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Search Results: 1 - 10 of 209547 matches for " Stefanie Lübberding "
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Compared Evaluation of Botulinum Toxin A and a Cosmetic Antiperspirant in the Treatment of Focal Axillary Hyperhidrosis  [PDF]
Meike Streker,Stefanie Lübberding,Martina Kerscher
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.33029
Abstract: Background: Primary focal hyperhidrosis can significantly reduce quality of life. Therefore a lot of treatment options in a range of conservative, physical and surgical techniques are available. Objective: To assess the efficacy of an antiperspirant containing aluminum chloride compared to a Botulinumtoxin A treatment for patients with primary focal hyperhidrosis. Methods and material: In this randomized, single-center, half-side trail, a clinical score was done by patients and physician to evaluate the severity of hyperhidrosis. Gravimetric tests were performed to gather the amount of sweat per unit of time. Furthermore the efficacy was determined using a four point questionnaire. Skin irritation was assessed by measuring pH value and transepidermal water loss. Results: A total of 22 patients were enrolled. Two weeks after baseline the hyperhidrosis level was significantly reduced (BTX-A: ﹣92.9%, AL: 66.7%). In addition both treatment options induced a significant reduction of sweat production (BTX-A: ﹣80.8%, AL: 68.8%). Please change in: Patients evaluated good resp, very good efficacy for both treatment options at day 28. pH value and TEWL never left physiological range. Conclusion: Both botulinum toxin A treatment and an antiperspirant containing aluminum chloride in the evaluated galenic formulation are an effective and safe treatment option for axillary focal hyperhidrosis.
Compared Evaluation of Botulinum Toxin A and a Cosmetic Antiperspirant in the Treatment of Focal Axillary Hyperhidrosis  [PDF]
Meike Streker, Stefanie Lübberding, Martina Kerscher
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.33029
Abstract:

Background: Primary focal hyperhidrosis can significantly reduce quality of life. Therefore a lot of treatment options in a range of conservative, physical and surgical techniques are available. Objective: To assess the efficacy of an antiperspirant containing aluminum chloride compared to a Botulinumtoxin A treatment for patients with primary focal hyperhidrosis. Methods and material: In this randomized, single-center, half-side trail, a clinical score was done by patients and physician to evaluate the severity of hyperhidrosis. Gravimetric tests were performed to gather the amount of sweat per unit of time. Furthermore the efficacy was determined using a four point questionnaire. Skin irritation was assessed by measuring pH value and transepidermal water loss. Results: A total of 22 patients were enrolled. Two weeks after baseline the hyperhidrosis level was significantly reduced (BTX-A: 92.9%, AL: 66.7%). In addition both treatment options induced a significant reduction of sweat production (BTX-A: 80.8%, AL: 68.8%). Please change in: Patients evaluated good resp, very good efficacy for both treatment options at day 28. pH value and TEWL never left physiological range. Conclusion: Both botulinum toxin A treatment and an antiperspirant containing aluminum chloride in the evaluated galenic formulation are an effective and safe treatment option for axillary focal hyperhidrosis.

Physical Activity Improves Mental Rotation Performance  [PDF]
Petra Jansen, Stefanie Pietsch
Creative Education (CE) , 2010, DOI: 10.4236/ce.2010.11009
Abstract: Even there seemed to be general knowledge that physical activity enhanced spatial cognitive performance almost none experimental studies on this influence exist. For that the influence of physical activity on mental rotation per-formance is investigated in this study. Mental rotation is the ability to imagine how an object would look if rotated away from the original orientation. Two groups of 44 students of educational science each solved a psychometrical mental rotation task with three-dimensional block figures. After this, the participants of the physical activity group took part in a sport lesson, whereas the participants of the cognitive activity group attended an oral lesson of kinematics. Both lessons took 45 minutes. Thereafter, all participants solved the mental rotation task again. The results showed that the participants of the physical activity group improved their mental rotation performance whereas the participants of the cognitive activity showed no improvement.
Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study
Erik Hohmann, Kevin Tetsworth, Stefanie Hohmann, Adam L Bryant
Journal of Orthopaedic Surgery and Research , 2010, DOI: 10.1186/1749-799x-5-93
Abstract: This study was designed as a prospective double blind randomized investigation. Five patients (treatment group) with a mean age of 66.2 (58-72), average BMI of 30.76 (24.3-35.3) received 50 mg nandrolone decanoate intramuscular bi-weekly for 6 months. The control group (five patients; mean age 65.2, range 59-72; average BMI 31.7, range 21.2-35.2) was injected with saline solution. "Pre-operatively" and "post-operatively" (6 weeks, 3,6,9 and 12 months) all patients were assessed using the knee society score (KSS), isokinetic strength testing and functional tests (a sit-to-stand and timed walking tests). In addition, a bone density scan was used preoperatively and 6 month postoperatively to assess bone mineral density.Whilst the steroid group generally performed better than the placebo group for all of the functional tests, ANOVA failed to reveal any significant differences. The steroid group demonstrated higher levels of quadriceps muscle strength across the postoperative period which reached significance at 3 (p = 0.02), 6 (p = 0.01), and 12 months (p = 0.02). There was a significant difference for the KSS at 6 weeks (p = 0.02), 6 (p = 0.02) and 12 month (p = 0.01). The steroid group demonstrated a reduction in the amount of bone mineral density at both the femur and lumbar spine from "pre-" to "post-surgery", however, these results did not reach significance (p < 0.05) using one-way ANOVA.This project strongly suggests that the use of anabolic steroids result in an improved outcome as assessed by the KSS and significantly increases extensor strength. No side effects were seen in either the study or control group.Regional Health District: Register No. 03.05Human Research Ethics Committee University: Clearance Number: 04/03-19Osteoarthritis of the knee is one of the leading causes of pain and disability for the knee [1]. Total joint replacement is generally accepted as the main treatment for end-stage osteoarthritis. In fact it has revolutionized the treatment of dis
The Effects of Fetal Surgery on Retinopathy of Prematurity Development
Sudha Nallasamy,Stefanie L. Davidson,Lori J. Howell,Holly Hedrick
Ophthalmology and Eye Diseases , 2009,
Abstract: Background: Fetal surgery is selectively offered for severe or life-threatening fetal malformations. These infants are often born prematurely and are thus at risk for retinopathy of prematurity (ROP). It is not known whether fetal surgery confers an increased risk of developing severe ROP relative to published rates in standard premature populations ≤37 weeks of age grouped by birth weight (
Language Development and Science Inquiry: The Head Start on Science and Communication Program
Evelyn R. Klein,Penny L. Hammrich,Stefanie Bloom,Anika Ragins
Early Childhood Research & Practice , 2000,
Abstract: There are ongoing discussions about the best way to teach science to young children during the preschool and early elementary school years. What practice is most likely to contribute to children's development and learning while cultivating exploration, questioning skills, and revision of thinking to accommodate new ideas in science? The Head Start on Science and Communication (HSSC) Program is based on collaborative research from the fields of science education and language development. Program objectives have been aligned with the curriculum and are based on the national science standards for young children. The HSSC Program evolved over four years of research and implementation at schools in Pennsylvania, New Jersey, and Washington, DC. The initial phase of the program included input from parents, teachers, and teaching assistants to help develop lessons and shape the inquiry-based strategies for young children learning about life science, earth science, and physical science. The second phase of the program incorporated curriculum materials and investigative experiments to promote inquiry-based, hands-on science as a vehicle for promoting young children's language development. Children learned to match, discriminate, categorize, sequence, and associate information as they worked with peers to understand science concepts, relate facts, and solve scientific problems. As a result of participating in the HSSC Program, teachers employed collaborative learning strategies, engaging in small-group problem-solving teams with verbal interactions among teachers and students. Outcomes also included positive changes in teachers' questioning strategies. Teachers became proficient in asking more open-ended questions at increasing levels of difficulty instead of basic factual and yes-no questions. Preliminary data from a study of 85 first-grade students who engaged in a series of 12 science experiments indicated that prior to the program, they answered an average of 58% of the factual-type questions correctly and 15% of the application-type questions correctly. After learning about topics such as earth surfaces, minerals, changing colors, seeds, and plants, these children answered the factual-type questions with 96% accuracy and the application-type questions with 92% accuracy, indicating a significant gain in knowledge beyond the p < .05 level for both types of questions. Students improved their knowledge of science concepts along with their ability to answer questions requiring higher-level cognitive skills. Teachers noted students' improved knowledge of science an
Jasmonate and ethylene dependent defence gene expression and suppression of fungal virulence factors: two essential mechanisms of Fusarium head blight resistance in wheat?
Gottwald Sven,Samans Birgit,Lück Stefanie,Friedt Wolfgang
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-369
Abstract: Background Fusarium head blight (FHB) caused by Fusarium species like F. graminearum is a devastating disease of wheat (Triticum aestivum) worldwide. Mycotoxins such as deoxynivalenol produced by the fungus affect plant and animal health, and cause significant reductions of grain yield and quality. Resistant varieties are the only effective way to control this disease, but the molecular events leading to FHB resistance are still poorly understood. Transcriptional profiling was conducted for the winter wheat cultivars Dream (moderately resistant) and Lynx (susceptible). The gene expressions at 32 and 72 h after inoculation with Fusarium were used to trace possible defence mechanisms and associated genes. A comparative qPCR was carried out for selected genes to analyse the respective expression patterns in the resistant cultivars Dream and Sumai 3 (Chinese spring wheat). Results Among 2,169 differentially expressed genes, two putative main defence mechanisms were found in the FHB-resistant Dream cultivar. Both are defined base on their specific mode of resistance. A non-specific mechanism was based on several defence genes probably induced by jasmonate and ethylene signalling, including lipid-transfer protein, thionin, defensin and GDSL-like lipase genes. Additionally, defence-related genes encoding jasmonate-regulated proteins were up-regulated in response to FHB. Another mechanism based on the targeted suppression of essential Fusarium virulence factors comprising proteases and mycotoxins was found to be an essential, induced defence of general relevance in wheat. Moreover, similar inductions upon fungal infection were frequently observed among FHB-responsive genes of both mechanisms in the cultivars Dream and Sumai 3. Conclusions Especially ABC transporter, UDP-glucosyltransferase, protease and protease inhibitor genes associated with the defence mechanism against fungal virulence factors are apparently active in different resistant genetic backgrounds, according to reports on other wheat cultivars and barley. This was further supported in our qPCR experiments on seven genes originating from this mechanism which revealed similar activities in the resistant cultivars Dream and Sumai 3. Finally, the combination of early-stage and steady-state induction was associated with resistance, while transcript induction generally occurred later and temporarily in the susceptible cultivars. The respective mechanisms are attractive for advanced studies aiming at new resistance and toxin management strategies.
Self-Care, Stress Management, and Primary Care: From Salutogenesis and Health Promotion to Mind-Body Medicine
Tobias Esch,Gregory L. Fricchione,Stefanie Joos,Michael Teut
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/327415
Abstract:
A Mid-Infrared Counterpart to the Magnetar 1E 2259+586
David L. Kaplan,Deepto Chakrabarty,Zhongxiang Wang,Stefanie Wachter
Physics , 2009, DOI: 10.1088/0004-637X/700/1/149
Abstract: We report the discovery of a 4.5 um counterpart to the anomalous X-ray pulsar (magnetar) 1E 2259+586 with the Spitzer Space Telescope. The mid-infrared flux density is 6.3+/-1.0 uJy at 4.5 um and <20 uJy (at 95% confidence) at 8 um, or 0.02% of the 2-10 keV X-ray flux (corrected for extinction). Combining our Spitzer measurements with previously published near-infrared data, we show that the overall infrared emission from 1E 2259+586 is qualitatively similar to that from the magnetar 4U 0142+61. Therefore the passive X-ray-heated dust disk model originally developed for 4U 0142+61 might also apply to 1E 2259+586. However, the IR data from this source can also be fitted by a simple power-law spectrum as might be expected from magnetospheric emission.
The UV Spectrum of the Ultra-compact X-ray Binary- 4U 1627-673
L. Homer,Scott F. Anderson,Stefanie Wachter,Bruce Margon
Physics , 2002, DOI: 10.1086/344600
Abstract: We have obtained Hubble Space Telescope/STIS low-resolution ultraviolet spectra of the X-ray pulsar 4U 1626-67 (=KZ TrA); 4U 1626-67 is unusual even among X-ray pulsars due to its ultra-short binary period (P=41.4 min) and remarkably low mass-function (<1.3e-6 Msun). The far-UV spectrum was exposed for a total of 32ks and has sufficient signal-to-noise to reveal numerous broad emission and prominent narrower absorption lines. Most of the absorption lines are consistent in strength with a purely interstellar origin. However, there is evidence that both CI and CIV require additional absorbing gas local to the system. In emission, the usual prominent lines of NV and HeII are absent, whilst both OIV and OV are relatively strong. We further identify a rarely seen feature at ~1660A as the OIII] multiplet. Our ultraviolet spectra therefore provide independent support for the recent suggestion that the mass donor is the chemically fractionated core of either a C-O-Ne or O-Ne-Mg white dwarf; this was put forward to explain the results of Chandra high-resolution X-ray spectroscopy. The velocity profiles of the ultraviolet lines are in all cases broad and/or flat-topped, or perhaps even double-peaked for the highest ionization cases of O; in either case the ultraviolet line profiles are in broad agreement with the Doppler pairs found in the X-ray spectra. Both the X-ray and far-UV lines are plausibly formed in (or in an corona just above) a Keplerian accretion disc; the combination of ultraviolet and X-ray spectral data may provide a rich data set for follow-on detailed models of the disk dynamics and ionization structure in this highly unusual low-mass X-ray pulsar system.
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