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Percutaneous penetration enhancement in transdermal drug delivery
Singh Inderjeet,Sri Prasanthi
Asian Journal of Pharmaceutics , 2010,
Abstract: The transdermal route has numerous advantages over the more traditional drug delivery routes. These include high bioavailability, absence of first pass hepatic metabolism, steady drug plasma concentrations, and the fact that therapy is non-invasive. The main obstacle to permeating drug molecules is the outermost layer of the skin, the stratum corneum. Consequently, research into enhancing transdermal drug delivery (TDD) by overcoming this layer, is an area of prime interest. This review article is written to provide a coverage commentary of the recent advancements in TDD enhancement techniques.
Efficacy of fluorochrome stain in the diagnosis of pulmonary tuberculosis co-infected with HIV
Prasanthi K,Kumari A
Indian Journal of Medical Microbiology , 2005,
Abstract: The resurgence of Mycobacterium tuberculosis in association with HIV infection has focussed much attention in the rapid diagnosis of high risk cases. Infection with HIV is known to alter the presentation of pulmonary tuberculosis. The present study was under taken to compare the efficacy of fluorochrome stain (Fl) with conventional Ziehl Neelsen (ZN) stain in the diagnosis of pulmonary tuberculosis. Two hundred cases of pulmonary tuberculosis were included in the study. Sputum smears were screened for acid fast bacilli (AFB) by ZN and Fl methods and blood samples were screened for HIV. Sputum positive cases detected by Fl stain were higher in number (69%) when compared to ZN stain (50%). Of the total cases studied 15.5% were HIV seropositive. Conclusions : Fluorochrome staining was found to be more efficient (45%) when compared to ZN staining (29%) in detecting cases associated with HIV seropositivity, especially paucibacillary cases.
Degradation of Primate Habitat at Tesso Nilo Forest with Special Emphasis on Riau Pale-Thighed Surili (Presbytis siamensis cana)  [PDF]
Jatna Supriatna, Sri Mariati
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.512112
Abstract: The habitat of Riau pale-thighed surili (Presbytis siamensis cana) located in Riau province of Sumatra island between Siak in the north and Indragiri rivers in the south, has been seriously degraded in the last a few decades. This swampy peat land forest has been degraded by frequent burning during the dry season. These problems originated because of poor governance on the forest management, and the construction of two access roads by the owners of logging concessions and wood pulp plantations. This forest block consists of Tesso Nilo National Park, Kerumutan protected area, Production Forest areas belong to two companies, and a small recreation Park. It also contains one of the most important mixed peat swamp forests. Here, we tracked changes in forest cover before and after road construction using GIS and remote sensing imagery. Deforestation rates have increased from 1.5% per year before road construction to 9.28% per year after road construction, which means that the area of forest has decreased by an annual average of 8156 ha in Tesso Nillo alone. The habitat of Riau pale-thighed surili decreased almost up to 60% in the last decade after companies started their converting forest for oil palm and acacia and roads were built crisscrossed. If the trend of deforestation continues, further decline of population of habitat of this species is unavoided. Researches should be carried out in more details to understand the status of population of this subspecies before this subspecies disappears in the wild.
Monolayers Langmuir-Blodgett Films of Synthetic Artificial Mimic Molecules That Resemble the Following Tetraether Lipids on Silicon Wafers  [PDF]
Sri Vidawati, Ulrich Rothe
Advances in Biological Chemistry (ABC) , 2015, DOI: 10.4236/abc.2015.54015
Abstract: This study investigated the behavior and molecular organization of synthetic artificial mimic molecules that resemble the following tetraether lipids: di-O-hexadecyl-glycero-3-phosphatidyl-glycerol (DHGPG) and bis-4-dodecylphenyl-12-phosphate. These molecules were analyzed using Langmuir film balance, ellipsometry and atomic force microscopy. The monolayer Langmuir-Blodgett films of DHGPG and bis-4-dodecylphenyl-12-phosphate were stable on the solid surface silicon wafers. The ellipsometry and AFM results showed that monolayers Langmuir-Blodgett films of DHGPG and bis-4-dodecylphenyl-12-phosphate were present, and the thickness of the observed films varied from 1.2 - 5.0 nm.
Radiographic Evidence of Osteomyelitis
Natalie Terese Desouza,Prasanthi Govindarajan
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2011,
Abstract: [West J Emerg Med. 2011;12(4):528–529.]
Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride
D. Prasanthi,P. K. Lakshmi
ISRN Pharmaceutics , 2012, DOI: 10.5402/2012/965280
Abstract:
Green Computing
K. Shalini,K. Naga Prasanthi
Journal of Telematics and Informatics , 2013, DOI: 10.12928/jti.v1i1.978
Abstract: Green computing is all about using computers in a smarter and eco-friendly way. It is the environmentally responsible use of computers and related resources which includes the implementation of energy-efficient central processing units, servers and peripherals as well as reduced resource consumption and proper disposal of electronic waste .Computers certainly make up a large part of many people lives and traditionally are extremely damaging to the environment. Manufacturers of computer and its parts have been espousing the green cause to help protect environment from computers and electronic waste in any way.Research continues into key areas such as making the use of computers as energy-efficient as Possible, and designing algorithms and systems for efficiency-related computer technologies.
Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride
D. Prasanthi,P. K. Lakshmi
ISRN Pharmaceutics , 2012, DOI: 10.5402/2012/965280
Abstract: The objective of the present study is to explore the efficient chemical penetration enhancer among the various enhancers available in overcoming the stratum corneum barrier in transdermal delivery of Alfuzosin hydrochloride (AH). The different enhancers were incorporated in 2% Carbopol gel which was selected as a control and evaluated by in vitro diffusion studies through dialysis membrane and permeation through the rat abdominal skin using Keshary-Chien diffusion cells. All the enhancers increased the release rate through the dialysis membrane when compared with control except oleic acid which decreased the release rate but showed maximum solubility of the drug. Among the various enhancers Transcutol 20% and tween-20 (2%) showed the highest cumulative amount (Q24) of 702.28 ± 6.97?μg/cm2 and 702.74 ± 7.49?μg/cm2, respectively. A flux rate of 31.08 ± 0.21?μg/cm2/hr by Transcutol 20% and 30.38 ± 0.18?μg/cm2/hr by tween-20 (2%) was obtained. Transcutol 20% showed decreased lag time of 0.13 ± 0.05?hr. The lowest skin content of 342.33 ± 5.30?μg/gm was seen with oleic acid 2.5%. Maximum enhancement of flux by 3.94-fold was obtained with transcutol 20%. Primary skin irritation studies were performed with rabbit. Histopathological studies of transcutol 20% showed marked changes such as degeneration and infiltration of mononuclear cells in dermis indicating the effect of transcutol on the skin. Among the different enhancers transcutol is efficient in enhancing transdermal delivery of AH. 1. Introduction Alfuzosin hydrochloride (AH), the -adrenoreceptor antagonist, is used for treating benign prostatic hyperplasia. It is indicated for long-term therapy in place of surgery. It undergoes extensive first pass metabolism, has a bioavailability of 60%, half-life (3–5 hour), (1.6), molecular weight (425.9 Daltons) and dose (10?mg per day) [1]. Its physicochemical properties suggest that transdermal drug delivery would be beneficial, but the challenging aspect in transdermal delivery route is permeation through stratum corneum [2]. Several technological approaches have been attempted to overcome this challenge. They are physical approaches, chemical approaches, formulation approaches, and so forth [3]. Chemical approach is the most widely implemented. Chemical enhancers based on their physico-chemical properties enhance permeation through the skin by different mechanisms such as creating diffusion pathways for drug by extracting lipids from the skin, disrupting highly ordered lipid lamellae by partitioning into lipid bilayers, fluidization of lipids, and enhancing the
Implementation Of Path Length Control For RLG Using FPGA
Prasanthi.Pasula,Rajesh Babu.Natha
International Journal of Engineering Science and Technology , 2012,
Abstract: Ring Laser Gyro(RLG) is used to sense angular information accurately and precisely.In a RLG,an optical ring is formed,and two laser beams are directed around the ring in opposite directions.When the beams are combined ,rotation of the ring appears as an interference shift in the combined beams.The amplitude of modulation of the light intensity is less .When RLG is operating at its peak, in comparison to when it is operating with pathlength which is either under or over the peak path length.It is difficult to detect,modulations at peak.The analog components are used to form a phase comparator.The voltage produced by a photo detector actuated by a small sample of light which is picked off by the laser beam.If two signals are in phase ,then the voltage to the PZT is increased,if it is out of phase ,it is decreased.The analog phase comparator and voltage feedback device suffers from the drawbacks of analog devices radiation softness bulk,weight, lack of tolerence.To overcome the above problem, path length control using FPGA is implemented.
Modern Approaches for Detecting Data leakage Problems
B. Sruthi Patil , Mrs. M. L. Prasanthi
International Journal of Engineering and Computer Science , 2013,
Abstract: In Organizations, detecting data leaker is facing many difficulties to find who cause for the data leakage. In previous approaches there are many techniques to find the leaker using fake objects and how much data leaked. In this paper, we present S-Random, S-Optimal, E-Random and E-Optimal techniques to find the (leaker). In this, we assigning the data with addition of fake objects through that, if the data is leaked then fake objecthelp to find the particular by using E-Random and S-Random techniques.It improves the efficiency for finding the leaker.
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