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Search Results: 1 - 10 of 145186 matches for " Stanley K. Brown "
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Resonance Control Cooling System for a Proto-Type Coupled Cavity Linac
Chrisine A. Treml,Stanley K. Brown,John D. Bernardin
Physics , 2001,
Abstract: Los Alamos National Laboratory (LANL) is designing a coupled cavity linac (CCL) for the Spallation Neutron Source (SNS) being built at Oak Ridge National Laboratory (ORNL). As part of the design process, a proto-type, Hot Model, consisting of two segments of the SNS CCL was manufactured and installed at LANL. An RF source was applied to the Hot Model to determine the success of the cavity design, the effectiveness of the control algorithms and cooling systems, and the validity of the Resonance Control Cooling System (RCCS) model used during the Hot Model design. From a system controls perspective, an overview of the hot model, a description of the RCCS, and the pertinent data from the RF tests will be presented.
Glomerular Filtration Rate Assessment Using Creatinine Related Parameters for Healthy Adult Kenyan Population
Stanley K. Waithaka
Asian Journal of Medical Sciences , 2010,
Abstract: The purpose of the study was to establish the reference ranges of measured creatinine clearance andestimated creatinine clearance for adult Kenyan population. A prospective study carried out in clinicalchemistry laboratory of Kenyatta National Hospital involving 265 healthy individuals between 18-60 years.Reference ranges were constructed by using the parametric methods to estimate 2.5 and 97.5 percentiles ofdistribution as lower and upper reference limits. The glomerular filtration rate assessment of the adult healthyKenyan population was carried out by investigating Serum Creatinine (SrCr), 24 h urine creatinine clearance(Mcrcl), estimated creatinine clearance (Ecrcl), Urine C reatinine (UC r) and Urine Volume (UV). Two hundredand sixty five voluntarily study subjects comprising of 106 male and 159 females were recruited in the study.Sex related reference values were established as follows: SrCr [male:68-128), female: 60-122] umol/l, Mcrcl[male:52-110), female: 50-92] ml/min, Ecrcl [male:54-118), female: 58-106] ml/min, UCr [male:3588-10,400,female:3262-9886] umol/l and UV [male:875-2301, female: 802-2092] ml/24 h. Same sex mean difference wasfound for the established reference ranges of M crcl and Ecrcl (male p = 0.021 and female p = 0.000).Decline rate in creatinine clearance in the ages under investigation were: male measured creatinine clearance(0.46 ml/min/year), male estimated creatinine clearance (0.29 ml/min), female measured creatinine clearance(0.39 ml/min/year) and female estimated creatinine clearance (0.2 ml/min). In conclusion, sex specific referenceranges for the assessment of glomerular filtration rate has been established. Age is an important factor in theinterpretation of creatinine clearance of an individual. These reference ranges are different from thosereported in literature, therefore each clinical chemistry laboratory should establish its own.
Competitive Coevolution through Evolutionary Complexification
R. Miikkulainen,K. O. Stanley
Computer Science , 2011, DOI: 10.1613/jair.1338
Abstract: Two major goals in machine learning are the discovery and improvement of solutions to complex problems. In this paper, we argue that complexification, i.e. the incremental elaboration of solutions through adding new structure, achieves both these goals. We demonstrate the power of complexification through the NeuroEvolution of Augmenting Topologies (NEAT) method, which evolves increasingly complex neural network architectures. NEAT is applied to an open-ended coevolutionary robot duel domain where robot controllers compete head to head. Because the robot duel domain supports a wide range of strategies, and because coevolution benefits from an escalating arms race, it serves as a suitable testbed for studying complexification. When compared to the evolution of networks with fixed structure, complexifying evolution discovers significantly more sophisticated strategies. The results suggest that in order to discover and improve complex solutions, evolution, and search in general, should be allowed to complexify as well as optimize.
Characterization of Campylobacter phages including analysis of host range by selected Campylobacter Penner serotypes
Vinni Hansen, Hanne Rosenquist, Dorte Baggesen, Stanley Brown, Bjarke Christensen
BMC Microbiology , 2007, DOI: 10.1186/1471-2180-7-90
Abstract: In this study, Campylobacter phages were isolated from the intestines of broilers and ducks and from abattoir sewage. Twelve phages were investigated to determine their ability to infect the Campylobacter Penner serotypes commonly present in Danish poultry and patients with campylobacteriosis. A total of 89% of the Campylobacter jejuni strains and 14% of the Campylobacter coli strains could be infected by at least one of the bacteriophages. The majority of the phages infected the most common serotypes in Danish broilers (O:1,44; O:2; O:4-complex), but showed limited ability to infect 21 of the less frequent Campylobacter serotypes. Pulse field gel electrophoresis (PFGE) and restriction endonuclease analysis (REA) were used to characterize the phage genomes. Three categories of bacteriophages were observed. I: a genome size of ~194 kb and refractory to digestion with HhaI; II: a genome size of ~140 kb and digestible by HhaI; and III: a genome size undeterminable in PFGE. The categorization of the phages correlated with the host range patterns displayed by the phages. Six phages were subjected to transmission electron microscopy (TEM). They all belonged to the family of Myoviridae.We have characterized and identified the host range of 12 Danish Campylobacter phages. Due to their ability to infect the majority of the common serotypes in Denmark we suggest the phages can become an effective agent in the effort to reduce the incidence of campylobacteriosis in Denmark. This study provides the basis for future experiments in Campylobacter phages and knowledge for the selection of Campylobacter phages for biocontrol in broilers.Campylobacter is a zoonotic pathogen naturally present in the gastrointestinal tract of many domestic animals and pets [1-4]. In Denmark and in many other developed countries, Campylobacter enteritis is the predominant food borne disease [3]. In Denmark, fresh poultry meat has been identified as the main risk factor for human campylobacteriosis [5].
Is the Urban Coyote a Misanthropic Synanthrope? The Case from Chicago
Stanley D. Gehrt,Justin L. Brown,Chris Anchor
Cities and the Environment , 2011,
Abstract: Coyotes appear to be one of the few mammalian carnivores that occur in urban areas, although their true relationship with urbanization remains poorly understood. We summarize results from a long-term study of the urban ecology of coyotes in the Chicago metropolitan area to determine the degree of synanthropy for this species and discuss the subsequent management implications for human-coyote conflicts. Local population densities were slightly higher, and survival rates for pups were five times higher compared to rural populations. In contrast to demographic patterns, behavioral responses to urbanization, including home range size, avoidance of developed land cover, activity budget, and diet, were not consistent with synanthropy, even for coyotes located in the urban matrix. We discuss the management implications of the paradoxical relationship coyotes have with people and cities.
Stability Puzzles in Phage Lambda
Erik Aurell,Stanley Brown,Johan Johanson,Kim Sneppen
Quantitative Biology , 2000,
Abstract: The lysogeny maintenance switch in phage lambda is one of the simplest examples on the molecular level of computation, command and control in a living system. If, following infection of the bacterium E. coli, the virus enters the lysogenic pathway, it represses its developmental functions, and integrates its DNA into the host chromosome. In this state the prophage may be passively replicated for many generations of E. coli. In fact, this repressed state is intrinsically more stable than the gene encoding the repressor. We develop a mathematical formalism to predict the stability of such epigenetic states from affinities of the molecular components. We apply the model to the behavior of recently published mutants at the right operator complex of lambda, and find that the reported stability indicates that the current view of the switch is incomplete. The approach described here should be generally applicable to the stability of expressed states
Univalence of normalized solutions of W ¢ € 3(z)+p(z)W(z)=0
R. K. Brown
International Journal of Mathematics and Mathematical Sciences , 1982, DOI: 10.1155/s0161171282000441
Abstract: Denote solutions of W ¢ € 3(z)+p(z)W(z)=0 by W ±(z)=z ±[1+ ¢ ‘n=1 ¢ anzn] and W 2(z)=z 2[1+ ¢ ‘n=1 ¢ bnzn], where 0< ¢ ( 2) ¢ ‰ ¤1/2 ¢ ‰ ¤ ¢ ( ±) and z2p(z) is holomorphic in |z|<1. We determine sufficient conditions on p(z) so that [W ±(z)]1/ ± and [W 2(z)]1/ 2 are univalent in |z|<1.
The public health implications of secondary measles vaccine failure
Ramsay M,Brown K
Journal of Primary Health Care , 2013,
John K. Brown
Essays in Economic & Business History , 1999,
Abstract: Standardization is a major theme in the literature of American industrial development with its focus on mass produced goods. By contrast, this artide considers the viability of standard product designs in three lines of batch produced capital goods — machine tools, steam locomotives, and stationary steam engines — from 1850 to 1925. Rigorous standardization could also offer notable advantages to builders of such heavy machinery. Yet it proved difficult to achieve largely because customers exerted a strong influence on design, blocking full product standardization. On the other hand, machinery makers found that true custom designs posed many production challenges. This article traces how American capital goods firms navigated between the conflicting demands of standard versus custom designs.
Kn?rrer Periodicity and Bott Periodicity
Michael K. Brown
Mathematics , 2015,
Abstract: The goal of this article is to explain a precise sense in which Kn\"orrer periodicity in commutative algebra and Bott periodicity in topological K-theory are compatible phenomena. Along the way, we prove an 8-periodic version of Kn\"orrer periodicity for real isolated hypersurface singularities, and we construct a homomorphism from the Grothendieck group of the homotopy category of matrix factorizations of a complex (real) polynomial $f$ into the topological K-theory of its Milnor fiber (positive or negative Milnor fiber).
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