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Search Results: 1 - 10 of 276 matches for " Sipke Dijkstra "
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Histological and Functional Benefit Following Transplantation of Motor Neuron Progenitors to the Injured Rat Spinal Cord
Sharyn L. Rossi,Gabriel Nistor,Tanya Wyatt,Hong Zhen Yin,Aleksandra J. Poole,John H. Weiss,Matthew J. Gardener,Sipke Dijkstra,David F. Fischer,Hans S. Keirstead
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011852
Abstract: Motor neuron loss is characteristic of cervical spinal cord injury (SCI) and contributes to functional deficit.
Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins
Douglas Macdonald, Michela A. Tessari, Ivette Boogaard, Melanie Smith, Kristiina Pulli, Agnieszka Szynol, Faywell Albertus, Marieke B. A. C. Lamers, Sipke Dijkstra, Daniel Kordt, Wolfgang Reindl, Frank Herrmann, George McAllister, David F. Fischer, Ignacio Munoz-Sanjuan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096854
Abstract: The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington's disease (HD). Recent studies have reported that RNAi suppression of polyglutamine-expanded huntingtin (mutant HTT) in HD animal models can ameliorate disease phenotypes. A key requirement for such preclinical studies, as well as eventual clinical trials, aimed to reduce mutant HTT exposure is a robust method to measure HTT protein levels in select tissues. We have developed several sensitive and selective assays that measure either total human HTT or polyglutamine-expanded human HTT proteins on the electrochemiluminescence Meso Scale Discovery detection platform with an increased dynamic range over other methods. In addition, we have developed an assay to detect endogenous mouse and rat HTT proteins in pre-clinical models of HD to monitor effects on the wild type protein of both allele selective and non-selective interventions. We demonstrate the application of these assays to measure HTT protein in several HD in vitro cellular and in vivo animal model systems as well as in HD patient biosamples. Furthermore, we used purified recombinant HTT proteins as standards to quantitate the absolute amount of HTT protein in such biosamples.
A Consistent Relaxation of the Consumption Invariant Rate in the Discounted-Utility Model  [PDF]
Mehraj Bin Yasaar Parouty, Sipke Visser, Maarten Jacobus Postma
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.35A1002

The main theoretical contribution of this paper is a mechanical result that relates growth rates across n commodities. We examplify through a 2-commodity economy of health and money where the results of current health economic theory are confirmed using this technology. The applications are, however, broad; both with regards to spacial discount rates by making relevant assumptions about interpersonal/international comparability and to sustainable growth by envisioning scenarios for the future.

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease
Daniel Todd, Ian Gowers, Simon J. Dowler, Michael D. Wall, George McAllister, David F. Fischer, Sipke Dijkstra, Silvina A. Fratantoni, Rhea van de Bospoort, Jessica Veenman-Koepke, Geraldine Flynn, Jamshid Arjomand, Celia Dominguez, Ignacio Munoz-Sanjuan, John Wityak, Jonathan A. Bard
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087923
Abstract: Huntington’s disease (HD) is a devastating, genetic neurodegenerative disease caused by a tri-nucleotide expansion in exon 1 of the huntingtin gene. HD is clinically characterized by chorea, emotional and psychiatric disturbances and cognitive deficits with later symptoms including rigidity and dementia. Pathologically, the cortico-striatal pathway is severely dysfunctional as reflected by striatal and cortical atrophy in late-stage disease. Brain-derived neurotrophic factor (BDNF) is a neuroprotective, secreted protein that binds with high affinity to the extracellular domain of the tropomyosin-receptor kinase B (TrkB) receptor promoting neuronal cell survival by activating the receptor and down-stream signaling proteins. Reduced cortical BDNF production and transport to the striatum have been implicated in HD pathogenesis; the ability to enhance TrkB signaling using a BDNF mimetic might be beneficial in disease progression, so we explored this as a therapeutic strategy for HD. Using recombinant and native assay formats, we report here the evaluation of TrkB antibodies and a panel of reported small molecule TrkB agonists, and identify the best candidate, from those tested, for in vivo proof of concept studies in transgenic HD models.
Seasonal resource use and niche breadth in an assemblage of coexisting grazers in a fenced Park  [PDF]
Shem M. Mwasi, Sipke E. Van Wieren, Ignas M. A. Heitk?nig, Herbert H. T. Prins
Open Journal of Ecology (OJE) , 2013, DOI: 10.4236/oje.2013.36043

Many small Parks inKenyaare being fenced to control human-wildlife conflict. Some of these Parks have a diversity of large herbivores which might increase in density in the wake of fencing and subsequent compression of their home ranges due to closure of their migratory routes. It is important to understand the consequences of such an increase on the structuring of insularised herbivore assemblages in such Parks. We studied seasonal resource segregation and niche breadth variation as mechanisms of coexistence in a high density grazer assemblage inLakeNakuruNational Parkwhich is small and completely fenced. Diet composition and habitat use were considered as variables of resource use. We predicted that overlap in resource use and niche breadth would be the smallest among grazers with similar body weights in the dry season which is the most resource limiting for grazers in East Africa. Our results were contrary to the predictions because of lack of seasonal differentiation in the overlap of diet composition and habitat use, and in niche breadth. Overlaps in resource use were consistently high during both the wet and dry seasons, and niche breadth contraction during the dry season was not possible probably because of lack of species-specific niches during the dry season. Our results suggest that there might be competitive interactions in this grazer assemblage which is an important parameter to consider in the management of the Park.

Social Comparison Orientation and Perspective Taking as Related to Responses to a Victim  [PDF]
Abraham P. Buunk, Pieternel Dijkstra
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.55054

The present study examined the effect of social comparison orientation (SCO) on the responses to a victim. Participants (n = 87) were exposed to an interview with the alleged victim of a traffic accident, that was either an unfamiliar or a close other. A close other induced more feelings of oneness and more personal distress, but not more empathy, than an unfamiliar other. Higher levels of SCO resulted in more feelings of oneness and more helping behavior only in response to an unfamiliar other. The results suggest that those high in SCO tend to perceive more identification with others they do not know than those low in SCO.

Christus Jesus, die Krag van God en die Wysheid van God
H. Dijkstra
Koers : Bulletin for Christian Scholarship , 2012, DOI: 10.4102/koers.v77i2.344
Slaan uit macht en onmacht. Mannen leren in groepswerk praten over het geweld en hun relaties met vrouwen en kinderen
Sietske Dijkstra
Journal of Social Intervention : Theory and Practice , 2011,
Abstract: Battering as a consequence of power and powerlessness. Men learn to talk about domestic violence and their relationships with women and children through group work This article reports on a working visit of a week (in September 2010), to three domestic abuse programmes aimed at male perpetrators of abuse, in Minnesota in the USA. So far, an effective domestic violence intervention, or a model or treatment which is superior, is lacking (Babcock, Green & Robie, 2004). An important goal of the visit was to gain more insight into the ways American colleagues, in research and practice, deal with male perpetrators of abuse; how they perform risk analyses; how they provide help, support and safety. Also, the author wanted to know how they deal with the fact that these men often are fathers. The working visit provided valuable inside information. The author spoke with experts and practitioners, observed group-work and, in doing so, gained insight into the power and powerlessness of male perpetrators of abuse and their roles as partners and fathers. Combining insights from these conversations and observations and existing theory, this article gives a practice based view on how American colleagues deal with these men. Slaan uit macht en onmacht. Mannen leren in groepswerk praten over het geweld en hun relaties met vrouwen en kinderen Dit artikel doet verslag van een werkbezoek, afgelegd in september 2010, aan een drietal projecten gericht op de behandeling van mishandelende mannen in Minnesota, Amerika. Wereldwijd is duidelijk geworden dat er tot op heden geen effectieve interventie is voor mishandelende mannen, noch een behandeling die superieur is aan anderen (Babcock, Green & Robie, 2004). Een belangrijk aandachtspunt van deze studiereis was de vader- en partnerrol van mannen die hun partner mishandelen. Een belangrijke vraag was hoe onze Amerikaanse collega’s zowel in onderzoek als in de praktijk met mishandelende mannen omgaan en hoe ze risico’s inschatten en hulp verlenen. Meer specifiek wilden we weten hoe ze omgaan met het feit dat veel van deze mishandelende mannen vaders zijn. Het werkbezoek verschafte ons waardevolle inside informatie. De auteur sprak met experts en professionals in de praktijk, observeerde groepen mishandelende mannen en kreeg inzicht in de macht en machteloosheid van mishandelende mannen in hun rol als partners en vaders. Dit artikel geeft een op de praktijk gebaseerd zicht op hoe men omgaat met mishandelende mannen en combineert de observaties van experts en professionals in de praktijk met enige literatuur
Kinderen in de vuurlinie
Sietske Dijkstra
Journal of Social Intervention : Theory and Practice , 2012,
EU External Representation in Conflict Resolution: When does the Presidency or the High Representative Speak for Europe?
Hylke Dijkstra
European Integration Online Papers , 2011,
Abstract: Who speaks for Europe is a major question in European integration, yet few systematic attempts have been made to study when the Presidency or the High Representative represents the European Union. This article uses two most-similar cases of conflict resolution with significant EU involvement to argue that the size of the Presidency matters. Large member states have more diplomatic resources and political experience. They were therefore less inclined to rely on the High Representative and his/her staff. The High Representative, on the other hand, had greater difficulties to compete with large member states for media attention and for third party recognition.
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