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Search Results: 1 - 10 of 229752 matches for " Stephen C. Bronack "
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A Virtual World for Collaboration: The AETZone
Amelia W. Cheney,Robert L. Sanders,Nita J. Matzen,Stephen C. Bronack
Themes in Science and Technology Education , 2009,
Abstract: Participation in learning communities, and the construction of knowledge in communities ofpractice, are important considerations in the use of 3D immersive worlds. This article describesthe creation of this type of learning environment in AETZone, an immersive virtualenvironment in use within graduate programs at Appalachian State University since 2000.Both student and faculty perceptions of elements such as presence, co-presence, and the forgingof active community are presented, along with examples of formal and informal activitieswhich serve as the base for teaching and learning in the Zone.
Rapid Detection Tool for Vancomycin-Resistant Enterococcus (VRE) Directly from Human Specimens  [PDF]
Stephen C. Edberg
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.412092

A new, simple, and one-step tool for the direct detection of vancomycin-resistant Enterocococcus (VRE) EPI-V® (Pilots Point LLC, Sarasota, FL) is presented. It contains all the ingredients in a unique stable powder form in a standard test tube. One only needs to add water, inoculate the specimen, and incubate. Specimens consisted of 553 sequential human rectal/perirectal swabs for VRE surveillance. The presence of VRE was denoted by the production of two sequential color changes corresponding to growth in bile-esculin and production of a positive PYR reaction. The EPI-V® tool was compared to reference VRE detection methods. EPI-V® showed a sensitivity of  102% and a specificity of 98.4% for the detection of VRE. The EPI-V® tool offers significant advantages: no skilled technologist time required, simple quality control, highly conserved incubator and refrigerator space, and low cost.

A New Epidemiological Tool for Staphylococcus aureus Surveillance  [PDF]
Stephen C. Edberg, J. Michael Miller
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.413102
Abstract: Epidemiological surveillance for microbes is currently based on either agar culture followed by identification, or genetic amplification. Both techniques are highly skilled-labor intensive, costly, and must be done in central laboratories. The Defined Substrate Utilization® (DSU®) format provides an epidemiological series of specific screening formulations that obviate these limitations. All reagents are present in optimized stable powder form in a test tube—add water, inoculate, and incubate. A specific color change provides a sensitive and specific detection of the target microbe. Two DSU® methods for Staphylococcus aureus (S. aureus) are presented: aureusAlert® for all S. aureus and EPI-M® for methicillin-resistant S. aureus (MRSA). Both aureusAlert
Morphants: A New Systematic Vertebrate Functional Genomics Approach
Stephen C. Ekker
Comparative and Functional Genomics , 2000, DOI: 10.1002/1097-0061(200012)17:4<302::aid-yea53>3.0.co;2-#
Abstract: The vertebrate genome contains a predicted 50 000 100 000 genes, many of unknown function. The recent development of morpholino-based gene knock-down technology in zebrafish has opened the door to the genome-wide assignment of function based on sequence in a model vertebrate. This review describes technical aspects of morpholino use for functional genomics applications, including the potential for multigene targeting and known methodological limitations. The result of successful gene inactivation by this agent is proposed to yield embryos with a ‘morphant’ phenotypic designation. The establishment of a morphant database opens the door to true functional genomics using the vertebrate, Danio rerio.
Welcome to Fibers—A New Open Access Journal for Fibrous Material Science
Stephen C. Bondy
Fibers , 2013, DOI: 10.3390/fib1010001
Abstract: Fibers are materials in the form of elongated threads. They can possess elastic features that are relevant to the integrity and bonding of cells. These features also give man-made fibers a wide range of applications. The large ratio of length to width (aspect ratio), which defines fibers, strongly influences their physical and chemical properties. This quality gives them a relatively large surface area, which can lead to powerful tensile and absorptive characteristics, which are remarkably different from, and cannot be predicted by study of the non-fibrous parent materials. An example of this is asbestos, where the toxicity of the material is heavily influenced by its structural anatomy. Distinctive chemical processes can take place on fibrous surfaces that may themselves seem to be chemically inert. Certain commonalities result from the distinctive geometry of fibers, and lie behind the apparently great diversity of fiber types and materials. [...]
Nanoparticles and Colloids as Contributing Factors in Neurodegenerative Disease
Stephen C. Bondy
International Journal of Environmental Research and Public Health , 2011, DOI: 10.3390/ijerph8062200
Abstract: This review explores the processes underlying the deleterious effects of the presence of insoluble or colloidal depositions within the central nervous system. These materials are chemically unreactive and can have a prolonged residence in the brain. They can be composed of mineral or proteinaceous materials of intrinsic or exogenous origin. Such nanoparticulates and colloids are associated with a range of slow-progressing neurodegenerative states. The potential common basis of toxicity of these materials is discussed. A shared feature of these disorders involves the appearance of deleterious inflammatory changes in the CNS. This may be due to extended and ineffective immune responses. Another aspect is the presence of excess levels of reactive oxygen species within the brain. In addition with their induction by inflammatory events, these may be further heightened by the presence of redox active transition metals to the large surface area afforded by nanoparticles and amphipathic micelles.
Planning and managing the physician workforce
Stephen C Schoenbaum
Israel Journal of Health Policy Research , 2012, DOI: 10.1186/2045-4015-1-14
Abstract: This is a commentary on http://www.ijhpr.org/content/1/1/13 webcite.In any country the ability of persons to get the health care services they need depends upon the size, composition, and accessibility of that country's health care workforce and health care facilities. The country's supply of physicians is a subset of the overall health care workforce. In turn, the supplies of specific types of physician generalists and specialists are subdivisions of the total physician supply. Furthermore, within countries there tends to be large geographic variation in the distribution of the various elements of the health care workforce, which affects accessibility of services or certain types of services.It appears that each of the abovementioned issues is relevant in Israel. Recently, to address an apparent shortage of domestically trained and retained physicians, medical schools have been increasing their class sizes, and a new medical school has opened for the first time since 1974. There has also been concern that new graduates of Israeli medical schools are not choosing to train in fields such as internal medicine, general surgery, and anesthesiology, and concern about the tendency of physicians to locate centrally within the country rather than in the periphery. It is in that context that Weissman et al. have surveyed fifth year medical students, studied medical specialty considerations at that stage of their training, and pointed out the opportunity to influence their specialty considerations in the early stages of clinical training [1].Workforce assessment and planning efforts are complex. Although the issues I present below are generally applicable to developed countries, my examples come primarily from the United States. Within the U.S., workforce assessment and planning efforts are not only complex but highly controversial and sometimes politically sensitive. The controversies relate to the data sources, the methods of analysis, and whether approaches to addressing w
Child PIP: Making mortality meaningful by using a structured mortality review process to improve the quality of care that children receive in the South African health system
M Patrick, C Stephen
South African Journal of Child Health , 2008,
Abstract: The Child Healthcare Problem Identification Programme (Child PIP) uses the mortality review process to assess the quality of care that children receive in the South African health system, and to suggest solutions for improvement. This paper describes the origins, growth and development of Child PIP over the last 5 years, and provides an overview of the findings and recommendations to date. South African Journal of Child Health Vol. 2 (2) 2008: pp. 38-43
第四纪研究 , 1992,
Abstract: 山岳冰川是气候变化的灵敏标志,其沉积物是一种不同时间幅度冰川进退规模和持续时间的潜在信息源。大陆冰盖对于气候变化的响应所需时间比温带小规模山岳冰川长,以致山岳冰川更适合于建立气候变化的时间序列。可是大部分山岳冰川变化时间序列的建立经常是运用相对的测年技术,即着眼于冰川序列,这是由于在很多地方缺乏适合放射测年的有机质或火山岩。最适合于取得放射性年龄控制的地区多数位于环太平洋地区,那
Hamiltonian Flows of Curves in G/SO(N) and Vector Soliton Equations of mKdV and Sine-Gordon Type
Stephen C. Anco
Symmetry, Integrability and Geometry : Methods and Applications , 2006,
Abstract: The bi-Hamiltonian structure of the two known vector generalizations of the mKdV hierarchy of soliton equations is derived in a geometrical fashion from flows of non-stretching curves in Riemannian symmetric spaces G/SO(N). These spaces are exhausted by the Lie groups G = SO(N+1),SU(N). The derivation of the bi-Hamiltonian structure uses a parallel frame and connection along the curve, tied to a zero curvature Maurer-Cartan form on G, and this yields the mKdV recursion operators in a geometric vectorial form. The kernel of these recursion operators is shown to yield two hyperbolic vector generalizations of the sine-Gordon equation. The corresponding geometric curve flows in the hierarchies are described in an explicit form, given by wave map equations and mKdV analogs of Schr dinger map equations.
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