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Search Results: 1 - 10 of 236 matches for " Sneh Lata "
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PRRDB: A comprehensive database of Pattern-Recognition Receptors and their ligands
Sneh Lata, Gajendra Raghava
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-180
Abstract: The current version of database contains around 500 patterns recognizing receptors from 77 distinct organisms ranging from insects to human. This includes 177 Toll-like receptors, 124 are Scavenger receptors and 67 are Nucleotide Binding Site-Leucine repeats rich receptors. The database also provides information about 266 ligands that includes carbohydrates, proteins, nucleic acids, glycolipids, glycoproteins, lipopeptides. A number of web tools have been integrated in PRRDB in order to provide following services: i) searching on any field; ii) database browsing; and iii) BLAST search against the pattern-recognition receptors. PRRDB also provides external links to standard databases like Swiss-Prot and Pubmed.PRRDB is a unique database of its kind, which provides comprehensive information about innate immunity. This database will be very useful in designing effective adjuvant for subunit vaccine and in understanding role of innate immunity. The database is available from the URL's in the Availabiltiy and requirements section.More than 20 million premature deaths occur every year in the world due to infectious diseases. Every year billions of dollars are spent for the treatment of patients suffering from such diseases, which in turn, poses a great economic burden on the developing nations. Thus, protection of mankind from these dreaded diseases is one of the major challenges in the present era. Fortunately, we have effective vaccines against a number of diseases (e.g. smallpox, polio), which not only save millions of lives but also endows long lasting immunity against these diseases. But these vaccines are available only against a few diseases and the vaccines against the other infectious diseases like malaria, tuberculosis are still wanted. So, developing effective and cheap vaccines against all the infectious diseases is the need of the hour. Strategies to develop vaccines have changed tremendously over the time i.e. from whole pathogen to antigens and from antigen
A Note on Fuzzy Initial Value Problem for Nth-Order Fuzzy Linear Differential Equations
Amit Kumar,Sneh Lata
Journal of Fuzzy Set Valued Analysis , 2012, DOI: 10.5899/2012/jfsva-00103
Abstract: Buckley and Feuring [1] solved a fuzzy linear differential equation and on the basis of the obtained solution, they introduced a new result. The main aim of this note is to show that the solution of the fuzzy linear differential equation, obtained by Buckley and Feuring [1], is incorrect and due to which the result, introduced by Buckley and Feuring [1], is also incorrect.
Amit Kumar,Sneh Lata
Journal of Reliability and Statistical Studies , 2011,
Abstract: Now days, internal combustion engines are used in most of the automobiles andmechanical machineries. The piston is a part without which no internal combustion engine canwork i.e., piston plays a vital role in almost all types of vehicles. So, the reliability of pistonmanufacturing system is most essential for the proper functioning of vehicles. In this paper, faulttree method is used to analyze the reliability of piston manufacturing system. Also, risk reductionworth is adopted as a measure of importance for identifying the crucial element that hassignificant impact on the reliability.
The Feichtinger Conjecture and Reproducing Kernel Hilbert Spaces
Sneh Lata,Vern I. Paulsen
Mathematics , 2010,
Abstract: We prove two new equivalences of the Feichtinger conjecture that involve reproducing kernel Hilbert spaces. We prove that if for every Hilbert space, contractively contained in the Hardy space, each Bessel sequence of normalized kernel functions can be partitioned into finitely many Riesz basic sequences, then a general bounded Bessel sequence in an arbitrary Hilbert space can be partitioned into finitely many Riesz basic sequences. In addition, we examine some of these spaces and prove that for these spaces bounded Bessel sequences of normalized kernel functions are finite unions of Riesz basic sequences.
MHCBN 4.0: A database of MHC/TAP binding peptides and T-cell epitopes
Sneh Lata, Manoj Bhasin, Gajendra PS Raghava
BMC Research Notes , 2009, DOI: 10.1186/1756-0500-2-61
Abstract: MHCBN is a comprehensive database comprising over 25,857 peptide sequences (1053 TAP binding peptides), whose binding affinity with either MHC or TAP molecules has been assayed experimentally. It is a manually curated database where entries are collected & compiled from published literature and existing immunological public databases. MHCBN has a number of web-based tools for the analysis and retrieval of information like mapping of antigenic regions, creation of allele specific dataset, BLAST search, various diseases associated with MHC alleles etc. Further, all entries are hyper linked to major databases like SWISS-PROT, PDB etc. to provide the information beyond the scope of MHCBN. The latest version 4.0 of MHCBN has 6080 more entries than previously published version 1.1.MHCBN database updating is meant to facilitate immunologist in understanding the immune system and provide them the latest information. We feel that our database will complement the existing databases in serving scientific community.The information about peptides binding to Major Histocompatibility Complex (MHC) or Transport associated Antigen Processing (TAP) molecules and their ability to activate T-cell response has a pivotal role to play in the development of computational methods for subunit vaccine designing. The key issue in subunit vaccine design is to search an antigenic region in an antigen [1] that has the potential to stimulate T cells, and hence are called T cell epitopes. Fortunately a large amount of data is available in literature about such peptides. There was a dire need to collect and compile the information about these peptides at one single place. In the past, a number of databases have been developed to serve the scientific community. The databases like SYFPEITHI [2], FIMM [3] and HIV database [4] are modest in size and provide precise information. MHCPEP [5] is a widely used comprehensive database of MHC binding peptides but has not been updated since 1998 and doesn't incl
Analysis and prediction of antibacterial peptides
Sneh Lata, BK Sharma, GPS Raghava
BMC Bioinformatics , 2007, DOI: 10.1186/1471-2105-8-263
Abstract: It was observed that certain types of residues are preferred over others in antibacterial peptides, particularly at the N and C terminus. These observations encouraged us to develop a method for predicting antibacterial peptides in proteins from their amino acid sequence. First, the N-terminal residues were used for predicting antibacterial peptides using Artificial Neural Network (ANN), Quantitative Matrices (QM) and Support Vector Machine (SVM), which resulted in an accuracy of 83.63%, 84.78% and 87.85%, respectively. Then, the C-terminal residues were used for developing prediction methods, which resulted in an accuracy of 77.34%, 82.03% and 85.16% using ANN, QM and SVM, respectively. Finally, ANN, QM and SVM models were developed using N and C terminal residues, which achieved an accuracy of 88.17%, 90.37% and 92.11%, respectively. All the models developed in this study were evaluated using five-fold cross validation technique. These models were also tested on an independent or blind dataset.Among antibacterial peptides, there is preference for certain residues at N and C termini, which helps to demarcate them from non-antibacterial peptides. Both the termini play a crucial role in imparting the antibacterial property to these peptides. Among the methods developed, SVM shows the best performance in predicting antibacterial peptides followed by QM and ANN, in that order. AntiBP (Antibacterial peptides) will help in discovering efficacious antibacterial peptides, which we hope will prove to be a boon to combat the dreadful antibiotic resistant bacteria. A user friendly web server has also been developed to help the biological community, which is accessible at http://www.imtech.res.in/raghava/antibp/ webcite.In the past few decades, a large number of bacterial strains have evolved ways to adapt or become resistant to the currently available antibiotics [1]. Researchers are focusing on alternative drugs based on antimicrobial peptides, which play an important role i
An operator algebraic proof of Agler's factorization theorem
Sneh Lata,Meghna Mittal,Vern I. Paulsen
Mathematics , 2008,
Abstract: We give a short direct proof of Agler's factorization theorem that uses the abstract characterization of operator algebras. the key ingredient of this proof is an operator algebra factorization theorem. Our proof provides some additional information about these factorizations in the case of polynomials.
Admissible fundamental operators
Tirthankar Bhattacharyya,Sneh Lata,Haripada Sau
Mathematics , 2014, DOI: 10.1016/j.jmaa.2015.01.006
Abstract: Let $F$ and $G$ be two bounded operators on two Hilbert spaces. Let their numerical radii be no greater than one. This note investigate when there is a $\Gamma$-contraction $(S,P)$ such that $F$ is the fundamental operator of $(S,P)$ and $G$ is the fundamental operator of $(S^*,P^*)$. Theorem 1 puts a necessary condition on $F$ and $G$ for them to be the fundamental operators of $(S,P)$ and $(S^*,P^*)$ respectively. Theorem 2 shows that this necessary condition is sufficient too provided we restrict our attention to a certain special case. The general case is investigated in Theorem 3. Some of the results obtained for $\Gamma$-contractions are then applied to tetrablock contractions to figure out when two pairs $(F_1, F_2)$ and $(G_1, G_2)$ acting on two Hilbert spaces can be fundamental operators of a tetrablock contraction $(A, B, P)$ and its adjoint $(A^*, B^*, P^*)$ respectively. This is the content of Theorem 4.
A Finite Multiplicity Helson-Lowdenslager-De Branges Theorem
Sneh Lata,Meghna Mittal,Dinesh Singh
Mathematics , 2009,
Abstract: This paper proves two theorems. The first of these simplifies and lends clarity to the previous characterizations of the invariant subspaces of $S$, the operator of multiplication by the coordinate function $z$, on $L^2(\mathbb{T};\mathbb{C}^n)$, where $\mathbb{T}$ is the unit circle, by characterizing the invariant subspaces of $S^n$ on scalar valued $L^p$ ($0
Use of LMA as ventilatory device for PCT: Our experience
Lata Sneh,Kumar Amit,Swami Adarsh,Rupal Sunny
Indian Journal of Anaesthesia , 2011,
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