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Sleep spindles: validated concepts and breakthroughs
Spinosa, M?nica Jaques;Garzon, Eliana;
Journal of Epilepsy and Clinical Neurophysiology , 2007, DOI: 10.1590/S1676-26492007000400006
Abstract: introduction: sleep spindles, the hallmark of sleep synchronization in stage 2 non-rem sleep, are rhythmic and monomorphic waves, between 10 and 14 hz, with a maximum amplitude in the vertex (cz), with bilateral irradiation to central regions (c3 and c4). objective: in this article we present an overview of sleep spindles ranging from well established concepts of morphology, generation mechanisms, maturational features, abnormal patterns and pathological aspects since the knowledge is important to identify the normal and abnormal patterns. conclusion: centro-parietal and frontal spindle are normal pattern and extreme spindle is abnormal, mostly found in children mentally retarded up to 5 years-old. in this review research boundaries of memory consolidation, synaptic potentiation and brain plasticity were also presented.
The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy
Guglielmo Lucchese,Jean Pierre Spinosa,Darja Kanduc
Epilepsy Research and Treatment , 2014, DOI: 10.1155/2014/236309
Abstract: Sequence matching analyses show that Clostridium tetani neurotoxin shares numerous pentapeptides (68, including multiple occurrences) with 42 human proteins that, when altered, have been associated with epilepsy. Such a peptide sharing is higher than expected, nonstochastic, and involves tetanus toxin-derived epitopes that have been validated as immunopositive in the human host. Of note, an unexpected high level of peptide matching is found in mitogen-activated protein kinase 10 (MK10), a protein selectively expressed in hippocampal areas. On the whole, the data indicate a potential for cross-reactivity between the neurotoxin and specific epilepsy-associated proteins and may help evaluate the potential risk for epilepsy following immune responses induced by tetanus infection. Moreover, this study may contribute to clarifying the etiopathogenesis of the different types of epilepsy. 1. Introduction The term epilepsy defines a group of disturbances whose only recognized commonality is the paroxysmal synchronous discharging of groups of neurons. Localization and physiological function of the neuronal populations involved determine the clinical picture, so that (1) clinical manifestations can be extremely subtle and the diagnosis can be challenging also in terms of differential definition; (2) epilepsy(ies) can produce extremely multiform clinical pictures with a large degree of overlap [1–3]. Indeed, epileptic syndromes can also be embedded in larger syndromic clinical pictures, that is, West and Lennox-Gastaut syndromes in tuberous sclerosis complex [4, 5]. This clinical diversity has noteworthy nosological implications. Syndromic or disease status of various forms of epilepsy and the terminology used to define them are indeed still matter of debate [7–9]. Likewise, the molecular etiopathogenesis of epilepsies has to be better defined at the molecular level. Although genetic alterations [10–12], inflammation [13], and viral infections [14–16] have been considered and thoroughly studied, nonetheless, the molecular basis and the causal mechanisms of epilepsies are still unclear. Recently, research on epilepsy has also outlined a neurodevelopmental context [17–21]. Spontaneous recurrent seizures have been observed after induction of status epilepticus during the second and third postnatal weeks in rodents, by use of chemoconvulsants such as pilocarpine, kainate, and tetanus toxin (TT) [22]. TT seizures as well as experimental febrile seizures and developmental lithium pilocarpine appear to share a common mechanism for enhancing hippocampal network
Declaración de docentes e investigadores sobre el conflicto laboral en Kraft Foods (ex Terrabusi)
Claudia Figari,Juan Montes Cató,Paula Lenguita,Martin Spinosa
Revista Theomai , 2009,
Cassava Flour: Quantification of Cyanide Content  [PDF]
André Rinaldi Fukushima, Maria Aparecida Nicoletti, Almir Junior Rodrigues, Caroline Pressutti, Jeandro Almeida, Tamires Brand?o, Rosilene Kinue Ito, Luis Ant?nio Bafille Leoni, Helenice De Souza Spinosa
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.77060
Abstract: Cassava flours are obtained from the roots of Manihot esculenta Crantz and daily fairly consumed by the Brazilian population considering it comes to hum food, and also inserted into food baskets, besides to present low cost and easy access, in addition to being plant easily cultivated by the population. However, the food obtained with cassava may contain hydrocyanic acid, in the form of cyanogenic glycoside when those meals are not cooked properly. The oral toxicity can range 30 - 210 mg/kg body, the average daily consumption per capita in larger rural areas than in urban areas for cassava flour 19.1 g against 4.7 g, respectively. Brazil’s North and Northeast have higher consumption of cassava flour, associated with family monthly monetary income, making this region more vulnerable to poisoning. The objective of this study was to quantify cyanogenic glycosides present in some types of Brazilian cassava foods by means of spectrophotometric technique (reading at a wavelength of 530 nm). For quantitative determination of cyanide content, linamarase hydrolysis was used. The amount of cyanide was determined, and results were: artisan toasted cassava flour: 15 mg/500g, sweet cassava starch: 32.5 mg/500g, artisan dried cassava flour: 37.5 mg/500g, “bijuzada” cassava flour: 60 mg/500g, industrialized, toasted cassava flour: 115 mg/500g, industrialized, raw cassava flour: 140 mg/500g, and wet cassava flour: 225 mg/500g. Considering the chronic ingestion of cyanide present in these foods, they can cause public health problems.
Ictal patterns in children: an illustrated review
Spinosa, M?nica Jaques;Liberalesso, Paulo Breno de Noronha;Mehl, Larissa;L?hr Júnior, Alfredo;
Journal of Epilepsy and Clinical Neurophysiology , 2011, DOI: 10.1590/S1676-26492011000400008
Abstract: detailed knowledge of electroencephalographic patterns accompanying epileptic seizures in children is paramount to the correct identification of epileptic seizures and syndromes. in this article, we present a review of ictal patterns of different seizure types in children, illustrating with examples collected in our video-eeg laboratory at pequeno príncipe hospital.
Use of polymerase chain reaction and enzymatic cleavage in the identification of Helicobacter spp. in gastric mucosa of human beings from North Paraná, Brazil
Camargo, PL;Alfieri, AA;Bracarense, APFRL;Menoli, R;Spinosa, SR;Hagiwara, MK;
Memórias do Instituto Oswaldo Cruz , 2003, DOI: 10.1590/S0074-02762003000200016
Abstract: helicobacter pylori is the most common gastric bacteria of human beings. animal-borne helicobacter have been associated with gastritis, ulceration, and gastric mucosa-associated lymphoid-tissue lymphoma in people. we attempted to identify the species of helicobacter spp. that infect human beings in north paraná, brazil. samples of gastric mucosa from 38 dyspeptic patients were analyzed by optic microscopy on silver stained slides, polimerase chain reaction (pcr), and enzymatic cleavage. genus and species-specific primers to h. pylori, h. heilmannii, h. felis, and consensual primers to h. bizzozeronii or h. salomonis were used. the pcr products were submitted to enzymatic cleavage by vspi (helicobacter spp. product) and hinfi (species products) enzymes. thirty-two out of 38 patients evaluated had 3.2 to 5 μm long bacteria that resembled h. pylori in warthin-starry stained slides and were positive to the genus helicobacter by pcr. in 30 of these patients the bacteria were identified as h. pylori. two samples positive by silver stain were negative to all species tested by pcr. none of the 38 samples was positive to animal-origin helicobacter species. these results show that pcr and enzymatic restriction are practical methods to identify the species of helicobacters present in gastric mucosa of human beings. people in north paraná appear to be infected mostly with h. pylori.
Electrocardiographic evaluation of two anesthetic combinations in dogs
Tárraga, K.M.;Spinosa, H.S.;Camacho, A.A.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2000, DOI: 10.1590/S0102-09352000000200009
Abstract: this study aimed to investigate electrocardiographic changes in dogs aged 5 years or more submitted to two anesthetic combinations: atropine, levomeprazine, thiopental and halothane (alth), and atropine, tiletamine and zolazepam (atz). forty dogs (24 males/16 females) weighing 5-24kg, were used. dogs had no cardiac problems and were submitted to tartarectomy. all animals were submitted to two electrocardiograms (ecg), one before anesthesia and other immediately before surgery. the dogs were divided into two groups: group 1 received alth and group 2 received atz. alterations in the st segment, t wave, cardiac rhythm and a significant reduction of vagal tonus index were observed in both groups, but in group 2 a significant reduction of the pr and qt intervals and an increase in heart rate were also observed. these data suggest that the alth combination caused fewer changes in the ecg than the atz combination.
De Morsier syndrome associated with periventricular nodular heterotopia: case reporte
Spinosa, M?nica Jaques;Liberalesso, Paulo Breno Noronha;Vieira, Simone Carreiro;L?hr Júnior, Alfredo;
Arquivos de Neuro-Psiquiatria , 2007, DOI: 10.1590/S0004-282X2007000400029
Abstract: introduction: septo-optic dysplasia (de morsier syndrome) is defined as the association between optic nerve hypoplasia, midline central nervous system malformations and pituitary dysfunction. case report: third child born to nonconsanguineous parents, female, adequate pre-natal medical care, cesarean term delivery due to breech presentation, apgar score 3 at the first minute and 8 at 5 minutes, symptomatic hypoglycemia at 18 hours. neurological follow-up identified a delay in acquisition of motor and language developmental milestones. epileptic generalized seizures began at 12 months and were controlled with phenobarbital. eeg was normal. mri revealed agenesis of the pituitary stalk, hypoplasia of the optic chiasm and periventricular nodular heterotopia. ophthalmologic evaluation showed bilateral optic disk hypoplasia. endocrine function laboratory tests revealed primary hypothyroidism and hyperprolactinemia. conclusion: the relevance of this case report relies on its uniqueness, since periventricular heterotopia had not been described in association with septo-optic dysplasia until 2006.
Nuclear medicine imaging technique in the erectile dysfunction evaluation: a mini-review
Ribeiro, Camila Godinho;Moura, Regina;Neves, Rosane de Figueiredo;Spinosa, Jean Pierre;Bernardo-Filho, Mario;
Brazilian Archives of Biology and Technology , 2007, DOI: 10.1590/S1516-89132007000600010
Abstract: functional imaging with positron emission tomography and single photon emission computed tomography is capable of visualizing subtle changes in physiological function in vivo. erectile dysfunction(ed) diminishes quality of life for affected men and their partners. identification of neural substrates may provide information regarding the pathophysiology of types of sexual dysfunction originating in the brain. the aim of this work is to verify the approaches of the nuclear medicine techniques in the evaluation of the erectile function/disfunction. a search using the words ed and nuclear medicine, ed and scintigraphy, ed and spect and ed and pet was done in the pubmed. the number of citations in each subject was determined. neuroimaging techniques offer insight into brain regions involved in sexual arousal and inhibition. to tackle problems such as hyposexual disorders or ed caused by brain disorders, it is crucial to understand how the human brain controls sexual arousal and penile erection.
Determination of cocaine in brazilian paper currency by capillary gas chromatography/mass spectrometry
Donato, Enrico Di;Martin, Carmen Cinira Santos;Martinis, Bruno Spinosa De;
Química Nova , 2007, DOI: 10.1590/S0100-40422007000800031
Abstract: the presence of illicit drugs such as cocaine and marijuana in us paper currency is very well demonstrated. however, there is no published study describing the presence of cocaine and/or other illicit drugs in brazilian paper currency. in this study, brazilian banknotes were collected from nine cities, extracted and analyzed by capillary gas chromatography/mass spectrometry, in order to investigate the presence of cocaine. bills were extracted with deionized water followed by ethyl acetate. results showed that 93% of the bills presented cocaine in a concentration range of 2.38-275.10 μg/bill.
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