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Search Results: 1 - 10 of 44 matches for " Sirpa; Zharkovsky "
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Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more
Gavronski,Maia; Hartikainen,Sirpa; Zharkovsky,Alexander;
Pharmacy Practice (Internet) , 2012, DOI: 10.4321/S1886-36552012000100003
Abstract: in estonia, warfarin is widely prescribed by general practitioners to prevent and treat thromboembolic diseases. to date, there has been no systematic analysis of the potential risk of warfarin interactions with other drugs in the outpatient population. objective: the aim of the study was to analyze the incidence of potential interactions in prescription schemes in estonia in a cohort of outpatients receiving warfarin treatment. methods: the retrospective study population included 203,646 outpatients aged 50 years or older of whom 7,175 received warfarin therapy. patients who had used at least one prescription drug for a minimum period of 7 days concomitantly with warfarin were analyzed. potential drug interactions were analyzed using epocrates online, stockley′s drug interactions and domestic drug interaction databases. results: the average number of drugs used concomitantly with warfarin was 4.8 (sd=1.9) (males: 4.7 sd=2.0, females: 4.9 sd=2.0). no potential interactions in treatment regimens were found in 38% of patients, one potential interaction was observed in 29% and two or more potential interactions were observed in 33% of patients. the mean number of all potential interactions was 1.2 per patient and about the same in men and women. potential interactions were associated with the number of drugs. warfarin-related interactions were detected in 57% of patients, and the number of interactions related to warfarin per patient varied from 1 to 5. most frequent were use of warfarin with nsaids (14%), followed by simvastatin (9%) and amiodarone (7%). conclusion: this study shows that 57% of outpatients in estonia receiving warfarin have drugs potentially interacting with warfarin in their treatment schemes. most interactions (14%) with warfarin are associated with the prescription of nsaids.
Is there a place for young people in the geography curriculum? Analysis of the aims and contents of the Finnish comprehensive school curricula
Sirpa Tani
Nordidactica : Journal of Humanities and Social Science Education , 2011,
Abstract: Geography is one of the school subjects in which children and young people’s own experiences and views on the world can be easily taken into account. In the last decade, interest has been growing in the geographies of children and young people in contemporary cultural geography, and therefore, these issues seem even more central than before. In this article, which is based on the situation in Finland, changes in the status and contents of the national curricula for comprehensive school will be explained. A closer analysis will be made of the child-centred approaches of the geography curricula published in 1970, 1985, 1994 and 2004. The results of the analysis show how children and young people’s experiences are taken into account in principle, but most often only in the overall aims of the subject. The specified contents of teaching in curricular texts include just a few mentions of child-centred approaches. The same omission has also been reflected in school textbooks, which have a powerful position in guiding teacher’s choices in their practices of teaching. Based on these findings, it will be argued how in the future curriculum renewal process, more emphasis should be put on the geographies of children and young people.
Images of sorrow—Experiences of losing a co-twin in old age  [PDF]
Sirpa Pietil? Rosendahl, Pia Bülow, Anita Bj?rklund
Health (Health) , 2013, DOI: 10.4236/health.2013.512A009
Abstract:

What it is like when a lifelong twin relationship ends through death in later life is the focus of this study. It draws on interview data from seven twins who are part of a longitudinal Swedish twin study (SATSA) and who lost their co-twins in old age. Data were analyzed using qualitative latent content analysis. The results showed that the experience of loss of the co-twin was profound, including an emotional as well as a behavioral dimension. Loss and loneliness were expressed as the dominant feelings related to the quality of the missing relationship as well as the loss of twin identity. However, the grief experiences in this study were primarily related to the closeness and quality of the twin relationship, rather than identity. Behavioral adjustments included the use of outside as well as internal cognitive resources to cope with life after the loss. Despite the devastating experience of losing a co-twin after a lifelong relationship, the participants engaged actively in their own grief processes. It was concluded that twin loss is unique, in the sense of losing the relational twin identity, as well as it is characterized by similar features as the loss of a close relationship among non-twins.  

Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more
Gavronski M,Hartikainen S,Zharkovsky A,Sautenkova N
Pharmacy Practice (Granada) , 2012,
Abstract: In Estonia, warfarin is widely prescribed by general practitioners to prevent and treat thromboembolic diseases. To date, there has been no systematic analysis of the potential risk of warfarin interactions with other drugs in the outpatient population.Objective: The aim of the study was to analyze the incidence of potential interactions in prescription schemes in Estonia in a cohort of outpatients receiving warfarin treatment.Methods: The retrospective study population included 203,646 outpatients aged 50 years or older of whom 7,175 received warfarin therapy. Patients who had used at least one prescription drug for a minimum period of 7 days concomitantly with warfarin were analyzed. Potential drug interactions were analyzed using Epocrates online, Stockley’s Drug Interactions and domestic drug interaction databases.Results: The average number of drugs used concomitantly with warfarin was 4.8 (SD=1.9) (males: 4.7 SD=2.0, females: 4.9 SD=2.0). No potential interactions in treatment regimens were found in 38% of patients, one potential interaction was observed in 29% and two or more potential interactions were observed in 33% of patients. The mean number of all potential interactions was 1.2 per patient and about the same in men and women. Potential interactions were associated with the number of drugs. Warfarin-related interactions were detected in 57% of patients, and the number of interactions related to warfarin per patient varied from 1 to 5. Most frequent were use of warfarin with NSAIDs (14%), followed by simvastatin (9%) and amiodarone (7%).Conclusion: This study shows that 57% of outpatients in Estonia receiving warfarin have drugs potentially interacting with warfarin in their treatment schemes. Most interactions (14%) with warfarin are associated with the prescription of NSAIDs.
Nuclear imaging of inflammation: homing-associated molecules as targets
Anu Autio, Sirpa Jalkanen, Anne Roivainen
EJNMMI Research , 2013, DOI: 10.1186/2191-219x-3-1
Abstract: Noninvasive imaging of inflammation could be a highly valuable tool as it could help diagnosing many inflammatory conditions, such as osteomyelitis, rheumatoid arthritis, sarcoidosis, inflammatory bowel disease, and fever of unknown origin [1,2]. Even though there are several imaging agents used for the imaging of inflammation by nuclear medicine, none of them are specific for inflammation [2]. Specific imaging of inflammatory processes is a demanding task. Unspecific accumulation, as a result of an increased blood flow and enhanced vascular permeability, increases the signal in the target tissue which makes specific detection difficult. Positron emission tomography (PET) imaging of inflammation offers a noninvasive, quantitative approach to diagnosis, therapy planning, and monitoring and to drug development. Nevertheless, clinical applications of this method are currently limited by the lack of specific imaging agents to visualize molecular events in vivo. 18F]FDG is the most widely used PET imaging agent in cancer and inflammation imaging, but it localizes general inflammation or cancer and does not define these specifically.Nuclear imaging modalities, such as single photon emission computed tomography (SPECT) and PET, offer functional and molecular information with high sensitivity. Of these two imaging modalities, PET is more sensitive and allows for quantitative imaging in a clinical setting [3]. The combination of molecular/functional and anatomic imaging is preferred in order to identify the exact location of the functional SPECT/PET signal.Most of the imaging agents for inflammation imaging are SPECT imaging agents. Currently, the golden standard in nuclear medicine imaging of inflammation is autologous radiolabeled leukocytes [1,2]. They accumulate in the inflamed tissue by specific leukocyte migration. First, the injected radiolabeled white blood cells (WBCs) adhere to the endothelium and further migrate into the tissue. The leukocytes are labeled either w
Production of transgenic strawberries by temporary immersion bioreactor system and verification by TAIL-PCR
Kati J Hanhineva, Sirpa O K?renlampi
BMC Biotechnology , 2007, DOI: 10.1186/1472-6750-7-11
Abstract: Hygromycin-resistant strawberries were developed in temporary immersion bioreactors by Agrobacterium-mediated gene transfer. Putative transformants were screened by TAIL-PCR to verify T-DNA integration and to distinguish between the individual transformation events. Several different types of border sequence arrangements were detected.This study demonstrates that temporary immersion bioreactor system suits well for the regeneration of transgenic strawberry plants as a labour-efficient technique. Small amount of DNA required by TAIL-PCR is easily recovered even from a small transformant, which allows rapid verification of T-DNA integration and detection of separate gene transfer events. These techniques combined clearly facilitate the generation of transgenic strawberries but should be applicable to other plants as well.Strawberry (Fragaria × ananassa) is among the most lucrative agricultural crops worldwide and its consumption has doubled since 1980 [1]. The fruits are rich in bioactive phytochemicals, especially phenolic compounds with high antioxidant capacity, and as a part of daily diet could be beneficial for human health [2]. The conventional breeding programmes aiming at the combination of optimal composition of natural products with outstanding cultivation characteristics and disease resistance are facing a significant barrier caused by the octoploid genome of cultivated strawberry. Breeding through genetic engineering offers a more straightforward strategy by allowing direct introduction of dominant traits to the parent cultivar. Once stably integrated into strawberry genome, the transgene remains in the subsequent rounds of vegetative propagation through runners. The transgene is thus not lost from the complex genome, as might be the case in sexual propagation. Since the first report on the in vitro regeneration of strawberry, resulting in the large-scale commercial micropropagation of a crop plant for the first time [3], ample number of protocols for gene
VARIABILITY OF SUBPOLAR NORTH ATLANTIC CIRCULATION FROM ALTIMETRY
H?kkinen,Sirpa; Rhines,Peter B;
Gayana (Concepción) , 2004, DOI: 10.4067/S0717-65382004000200048
Abstract: altimeter data show that subpolar north atlantic sea surface height has underwent large variations during the last two decades. similarly the associated geostrophic velocity field exhibits large fluctutations in the strength of the subpolar gyre circulation such that the gyre was extremely strong in the early 1990's but may have been weaker in the late 1990s than in the late 1970s and 1980s. numerical model experiments suggests that the 1990s had also large coincident changes in the meridional overturning in the north atlantic ocean
VARIABILITY OF SUBPOLAR NORTH ATLANTIC CIRCULATION FROM ALTIMETRY
Sirpa H?kkinen,Peter B Rhines
Gayana (Concepción) , 2004,
Abstract: Altimeter data show that subpolar North Atlantic sea surface height has underwent large variations during the last two decades. Similarly the associated geostrophic velocity field exhibits large fluctutations in the strength of the subpolar gyre circulation such that the gyre was extremely strong in the early 1990's but may have been weaker in the late 1990s than in the late 1970s and 1980s. Numerical model experiments suggests that the 1990s had also large coincident changes in the meridional overturning in the North Atlantic Ocean
Jurisdictional Boundaries in the Making: The Case of Parish Diaconal Work in Finland
Raija Pyykk?,Lea Henriksson,Sirpa Wrede
Professions & Professionalism , 2011, DOI: 10.7577/pp.v1i1.148
Abstract: Diaconal workers of the Evangelical Lutheran Church of Finland have traditionally worked on the borderline between parish work and public welfare services. However, the role of parish diaconal workers in social services and nursing services has diminished as the Finnish welfare state has expanded. In conjunction with this downsizing, the so-called intra-church diaconate process has re-demarcated parish diaconal work. Andrew Abbott’s theory of how professional jurisdictions are negotiated in the societal arenas in which different actors are engaged inspired the analysis in this article. Using Thomas F. Gieryn’s concept of boundary work, the jurisdictional settlements that reshape professional parish diaconal work are examined. It is argued that institutional boundary work and disputes over whether the culture of diaconal work is secular or spiritual, serve to renew its cultural jurisdiction.
Twinship and Marriage – Experiences during the Course of Twin Relationships
Sirpa Pietila,Pia Bulow,Anita Bjorklund
Review of European Studies , 2012, DOI: 10.5539/res.v4n4p45
Abstract: The aim of this study was to explore and describe older twins’ experiences of their marriages in relation to the co-twin relationship. Material and Methods: The material consisted of 34 life story interviews with older twins (70+), representing various experiences of twinship and marriage. The data was analysed with qualitative latent content analysis. Results: Phases of marriage describe the time of Courtship - partners were chosen based on infatuation. Most were non-related, but some were relatives or friends. Twinship and quality of married life showed that marriages were either disharmonious or harmonious. The most common cause of conflicts was spouses not getting along, second common cause to conflicts was the twin relationship itself. In the harmonious marriages, the spouses were sympathetic and accepting of the twin relationship. In later life 14 of 34 were widowed and 7 of 34 had gone through a divorce. The most common cause of divorce was an unfaithful spouse, rather than the close relationship with the co-twin. In difficult times the twin relationship served as a source of comfort and support. Conclusions: The most harmonious marriages were with spouses related to one another. In this way the twins could keep both the twin relationship and have a marriage. Since twins often regard each other as attachment figures, the combination of twinship and marriage seem to be a challenge for the spouse to be most of all.
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