/2.
Dynamical Electroweak Symmetry Breaking
Stephen F King
Physics , 1994, DOI: 10.1088/0034-4885/58/3/001
Abstract: We review the status of and recent developments in dynamical electroweak symmetry breaking, concentrating on the ideas of technicolour and top quark condensates. The emphasis is on the essential physical ideas and experimental implications rather than on detailed mathematical formalism.
Supersymmetric Higgs Bosons at the Limit
Stephen F. King
Physics , 1993,
Abstract: Using a combination of renormalisation group and effective potential methods, we discuss the bound on the lightest CP-even Higgs boson mass $m_h$ in the next-to-minimal supersymmetric standard model. We find $m_h\leq 146,139,149 \ GeV$ for $m_t=90,140,190 \ GeV$.
Low Scale Technicolour at LEP
Stephen F. King
Physics , 1993, DOI: 10.1016/0370-2693(93)91250-Q
Abstract: We discuss the phenomenology of an $SU(2)_{TC}$ technicolour model with a low technicolour confinement scale ${\Lambda}_{TC} \sim 50-100 GeV$. Such a low technicolour scale may give rise to the first hints of technicolour being seen at LEPI and spectacular technicolour signals at LEPII.
Determination of the strange form factors of the nucleon from $νp$, $\barν p$, and parity-violating $\vec{e}p$ elastic scattering
Stephen F. Pate
Physics , 2003, DOI: 10.1103/PhysRevLett.92.082002
Abstract: A new method of obtaining the strange form factors of the nucleon is presented, in which forward-angle parity-violating $\vec{e}p$ elastic scattering data is combined with $\nu p$ and $\bar{\nu} p$ elastic scattering data. The axial form factor in electron-nucleon scattering is complicated by the presence of electro-weak radiative corrections that in principle need to be calculated or separately measured, but this axial form factor is suppressed at forward angles. The neutrino data has no such complication. Hence the use of forward-angle parity-violating $\vec{e}p$ data with $\nu p$ and $\bar{\nu} p$ data allows the extraction of all three strange form factors: electric, magnetic and axial ($G_E^s$, $G_M^s$, and $G_A^s$). In this letter, $\nu p$ and $\bar{\nu} p$ data from the Brookhaven E734 experiment are combined with the Jefferson Lab HAPPEX $\vec{e}p$ data to obtain two distinct solutions for the strange form factors at $Q^2$ = 0.5 GeV$^2$. More generally, combining the neutrino elastic scattering data from E734 with the existing and upcoming $\vec{e}p$ data will yield the strange form factors of the nucleon for $Q^2$ of 0.45-1.05 GeV$^2$. Measurement of $G_A^s$ is crucial to the determination of the strange quark contribution to the nucleon spin, $\Delta s$.
Threebranes in twelve dimensions
Stephen F. Hewson
Physics , 1998,
Abstract: In this note we discuss the theory of super-threebranes in a spacetime of signature (10,2). Upon reduction, the threebrane provides us with the classical representations of the M-2-brane and the type IIB superstring. Many features of the original super (2+2)-brane theory are clarified. In particular, the (10,2) superspace and the spinors required to construct the brane action are discussed.
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