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Search Results: 1 - 10 of 263931 matches for " Stephanie C. Wu "
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A Growing Troubling Triad: Diabetes, Aging, and Falls
Ryan T. Crews,Sai V. Yalla,Adam E. Fleischer,Stephanie C. Wu
Journal of Aging Research , 2013, DOI: 10.1155/2013/342650
A Growing Troubling Triad: Diabetes, Aging, and Falls
Ryan T. Crews,Sai V. Yalla,Adam E. Fleischer,Stephanie C. Wu
Journal of Aging Research , 2013, DOI: 10.1155/2013/342650
Abstract: There is a significant and troubling link between diabetes (DM) and falls in the elderly. Individuals with DM are prone to fall for reasons such as decreased sensorimotor function, musculoskeletal/neuromuscular deficits, foot and body pain, pharmacological complications, and specialty (offloading) footwear devices. Additionally, there is some concern that DM patients are prone to have more severe problems with falls than non-DM individuals. Fractures, poorer rehabilitation, and increased number of falls are all concerns. Fortunately, efforts to mitigate falls by DM patients show promise. A number of studies have shown that balance, strength, and gait training may be utilized to successfully reduce fall risk in this population. Furthermore, new technologies such as virtual reality proprioceptive training may be able to provide this reduced risk within a safe training environment. 1. Introduction From 2000 to 2010 the elderly (65+ years) population in the USA has continued its upward trend, increasing by 5.25 million (15%) to a total of 40.26 million [1]. This amounts to 13% of the entire population [1]. Thanks to the aging baby boomers population, by the year 2050 the elderly population is expected to reach 88.5 million, which would represent 20% of the total population [2]. One of the greatest health challenges facing this population is falls. In 2000 there were a reported 10,300 fatal falls by the elderly in the USA that incurred $179 million in direct medical costs [3]. There were an additional 2.6 million medically treated falls that cost $19 billion in medical costs. Other western nations report similar significant burdens with the United Kingdom reporting £981 million (US $1.9 billion) in costs for falls in those 60 or more years old in 1999 [4], and in 2001 the annual cost of care attributable to falls in those 65 or older in Australia was $86.4 million (US $66.1 million) [5]. While the cause of falls is often multifactorial, diabetes mellitus (DM) has been shown to be a significant factor. The significance of the relationship between aging, DM, and falls has been highlighted by previous work that found the annual incidence of falls in elderly individuals with DM to be 39% [6]. This paper will review the association of fall occurrence and diabetes, the association of fall severity and diabetes, and efforts to limit diabetes associated risks for falls. 2. Association between Diabetes and Falls Falls are a major concern for elderly adults with DM [7]. The high prevalence of falls in ambulatory elderly individuals with DM is well established with
Behavioral and Histopathological Assessment of Adult Ischemic Rat Brains after Intracerebral Transplantation of NSI-566RSC Cell Lines
Naoki Tajiri, David M. Quach, Yuji Kaneko, Stephanie Wu, David Lee, Tina Lam, Ken L. Hayama, Thomas G. Hazel, Karl Johe, Michael C. Wu, Cesar V. Borlongan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091408
Abstract: Stroke is a major cause of death and disability, with very limited treatment option. Cell-based therapies have emerged as potential treatments for stroke. Indeed, studies have shown that transplantation of neural stem cells (NSCs) exerts functional benefits in stroke models. However, graft survival and integration with the host remain pressing concerns with cell-based treatments. The current study set out to investigate those very issues using a human NSC line, NSI-566RSC, in a rat model of ischemic stroke induced by transient occlusion of the middle cerebral artery. Seven days after stroke surgery, those animals that showed significant motor and neurological impairments were randomly assigned to receive NSI-566RSC intracerebral transplants at two sites within the striatum at three different doses: group A (0 cells/μl), group B (5,000 cells/μl), group C (10,000 cells/μl), and group D (20,000 cells/μl). Weekly behavioral tests, starting at seven days and continued up to 8 weeks after transplantation, revealed dose-dependent recovery from both motor and neurological deficits in transplanted stroke animals. Eight weeks after cell transplantation, immunohistochemical investigations via hematoxylin and eosin staining revealed infarct size was similar across all groups. To identify the cell graft, and estimate volume, immunohistochemistry was performed using two human-specific antibodies: one to detect all human nuclei (HuNu), and another to detect human neuron-specific enolase (hNSE). Surviving cell grafts were confirmed in 10/10 animals of group B, 9/10 group C, and 9/10 in group D. hNSE and HuNu staining revealed similar graft volume estimates in transplanted stroke animals. hNSE-immunoreactive fibers were also present within the corpus callosum, coursing in parallel with host tracts, suggesting a propensity to follow established neuroanatomical features. Despite absence of reduction in infarct volume, NSI-566RSC transplantation produced behavioral improvements possibly via robust engraftment and neuronal differentiation, supporting the use of this NSC line for stroke therapy.
A palpable tender abdominal mass in a patient with endocarditis on antibiotics for 5 weeks  [PDF]
Stephanie L. Smeltzer, Lourdes C. Corman
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.21016

Mycotic aneurysms are a rare finding in the post-antibiotic era but must still be considered as a cause of abdominal pain in a patient with endocarditis. We present a case of a 47-year-old man with a history of IV drug use and a prior episode of endocarditis who developed a mycotic aneurysm while hospitalized on IV antibiotic therapy for aortic valve endocarditis. Due to their life-threatening character and often lack of evident clinical picture, mycotic aneurysms should still remain in high suspicion for a patient with abdominal pain in the setting of endocarditis.

Case report: Rhabdomyolysis in the setting of acute human immunodeficiency virus infection  [PDF]
Jason C. Huang, Stephanie Gold, Kathleen A. McManus, Brian Wispelwey
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.23054

Acute HIV infection (AHI) is often marked by nonspecific and vague complaints, which make detection difficult. An 18-year-old man presented with one week history of subjective fevers with chills, nonproductive cough and generalized body aches. He was found to have rhabdomyolysis due to AHI. This report adds the most thoroughly investigated case of AHI-associated rhabdomyolysis to date, having ruled out erlichia, legionella, parainfluenza, adenovirus, enterovirus, metapneumovirus, RSV and DILS.

Technology and engineering to support work with refugees
Stephanie Hunt,Geoffrey C Orsak
Forced Migration Review , 2011,
Abstract: New partnerships are being forged to encourage young engineers to use their skills in the service of refugees.
Convergence of SDP hierarchies for polynomial optimization on the hypersphere
Andrew C. Doherty,Stephanie Wehner
Mathematics , 2012,
Abstract: We show how to bound the accuracy of a family of semi-definite programming relaxations for the problem of polynomial optimization on the hypersphere. Our method is inspired by a set of results from quantum information known as quantum de Finetti theorems. In particular, we prove a de Finetti theorem for a special class of real symmetric matrices to establish the existence of approximate representing measures for moment matrix relaxations.
Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes
Ji-Dong Fu,Stephanie N. Rushing,Deborah K. Lieu,Camie W. Chan,Chi-Wing Kong,Lin Geng,Kitchener D. Wilson,Nipavan Chiamvimonvat,Kenneth R. Boheler,Joseph C. Wu,Gordon Keller,Roger J. Hajjar,Ronald A. Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0027417
Abstract: MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain elusive.
The twisted path from farm subsidies to health care expenditures  [PDF]
Stephanie Bernell
Health (Health) , 2012, DOI: 10.4236/health.2012.412A216

Overweight and obese individuals are at increased risk for many diseases and health conditions, including but not limited to the following: hypertension; osteoarthritis; dyslipidemia; type 2 diabetes; coronary heart disease and stroke. Consequently, individuals who are obese are more likely to use health services and are more likely to use costly health services than non-obese individuals. Between 1987 and 2001, growth in obesity related health expenditures accounted for 27 percent of the growth in inflation-adjusted per capita health care spending. Researchers, popular press and the television news media have paid considerable attention to the effect that farm subsidies have on dietary habits and obesity. Prominent researchers in the field have concluded that US farm subsidies have had a negligible impact on obesity. However, even small increases in obesity rates are associated with higher health care expenditures. The primary intent of this study is to break down the linkages from farm subsidy to health expenditure and shed light on the unintended implications of the farm subsidy program. We find that agricultural subsidies have the potential to influence health care expenditures.

Action-oriented obesity counseling attains weight stabilization and improves liver enzymes among overweight and obese children and adolescents  [PDF]
Allison C. Sylvetsky, Jean A. Welsh, Stephanie M. Walsh, Miriam B. Vos
Open Journal of Pediatrics (OJPed) , 2012, DOI: 10.4236/ojped.2012.23037
Abstract: Introduction: Pediatricians are encouraged to promote behavior modification to reduce childhood obesity and its co-morbidities, yet the effectiveness of office counseling is unclear. We aimed to evaluate if a low-intensity intervention (action-oriented counseling) in a clinic setting results in weight stabilization, and if the effect is modified by a diagnosis of non-alcoholic fatty liver disease (NAFLD). We hypothesized that patients with NAFLD would be more motivated to adhere to the lifestyle goals set in clinic, due to the diagnosis of an obesity-related condition; and, would therefore achieve greater weight reduction compared to similarly overweight and obese patients without a diagnosis of NAFLD. Methods: A retrospective chart review was conducted on 73 (35 male, 38 female) overweight and obese patients (BMI ≥ 85th percentile) attending a pediatric GI clinic between January 2006 and October 2011. Analysis was conducted to determine if lifestyle goals discussed with the patient at each clinic visit were associated with improved BMI, BMI z-score, and liver enzymes. Treatment outcomes among NAFLD patients and similarly obese patients without NAFLD were compared using t-tests and chi-square tests. Results: Of the children evaluated, 74.0% achieved a reduction or stabilization in BMI z-score after 3 months of follow-up. Among NAFLD patients, liver enzymes improved in 72% of those who were able to stabilize or reduce their BMI and among 43% of those who gained weight. Treatment outcome did not significantly differ based on having a diagnosis of NAFLD, although there was a trend towards greater improvements. Conclusion: Our study suggests that action oriented counseling including goal-setting in a low intensity, clinic based approach is effective in improving patient BMI, in the presence or absence of an obesity-related co-morbidity, such as NAFLD. Further, we demonstrated that lifestyle modification led to improvement of liver enzymes in NAFLD patients and may result in other clinically relevant improvements. Longer studies will be needed to determine if the improvements are sustained.
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