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Search Results: 1 - 10 of 139899 matches for " Sophia K Mirza "
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Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
Sophia K Mirza, Sandra M Johnson
Clinical Ophthalmology , 2010, DOI: http://dx.doi.org/10.2147/OPTH.S6292
Abstract: acy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension Review (3313) Total Article Views Authors: Sophia K Mirza, Sandra M Johnson Published Date July 2010 Volume 2010:4 Pages 877 - 888 DOI: http://dx.doi.org/10.2147/OPTH.S6292 Sophia K Mirza, Sandra M Johnson Department of Ophthalmology, University of Virginia, Charlottesville, Virginia, USA Abstract: The medical treatment of glaucoma has evolved significantly over the past several decades. The main driving forces behind this evolution are the safety profiles and efficacy of these medications. Prostaglandin (PG) analogs are shown to be superior to older drugs in both efficacy and tolerability. Though there are much fewer side effects that manifest after using PG analogs, the adherence and compliance to medication regimens are surprisingly lower than expected. A commonly sited reason is the ocular irritation and inflammation with these medications. Much of this inflammation can be attributed to the preservative, benzalkonium chloride (BAK). The chronic clinical and subclinical inflammation becomes increasingly detrimental when filtration surgery fails from bleb fibrosis secondary to this hypercellularity. A BAK-free formulation of a PG analog recently became available. BAK-free travoprost is reviewed here. It has demonstrated equal efficacy and less ocular surface toxicity than its preserved counterparts. It is expected to serve as an instrumental resource in managing ocular hypertension and glaucoma in patients who demonstrate significant sensitivity to BAK. More randomized, controlled, double-blind studies are encouraged to evaluate its improved safety and tolerability.
Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension
Sophia K Mirza,Sandra M Johnson
Clinical Ophthalmology , 2010,
Abstract: Sophia K Mirza, Sandra M JohnsonDepartment of Ophthalmology, University of Virginia, Charlottesville, Virginia, USAAbstract: The medical treatment of glaucoma has evolved significantly over the past several decades. The main driving forces behind this evolution are the safety profiles and efficacy of these medications. Prostaglandin (PG) analogs are shown to be superior to older drugs in both efficacy and tolerability. Though there are much fewer side effects that manifest after using PG analogs, the adherence and compliance to medication regimens are surprisingly lower than expected. A commonly sited reason is the ocular irritation and inflammation with these medications. Much of this inflammation can be attributed to the preservative, benzalkonium chloride (BAK). The chronic clinical and subclinical inflammation becomes increasingly detrimental when filtration surgery fails from bleb fibrosis secondary to this hypercellularity. A BAK-free formulation of a PG analog recently became available. BAK-free travoprost is reviewed here. It has demonstrated equal efficacy and less ocular surface toxicity than its preserved counterparts. It is expected to serve as an instrumental resource in managing ocular hypertension and glaucoma in patients who demonstrate significant sensitivity to BAK. More randomized, controlled, double-blind studies are encouraged to evaluate its improved safety and tolerability.Keywords: glaucoma, benzalkonium chloride, Travatan Z, sofZia
Effects of pre-harvest foliar application of different rates and sources of calcium on yield and quality of ‘Illona’ cut rose flower
Sh. Kiani,K. Mirza Shahi
Journal of Science and Technology of Greenhouse Culture , 2011,
Abstract: Short vase life and low quality of cut rose flowers are the main problems of most rose greenhouses in Iran. Calcium is one of the most important nutrients that plays a major role in vase life of cut rose flowers. In this study, a factorial experiment was conducted based on completely randomized blocks design to elucidate the effects of foliar application of calcium rates and sources on yield and quality of rose flowers cv. Illona. Rose plants were sprayed by three rates of 0, 0.3 and 0.6 g/L calcium in combination with two sources of calcium nitrate (Ca(NO3)2.4H2O) and calcium chelate (Ca-EDTA) before the harvest. The experiment was conducted in 3 replications during 2005-2007 in Safi Abad Agricultural Research Center, Dezful. The results revealed that rose yield and flower quality indices at harvest time consisting of flowering stem fresh weight and length and length and diameter of buds were not affected by different rates and sources of calcium. But, vase life of cut rose flowers was increased significantly by 2.7 and 2.9 days in 0.3 and 0.6 g/L treatments, respectively (P<0.01). This was due to increased Ca concentration in the rose leaves and petals. There was no significant difference between the calcium nitrate and calcium chelate in supplying calcium and increasing vase life of cut rose flowers. According to the results of the present study, pre-harvest foliar application of calcium nitrate or calcium chelate at the rate of 0.3 g/L is recommended to improve vase life of cut rose flowers in north Khuzestan under greenhouse conditions.
Accuracy and Reliability of Uterine Contraction Identification Using Abdominal Surface Electrodes
Barrie Hayes-Gill,Sarmina Hassan,Fadi G. Mirza,Sophia Ommani
Clinical Medicine Insights: Women's Health , 2012,
Abstract:
Baryon Number-Induced Chern-Simons Couplings of Vector and Axial-Vector Mesons in Holographic QCD
Domokos, Sophia K.;Harvey, Jeffrey A.
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevLett.99.141602
Abstract: We show that holographic models of QCD predict the presence of a Chern-Simons coupling between vector and axial-vector mesons at finite baryon density. In the AdS/CFT dictionary, the coefficient of this coupling is proportional to the baryon number density, and is fixed uniquely in the five-dimensional holographic dual by anomalies in the flavor currents. For the lightest mesons, the coupling mixes transverse $\rho$ and $a_1$ polarization states. At sufficiently large baryon number densities, it produces an instability, which causes the $\rho$ and $a_1$ mesons to condense in a state breaking both rotational and translational invariance.
A Survey on Compound Image Classification and Compression Techniques.
K.Kalpana,G.Sophia Reena
International Journal of Engineering Sciences & Research Technology , 2013,
Abstract: Compound images are combinations of text, graphics and natural images. This paper presents a review of recent developments in compound image segmentation and compression in the field of image processing.
Cobalt Hexacyanoferrate-Decorated Titania Nanotube: CoHCF@TNT Modified GCE as an Electron Transfer Mediator for the Determination of Hydrazine in Water Samples
S. Jancy Sophia,S. Devi,K. Pandian
ISRN Analytical Chemistry , 2012, DOI: 10.5402/2012/192698
Abstract:
Complement C3a signaling mediates production of angiogenic factors in mesenchymal stem cells  [PDF]
Richard G. DiScipio, Sophia K. Khaldoyanidi, Rosita Moya-Castro, Ingrid U. Schraufstatter
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.68A1001
Abstract: A major portion of the beneficial effect of mesenchymal stem cells (MSC) is due to the production of trophic and angiogenic factors by these cells, and one of the efforts to improve the therapeutic efficacy of these cells lies in enhancing this capacity. Since there is complement activation in all areas of tissue injury, and both C3a and C5a activate MSC, it was asked whether stimulation with C3a or C5a would upregulate the production of trophic factors by MSC. C3a caused significant up-regulation of various angiogenic factors, including VEGF, CXCL8/IL-8 and IL-6. In contrast there was no detectable production of the pro-inflammatory cytokines TNF-α and IL-1β in spite of nuclear translocation of NFκB. Although C5a also caused moderate up-regulation of angiogenic factors, the effect was borderline significant. Furthermore the production of angiogenic factors induced by C3a was of physiological relevance: Supernatants of MSCs cultured under serum-free conditions induced minimal tube formation of HUVECs as an in vitro measure of angiogenesis; tube formation was considerably enhanced, when supernatants from C3a-stimulated MSC were used, while C3a itself had no direct angiogenic effect on HUVECs. The signaling cascade responsible for the production of angiogenic factors by C3a or C5a could be defined as activation of the rho cascade which was necessary for nuclear translocation of NFκB p65 and of phospho-ERK1/2. Although rho was only transiently activated, inhibition of the rho or “downstream of it” of the NFκB pathway, prevented C3a-and C5a-induced up-regulation of angiogenic factors.

Cobalt Hexacyanoferrate-Decorated Titania Nanotube: CoHCF@TNT Modified GCE as an Electron Transfer Mediator for the Determination of Hydrazine in Water Samples
S. Jancy Sophia,S. Devi,K. Pandian
ISRN Analytical Chemistry , 2012, DOI: 10.5402/2012/192698
Abstract: The cobalt hexacyanoferrate-decorated titania nanotube (CoHCF@TNT) was prepared by dispersing 100?mg of titania nanotube (TNT) to a solution of an equimolar concentration of CoCl2?·?6H2O and K3[Fe(CN)6] containing 0.05?M KCl solution (35?mL). The TNT was synthesized by hydrothermal method using Degussa P-25 TiO2 in 2?M NaOH as reported in the literature. The CoHCF@TNT was isolated and characterized by DRS-UV, FE-SEM, FT-IR, and XRD analysis. The electrochemical behavior of the CoHCF@TNT was carried out in 0.1?M phosphate buffer. The CoHCF@TNT modified system showed an excellent electron transfer mediator for the oxidation of hydrazine at +0.5?V versus Ag wire. The proposed method can be utilized for the amperometry detection of hydrazine from environmental samples. A calibration plot was constructed by plotting the concentration of hydrazine against the peak current. The current response was linear in the ranges of the hydrazine concentration from 5 × 10?4?M to 2.5 × 10?3?M with a slope of 72.8?μAmM?1 and the linear correlation coefficient of 0.9972. The detection limit was found to be 1 × 10?3?M. 1. Introduction There is an increasing demand for the development of a novel electrocatalytic mediator which has been used for various kinds of sensors for the detection of environmentally important pollutant in recent days. Though metal hexacyanoferrates are most studied as an important class of electron transfer mediator for the electrocatalytic oxidation and reduction, still there are numerous developments have been made to study their unique inherent physicochemical properties and electron transfer characteristics. The metal hexacyanoferrate-modified electrode shows excellent electrocatalytic behavior and selectivity. They can be widely used in various fields of research including photomagnetic [1], solid batteries [2], electrocatalysis [3], and biosensors [4]. Itaya et al., [5] and others have extensively studied the electrochemical behavior and stability of the Prussian blue and its analogues due to their similar electrochemical behavior, stability, and wider electrochemical window. These metal hexacyanoferrate-modified electrodes have mostly been utilized for the electrocatalytic detection of biological important thiols [6], selective detection of neurotransmitters [7], and environmental important pollutants like hydrazine [8], peroxide [9], and thiosulfate [10]. Because of its zeolite-like characteristics, PB and its analogues have been utilized for selective removal of radioactive Cs and toxic metals like Tl [11, 12]. To improve the electrochemical
Optimization of Physical Activity as a Countermeasure of Bone Loss: A 5-Year Study of Bikram Yoga Practice in Females  [PDF]
Sophia N. Sangiorgio, Arnob K. Mukherjee, Nicole W. Lau, Apurba Mukherjee, Prithwis Mukhopadhyay, Edward Ebramzadeh
Health (Health) , 2014, DOI: 10.4236/health.2014.611139
Abstract: Over the last decade, the number of people diagnosed with osteoporosis has increased dramatically due to many factors. While it has been asserted that one variable associated with preserving bone health is participation in high-impact exercises, those same exercises are also well documented to damage the hip and knee joints. Therefore, the goal of the present study was to evaluate the potential benefits of a highly regimented, low impact weight-bearing exercise, Bikram Yoga. Specifically, the bone mineral content was measured using DEXA analysis of the proximal femur and lumbar spine of nine female Bikram Yoga instructors between the ages of 30 and 59, who not only participated in a minimum of 3 classes (4.5 hours) a week, but also actively taught Bikram Yoga classes. These same participants, who remained active as instructors and practitioners, were rescanned five years later. The results of the study, which focused on the percent change in individual bone mineral density over the five-year period were as follows: the premenopausal subjects showed a mean increase in BMD of 6.6% at the femoral neck, 2.0% for the total hip, and 1.0% for the total lumbar spine. In contrast, post-menopausal subjects revealed a mean decrease in bone mineral density (BMD) of ﹣6.0%, ﹣8.1%, and ﹣5.6% in the femoral neck, total hip, and total lumbar spine, respectively. Consequently, the results of this study suggest that performing Bikram Yoga may preserve, or even perhaps, increase bone mineral density in pre-menopausal women and hence, may be an effective countermeasure for preventing osteoporosis.
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