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Neuroprotective effect of wormwood against lead exposure
Kharoubi O,Slimani M,Aoues A
Journal of Emergencies, Trauma and Shock , 2011,
Abstract: Background : Lead poisoning is a potential factor in brain damage, neurochemical dysfunction and severe behavioral problems. Considering this effect, our study was carried out to investigate the effects of wormwood to restore enzymes activities, lipid peroxidation and behavioral changes induced by lead. Methods : Thirty Wistar rats were divided into five groups (n = 6 in each group): three groups exposed to 750 ppm of lead acetate in the drinking water for 11 weeks and two groups as control. Aqueous wormwood extract (200 mg/kg body weight) was administrated to intoxicated (Pb(-)+A.AB) and control groups (A.AB) for four supplemental weeks. Activities of acetylcholinesterase (AchE), monoamine oxidase (MAO) and thiobarbituric acid-reactive substances (TBARS) level were determined in the hypothalamus, hippocampus, cortex and striatum of male rats and the grooming and locomotors activity were defined in all groups. Results: The intoxicated group (Pb) has a significantly increased TBARS value compared with the control in all brain regions (P < 0.05) and, after treatment with the wormwood extract, a significant reduction was noted. The enzyme activity decreased significantly (P < 0.05) in the Pb group compared with the control, essentially for the hippocampus (AchE: -57%, MAO: -41%) and the striatum (AchE: -43%, MAO: -51%). After wormwood extract administration, the AchE and MAO activity were significantly increased in all brain regions compared with the Pb group (P < 0.05). The behavioral test (locomotors and grooming test) indicates a significant hyperactivity in the Pb group compared with the control group. After treatment with wormwood extract, the Pb(-)+A.Ab indicates a lower activity compared with Pb. Conclusion : These data suggest that wormwood extract may play a very useful role in reduction of the neurotoxicological damage induced by lead.
A Genetic Algorithm for Solving the Optimal Power Flow Problem
Tarek BOUKTIR,Linda SLIMANI,M. BELKACEMI
Leonardo Journal of Sciences , 2004,
Abstract: This paper presents solution of optimal power flow problem of large distribution systems via a simple genetic algorithm. The objective is to minimize the fuel cost and keep the power outputs of generators, bus voltages, shunt capacitors/reactors and transformers tap-setting in their secure limits. CPU times can be reduced by decomposing the optimization constraints to active constraints manipulated directly by the genetic algorithm, and passive constraints maintained in their soft limits using a conventional constraint load flow. The IEEE 30-bus system has been studied to show the effectiveness of the algorithm.
The calculations of thermodynamic and opto-electronics properties of Pb1-xCaxSe semiconducting ternary Alloys
Sifi C.,Slimani M.,Meradji H.
EPJ Web of Conferences , 2012, DOI: 10.1051/epjconf/20122900033
Abstract: The ab initio full potential linearized augmented plane wave (FP-LAPW) method within density functional theory was applied to study the effect of composition on the structural and electronic properties Pbl-xCaxSe temary alloys. The effect of composition on lattice parameter, bulk modulus, band gap was investigate. Deviations of the lattice constant from Vegard’s law and the bulk modulus from linear concentration dependence were observed. In addition, the microscopic origins of compositional disorder were explained by using the approach of Zunger and co-workers. The disorder parameter (gap bowing) was found to be strong and was mainly caused by the chemical charge transfer effect. The volume deformation contributions for all alloys were also found to be significant, while the structural relaxation contributions to the gap bowing parameter were relatively smaller. On the other hand, the thermodynamic stability and optical properties are attempted in the calculations. The calculated refractive indices and optical dielectric constants for the parent compounds show better agreement with the known data when the Moss relation is used. Compositional dependence of the optical and electronic properties studied is also investigated.
A case of tubal hydatidiform mole  [PDF]
Ouafae Slimani, Fz Fdili Alaoui, Sofia Jayi, Hekmat Chaara, Hakima Bouguern, M. A. Malhouf, Nawal Hamas, Amal Bennani, Afaf Amarti
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.38112
Abstract:

Tubal hydatidiform mole is an uncommon condition with about 40 confirmed cases in the accessible literature. The patient usually presents with symptoms and signs of a classical ectopic pregnancy, and it is only after histological examination and DNA ploidy analysis of the conceptus that a hydatidiform mole is diagnosed. We present an unusual case of primi gravida at 6 weeks gestation that was diagnosed as having ectopic pregnancy.

D-cycloserine enhances spatial learning performances of rats chronically exposed to lead during the developmental period.
K Kahloula, M Slimani, M Dubois, J Bonnet
African Journal of Neurological Sciences , 2009,
Abstract: Chronic developmental lead (Pb) exposure has long been associated with cognitive dysfunction in children and animals. N-methyl-D-aspartate (NMDA) receptors, important in the synaptic mechanisms involved in learning and memory, are key target of lead toxicity. D-cycloserine (DCS), a partial agonist of the NMDAassociated glycine site, has been recognised as a potential cognitive enhancer. We investigated the potential effects of Pb exposure (lead acetate 0.2% through the drinking water) during gestation and lactation (GL), on the spatial learning and memory capacities of PN32 rats. We also evaluate the ability of DCS (30 mg/ml), administered daily 24h after weaning during 15 days, to attenuate Pb neurotoxicity-induced cognitive deficits. Results indicate that rats exposed to lead during gestation and lactation have a significantly increased latency to find the hidden platform and cover a significant longer distance compared to control-vehicle in the learning phase of the Morris water maze. However, the administration of DCS to GL animals improved significantly their learning performances compared with GL-vehicle. In contrast, there is no significant difference between all groups during the probe test and the visual cue test. In conclusion, DCS enhancement of the NMDA receptor function is an effective strategy to ameliorate neurotoxicity leadassociated spatial learning deficits.
Five Years of Phenologic Observations and Agronomic Features of Three Local Poaceae Fodder in North East Algeria
M. Boudelaa,S. Slimani,T.O. Boutebba,S. Boussora
Agricultural Journal , 2013,
Abstract: After the prospecting and the harvest of the seeds, a behavioural test was made to put in evidence the different phenologic stages and the notation of some agronomic features as the vigour, the alternativity, the sensitivity to the diseases, the resistance to the cold weather and rainfall, in addition to the faculty of the remontaison of three local graminaceous fodder, Lolium multiflorum Lamk, Festuca arundinacea Schreb and Phalaris arundinacea L. The obtained results show that generally, the three species present a higher germinative faculty in laboratory conditions and good germination (> 70%) in soil. With regard to the phenologic stages, from the lifting until flowering, it was noted that the rye-grass and the tall fescue have a similar chronological evolution. The red canary grass cycle was different as it spends more time to raise and tiller and in spite of that, it flowers one week before the two other species. Otherwise, the notation of the agronomic characters showed that in the montaison stage, the rye-grass was vulnerable to laying down; the tall fescue was less vigorous during the winter especially, in the first year of sowing. The following years, the tall fescue reacted better to the cold weather, the dryness and floods. The red canary grass was slightly sensitive to the rust and oidium diseases. As a whole, these ecotypes seem to have a rather good general rusticity.
Growth Study of Three Local Populations of Graminaceous Fodder According to Bioclimatic Index of Sum Temperatures (E0)
M. Boudelaa,S. Slimani,A. Boutebba,S. Boussora
Agricultural Journal , 2013,
Abstract: The yearly growth study (accumulated growth elongations, the number of leaves and tillers by plant as well as the output of dry matter) of three local Graminaceous fodder, has been achieved according to bioclimatic index of sum temperatures (E0). The obtained results showed that during the last growth phase, the rye-grass was characterized by a higher increase of both accumulated growth elongations of the initiated leaves and of dry matter production, compared to the tall fescue which has the weakest of such characters. With regard to the broadcast of new tillers, the rye-grass comes in the second position after the tall fescue which marked the most elevated growths. It should mentioned that the accumulated growth of the studied parameters is proportional to the sum temperature index (E0) and follows the same evolutionary manner at the three studied species, but the differences are of quantitative order.
Protective effect of Wormwood extract on lead induced neurotoxicity and cognitive disorder
Kharoubi O,Slimani M,Hamadouche N,Krouf D
International Journal of Green Pharmacy , 2010,
Abstract: Lead is a ubiquitous and a potent neurotoxicant causes several neurophysiological and behavioural alterations. Considering the vulnerability of the developing brain to Pb neurotoxicity, this study was carried out to investigate the effects of Pb exposure on brain regions acetylcholinesterase (AchE) and monoamino oxidase (MAO) enzymes activities and on behavioural changes. Wister rat were exposed to 750 ppm of lead acetate in the drinking water for 11-weeks after weaning, and treated by Artemisia Absinthium L. (wormwood) extract (200 mg.kg-1 body weight) for 4 weeks. The activities of AchE and MAO were determined in the hypothalamus, hippocampus, cortex and striatum of male rat; and general/ Locomotors activity was evaluated in the open-field test. Results indicated a significant decrease in AchE activity in intoxicated group (Pb) compared to untreated group (as contral) (hypothalamus: -12%, hippocampus: -57%, cerebral cortex: -18% and striatum: -43%) and in MAO activity (hypothalamus: -29%, hippocampus: -41%, cerebral cortex: -28% and striatum: -51%) respectively, with decrease crossing test score and increase sniffing test score. After, wormwood extract administration, the activity of AchE and MAO were significantly increased in all brain region compared to Pb group, but were significantly lower than control. The locomotors activity was reduced compared to Pb group. These data suggest that administration of wormwood extract for 4 weeks protect against the lead acetate-induced change in behavioural and neurobiochemical parameters changes.
Involvement of the Catecholamine in Glucagon-Induced Thermogenesis in Duckling (Carina Moschata)
M. Slimani,,S. El Antri,,S.Lazar,H. Barré
Türk Biyokimya Dergisi , 2007,
Abstract: Physiological studies have shown that glucagon is a potential mediator of nonshiveringthermogenesis in birds. The present work was undertaken in order to investigatewhether the observed thermogenesis results from a direct action of glucagon onavian thermoregulatory mechanisms or in fact requires the participation of thecatecholamines.We focused our study on the effects of central glucagon on plasma catecholamine andheart rate on cold acclimated and glucagon treated ducklings in cold environment.Our results showed that cold exposure (4 °C) induced an increase of circulatingnorepinephrine in thermoneutrality (42 %) and cold acclimated (43 %) but notsignificantly in glucagon treated, while epinephrine decreased only in thermoneutrality(-45 %). After glucagon injection, circulating epinephrine increased in thermoneutrality(280 %) and CA (516 %), whereas norepinephrine concentrations decreased only inthermoneutral ducklings (-23 %). Plasma norepinephrine and epinephrine remainedunchanged in glucagon treated ducklings. Injection of glucagon caused a decrease inheart rate in thermoneutral duckling whereas it had no effect on cold acclimated andglucagon treated ducklings.The large increase in epinephrine levels in cold acclimated and thermoneutral ducklingsmay be due to a massive release of adrenal catecholamine in response to the conditions.Treatment with glucagon twice daily rendered probably ducks insensitive to the effectof intra-cerebroventricular glucagon injection
Relaxed Locally Identifying coloring of Graphs
Méziane A?der,Sylvain Gravier,Souad Slimani
Mathematics , 2014,
Abstract: A \textit{locally identifying coloring} ($lid$-coloring) of a graph is a proper coloring such that the sets of colors appearing in the closed neighborhoods of any pair of adjacent vertices having distinct neighborhoods are distinct. Our goal is to study a \textit{relaxed locally identifying coloring} ($rlid$-coloring) of a graph that is similar to locally identifying coloring for which the coloring is not necessary proper.We denote by $\chi_{rlid}(G)$ the minimum number of colors used in a relaxed locally identifying coloring of a graph $G$ In this paper, we prove that the problem of deciding that $\chi_{rlid}(G)=3$ for a $2$-degenerate planar graph $G$ is $NP$-complete. We give several bounds of $\chi_{rlid}(G)$ and construct graphs for which some of these bounds are tightened. Studying some families of graphs allows us to compare this parameter with the minimum number of colors used in a locally identifying coloring of a graph $G$ ($\chi_{lid}(G)$), the size of a minimum identifying code of $G$ ($\gamma_{id}(G)$) and the chromatic number of $G$ ($\chi(G)$).
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