oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 35 )

2018 ( 221 )

2017 ( 199 )

2016 ( 281 )

Custom range...

Search Results: 1 - 10 of 119307 matches for " Stacey T. Gray "
All listed articles are free for downloading (OA Articles)
Page 1 /119307
Display every page Item
Role of Osteoplastic Frontal Sinus Obliteration in the Era of Endoscopic Sinus Surgery
Joshua B. Silverman,Stacey T. Gray,Nicolas Y. Busaba
International Journal of Otolaryngology , 2012, DOI: 10.1155/2012/501896
Abstract: Objective. Determining the indications for osteoplastic frontal sinus obliteration (OFSO) for the treatment of inflammatory frontal sinus disease. Study Design. Retrospective case series from a single tertiary care facility. Methods. Thirty-four patients who underwent OFSO for chronic frontal sinusitis () and frontal sinus mucocele () comprised our study group. Data reviewed included demographics, history of prior frontal sinus operation(s), imaging, diagnosis, and operative complications. Results. The age range was 19 to 76 years. Seventy percent of patients with chronic frontal sinusitis underwent OFSO as a salvage surgery after previous frontal sinus surgery failures, while 30% underwent OFSO as a primary surgery. For those in whom OFSO was a salvage procedure, the failed surgeries were endoscopic approaches to the frontal sinus (69%), Lynch procedure (12%), and OFSO outside this study period (19%). For patients with frontal sinus mucocele, 72% had OFSO as a first-line surgery. Within the total study population, 15% of patients presented for OFSO with history of prior obliteration, with a range of 3 to 30 years between representations. Conclusions. Osteoplastic frontal sinus obliteration remains a key surgical treatment for chronic inflammatory frontal sinus disease both as a salvage procedure and first-line surgical therapy.
Role of Osteoplastic Frontal Sinus Obliteration in the Era of Endoscopic Sinus Surgery
Joshua B. Silverman,Stacey T. Gray,Nicolas Y. Busaba
International Journal of Otolaryngology , 2012, DOI: 10.1155/2012/501896
Abstract: Objective. Determining the indications for osteoplastic frontal sinus obliteration (OFSO) for the treatment of inflammatory frontal sinus disease. Study Design. Retrospective case series from a single tertiary care facility. Methods. Thirty-four patients who underwent OFSO for chronic frontal sinusitis ( ) and frontal sinus mucocele ( ) comprised our study group. Data reviewed included demographics, history of prior frontal sinus operation(s), imaging, diagnosis, and operative complications. Results. The age range was 19 to 76 years. Seventy percent of patients with chronic frontal sinusitis underwent OFSO as a salvage surgery after previous frontal sinus surgery failures, while 30% underwent OFSO as a primary surgery. For those in whom OFSO was a salvage procedure, the failed surgeries were endoscopic approaches to the frontal sinus (69%), Lynch procedure (12%), and OFSO outside this study period (19%). For patients with frontal sinus mucocele, 72% had OFSO as a first-line surgery. Within the total study population, 15% of patients presented for OFSO with history of prior obliteration, with a range of 3 to 30 years between representations. Conclusions. Osteoplastic frontal sinus obliteration remains a key surgical treatment for chronic inflammatory frontal sinus disease both as a salvage procedure and first-line surgical therapy. 1. Introduction Chronic frontal rhinosinusitis remains a highly prevalent disease with significant associated morbidity despite advances in pharmacology, physiology, and technology [1]. Current frontal sinus surgery has evolved to include minimally invasive endoscopic techniques in addition to more traditional open frontal sinus obliteration [2]. However, the proper utilization of each of these different techniques remains a controversial topic. The osteoplastic flap frontal sinus obliteration (OFSO) procedure popularized by Montgomery in the 1960s has historically been accepted as the gold standard for treatment of frontal sinus disease [2]. The main impetus for developing this technique was the high failure rate associated with earlier external techniques such as the Lynch and Lothrop procedures, which produced short-term patency rates up to 90% but failed at least an additional 20% over a seven-year follow-up period [2]. This led to the prevailing dogma in the otolaryngology specialty that trauma to the mucosa of the frontal recess inevitably leads to scarring and obstruction of the frontal sinus outflow tract. Hence, any surgical manipulation of the frontal recess was discouraged. Even though OFSO with fat obliteration
An Efficient Method for Generating Poxvirus Recombinants in the Absence of Selection
Amanda D. Rice,Stacey A. Gray,Yu Li,Inger Damon,Richard W. Moyer
Viruses , 2011, DOI: 10.3390/v3030217
Abstract: The use of selectable markers (ecogpt) and selection pressures to aid in detection of poxvirus (Vaccinia, VV) recombinants has been implicated in the unintended introduction of second site mutations. We have reinvestigated the use of the helper virus system described by Scheiflinger et al. [1] and adapted by Yao and Evans [2] which produces recombinants at a high frequency in the absence of any selection, at a rate of 6–100%. Our system uses fowlpox virus (FPV) as the infectious helper virus which in infected cells provides the enzymatic apparatus for transcription and replication of a purified, transfected VV genome and for recombination with a second transfected PCR generated DNA fragment. To optimize the system, a PCR DNA fragment was generated that contained poxvirus promoter driven gfp and lacZ genes inserted within the coding sequences of the viral thymidine kinase gene. This PCR fragment was co-transfected together with VV genomic DNA. Recombinant VV was identified by plaquing the mixture on cells non-permissive for FPV and selection of green fluorescent or LacZ positive recombinant vaccinia plaques. The system was optimized using FPV permissive cells (CEF) and non-permissive cells (A549, CV-1) for both the initial infection/transfection and the subsequent selection. Up to 70% of the progeny vaccinia virus contained the gfp/LacZ insertion. In order to test for the presence of FPV/VV intertypic recombinants or other unintended mutations, recombinant wtVV (RwtVV) was regenerated from the gfp/LacZ viruses and evaluated by RFLP analysis and pathogenesis in animals. While all RwtVVs were viable in cell culture, in many of the RwtVV isolates, RFLP differences were noted and while some recombinant viruses exhibited wild type behavior in mice, a wide range of virulence indicative of unintended changes suggests that mutants created by “rescue” systems require careful analysis particularly before use for in vivo studies employing animal models.
A Life in Passing: Jonathan Gray
Michael T Lotze, Jonathan Gray
Journal of Translational Medicine , 2007, DOI: 10.1186/1479-5876-5-54
Abstract: Believing that an immune response was his best hope for success, he visited and encouraged the tumor immunologists in the world that he felt were most capable of helping him. I find myself fortunate in being one of those. In spite of the extraordinary demands of his treatments over the last few years, he persisted in making appeals to his friends and colleagues to press the case for the urgency of cancer research and rapid application of novel therapies. With pain from a celiac plexus mass, a fungal infection in trapped lung requiring multiple hospitalizations, and diffuse metastatic hepatic disease, he rallied others to find new strategies for cancer. For all of us who Jonathan consulted, we are diminished by his passing, and furthermore chastened to do more, imagine more, find more and apply to others like him. He deserves no less.All of us who work in the fields of cancer research and therapy should applaud his vision, his magnanimity, and devotion to what we hope will make the future scientists and clinicians stand erect to take on the challenge of the disease that ultimately took his life. We can indeed do more, imagine more, find more and apply. Jonathan, bless you and rest in peace. We are driven by your example and your extraordinary hope. We too, like his remarkable supportive family, are saddened by his passing, but pass on his thoughtful reflections [with only modest editing] on the needs he perceived but woefully too slow in responding to his need to see his sons futures realized and live for his parents and loved ones, just shy of his 60th birthday. Jonathan, you live on in our hearts and dedication to delivering better therapies, more expeditiously, and more effectively. Thank you for being there when we needed you and for projecting your concerns on a receptive oncologic audience. We are working now for others; and of course want your just repose.Jonathan E. GrayManhattan, New York City, USAApproximately 50% of all American men and 33% of all women al
The G4 Genome
Nancy Maizels ,Lucas T. Gray
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003468
Abstract: Recent experiments provide fascinating examples of how G4 DNA and G4 RNA structures—aka quadruplexes—may contribute to normal biology and to genomic pathologies. Quadruplexes are transient and therefore difficult to identify directly in living cells, which initially caused skepticism regarding not only their biological relevance but even their existence. There is now compelling evidence for functions of some G4 motifs and the corresponding quadruplexes in essential processes, including initiation of DNA replication, telomere maintenance, regulated recombination in immune evasion and the immune response, control of gene expression, and genetic and epigenetic instability. Recognition and resolution of quadruplex structures is therefore an essential component of genome biology. We propose that G4 motifs and structures that participate in key processes compose the G4 genome, analogous to the transcriptome, proteome, or metabolome. This is a new view of the genome, which sees DNA as not only a simple alphabet but also a more complex geography. The challenge for the future is to systematically identify the G4 motifs that form quadruplexes in living cells and the features that confer on specific G4 motifs the ability to function as structural elements.
Absolute Total Single–Electron–Capture Cross Sections of O2+ with N2 Gas
A. T. Hasan,T. J. Gray
International Journal of Molecular Sciences , 2003, DOI: 10.3390/i4050284
Abstract: Absolute total single-electron-capture cross sections have been measured for lowenergy O2+ + N2 system in the collision energy range between 0.50 to 2.0 keV. These cross sections are found to be in the range of 0.67 to 2.08 x10-16 cm2. The measured total cross sections for single-electron- capture display a slowly increasing behavior as a function of the incident energy. Several measurements of total cross sections for electron-capture from N2 by slow N2+ and O+ ions, and from O2 by slow O2+ ions presently exist in the literature. In the measurements reported here, we measured the total cross sections for electron-capture from N2 by slow O2+ ions, such measurements are not found in the literature. The increasing availability of data on this system may stimulate work in this direction.
Factors Associated with Accessing ICDS Services among Women in Rural Rajasthan, India  [PDF]
Siena F. Davis, Hannah E. Payne, Cassidy A. Hine, Bobbi L. Gray, Benjamin T. Crookston
Health (Health) , 2018, DOI: 10.4236/health.2018.1010098
Abstract: Background: The Integrated Child Development Services (ICDS) Scheme, launched in 1975 by the Government of India, provides various health services to children and their mothers at ICDS centres. Objectives: The purpose of this study is to understand 1) the extent to which women living in Rajasthan, India utilize services provided by ICDS centres and 2) the factors that are associated with their use. Methods: Freedom from Hunger and Freedom from Hunger India Trust, in collaboration with two local partners in Rajasthan, India, conducted a baseline assessment with 403 pregnant women and women with young children belonging to self-help groups to compare use of ICDS centres with key demographic variables and measures of poverty, food security and nutrition, curative care related to diarrhea, coping strategies, and household decision-making. Results: The results revealed that households that accessed ICDS services were more likely to report receiving nutrition information from ICDS centres, to purchase ORS in the last year, and to give oral rehydration solution (ORS) to children who had diarrhea. Women who decide how much food to serve each family member or spend money without discussing it first with someone else were more likely to receive benefits from ICDS centres. Those who spoke with their spouse about household nutrition needs were less likely to report accessing ICDS services. Conclusion: Interventions aimed at increasing utilization of ICDS centres in this region may find it beneficial to increase female participation in health care decisions, likely through spousal communication and gender relations.
Electron-Capture Cross Sections of Ground-State O2+ Recoil Ions in Slow Collisions with H2 and O2
Asad T. Hasan,Tom J. Gray
International Journal of Molecular Sciences , 2007, DOI: 10.3390/i8111158
Abstract: We report the measured total charge-transfer (electron-capture) cross sectionsfor the ground state O2+ (X2πg) ions with H2 and O2 molecular gases in the collisionenergy range between 0.50 and 2 keV. The time-of-flight technique has been used tomeasure the fast neutral products from O2+ charge transfer reactions. The analyzedprocess has cross sections that continue to increase slowly, as a function of incidentenergy. Measured cross sections for O2+ H2, O2 systems are compared with previouslyavailable experimental and theoretical results in the literature.
The Effects Employing Sign Language and Rewards to Teach Rote Counting to 50 with a Student with Down Syndrome and Intellectual Disabilities
Christina Griffin,T. F. McLaughlin,Jennifer Neyman,Stacey Higgins
International Journal of Basics and Applied Science , 2013,
Abstract: The purpose of this study was to examine the effects of sign language to teach a second grade student with developmental delays to rote count to fifty. The second grade student with a communication delay that impacted his ability to produce oral communication served as our participant. An ABAB reversal design was used to evaluate the effects of employing sign language. The outcomes indicated an initial gradual improvement in our participant’s skills in rote counting. A return to baseline resulted in a large decrease in performance. A replication of the sign language condition resulted in a large improvements in correct counting. The efficacy of employing manual sign language in the classroom was discussed. Both teachers and parents were satisfied with the outcomes.
Consumer Ideology Determines Shopping Preferences at Farmers Markets in Two US Geographical Regions  [PDF]
Deanna Pucciarelli, Stacey Faith
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.519205
Abstract: The purpose of this study was to identify if there were differences that existed in the behaviors, attitudes, awareness, and motivating factors that influenced people to shop at farmers’ markets and purchase USDA certified organic food in two geographic regions: Corvallis, Oregon and Muncie, Indiana. A survey was administered to consumers who shopped at the Minnetrista Farmers’ Market (MFM) and the Corvallis-Albany Farmers’ Market (CAFM) in the summer of 2012 to measure the shoppers’ purchasing perceptions. Specific areas of interest in this study included consumer values towards supporting local farmers and consuming USDA certified organic food. A comparison of responses between regions was analyzed. Results of the study provide insights on consumers’ purchasing attitudes and behaviors regarding USDA certified organic products, and why they chose to shop at Farmers’ Markets. Ideology was the strongest predictor for consumer purchasing behaviors. Understanding how regional differences affect food choice has implications for wellness programs and industry marketing materials.
Page 1 /119307
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.