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Search Results: 1 - 10 of 193925 matches for " Steffen G Jensen "
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aHUGIN: A System Creating Adaptive Causal Probabilistic Networks
Kristian G. Olesen,Steffen L. Lauritzen,Finn Verner Jensen
Computer Science , 2013,
Abstract: The paper describes aHUGIN, a tool for creating adaptive systems. aHUGIN is an extension of the HUGIN shell, and is based on the methods reported by Spiegelhalter and Lauritzen (1990a). The adaptive systems resulting from aHUGIN are able to adjust the C011ditional probabilities in the model. A short analysis of the adaptation task is given and the features of aHUGIN are described. Finally a session with experiments is reported and the results are discussed.
Evaluation of two commercial global miRNA expression profiling platforms for detection of less abundant miRNAs
Steffen G Jensen, Philippe Lamy, Mads H Rasmussen, Marie S Ostenfeld, Lars Dyrskj?t, Torben F ?rntoft, Claus L Andersen
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-435
Abstract: Using synthetic miRNA samples and plasma RNA samples spiked with different ratios of 174 synthetic miRNAs we assessed the performance characteristics reproducibility, recovery, specificity, sensitivity and linearity. It was found that while the qRT-PCR based platforms were sufficiently sensitive to reproducibly detect miRNAs at the abundance levels found in human plasma, the array based platform was not. At high miRNA levels both qRT-PCR based platforms performed well in terms of specificity, reproducibility and recovery. At low miRNA levels, as in plasma, the miRCURY platform showed better sensitivity and linearity than the TaqMan platform.For profiling clinical samples with low miRNA abundance, such as plasma samples, the miRCURY platform with its better sensitivity and linearity would probably be superior.microRNAs (miRNAs) are short 20-23 nucleotide long non-coding RNAs that are widely distributed in almost all eukaryotic organisms. They have multiple functions however the main function is believed to be post transcriptional regulation of protein levels [1,2]. While miRNAs are often abundant in tissues, the amount found circulating in body fluids such as plasma and serum is often limited. It has been reported that the total RNA level in plasma is in the range 6-300 ng/ml [3,4] and that the miRNA fraction constitutes only a few percent of this [5]. The mechanisms regulating secretion of miRNA into circulation is still unclear. Reports have shown that while endogenous miRNAs appear stable in plasma/serum exogenous miRNAs are not, and as a result of this it has been suggested that endogenous circulating miRNAs are either encapsulated in microvesicles or bound to RNA-binding proteins in complexes, e.g. Ago2 and NPM1, protecting them from degradation [6-8]. Detailed knowledge of the biological function of circulating miRNA does not exist, however it has been shown that vesicular miRNAs can be transferred from cell to cell and influence the behavior of the recipient c
Data Compaction - Compression without Decompression
Steffen G?rzig
Computer Science , 2014,
Abstract: Data compaction is a new approach for lossless and lossy compression of read-only array data. The biggest advantage over existing approaches is the possibility to access compressed data without any decompression. This makes data compaction most suitable for systems that could currently not apply compression techniques due to real-time or memory constraints. This is true for the majority of all computers, i.e. a wide range of embedded systems.
Fascia iliaca compartment block performed by junior registrars as a supplement to pre-operative analgesia for patients with hip fracture
Annette H gh,Lene Dremstrup,Steffen Skov Jensen,Jes Lindholt
Strategies in Trauma and Limb Reconstruction , 2008, DOI: 10.1007/s11751-008-0037-9
Abstract: This study investigate the efficacy of pre-operative pain treatment for patients with hip fractures using fascia lliaca compartment block (FIB) technique performed by junior registrars (JR) as a supplement to conventional pain treatment. The FIB technique has routinely been used pre-operatively in the emergency department since 1 January 2004 for all patients with hip fractures. Over an 8-month period, 187 patients were treated. FIB was performed with 40 ml lidocaine and bubivacaine. A simple 5-step verbal pain score and maximal passive hip flexion was used as objective and subjective pain measurements. Effect of FIB was prospectively assessed on 70 patients: 2/3 females, mean age 80.7 (SD = 7.8), 36% in ASA-group III and IV (95% CI, 0.25–0.48). The median pain-free hip flexion pre-block was 15° (SD = 17) this improved to a median of 28° (SD = 21) 15 min post-block (P = 0.014) and 37° (SD = 26) 60 min post-block (P = 0.030). The median simple verbal pain score (0–4) pre-block was 2.2 (SD = 0.92). This decreased to a median of 1.5 (SD = 0.78) 15 min post-block (P < 0.001) and 1.3 (SD = 0.71) 60 min post-block (P = 0.021). No side-effects were observed. There was no correlation between the number of FIB previously performed by the attending registrar and the improved maximal hip flexion (ρ = 0.090, P = 0.50) or reduction in subjective pain score (ρ = 0.005, P = 0.971). FIB performed by JR is a feasible, efficient pre-operative supplement to conventional pain-treatment for patients with hip fractures. FIB is easy to perform, requires minimal introduction, no expensive equipment and is connected with a minimal risk approach.
Solving a real-life large-scale energy management problem
Steffen Godskesen,Thomas Sejr Jensen,Niels Kjeldsen,Rune Larsen
Computer Science , 2010,
Abstract: This paper introduces a three-phase heuristic approach for a large-scale energy management and maintenance scheduling problem. The problem is concerned with scheduling maintenance and refueling for nuclear power plants up to five years into the future, while handling a number of scenarios for future demand and prices. The goal is to minimize the expected total production costs. The first phase of the heuristic solves a simplified constraint programming model of the problem, the second performs a local search, and the third handles overproduction in a greedy fashion. This work was initiated in the context of the ROADEF/EURO Challenge 2010, a competition organized jointly by the French Operational Research and Decision Support Society, the European Operational Research Society, and the European utility company Electricite de France. In the concluding phase of the competition our team ranked second in the junior category and sixth overall. After correcting an implementation bug in the program that was submitted for evaluation, our heuristic solves all ten real-life instances, and the solutions obtained are all within 2.45% of the currently best known solutions. The results given here would have ranked first in the original competition.
Influence of Forest Management on Acorn Production in the Southeastern Missouri Ozarks: Early Results of a Long-Term Ecosystem Experiment  [PDF]
Matthew G. Olson, Alexander J. Wolf, Randy G. Jensen
Open Journal of Forestry (OJF) , 2015, DOI: 10.4236/ojf.2015.55051
Abstract: Since acorn production is a foundational process of ecosystems dominated by oaks, understanding the impact of forest management practices on acorn production is critical to the sustainable management of oak forests. This investigation addressed the impact of even-aged management (EAM), uneven-aged management (UAM), and no-harvest management (NHM) on the production of mature, sound acorns over an 18-year period (1993-2010) of a long-term, landscape-scale forest management experiment in the Missouri Ozarks. Forest management impacts were investigated at two operational scales: the multi-stand compartment and the stand. We hypothesized that acorn production at both scales would be lower under active management (EAM and UAM) than NHM on these oak-dominated landscapes. Acorn production (acorns/ha/year) of red oaks (mainly black oak (Quercus velutina) and scarlet oak (Q. coccinea)) at the compartment level was lower under active management than NHM during the post-treatment period (1997-2010), but not for white oaks (mainly white oak (Q. alba) and post oak (Q. stellata)), which was largely a result of greater abundance and preferential harvesting of mature red oaks. At the stand scale, acorn production following either intermediate thinning or single-tree selection was comparable to yields observed in untreated stands suggesting that partial overstory removal can be implemented for harvesting timber and other silvicultural objectives without sacrificing acorn production. In many oak-dominated forests, active management will be necessary to mitigate future losses of acorn production driven by oak decline, succession, and climate change, including approaches for sustaining oak recruitment and acorn production.
HALLAZGO DE ADESMIA BIJUGA PHIL. (FABACEAE) EN LA ZONA COSTERA, REGION DEL MAULE, CHILE CENTRAL
Hahn,Steffen; Gómez,Persy;
Gayana. Botánica , 2008, DOI: 10.4067/S0717-66432008000100013
Abstract: this article reports the rediscovery of the specie adesmia bijuga phil. (fabaceae), in the coastal zone of the maule region (35°29'31" s - 72°22'47" w) in central chile. the population was found between two pinus radiata d.don plantations and species of the sclerophyllous shrub. its state of conservation is unknown.
HALLAZGO DE ADESMIA BIJUGA PHIL. (FABACEAE) EN LA ZONA COSTERA, REGION DEL MAULE, CHILE CENTRAL REDISCOVERY OF ADESMIA BIJUGA PHIL. (FABACEAE) IN THE COASTAL ZONE, MAULE REGION, CENTRAL CHILE
Steffen Hahn,Persy Gómez
Gayana. Botanica , 2008,
Abstract: This article reports the rediscovery of the specie Adesmia bijuga Phil. (Fabaceae), in the coastal zone of the Maule Region (35°29'31" S - 72°22'47" W) in central Chile. The population was found between two Pinus radiata D.Don plantations and species of the sclerophyllous shrub. Its state of conservation is unknown.
Nanomedicine: Techniques, Potentials, and Ethical Implications
Mette Ebbesen,Thomas G. Jensen
Journal of Biomedicine and Biotechnology , 2006, DOI: 10.1155/jbb/2006/51516
Abstract: Nanotechnology is concerned with materials and systems whose structures and components exhibit novel physical, chemical, and biological properties due to their nanoscale size. This paper focuses on what is known as nanomedicine, referring to the application of nanotechnology to medicine. We consider the use and potentials of emerging nanoscience techniques in medicine such as nanosurgery, tissue engineering, and targeted drug delivery, and we discuss the ethical questions that these techniques raise. The ethical considerations involved in nanomedicine are related to risk assessment in general, somatic-cell versus germline-cell therapy, the enhancement of human capabilities, research into human embryonic stem cells and the toxicity, uncontrolled function and self-assembly of nanoparticles. The ethical considerations associated with the application of nanotechnology to medicine have not been greatly discussed. This paper aims to balance clear ethical discussion and sound science and so provide nanotechnologists and biotechnologists with tools to assess ethical problems in nanomedicine.
A Simple Algorithm for Local Conversion of Pure States
Jens G Jensen,Ruediger Schack
Physics , 2000, DOI: 10.1103/PhysRevA.63.062303
Abstract: We describe an algorithm for converting one bipartite quantum state into another using only local operations and classical communication, which is much simpler than the original algorithm given by Nielsen [Phys. Rev. Lett. 83, 436 (1999)]. Our algorithm uses only a single measurement by one of the parties, followed by local unitary operations which are permutations in the local Schmidt bases.
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