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Search Results: 1 - 10 of 4628 matches for " Soon Jae Moon "
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Acidic pH shock induces the expressions of a wide range of stress-response genes
Yoon Kim, Myung Moon, Jae Song, Colin P Smith, Soon-Kwang Hong, Yong Chang
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-604
Abstract: According to the results of transcriptional and proteomic analyses, the major number of sigma factor genes were upregulated by an acidic pH shock. Well-studied sigma factor genes of sigH (heat shock), sigR (oxidative stress), sigB (osmotic shock), and hrdD that play a major role in the secondary metabolism, were all strongly upregulated by the pH shock. A number of heat shock proteins including the DnaK family and chaperones such as GroEL2 were also observed to be upregulated by the pH shock, while their repressor of hspR was strongly downregulated. Oxidative stress-related proteins such as thioredoxin, catalase, superoxide dismutase, peroxidase, and osmotic shock-related protein such as vesicle synthases were also upregulated in overall.From these observations, an acidic pH shock was considered to be one of the strongest stresses to influence a wide range of sigma factors and shock-related proteins including general stress response proteins. The upregulation of the sigma factors and shock proteins already found to be related to actinorhodin biosynthesis was considered to have contributed to enhanced actinorhodin productivity by mediating the pH shock signal to regulators or biosynthesis genes for actinorhodin production.Various environmental signals are known to enhance secondary metabolites production in Streptomycetes by initiating complex signal transduction system [1]. There have been a number of studies on the application of an environmental stimulus for the enhancement of productivity. These environmental stimuli include heat shock, cold shock, oxidative stress, osmotic stress, acidic sock, alkali shock [2-6].It is known that different sigma factors respond to different types of stresses, respectively in Streptomyces strains, which have a number of unique signal transduction mechanisms depending on the types of environmental shock [1]. Those sigma factors coordinate gene expression in response to various environmental and endogenous signals.A research group h
Acetabular Central Fracture Dislocation after Generalized Seizure during Lumbar Myelography with Iohexol
Kyung-Soon Park,Jae-Young Moon,Chang-Seon Oh,Taek-Rim Yoon
Case Reports in Orthopedics , 2013, DOI: 10.1155/2013/190917
Abstract:
Acetabular Central Fracture Dislocation after Generalized Seizure during Lumbar Myelography with Iohexol
Kyung-Soon Park,Jae-Young Moon,Chang-Seon Oh,Taek-Rim Yoon
Case Reports in Orthopedics , 2013, DOI: 10.1155/2013/190917
Abstract: Fracture is a less common complication in seizure patients, and fractures as a consequence of convulsive seizures without direct trauma occur in 0.3% of cases. Acetabular fractures after convulsions are even more rare, and only a few cases of acetabular fracture dislocations, purely caused by convulsive activity, have been reported. Therefore, we report a case of unilateral acetabular central fracture dislocation after a seizure episode, with relevant literature review. The seizure attack occurred after contrast media (Iohexol) injection for checking the myelography. 1. Introduction Seizure patients represent only 0.4% of emergency departmental visits, and 14% of these patients have accompanying injuries [1]. Fracture is not a common complication in seizure patients. Fractures as a consequence of convulsive seizures without direct trauma occur in only 0.3% of seizure cases [2]. Furthermore, fractures are directly related to trauma in 50% of those with a seizure-related fracture and only in 25% fractures are a consequence of seizure alone. Some of the more common locations for this type of trauma include the skull, proximal humerus, nasal bones, and clavicle [3]. Acetabular fractures after convulsions are extremely rare, and only a few cases of acetabular fracture dislocations, caused purely by convulsive activity, have been described in the literature. Here, we report a case of unilateral acetabular central fracture dislocation after a seizure episode without direct trauma and include a relevant review of the literature. The seizure attack in our patient occurred after contrast media (Iohexol) injection prior to myelography. Informed consent was taken prior to publication from the patient and her family. 2. Case Report A 73-year-old woman was referred to our hospital due to a left acetabular fracture. She had undergone L4-5 fusion for spinal stenosis 5 years ago, and after surgery she had persistent radiating pain. For pain control, a check lumbar myelography and spinal cord stimulator insertion was planned 4 months ago. But she had a grand mal seizure when the myelography was being performed. The seizure developed at the moment of contrast media injection of about 7?mL of the total 10?mL (Figure 1(a)). The contrast media used was Iohexol (IO-Brix, Taejoon Pharm, Seoul, Korea). Emergency management was performed. During seizure attack, there was no fall or trauma. She had no history of a previous seizure. Figure 1: (a) Myelography taken after emergency care showing instrument on L4-5. (b) Radiograph taken 2 days after seizure episode showing left
Dimensional crossover of polaron dynamics in Nb:SrTiO3/SrTiO3 superlattices: Possible mechanism of thermopower enhancement
Woo Seok Choi,Hiromichi Ohta,Soon Jae Moon,Yun Sang Lee,Tae Won Noh
Physics , 2009, DOI: 10.1103/PhysRevB.82.024301
Abstract: Using optical spectroscopy, we investigated the electrodynamic properties of Nb:SrTiO3/SrTiO3 superlattices. In these superlattices, a large enhancement of the Seebeck coefficient (S) has been reported with decreasing Nb:SrTiO3 layer thickness [refer to H. Ohta et al., Nature Mater. 6, 129 (2007)]. By analyzing the optical spectra, we found that the polaron plays an important role in determining the electrodynamic properties of the superlattices. With decreasing Nb:SrTiO3 layer thickness from eleven to one unit cell, we observed a threefold enhancement of the polaron effective mass and relaxation time. Such increases were attributed to a dimensional crossover of polaron from 3D to quasi-2D. Moreover, the modified nature of the polaron at low dimensions enhanced the thermoelectric properties of the oxide superlattice, by simultaneously increasing S and preventing the decrease of carrier mobility. Our results indicate that strong electron-phonon coupling can provide an alternative pathway in searching efficient thermoelectric materials.
Dimensionality Control of d-orbital Occupation in Oxide Superlattices
Da Woon Jeong,Woo Seok Choi,Satoshi Okamoto,Jae-Young Kim,Kyung Wan Kim,Soon Jae Moon,Deok-Yong Cho,Ho Nyung Lee,Tae Won Noh
Physics , 2014, DOI: 10.1038/srep06124
Abstract: Manipulating the orbital state in a strongly correlated electron system is of fundamental and technological importance for exploring and developing novel electronic phases. Here, we report an unambiguous demonstration of orbital occupancy control between t2g and eg multiplets in quasi-twodimensional transition metal oxide superlattices (SLs) composed of a Mott insulator LaCoO3 and a band insulator LaAlO3. As the LaCoO3 sublayer thickness approaches its fundamental limit (i.e. one unit-cell-thick), the electronic state of the SLs changed from a Mott insulator, in which both t2g and eg orbitals are partially filled, to a band insulator by completely filling (emptying) the t2g (eg) orbitals. We found the reduction of dimensionality has a profound effect on the electronic structure evolution, which is, whereas, insensitive to the epitaxial strain. The remarkable orbital controllability shown here offers a promising pathway for novel applications such as catalysis and photovoltaics, where the energy of d level is an essential parameter.
Circulating CD62E+ Microparticles and Cardiovascular Outcomes
Soon-Tae Lee, Kon Chu, Keun-Hwa Jung, Jeong-Min Kim, Hye-Jin Moon, Jae-Jun Bahn, Woo-Seok Im, Junsang Sunwoo, Jangsup Moon, Manho Kim, Sang Kun Lee, Jae-Kyu Roh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035713
Abstract: Background Activated endothelial cells release plasma membrane submicron vesicles expressing CD62E (E-selectin) into blood, known as endothelial microparticles (EMPs). We studied whether the levels of endothelial microparticles expressing CD62E+, CD31+/Annexin-V+, or CD31+/CD42? predict cardiovascular outcomes in patients with stroke history. Methods/Principal Findings Patients with stroke history at least 3 months prior to enrolment were recruited. Peripheral blood EMP levels were measured by flow cytometry. Major cardiovascular events and death were monitored for 36 months. Three hundred patients were enrolled, of which 298 completed the study according to protocol. Major cardiovascular events occurred in 29 patients (9.7%). Nine patients died, five from cardiovascular causes. Cumulative event-free survival rates were lower in patients with high levels of CD62E+ microparticles. Multivariate Cox regression analysis adjusted for cardiovascular risk factors, medications and stroke etiologic groups showed an association between a high CD62E+ microparticle level and a risk of major cardiovascular events and hospitalization. Levels of other kinds of EMPs expressing CD31+/Annexin-V+ or CD31+/CD42? markers were not predictive of cardiovascular outcomes. Conclusion A high level of CD62E+ microparticles is associated with cardiovascular events in patients with stroke history, suggesting that the systemic endothelial activation increases the risk for cardiovascular morbidities.
Inhibitory Effect of Inflexinol on Nitric Oxide Generation and iNOS Expression via Inhibition of NF- Activation
Jae Woong Lee,Moon Soon Lee,Tae Hun Kim,Hwa Jeong Lee,Seong Su Hong,Young Hee Noh,Bang Yeon Hwang,Jai Seup Ro,Jin Tae Hong
Mediators of Inflammation , 2007, DOI: 10.1155/2007/93148
Abstract: Inflexinol, an ent-kaurane diterpenoid, was isolated from the leaves of Isodon excisus. Many diterpenoids isolated from the genus Isodon (Labiatae) have antitumor and antiinflammatory activities. We investigated the antiinflammatory effect of inflexinol in RAW 264.7 cells and astrocytes. As a result, we found that inflexinol (1, 5, 10 μM) suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and astrocytes. Consistent with the inhibitory effect on iNOS and COX-2 expression, inflexinol also inhibited transcriptional and DNA binding activity of NF-κB via inhibition of IκB degradation as well as p50 and p65 translocation into nucleus. These results suggest that inflexinol inhibits iNOS and COX-2 expression through inhibition of NF-κB activation, thereby inhibits generation of inflammatory mediators in RAW 264.7 cells and astrocytes, and may be useful for treatment of inflammatory diseases.
Optical spectroscopic investigation on the coupling of electronic and magnetic structure in multiferroic hexagonal RMnO3 (R = Gd, Tb, Dy, and Ho) thin films
Woo Seok Choi,Soon Jae Moon,Sung Seok A. Seo,Daesu Lee,Jung Hyuk Lee,Pattukkannu Murugavel,Tae Won Noh,Yun Sang Lee
Physics , 2008, DOI: 10.1103/PhysRevB.78.054440
Abstract: We investigated the effects of temperature and magnetic field on the electronic structure of hexagonal RMnO3 (R = Gd, Tb, Dy, and Ho) thin films using optical spectroscopy. As the magnetic ordering of the system was disturbed, a systematic change in the electronic structure was commonly identified in this series. The optical absorption peak near 1.7 eV showed an unexpectedly large shift of more than 150 meV from 300 K to 15 K, accompanied by an anomaly of the shift at the Neel temperature. The magnetic field dependent measurement clearly revealed a sizable shift of the corresponding peak when a high magnetic field was applied. Our findings indicated strong coupling between the magnetic ordering and the electronic structure in the multiferroic hexagonal RMnO3 compounds.
Profiles of Multidrug Resistance Protein-1 in the Peripheral Blood Mononuclear Cells of Patients with Refractory Epilepsy
Jae-Jun Ban, Keun-Hwa Jung, Kon Chu, Soon-Tae Lee, Daejong Jeon, Kyung-Il Park, Hye-Jin Moon, Hyeyun Kim, Sunghun Kim, Sang Kun Lee, Jae-Kyu Roh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036985
Abstract: Background About one third of patients with epilepsy become refractory to therapy despite receiving adequate medical treatment, possibly from multidrug resistance. P-glycoprotein, encoded by multidrug resistance protein-1 (MDR1) gene, at the blood brain barrier is considered as a major factor mediating drug efflux and contributing to resistance. Given that peripheral blood mononuclear cells (PBMNCs) express MDR1, we investigated a MDR1 status of PBMNCs in various subsets of epilepsy patients and demonstrated their association with clinical characteristics. Methodology/Principal Findings Clinical and MDR1 data were collected from 140 patients with epilepsy, 30 healthy volunteers, and 20 control patients taking anti-epileptic drugs. PBMNCs were isolated, and basal MDR1 levels and MDR1 conformational change levels were measured by flow cytometry. MDR1 profiles were analyzed according to various clinical parameters, including seizure frequency and number of medications used in epilepsy patients. Epilepsy patients had a higher basal MDR1 level than non-epilepsy groups (p<0.01). Among epilepsy patients, there is a tendency for higher seizure frequency group to have higher basal MDR1 level (p = 0.059). The MDR1 conformational change level was significantly higher in the high-medication-use group than the low-use group (p = 0.028). Basal MDR1 (OR = 1.16 [95% CI: 1.060–1.268]) and conformational change level (OR = 1.11 [95% CI: 1.02–1.20]) were independent predictors for seizure frequency and number of medications, respectively. Conclusions/Significance The MDR1 profile of PBMNCs is associated with seizure frequency and medication conditions in patients with epilepsy.
Atmospheric Dispersion and Deposition of Radionuclides (137Cs and 131I) Released from the Fukushima Dai-ichi Nuclear Power Plant  [PDF]
Soon-Ung Park, Anna Choe, Moon-Soo Park
Computational Water, Energy, and Environmental Engineering (CWEEE) , 2013, DOI: 10.4236/cweee.2013.22B011
Abstract: The Lagrangian Particle Dispersion Model (LPDM) in the 594 km× 594 km model domain with the horizontal grid scale of 3 km×3 km centered at a power plant and the Eulerian Transport Model (ETM) modified from the Asian Dust Aerosol Model 2 (ADAM2) in the domain of 70° LAT × 140° LON with the horizontal grid scale of 27 km×27 km have been developed. These models have been implemented to simulate the concentration and deposition of radionuclides (137Cs and 131I) released from the accident of the Fukushima Dai-ichi nuclear power plant. It is found that both models are able to simulate quite reasonably the observed concentrations of 137Cs and 131I near the power plant. However, the LPDM model is more useful for the estimation of concentration near the power plant site in details whereas the ETM model is good for the long-range transport processes of the radionuclide plume. The estimated maximum mean surface concentration, column integrated mean concentration and the total deposition (wet+dry) by LPDM for the period from 12 March to 30 April 2011 are, respectively found to be 2.975 × 102 Bq m-3, 3.7 × 107 Bq m-2, and 1.78 × 1014 Bq m-2 for 137Cs and 1.96 × 104 Bq m-3, 2.24 × 109 Bq m-2 and 5.96 × 1014 Bq m-2 for 131I. The radionuclide plumes released from the accident power plant are found to spread wide regions not only the whole model domain of downwind regions but the upwind regions of Russia, Mongolia, Korea, eastern China, Philippines and Vietnam within the analysis period.
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