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Search Results: 1 - 10 of 3502 matches for " Stephan Lingner "
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J. Loomis, G. Helfand: Environmental policy analysis for decision making
Stephan Lingner
Poiesis & Praxis , 2004, DOI: 10.1007/s10202-003-0040-7
Science, interdisciplinarity, and the society
Stephan Lingner
Poiesis & Praxis , 2011, DOI: 10.1007/s10202-011-0092-z
Pablo C. Benítez-Ponce: Essays on the economics of forestry-based carbon mitigation
Stephan Lingner
Poiesis & Praxis , 2006, DOI: 10.1007/s10202-005-0004-1
O. Renn, P.-J. Schweizer, M. Dreyer, A. Klinke: Risiko. über den gesellschaftlichen Umgang mit Unsicherheit
Stephan Lingner
Poiesis & Praxis , 2009, DOI: 10.1007/s10202-009-0071-9
Legitimacy of tolerating limited environmental pollution? The case for natural attenuation
Stephan Lingner
Poiesis & Praxis , 2003, DOI: 10.1007/s10202-003-0038-1
Abstract: Degradations of environmental quality often pose severe harms or at least adverse effects to individuals and societies. Perceiving any environmental pollution thus appears to be connected with an implicit claim for its prompt and complete removal. For example, the oil-spill from the "Prestige" accident at the western Spanish shoreline is surely still in everyone's mind, where—in a somewhat Sysiphos-effort—a lot of helpers tried to remove the huge masses of oil mud, washed repeatedly ashore. However, alternative rehabilitation conceptions are also conceivable for certain pollution problems, which may be less unhealthy and possibly more efficient. Among them, taking advantage of natural occurring processes, which are grouped in this context as "natural attenuation" (NA), is an emerging and challenging but possibly also a questionable approach. NA as remediation strategy is, therefore, often discussed controversially among experts and actors as well as in the public (Teutsch/Rügner 2000). This is partly due to still open scientific or technical questions but also due to legitimacy problems of natural attenuation on ethical and juridical levels (Steffens et al. 2002; Heinz 2002). Therefore, a balanced view on adequate natural attenuation seems to be necessary. The following analysis will review NA as rehabilitation means from the normative perspective, giving some general statements—and thus orientation—for public policy making as well as for the administrative level.
Reflecting biomedical, technological and environmental issues of our modern society. The recent “Forum” section in Poiesis & Praxis
Stephan Lingner
Poiesis & Praxis , 2011, DOI: 10.1007/s10202-011-0097-7
Editors’ Note
Stephan Lingner,Katharina Mader
Poiesis & Praxis , 2012, DOI: 10.1007/s10202-012-0114-5
TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends
Verena Pfeiffer,Joachim Lingner
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002747
Abstract: The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telomeres. To study the mechanism of telomere length control by TERRA in Saccharomyces cerevisiae, we mapped the transcriptional start site of TERRA at telomere 1L and inserted a doxycycline regulatable promoter upstream. Induction of TERRA transcription led to telomere shortening of 1L but not of other chromosome ends. TERRA interacts with the Exo1-inhibiting Ku70/80 complex, and deletion of EXO1 but not MRE11 fully suppressed the TERRA–mediated short telomere phenotype in presence and absence of telomerase. Thus TERRA transcription facilitates the 5′-3′ nuclease activity of Exo1 at chromosome ends, providing a means to regulate the telomere shortening rate. Thereby, telomere transcription can regulate cellular lifespan through modulation of chromosome end processing activities.
Word correlation matrices for protein sequence analysis and remote homology detection
Thomas Lingner, Peter Meinicke
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-259
Abstract: In this work we present a novel kernel for protein sequences based on average word similarity between two sequences. We show that this kernel gives rise to a feature space that allows analysis of discriminative features and fast classification of new sequences. We demonstrate the performance of our approach on a widely-used benchmark setup for protein remote homology detection.Our word correlation approach provides highly competitive performance as compared with state-of-the-art methods for protein remote homology detection. The learned model is interpretable in terms of biologically meaningful features. In particular, analysis of discriminative words allows the identification of characteristic regions in biological sequences. Because of its high computational efficiency, our method can be applied to ranking of potential homologs in large databases.Advances in large-scale sequencing have led to a vast amount of protein sequences that have to be classified into structural and functional classes. Because experimental determination is time consuming and expensive, several computational methods based on sequence similarity were introduced to automatically annotate sequences by homology transfer. For close homologs, i.e. sequences with a similarity of more than 80% at the amino acid level, this can be done by pairwise comparison methods like the Smith-Waterman local alignment algorithm [1] or BLAST [2]. However, these methods often fail in cases where sequence similarity is low. In the so-called "twilight-zone", the detection of remote homologies still remains a challenging task in computational biology.Remote homology detection methods are often based on a statistical representation of protein families and can be divided into two major categories: first, profile-based methods provide a non-discriminative approach to family-specific representation of sequence properties. The corresponding generative models are usually trained using only known example sequences of the par
Disclosing conflicts of interest in German publications concerning health services research
Nils Schneider, Heidrun Lingner, Friedrich W Schwartz
BMC Health Services Research , 2007, DOI: 10.1186/1472-6963-7-78
Abstract: We performed a systematic literature search in the PubMed data base using the MeSH term "health services research". The review was conducted on July 10, 2006, setting the limits "dates: published in the last 2 years" and "languages: German" (only articles with abstracts). 124 articles in 31 magazines were found. In the magazines the instructions for authors were examined as to whether a statement on conflicts of interest is expected – and if, in which form. Regarding the articles in the journals which require a statement, we examined whether the statement is explicitly published. The results are descriptively represented.13 magazines (42%) do not require any statement on conflicts of interest, whereas 18 journals (58%) expect a statement. Two of these 18 magazines refer explicitly to the uniform requirements of the International Committee of the Medical Journal Editors (ICMJE); the remaining 16 magazines give differently accentuated instructions on how to disclose conflicts of interest, whereby the focus is primarily on financial issues. A statement on conflicts of interest is explicitly published in 11 of the 71 articles (15%) which are found in the magazines that require a statement with the submission of a manuscript. Related to the total number of included articles, this means that the reader explicitly receives information on potential conflicts of interest in 9% of the cases (11 of 124 articles). Statements of others that are involved in the publication process (reviewers, editors) are not available in any of the articles examined.A better sensitization for possible conflicts of interest in German publications concerning health services research is necessary. We suggest tightening the criteria for disclosure in the instructions for authors in the scientific journals. Among other things the equivalent consideration of financial and non-financial conflicts of interest as well as the obligatory publication of the statements should be part of good practice.The inf
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