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Search Results: 1 - 10 of 126 matches for " Sotirios Tsiodras "
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Influenza pandemic: Is there a real threat?
Sotirios Tsiodras
Pneumon , 2009,
Extraparenchymal neurocysticercosis in the United States: a case report
Theodoros Kelesidis, Sotirios Tsiodras
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-359
Abstract: A 26-year-old Caucasian man presented with headache, nausea and vomiting and was found to have hydrocephalus and meningitis. Brain imaging and immunological studies were suggestive of neurocysticercosis. Endoscopic removal of the cyst resulted in resolution of symptoms. This case represents a combination of two rare presentations of extraparenchymal neurocysticercosis; intraventricular neurocysticercosis and subarachnoid neurocysticercosis.Although neurocysticercosis is pleomorphic in its presentation, extraparenchymal neurocysticercosis may be challenging to diagnose and treat. Clinicians should be aware of this condition given increasing incidence in the United States.Neurocysticercosis (NCC) is the most common disease causing cystic lesions in the central nervous system, especially in developing and tropical countries [1]. However, extraparenchymal NCC may be challenging to diagnose and treat. Increasing immigration from endemic areas will lead to an increasing frequency of extraparenchymal NCC in the United States. Clinicians and neuroradiologists in the United States are often unaware of the radiographic patterns of extraparenchymal NCC and the potentially poor prognosis if not correctly diagnosed and managed. Here, we describe a case of extraparenchymal NCC as a cause of chronic meningitis and hydrochephalus in a patient and we discuss challenges in the diagnosis and management of these cases.A 26-year-old Caucasian man with history of diabetes mellitus presented to our emergency department complaining of diffuse headache that had developed two months prior to presentation. He also reported nausea and vomiting that became progressively worse. He denied fever, chills, photophobia or any other symptoms. He was born in Mexico and moved to California when he was 18 years old. A physical examination revealed a temperature of 37°C and mild neck stiffness but an examination including funduscopy and ophthalmologic examination was otherwise normal. Initial laboratory f
Ampicillin/Sulbactam versus Cefuroxime as antimicrobial prophylaxis for cesarean delivery: a randomized study
Eleftherios Ziogos, Sotirios Tsiodras, Ioannis Matalliotakis, Helen Giamarellou, Kyriaki Kanellakopoulou
BMC Infectious Diseases , 2010, DOI: 10.1186/1471-2334-10-341
Abstract: Women scheduled for cesarean delivery were randomized to receive a single dose of either 3 g of ampicillin-sulbactam or 1.5 g of cefuroxime intravenously, after umbilical cord clamping. An evaluation for development of postoperative infections and risk factor analysis was performed.One hundred and seventy-six patients (median age 28 yrs, IQR: 24-32) were enrolled in the study during the period July 2004 - July 2005. Eighty-five (48.3%) received cefuroxime prophylaxis and 91 (51.7%) ampicillin/sulbactam. Postoperative infection developed in 5 of 86 (5.9%) patients that received cefuroxime compared to 8 of 91 (8.8%) patients that received ampicillin/sulbactam (p = 0.6). In univariate analyses 6 or more vaginal examinations prior to the operation (p = 0.004), membrane rupture for more than 6 hours (p = 0.08) and blood loss greater than 500 ml (p = 0.018) were associated with developing a postoperative surgical site infection (SSI). In logistic regression having 6 or more vaginal examinations was the most significant risk factor for a postoperative SSI (OR 6.8, 95% CI: 1.4-33.4, p = 0.019). Regular prenatal follow-up was associated with a protective effect (OR 0.04, 95% CI: 0.005-0.36, p = 0.004).Ampicillin/sulbactam was as safe and effective as cefuroxime when administered for the prevention of infections following cesarean delivery.Clinicaltrials.gov identifier: NCT01138852The majority of obstetrical interventions involves some degree of bacterial contamination. Thus they are classified as "clean-contaminated" even when the patient has no preoperative symptoms of active infection [1]. Cesarean delivery is considered a clean-contaminated procedure when scheduled cesarean delivery without labor and/or ruptured membranes occurs and, contaminated when emergency cesarean delivery with labor and/or ruptured membranes occurs. Several studies have shown the beneficial effect of peri-operative antimicrobial prophylaxis in preventing post-surgical infection after cesarean deliv
Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women
Sotirios Tsiodras, John Georgoulakis, Aikaterini Chranioti, Zanis Voulgaris, Amanda Psyrri, Angeliki Tsivilika, John Panayiotides, Petros Karakitsos
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-53
Abstract: All women with liquid-based cytology performed at a University Hospital between 2000 and 2003 were included. The Hybrid Capture 2 (HC2) kit and in house Polymerase Chain Reaction (PCR) were used for HPV DNA detection. Cervical biopsy was performed for women with ASCUS+ cytology, HPV detection, or abnormal colposcopy. Positive (PLR) and negative (NLR) likelihood ratios were calculated for cytology and HPV molecular testing for the prediction of CIN2 and greater histology.Of the 1270 women evaluated 241 (18.5%) had abnormal cytology. Cytology diagnosed high-grade squamous intraepithelial lesion (HSIL) or invasive carcinoma in 21(1.7%) cases whereas 26 (2%) women had CIN2+ or greater histology. PCR detected HPV in 397/1270 (31.3%) and HC2 in 260/1270 (20.4%) samples. Both molecular tests exhibited high reproducibility (Cohen's kappa value 0.691, 95% CI: 0.664 - 0.718). Positive likelihood ratios (PLR) of 9.4, 3.8 and 3.4 and negative likelihood ratios of 0.13, 0.21, and 0 were noted for ≥ LSIL, any positive HC2 or any positive PCR-HPV testing, for predicting CIN2+ histology, respectively. All CIN 3+ lesions harbored high risk oncogenic HPV type infections.HPV infection was found in a large proportion of this population and was associated with CIN 2/3 lesions and infiltrating carcinomas. Thin prep testing and HPV detection by HC2 or PCR performed very well with regards to identifying high grade lesions in an environment with experienced examiners.Large epidemiological studies performed over the last two decades have identified infection with human papilloma virus (HPV) as a necessary cause for cervical cancer[1,2]. Furthermore, newer molecular techniques have greatly helped in identifying the association of high-risk HPV types with the development of precancerous lesions, as well as their role in cervical carcinogenesis[3,4]. Since the vast majority of invasive cervical carcinoma cases are associated with HPV type 16 or 18 infections[5,6], efforts have been made to deve
Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature
Andreas S Kalogeropoulos, Sotirios Tsiodras, Dionysios Loverdos, Panagiotis Fanourgiakis, Athanasios Skoutelis
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-13
Abstract: A rare case of eosinophilic pneumonia occurring 10 days after daptomycin administration in a 78-year-old Caucasian man with possible infectious endocarditis is described. He developed new onset fever, up to 38.5°C, with bilateral pulmonary crackles on physical examination and with no signs of severe respiratory failure. A chest computed tomography-scan showed bilateral nodular consolidations with air bronchograms and pleural effusions. Immediate discontinuation of daptomycin was followed by vigorous improvement of clinical signs and symptoms with progressive resolution of pulmonary consolidations a month later.Physicians should be aware of this rare but serious complication during daptomycin treatment, and prompt discontinuation of the offending agent, with or without additional supportive treatment, must occur immediately.Eosinophilic pneumonia (EP) belongs to a heterogeneous group of lung diseases characterized by pulmonary infiltrates and increased numbers of eosinophils in lung tissue or broncho-alveolar lavage (BAL) fluid, with or without increased levels of eosinophils in the peripheral blood [1]. Acute EP due to drugs or toxins has similar clinical, radiographic and histopathologic manifestations to idiopathic acute or chronic EP, making the distinction of these entities difficult. The most common drugs associated with EP are antibiotics and anti-inflammatory drugs [2]. A complete and updated list of drugs suspected of causing lung disease can be found on a website maintained by the Groupe Etude de la Pathologie Pulmonaire Iatrogene at http://www.pneumotox.com. webciteDaptomycin, an antimicrobial agent of the cyclic lipopeptide group of antibiotics, has an outstanding coverage for Gram-positive bacteria and is licensed for the treatment of bacteraemia and right-sided endocarditis due to methicillin-susceptible and methicillin-resistant Staphylococcus aureus [3]. It is also effective for vancomycin-resistant enterococci [3]. Although daptomycin has a favorable
Estimating the Disease Burden of 2009 Pandemic Influenza A(H1N1) from Surveillance and Household Surveys in Greece
Vana Sypsa,Stefanos Bonovas,Sotirios Tsiodras,Agoritsa Baka,Panos Efstathiou,Meni Malliori,Takis Panagiotopoulos,Ilias Nikolakopoulos,Angelos Hatzakis
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020593
Abstract: The aim of this study was to assess the disease burden of the 2009 pandemic influenza A(H1N1) in Greece.
Novel association patterns of cardiac remodeling markers in patients with essential hypertension and atrial fibrillation
Andreas S Kalogeropoulos, Sotirios Tsiodras, Angelos G Rigopoulos, Eleftherios A Sakadakis, Andreas Triantafyllis, Dimitrios TH Kremastinos, Ioannis Rizos
BMC Cardiovascular Disorders , 2011, DOI: 10.1186/1471-2261-11-77
Abstract: Serum levels of MMP-2, MMP-3, MMP-9 and TIMP-1 were measured in 86 patients: 27 on SR without any AF history, 33 with paroxysmal and 26 with permanent AF. All subjects had essential hypertension, normal systolic function and no coronary artery disease.Patients with AF had higher MMP-2, MMP-3 and MMP-9 and lower TIMP-1 compared to SR subjects (all p < 0.001). Paroxysmal AF was associated with higher MMP-2 levels compared to permanent AF (p < 0.001). Matrix metalloproteinase-9 but not MMP-3 was higher in permanent compared to paroxysmal AF group (p < 0.001). Patients with AF had lower levels of TIMP-1 compared to those with SR while permanent AF subjects had lower TIMP-1 levels than those with paroxysmal AF (p < 0.001 for both comparisons). Lower TIMP-1 was the only independent factor associated with AF (OR: 0.259, 95%CI: 0.104-0.645, p = 0.004).In hypertensives, paroxysmal AF and permanent AF differ with respect to serum MMPs. Increased MMP-2 is associated with paroxysmal, whereas increased MMP-9 with permanent AF. Additionally, lower levels of TIMP-1 had a strong association with AF incidence.Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, with the highest prevalence observed among elderly people. Atrial fibrillation is responsible for markedly increased cardiovascular morbidity, and mortality and has been associated with various cardiovascular disorders, predominantly with hypertension, coronary artery disease, heart failure and valvular heart disease [1]. Various factors, including atrial remodeling and inflammation, have been implicated in the pathogenesis and perpetuation of AF; nevertheless the exact mechanism still remains uncertain [2-6]. Electrical remodeling is the possible substrate for persistence of AF after the initial event [7,8]. On the other hand, an underlying structural remodeling might occur before, during and after electrical remodeling, that is only in part reversible and can additionally contri
Prevention of Malaria Resurgence in Greece through the Association of Mass Drug Administration (MDA) to Immigrants from Malaria-Endemic Regions and Standard Control Measures
Maria Tseroni?,Agoritsa Baka?,Christina Kapizioni?,Georges Snounou?,Sotirios Tsiodras,Maria Charvalakou?,Maria Georgitsou?,Maria Panoutsakou?,Ioanna Psinaki?,Maria Tsoromokou
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0004215
Abstract: Greece was declared malaria-free in 1974 after a long antimalarial fight. In 2011–2012, an outbreak of P. vivax malaria was reported in Evrotas, an agricultural area in Southern Greece, where a large number of immigrants from endemic countries live and work. A total of 46 locally acquired and 38 imported malaria cases were detected. Despite a significant decrease of the number of malaria cases in 2012, a mass drug administration (MDA) program was considered as an additional measure to prevent reestablishment of the disease in the area. During 2013 and 2014, a combination of 3-day chloroquine and 14-day primaquine treatment was administered under direct observation to immigrants living in the epicenter of the 2011 outbreak in Evrotas. Adverse events were managed and recorded on a daily basis. The control measures implemented since 2011 continued during the period of 2013–2014 as a part of a national integrated malaria control program that included active case detection (ACD), vector control measures and community education. The MDA program was started prior to the transmission periods (from May to December). One thousand ninety four (1094) immigrants successfully completed the treatment, corresponding to 87.3% coverage of the target population. A total of 688 adverse events were recorded in 397 (36.2%, 95% C.I.: 33.4–39.1) persons, the vast majority minor, predominantly dizziness and headache for chloroquine (284 events) and abdominal pain (85 events) for primaquine. A single case of primaquine-induced hemolysis was recorded in a person whose initial G6PD test proved incorrect. No malaria cases were recorded in Evrotas, Laconia, in 2013 and 2014, though three locally acquired malaria cases were recorded in other regions of Greece in 2013. Preventive antimalarial MDA to a high-risk population in a low transmission setting appears to have synergized with the usual antimalarial activities to achieve malaria elimination. This study suggests that judicious use of MDA can be a useful addition to the antimalarial armamentarium in areas threatened with the reintroduction of the disease.
Differentiation of the Aging Process of PEDOT:PSS Films under Inert Helium and Ambient Atmosphere for Two Different Rates of Thermal Treatment  [PDF]
Sotirios Sakkopoulos, Evangelos Vitoratos
Open Journal of Organic Polymer Materials (OJOPM) , 2014, DOI: 10.4236/ojopm.2014.41001

The conductivity difference Δσ between two similar PEDOT:PSS films, 120 nm thick, heated by 5 and 15 K/min from 80 to 440 K, the one under inert He and the other under ambient air gives an approximate measure of the influence of oxygen and moisture on the conductivity vs temperature T. The resulting curves Δσ = f(T) exhibit three different regions: at temperatures from 80 to 145 K for heating rate 5 K/min and from 80 to 200 K for 15 K/min, an intense degradation of the sample under ambient atmosphere was revealed by the abrupt increase of the difference of the conductivities between He and atmospheric air. At intermediate temperatures from 145 to 380 K for 5 K/min and 200 to 400 K for 15 K/min, the conductivity difference remains basically constant indicating a stabilization of the damage produced by oxygen and moisture. Finally, for temperatures higher than 380 to 400 K the degradation increases again. An explanation of this behavior is proposed based on the hydrophilic character of the PSS and the destructive role of oxygen at high temperatures. Moreover, the isotherms σ = σ(t), where t is the heating time, at 443 K, under inert He and under atmospheric air for one hour verify the significant role of oxygen and moisture on the electrical conductivity. Under He the conductivity increases monotonically with t, but under ambient air factors the conductivity competes with others decreasing it producing a maximum at about t = 10 min.

A note on tamed Euler approximations
Sotirios Sabanis
Mathematics , 2013, DOI: 10.1214/ECP.v18-2824
Abstract: Strong convergence results on tamed Euler schemes, which approximate stochastic differential equations with superlinearly growing drift coefficients that are locally one-sided Lipschitz continuous, are presented in this article. The diffusion coefficients are assumed to be locally Lipschitz continuous and have at most linear growth. Furthermore, the classical rate of convergence, i.e. one--half, for such schemes is recovered when the local Lipschitz continuity assumptions are replaced by global and, in addition, it is assumed that the drift coefficients satisfy polynomial Lipschitz continuity.
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