Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Search Results: 1 - 10 of 1054 matches for " Soichiro Itoh "
All listed articles are free for downloading (OA Articles)
Page 1 /1054
Display every page Item
The Therapeutic Effectiveness of the Coadministration of Weekly Risedronate and Proton Pump Inhibitor in Osteoporosis Treatment
Mizue Tanaka,Soichiro Itoh,Taro Yoshioka,Kimihiro Yamashita
Journal of Osteoporosis , 2014, DOI: 10.1155/2014/607145
Abstract: This trial was conducted to investigate the long-term effects of proton pump inhibitor (PPI) coadministration on the efficacy of weekly risedronate treatment for osteoporosis. Ninety-six women over 50 years old with low bone mineral density (BMD) participated in this trial. Subjects were randomly divided into 2 groups: a 17.5?mg dose of sodium risedronate was administered weekly, with or without a daily 10?mg dose of sodium rabeprazole ( and 47 in the BP + PPI and BP groups, resp.). The following biomarkers were measured at the baseline and every 3 months: bone-specific alkaline phosphatase, N-terminal telopeptide of type I collagen corrected for creatinine, parathyroid hormone, BMD of the lumbar spine, and physical parameters evaluated according to the SF-36v2 Health Survey. Statistical comparisons of these parameters were performed after 6, 12, 18, and 24 months. The Δ values of improvement in physical functioning after 12 months and bodily pain after 6 and 12 months in the BP + PPI group were significantly larger than those in the BP group. These results suggest that PPI does not adversely affect bone metabolism. Alternatively, approved bone formation by concomitant PPI treatment may have had favorable effects on the improvement of bodily pain and physical functions. 1. Introduction Various types of therapeutic products for osteoporosis have been developed. Among them, bisphosphonate (BP) is currently the most commonly prescribed drug for the treatment of osteoporosis. This compound can selectively inhibit osteoclast-mediated bone resorption, thereby resulting in an increase in bone mineral density (BMD). Pyridinyl BP risedronate ([1-hydroxy-2-(3-pyridinyl)-ethylidene] bis[phosphonic acid] monosodium salt) in the risedronate group is effective for the treatment of postmenopausal osteoporosis and reduces the risk of vertebral fracture within the first year of treatment [1, 2]. Gastrointestinal medicine is occasionally used to prevent upper gastrointestinal (GI) tract adverse events for the prolonged administration of risedronate. It is reported that the infusion of ranitidine, which is a histamine H2-receptor antagonist that inhibits stomach acid production, increases the gastric pH and doubles the bioavailability of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate monosodium [3]. Hence, it is expected that risedronate administered in combination with a proton pump inhibitor (PPI) may be more effective than the administration of risedronate alone in inhibiting bone resorption and treating osteoporosis as well as preventing GI tract adverse events.
Asymptotic pointwise behavior for systems of semilinear wave equations in three space dimensions
Soichiro Katayama
Mathematics , 2011, DOI: 10.1142/S0219891612500099
Abstract: In connection with the weak null condition, Alinhac introduced a sufficient condition for global existence of small amplitude solutions to systems of semilinear wave equations in three space dimensions. We introduce a slightly weaker sufficient condition for the small data global existence, and we investigate the asymptotic pointwise behavior of global solutions for systems satisfying this condition. As an application, the asymptotic behavior of global solutions under the Alinhac condition is also derived.
Asymptotic bahavior for systems of nonlinear wave equations with multiple propagation speeds in three space dimensions
Soichiro Katayama
Mathematics , 2012, DOI: 10.1016/j.jde.2013.04.003
Abstract: We consider the Cauchy problem for systems of nonlinear wave equations with multiple propagation speeds in three space dimensions. Under the null condition for such systems, the global existence of small amplitude solutions is known. In this paper, we will show that the global solution is asymptotically free in the energy sense, by obtaining the asymptotic pointwise behavior of the derivatives of the solution. Nonetheless we can also show that the pointwise behavior of the solution itself may be quite different from that of the free solution. In connection with the above results, a theorem is also developed to characterize asymptotically free solutions for wave equations in arbitrary space dimensions.
Global existence for coupled systems of nonlinear wave and Klein-Gordon equations in three space dimensions
Soichiro Katayama
Mathematics , 2009, DOI: 10.1007/s00209-010-0808-0
Abstract: We consider the Cauchy problem for coupled systems of wave and Klein-Gordon equations with quadratic nonlinearity in three space dimensions. We show global existence of small amplitude solutions under certain condition including the null condition on self-interactions between wave equations. Our condition is much weaker than the strong null condition introduced by Georgiev for this kind of coupled system. Consequently our result is applicable to certain physical systems, such as the Dirac-Klein-Gordon equations, the Dirac-Proca equations, and the Klein-Gordon-Zakharov equations.
Turn Control of a Three-Dimensional Quasi-Passive Walking Robot by Utilizing a Mechanical Oscillator  [PDF]
Ying Cao, Soichiro Suzuki, Yohei Hoshino
Engineering (ENG) , 2014, DOI: 10.4236/eng.2014.62013

A turn control strategy is proposed in order to improve environmental adaptability of a quasi-passive walking robot by utilizing a mechanical oscillator. The target trajectory of the fmechanical oscillator is determined by online planning of its period, phase, amplitude and angle of the central axis of oscillation. The motion of the mechanical oscillator is always entrained with the rocking motion of the robot based on forced entrainment in order to stabilize the robot. The turn radius can be controlled by adjusting the inclination angle of the central axis of the mechanical oscillator movement, and the control method is numerically and experimentally examined. Results show that the robot can turn with different radius and it is possible for the robot to walk in various environments. Finally, the gait of turn is compared with that of straight walking and analyzed in terms of mechanical work and energy.

Review on People’s Lifestyle and Energy Consumption of Asian Communities: Case Study of Indonesia, Thailand, and China  [PDF]
Didit Novianto, Weijun Gao, Soichiro Kuroki
Energy and Power Engineering (EPE) , 2015, DOI: 10.4236/epe.2015.710045
Abstract: This paper focuses on the residential housing performance and people’s lifestyle in terms of energy use. The research has to be continuously study in order to change the Asian people’s lifestyle moving toward the low energy consumption. The research began with collecting data by questionnaires which already distributed to some cities of some countries in Asia. In this paper, we conducted review of energy behavior in housing of three different countries, Indonesia, China, and Thailand. Through questionnaire surveys distributed to more than 600 households, we revealed the housing unit characteristics, household characteristics, ownership of domestic electrical appliances, use of indoor thermal equipment, and monthly energy use. Based on questionnaire results from all households in the seven districts, we conducted statistical analyses to find the major factors influencing the energy use in households. Finally, the research results will be used to indicate the energy use and develop an idea for energy conservation in Asian countries. For further studies, the researchers also try to discover the new way of changing the people’s lifestyle in terms of energy consumption.
Evaluation of Asthma Symptoms to Assess Asthma Control Status in a Primary Care Setting: An Exploratory Analysis of Pooled Data from Three Trials  [PDF]
Soichiro Hozawa, Michikazu Terada, Maki Hozawa
Open Journal of Respiratory Diseases (OJRD) , 2018, DOI: 10.4236/ojrd.2018.82003
Background: Primary care physicians in Japan see many patients in a given day; consequently, they find it challenging to devote sufficient time for detailed clinical consultation and evaluation of asthma control status. The aim of this study was to investigate asthma symptoms that reveal the presence of inadequately controlled asthma. Methods: A pooled analysis of baseline data from 100 patients with asthma treated with inhaled corticosteroid(s) (ICS) alone or ICS/long-acting beta-agonist who participated in three previous clinical trials was performed. Asthma control status and asthmatic symptoms were determined using a five-item Asthma Control Questionnaire, and whether asthmatic symptoms reflect clinical markers was investigated. Results: Nocturnal awakening owing to asthmatic symptoms was observed only in the uncontrolled asthma group. Patient-reported wheezing was not observed in the group with well-controlled asthma, but was observed in all patients in the uncontrolled asthma group. Virtually all patients, irrespective of asthma control status, reported symptoms in the morning, limitation of normal daily activities, and shortness of breath. Conclusions: The presence of nocturnal awakening due to asthma and wheezing likely reflected uncontrolled asthma. These results will lead to re-recognition that clinical interview, querying nocturnal awakening from asthma and wheezing is a simple and useful approach to assess asthma control status in a primary care setting.
Takayoshi Kuribara,Soichiro Kyushin
Acta Crystallographica Section E , 2013, DOI: 10.1107/s160053681205074x
Abstract: The molecule in the structure of the title compound, C34H60Si4, lies on a twofold rotation axis that passes through the two Si atoms, resulting in a planar cyclotetrasilane ring. The dihedral angle between the cyclotetrasilane ring and the phenyl ring is 68.20 (5)°. The Si—Si bonds [2.4404 (8) and 2.4576 (8) ] are longer than a standard Si—Si bond (2.34 ) and the C—Si—C bond angle [97.07 (14)°] of the phenyl-substituted Si atom is smaller than the tetrahedral bond angle (109.5°). These long bonds and small bond angle are favorable for reducing the steric hindrance among the bulky substituents.
Liver Dysfunction Revealed Marked Hyperdensity on Computed Tomography
Soichiro Ichikawa,Shigeru Fukuzawa
Oman Medical Journal , 2012,
Chiral condensate in nuclear matter beyond linear density using chiral Ward identity*
Goda Soichiro,Jido Daisuke
EPJ Web of Conferences , 2012, DOI: 10.1051/epjconf/20123708010
Abstract: We discuss density corrections of the chiral condensate up to a NLO order using the chiral Ward identity and an in-medium chiral perturbation theory. The in-medium chiral condensate is calculated by a correlation function of the axial current and pseudoscalar density in the nuclear matter as a consequence of the chiral Ward identity. The correlation function is evaluated using the chiral perturbation theory with the hadronic quantities of pion-nucleon dynamics. We assume that the in-vacuum interaction vertices are known, which means that the in-vacuum loop corrections are renormalized to the tree chiral couplings by taking the values of the couplings in chiral Lagrangian as the physical values. We focus on density order in the physical quantities in our perturbative calculation. This study shows that the medium effects to the chiral condensate beyond the linear density come from density corrections to the πN sigma term. It implies that calculating the density dependence of the chiral condensate in nuclear matter is essentially equivalent to describe nuclear matter in chiral effective theory.
Page 1 /1054
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.