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Search Results: 1 - 10 of 7602 matches for " Sobia Khan "
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Can Simple Preoperative Hemoglobin Testing Screen Symptomatic Anemia in Patients Undergoing Ambulatory Surgeries in Third World Countries?  [PDF]
Sobia Khan, Mueen Ullah Khan, Khalid Samad
Open Journal of Anesthesiology (OJAnes) , 2012, DOI: 10.4236/ojanes.2012.24034
Abstract: Background: Patients coming for ambulatory surgeries are mostly healthy adults and asymptomatic anemia in these patients is rare. According to international standards, perioperative period is not an appropriate setting to screen and investigate the cause of asymptomatic anemia, but in third world countries where iron deficiency is rampant, it is generally required as per local hospitals policy to test hemoglobin levels prior to any surgery in order to prevent morbidity. The purpose of our study is to look at the prevalence of anemia in patient undergoing minor elective ambulatory surgeries. Method: This was a cross sectional observational study conducted at tertiary care unit, Karachi, Pakistan. A total of 385 ASA-I (American Society of Anesthesiologist) and II patient’s age ranged 18 - 60 years, scheduled for day care surgical procedures were enrolled in the study. Results: Anemia was detected in 74 (19.2%) patients and its prevalence was found to be higher in females and in patients above 50 years of age. However, the presence of anemia did not have any influence on the perioperative outcomes or management. Conclusion: The routine preoperative hemoglobin testing does not have any effect on the perioperative outcomes in asymptomatic patients who are planned for elective day care surgeries.
Share of afghanistan populace in hepatitis B and hepatitis C infection's pool: is it worthwhile?
Sanaullah Khan, Sobia Attaullah
Virology Journal , 2011, DOI: 10.1186/1743-422x-8-216
Abstract: Thirty one studies dating from October 2003 to 2011 were included, consisting the data of 1,32,981 individuals for HBV and 1,32,500 individuals for HCV. Percentage prevalence was 1.9% for HBV and 1.1% for HCV in all available Afghanistan population. Most at risk population to hepatitis include injecting drug users who share needles and female sex workers, while truck drivers, prisoners and homosexual men needs attention, as their statistical figure are missing. Data suggests that high incidence of intravenous drug use, sexual activities, unsafe blood transfusion procedures and mobility are major risk factors for hepatitis transmission.This review is based on analysis of the limited available data in Afghanistan. Although there are many underlying vulnerability factors, it appears that Afghanistan remains at an early epidemic phase. Further research is required to determine the seroprevalence and prevalent genotype(s) of HBV and HCV in all provinces in Afghanistan. This article provides some key insights into the potential and likely future transmission dynamics of Hepatitis which will serve as a guide in the identification of priority areas in term of high risk groups and risk behaviours in the country and will assist to develop urgent strategic plans to combat the future burden of Hepatitis in Afghanistan.Both HBV and HCV are major cause of dreadful liver diseases including acute hepatitis, chronic liver diseases and hepatocellular carcinoma [1]. It is estimated that 30% of the global population (about 2 billion persons) have serologic evidence of HBV infection while over 350 million people are carriers of chronic HBV worldwide [2]. Approximately 3% of the world's population (approximately 170 million people) have chronic hepatitis C virus (HCV) infection and 3-4 million people are newly infected annually [3].Afghanistan is the world's 41st largest country of about 28,150 million inhabitants [4] and fertility rate of 6.5 children per woman [5]. It is among the leas
Orthogonal Fault Tolerance for Dynamically Adaptive Systems
Sobia K Khan
Computer Science , 2014,
Abstract: In dynamic systems that adapt to users' needs and changing environments, dependability needs cannot be avoided. This paper proposes an orthogonal fault tolerance model as a means to manage and reason about multiple fault tolerance mechanisms that co-exist in dynamically adaptive systems. One of the key challenges associated with dynamically evolving fault tolerance needs is the feature interaction problem arising from the integration of fault tolerance features. The proposed approach provides a separation of fault tolerance concerns to study the effects of integrated fault tolerance on the system. This approach uses state machine and operational semantics to reason about these interactions and inconsistencies. The proposed approach is supported by the tool NuSMV to simulate and verify the state machines against logic statements.
Walnut Trim down Lipid Profile and BMI in Obese Male in Different Ethnic Groups of Quetta Population, Pakistan  [PDF]
Rehana Mushtaq, Rubina Mushtaq, Sobia Khwaja, Zahida Tasawar Khan
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.410139
Abstract:

A total of 64 male obese subjects were randomized to observe the effect of 40 g of walnut in daily breakfast on lipid profile and Body Mass Index (BMI), total Cholesterol (CHO), Triglyceride (TG) High Density Lipoprotein (HDL) cholesterol and Low Density Lipoprotein (LDL) cholesterol in obese male subjects of various ethnics i.e. Baloch (B), Pathan (P), Hazara (H) and Punjabi (PU) residing in Quetta region of Balochistan for this purpose four weeks controlled study was designed. A batch of 32 obese male subjects 8 from each ethnic group as a control and another batch of 32 obese males 8 from each ethnic group as treated were selected. Twelve hour fasting blood samples a day after stoppage of walnut were taken from obese control and obese treated subjects. Daily walnut consumption in obese male subjects evidently demonstrated reduced BMI in all ethnic groups. Walnut supplementation in obese exhibited significant reduction in cholesterol level in Baloch (P < 0.001) and Punjabi (P < 0.01) males. There was profound and statistically significant [B (P < 0.05), P (P < 0.05), H (P < 0.01) and PU (P < 0.05)] elevation in HDL-C in all male ethnic groups. In male sub-population LDL-C was significantly [P (P < 0.01), H (P < 0.001) and PU (P < 0.05)] reduced in these groups. In these subjects walnut supplementation showed pronounced reduction [B (P < 0.001), P (P < 0.05), H (P < 0.001) and PU (P < 0.001)] in triglyceride levels. The constructive influence of walnut on lipid profile suggests that walnut rich diet may have advantageous effects beyond changes in plasma lipid level.

Role of Gata-4 Transcription Factor Associated With B-Type Natriuretic Peptides in Heart Failure
Fehmida Farid Khan,Sobia Tabassum
Journal of Asian Scientific Research , 2013,
Abstract: Congestive heart failure is a condition in which heart loses its ability to fill with or pump sufficient amount of blood through the body. Two cardiac natriuretic peptides aterial natriuretic peptide and brain natriuretic peptide are secreted by the heart with a homologous structure. The level of brain natriuretic peptide surges in Heart Failure so brain natriuretic peptide level is used to diagnose Heart failure. Brain natriuretic peptide physiology is exaggerated by NPPB sequence variants, possibly via transcriptional regulation. The GATA cofactors are involved in the regulation of ANP and BNP promoters and a single mutation in the GATA -4 leads towards the diseases linked with heart. Mutations of GATA 4 transcription factor in promoter region of brain natriuretic peptide may cause increase level of brain natriuretic peptide.
Trend of transfusion transmitted infections frequency in blood donors: provide a road map for its prevention and control
Sobia Attaullah, Sanaullah Khan, Jabbar Khan
Journal of Translational Medicine , 2012, DOI: 10.1186/1479-5876-10-20
Abstract: A retrospective study was carried out in healthy blood donors in the Lady Reading Hospital Peshawar, Pakistan over a period of three and a half years i.e., from January 2008 to June 2011, to determine the prevalence of HBV, HCV, HIV and syphilis in order to provide information for relevant polices.Out of 1,27,828 sample of blood donors, recorded mean prevalence for HBs Ag, anti-HCV, anti-HIV and syphilis was 2.68%, 2.46%, 0.06% and 0.43%, respectively, with an increasing trend in frequencies of transfusion transmitted infections (TTIs).This study reflects that blood transfusion is one of the leading risk factor of spread of the TTIs, which showed the need and importance of the mandatory screening of these infectious markers in blood donations.Hepatitis B virus (HBV), hepatitis C virus (HCV), Human immune deficiency virus (HIV) and syphilis are the most important lethal agents in transfusion transmitted infections (TTIs) and it remains a large health care burden globally. The incidence rates across the world are difficult to calculate given the asymptomatic and often latent nature of the disease prior to clinical presentation [1]. Every blood transfusion therefore carries a potential risk for transmissible diseases [1,2].TTIs are significant contemporary for medicine and society problem in Pakistan, but there exact burden is still unknown due to lack of awareness, poor use of screening tests or their high cost, limited access to a health facility, nonexistence of surveillance system and due to there asymptomatic or have non-specific symptoms. The incidence rates across the world have declined due to the awareness while Pakistan is still in the state of war against these killer infections [3,4].Blood transfusion is a therapeutic procedure, as there is no genuine substitution. But contaminated blood transfusion can transmit infectious diseases and can be fatal instead of saving life. Safe blood transfusion services are a cornerstone of an effective high quality health
Hepatitis C virus genotypes in Pakistan: a systemic review
Sobia Attaullah, Sanaullah Khan, Ijaz Ali
Virology Journal , 2011, DOI: 10.1186/1743-422x-8-433
Abstract: HCV genotype/s distribution from all 34 studies was observed in 28,400 HCV infected individuals in the following pattern: 1,999 (7.03%) cases of genotype 1; 1,085 (3.81%) cases of genotype 2; 22,429 (78.96%) cases of genotype 3; 453 (1.59%) cases of genotype 4; 29 (0.10%) cases of genotype 5; 37 (0.13%) cases of genotype 6; 1,429 (5.03%) cases of mixed genotypes, and 939 (3.30%) cases of untypeable genotypes. Overall, genotype 3a was the predominant genotype with a rate of 55.10%, followed by genotype 1a, 3b and mixed genotype with a rate of 10.25%, 8.20%, and 5.08%, respectively; and genotypes 4, 5 and 6 were rare. Genotype 3 occurred predominately in all the provinces of Pakistan. Second more frequently genotype was genotype 1 in Punjab province and untypeable genotypes in Sindh, Khyber Pakhtunkhwa and Balochistan provinces.Hepatitis C virus (HCV) infection, the sole member of the genus Hepacivirus, in the family Flaviviridae [1], is a global public health problem [1-3] and is accountable for the second most common cause of viral hepatitis [4]. Pakistani HCV serofrequency figures are significantly higher (4.7%, varying from 0.4%-33.7%) when compared to the corresponding populations in surrounding countries like India (0.66%), Nepal (1.0), Myanmar (2.5%), Iran (0.87%) [5], China (1%) [6] and Afghanistan (1.1%) [7].HCV has been recognized to be both hepatotropic and lymphotropic virus [8]. The complete HCV genome was determined by Choo et al in 1991 and the consensual international classification was made in 1994 [6]. HCV genome is comprised of linear single stranded RNA molecule of positive polarity of ~9.6 kb [1]. The RNA encodes a large polyprotein of about 3,000 amino acids in a single continuous open reading frame (ORF) which is flanked at the 5' and 3' ends by nontranslated regions (5' UTR) [1,2,9]. The ORF comprised of 3 structural genes (C, E1, E2) and 4 nonstructural genes (NS2, NS3, NS4 and NS5) [2,9]. Mutation rate are different in different region of HCV
Aurora kinase-C-T191D is constitutively active mutant
Jabbar Khan, Sanaullah Khan, Sobia Attaullah, Ijaz Ali, Shahid Khan
BMC Cell Biology , 2012, DOI: 10.1186/1471-2121-13-8
Abstract: Aurora-C-T191D variant form was investigated and compared with wild type. The overexpression of Aurora-C-T191D was observed that it behaves like Aurora-C wild type (aurC-WT). Both Aurora-C-T191D and aurC-WT induce abnormal cell division resulting in centrosome amplification and multinucleation in transiently transfected cells as well as in stable cell lines. Similarly, Aurora-C-T191D and aurC-WT formed foci of colonies when grown on soft agar, indicating that a gain of Aurora-C activity is sufficient to transform cells. Furthermore, we reported that NIH-3 T3 stable cell lines overexpressing Aurora-C-T191D and its wild type partner induced tumour formation when injected into nude mice, demonstrating the oncogenic activity of enzymatically active Aurora kinase C. Interestingly enough tumour aggressiveness was positively correlated with the rate of kinase activity, making Aurora-C a potential anti-cancer therapeutic target.These findings proved that Aurora C-T191D is not hyperactive but is constitutively active mutant.Aurora kinases are a conserved family of serine/threonine kinases that are pivotal to the successful execution of cell division. Three Aurora kinases (Aurora-A, -B, and -C), which share sequence homology in their central catalytic kinase domains, have been identified in mammals [1]. All the three mammalian Aurora kinases are implicated as mitotic regulators and due to their elevated expression profiles detected in many human cancers, have generated significant interest in the cancer research field.Aurora-C is predominantly expressed in the testis [2,3] and is mainly restricted to meiotically dividing spermatocytes [4] and mouse oocytes [5]. Aurora-C is also associated with inner centromere protein (INCENP) in male spermatocytes. Moreover, it is reported that overexpressed Aurora-C kinase behaves like a dominant negative kinase for Aurora-B leading to a cytokinesis defect [6]. Aurora-C disrupts the chromosome passenger protein complexes necessary for cytok
Plants of Ethno-Veterinary Uses of Tunglai Mountain Baffa Mansehra, Pakistan
Mazhar ul Islam,Zubair Anwar,Sobia Tabassum,Siraj Ahmed Khan
International Journal of Animal and Veterinary Advances , 2012,
Abstract: A total of 30 plants species were collected which are used for ethnovetinary purposes. Out of 30 plant species, belongs to 24 different families, among which 12 are tree, 13 annual herbs, 1 perennial herb and 4 shrubs. Plant specimens collected, identified, preserved and mounted were deposited in the Herbarium of Hazara University Mansehra, for future references.
Retraction: Aurora kinase-C-T191D is constitutively active mutant
Jabbar Khan, Sanaullah Khan, Sobia Attaullah, Ijaz Ali, Shahid Niaz Khan
BMC Cell Biology , 2012, DOI: 10.1186/1471-2121-13-17
Abstract:
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