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Search Results: 1 - 10 of 1301 matches for " Soni Sachin "
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Vitamin D Dependent Rickets Type II: Late Onset of Disease and Response to High Doses of Vitamin D
Soni Sachin,Adikey Gopal,Raman Anuradha
Saudi Journal of Kidney Diseases and Transplantation , 2008,
Abstract: Vitamin D dependent rickets Type II is a rare autosomal recessive disorder. The disorder is characterized by end organ hyporesponsiveness to vitamin D. Common presentation of the disorder is total body alopecia and onset of rickets during the second half of the first year of life. Patients may display progressive rachitic bone changes, hypocalcemia and secondary hyper-parathyroidism. It is differentiated from vitamin D dependent rickets type I by virtue of response to physiological doses of exogenous vitamin D in the later. Target organ hyporesponsiveness can be overcome by higher doses of vitamin D or its analogues. We report a case of vitamin D dependent rickets type II with onset of rickets at the age of thirteen years without alopecia progressing to marked disability by twenty three years of age. She responded to massive doses of vitamin D with significant clinical improvement after six months of therapy.
Using continuous renal replacement therapy to manage patients of shock and acute renal failure
Soni Sachin,Nagarik Amit,Adikey Gopal,Raman Anuradha
Journal of Emergencies, Trauma and Shock , 2009,
Abstract: Background: The incidence of acute renal failure (ARF) in the hospital setting is increasing. It portends excessive morbidity and mortality and a considerable burden on hospital resources. Extracorporeal therapies show promise in the management of patients with shock and ARF. It is said that the potential of such therapy goes beyond just providing renal support. The aim of our study was to analyze the clinical setting and outcomes of critically ill ARF patients managed with continuous renal replacement therapy (CRRT). Patients and Methods: Ours was a retrospective study of 50 patients treated between January 2004 and November 2005. These 50 patients were in clinical shock and had concomitant ARF. All of these patients underwent CVVHDF (continuous veno-venous hemodiafiltration) in the intensive care unit. For the purpose of this study, shock was defined as systolic BP < 100 mm Hg in spite of administration of one or more inotropic agents. SOFA (Sequential Organ Failure Assessment) score before initiation of dialysis support was recorded in all cases. CVVHDF was performed using the Diapact (Braun) CRRT machine. The vascular access used was as follows: femoral in 32, internal jugular in 8, arteriovenous fistula (AVF) in 4, and subclavian in 6 patients. We used 0.9% or 0.45% (half-normal) saline as a prefilter replacement, with addition of 10% calcium gluconate, magnesium sulphate, sodium bicarbonate, and potassium chloride in separate units, while maintaining careful monitoring of electrolytes. Anticoagulation of the extracorporeal circuit was achieved with systemic heparin in 26 patients; frequent saline flushes were used in the other 24 patients. Results: Of the 50 patients studied, 29 were males and 21 females (1.4:1). The average age was 52.88 years (range: 20-75 years). Causes of ARF included sepsis in 24 (48%), hemodynamically mediated renal failure (HMRF) in 18 (36%), and acute over chronic kidney disease in 8 (16%) patients. The overall mortality was 74%. The average SOFA score was 14.31. The variables influencing mortality on multivariate analysis were: age [odds ratio (OR):1.65; 95% CI: 1.35 to 1.92; P = 0.04], serum creatinine (OR:1.68; 95% CI: 1.44 to 1.86; P = 0.03), and serum bicarbonate (OR: 0.76; 95% CI: 0.55 to 0.94; P = 0.01). On univariate analysis the SOFA score was found to be a useful predictor of mortality. Conclusions: Despite advances in treating critically ill patients with newer extracorporeal therapies, mortality is dismally high. Multiorgan dysfunction adversely affects outcome of CRRT. Older age, level of azotemia, and sever
Encryption using XOR based Extended Key for Information Security – A Novel Approach
E. Anupriya,,Amit Agnihotri,,Sachin Soni,,Sourabh Babelay
International Journal on Computer Science and Engineering , 2011,
Abstract: The explosive growth of information, places a high demand for Information Security. Information Security deals with securing the information from unauthorized access or misuse of information either intentionally or accidentally. Information may be represented in many forms like text, documents, audio, video, images or maps. The standard and widely used form is documents. The objective of our work is to secure information present in these documents especially in a shared environment like peer-to- peer environment. We have proposed a novel symmetric encryption method which uses XOR based extended key to encrypt all characters which includes alphabets, numerals and special characters. Our approach differs from traditional approaches which rely on numeric key values. [6], [1]. Our intention is to strengthen the confusion which inherently makes the decryption a challenging task.
Hereditary leiomyomatosis with renal cell carcinoma
Soni Sachin,Gowrishankar Swarnalata,Adikey Gopal,Raman Anuradha
Indian Journal of Dermatology, Venereology and Leprology , 2008,
Effect of neutral collision and radiative heat-loss function on self-gravitational instability of viscous thermally conducting partially-ionized plasma
Sachin Kaothekar,Ghanshyam D. Soni,Rajendra K. Chhajlani
AIP Advances , 2012, DOI: 10.1063/1.4773348
Abstract: The problem of thermal instability and gravitational instability is investigated for a partially ionized self-gravitating plasma which has connection in astrophysical condensations. We use normal mode analysis method in this problem. The general dispersion relation is derived using linearized perturbation equations of the problem. Effects of collisions with neutrals, radiative heat-loss function, viscosity, thermal conductivity and magnetic field strength, on the instability of the system are discussed. The conditions of instability are derived for a temperature-dependent and density-dependent heat-loss function with thermal conductivity. Numerical calculations have been performed to discuss the effect of various physical parameters on the growth rate of the gravitational instability. The temperature-dependent heat-loss function, thermal conductivity, viscosity, magnetic field and neutral collision have stabilizing effect, while density-dependent heat-loss function has a destabilizing effect on the growth rate of the gravitational instability. With the help of Routh-Hurwitz's criterion, the stability of the system is discussed.
Systemic toxicity of paraphenylenediamine
Soni Sachin,Nagarik Amit,Dinaker Manjunath,Adikey Gopal
Indian Journal of Medical Sciences , 2009,
Comparative study of anticoagulation versus saline flushes in continuous renal replacement therapy
Nagarik Amit,Soni Sachin,Adikey Gopal,Raman Anuradha
Saudi Journal of Kidney Diseases and Transplantation , 2010,
Abstract: Systemic heparinization during continuous renal replacement therapy (CRRT) is associated with disadvantage of risk of bleeding. This study analyses the efficacy of frequent saline flushes compared with heparin anticoagulation to maintain filter life. From January 2004 to November 2007, 65 critically ill patients with acute renal failure underwent CRRT. Continuous venovenous hemodialfiltration (CVVHDF) was performed using Diapact Braun CRRT machine. 1.7% P.D. fluid was used as dialysate. 0.9% NS with addition of 10% Ca Gluconate, Magnesium Sulphate, Soda bicarbonate and Potassium Chloride added sequentially in separate units were used for replacement, carefully monitoring their levels. Anticoagulation of extracorporeal circuit was achieved with unfractionated heparin (250-500 units alternate hour) in 35 patients targeting aPTT of 45-55 seconds. No anticoagulation was used in 30 patients with baseline APTT > 55 seconds and extracorporeal circuit was maintained with saline flushes at 30 min interval. 65 pa-tients including 42 males. Co-morbidities were comparable in both groups. HMARF was signifi-cantly more common in heparin group while Sepsis was comparable in both the groups. CRRT parameters were similar in both groups. Average filter life in heparin group was 26 ± 6.4 hours while it was 24.5 ± 6.36 hours in heparin free group ( P=NS). Patients receiving heparin had 16 bleeding episodes (0.45/patient) while only four bleeding episodes occurred in heparin free group (0.13/patient, P< 0.05). Mortality was 71% in heparin group and 67% in heparin free group. Frequent saline flushes is an effective mode of maintainance of extracorporeal circuit in CRRT when aPTT is already on the higher side, with significantly decreased bleeding episodes.
Collagenofibrotic glomerulopathy in association with hodgkin′s lymphoma
Soni Sachin,Gowrishankar Swarnalata,Nagarik Amit,Barnela Sriganesh
Saudi Journal of Kidney Diseases and Transplantation , 2011,
Abstract: Deposit glomerulopathies are characterized by fibrillary deposits of various sizes, mainly in the mesangial area. Collagenofibrotic glomerulopathy is a rare type of such fibrillary glomerulopathies characterized by deposits of 60-80 nm fibrils in the sub-endothelial and mesan-gial areas. It is also associated with increased levels of serum pro-collagen type III peptide (PIIINP). Although most of the initial reports have emanated from Japan, many other scientists around the globe have later reported this disease. Possibility of systemic disease affecting metabolism of type III collagen is postulated but so far no such association has been identified. We report a 26-year-old male patient who presented with insidious onset of febrile illness associated with lympha-denopathy and proteinuria. Lymph node biopsy revealed features of Hodgkin′s lymphoma while percutaneous renal biopsy showed features of collagenofibrotic glomerulopathy.
A Study on Knowledge, Attitude And Practice of Laboratory Safety Measures Among Paramedical Staff of Laboratory Services
Hansa M Goswami, Sumeeta T Soni, Sachin M Patel, Mitesh K Patel
National Journal of Community Medicine , 2011,
Abstract: Purpose: A lot of accidents occur in the laboratory due to lack of proper knowledge regarding laboratory safety measures, indifferent attitude & improper implementation of safe laboratory practices. In view of this, the present study on knowledge, Attitude & Practice (KAP) of laboratory safety measures was carried out among paramedical staff of laboratory services of tertiary care teaching hospital, western India. Method: This was a comparative study which used a standardized, structured self-administered questionnaire to survey knowledge, attitude and practice of paramedical staff. The KAP study enrolled 81 respondents. Results: Regarding knowledge- the majority knew the very important issues related with laboratory safety like Post Exposure Prophylaxis (96.55%) & discarding of blood samples (93.10%) etc. In regard to attitude towards the scientific process, all are very much aware about importance of protective devices (i.e. Wearing Gloves) and Biomedical waste management. In regard to the practice in laboratory, the entire study subject group (100%) replied a€ YESa€ in each question that shows the good quality work of the laboratory. Conclusion: The induction training on Laboratory safety is very important and motivating exercise for improving the laboratory safety measures.
Surgical Site Infections: Incidence and Risk Factors in a Tertiary Care Hospital, Western India
Patel Sachin M,Patel Mitesh H,Patel Sangeeta D,Soni Sumeeta T
National Journal of Community Medicine , 2012,
Abstract: Purpose: The present study was aimed at obtaining the incidence of Surgical Site Infections (SSI) and determining various risks the factors influencing the Surgical Site Infections rate with special reference to the NNIS risk index at tertiary care hospital, Gujarat. Western India. Methods: In this study, 200 patients who underwent various surgeries were included and various risk factors were studied. Swabs were obtained from wounds and were processed without delay using standard microbiological methods. Results: Overall SSI rate was 16% (32/200).The most common organism isolated was Escherichia coli (35.7%, 10/28). Increase in pre-operative hospital stay, ASA (American Society of Anesthesiology) score > 2, increase in surgical wound class, emergency surgeries, longer duration of surgery were associated with increased SSI rates. NNIS risk index was calculated for all patients and it was found that SSI rate increases with increase in NNIS risk index. Conclusion: The risk indices, like the NNIS risk index provide information about potential risk factors for development of SSI. Surveillance of surgical site infections with feedback of appropriate data to surgeons would be desirable to reduce SSI rates.
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