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Search Results: 1 - 10 of 1627 matches for " Siong-Hoe Lau "
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An Empirical Study on Students` Acceptance of Learning Objects
Siong-Hoe Lau,Peter C. Woods
Journal of Applied Sciences , 2008,
Abstract: In this study, the Learning Object Acceptance Model (LOAM) was developed to examine the underlying factors and causal relationships that determine students` behavioral intention to use learning objects in higher education. The target population for the study consisted of undergraduate students who enrolled in Digital Systems course. Two sample data were collected via online survey instruments resulting in a total sample of 601 potential users of learning objects. This study called for the respondents in two samples to progress through two phases of learning objects participation: Introduction and Direct-use experience. Structural Equation Modeling (SEM) was used to evaluate data from the resultant surveys by using the two-step approach to model construction and testing with the computer program AMOS 4.0. The results showed that the study model produced measurement and structural models with adequate model fits. Learners` perceived of usefulness and ease of use fully mediated the relationship between learning object characteristics and behavioral intention. However, individual characteristics were found to have no statistically significance on behavioral intention in this context. This indicated that learning object characteristics were important external stimuli for learners as they formed the perception and intention to use learning objects.
An Empirical Study of Learning Object Acceptance in Multimedia Learning Environment
Siong-Hoe Lau,Peter C. Woods
Communications of the IBIMA , 2008,
Abstract: The purpose of this study was to develop Learning Object Acceptance Model (LOAM) to examine the underlying factors and causal relationships that determine learners’ behavioral intention to use multimedia learning objects in higher education. This study called for the 342 respondents to progress through two phases of learning objects participation: Introduction and Direct-use experience. Structural Equation Modeling (SEM) was used to evaluate data from the resultant surveys with the AMOS 4.0. The results showed that the study model produced measurement and structural models with adequate model fits. Learners’ perceived of usefulness and ease of use fully mediated the relationship between learning object characteristics and behavioral intention. However, individual characteristics were found to have no statistically significance on behavioral intention in this context.
Graphing Calculator for Probability Students: How Was It Perceived?
Choo-Kim Tan,Madhubala Bava Harji,Siong-Hoe Lau
IBIMA Business Review , 2011,
Abstract: Most students see Mathematics as one of the most challenging and stressful subjects, which if given an option, would rather opt out than undertake it. With low motivation and interest levels, the thought of undertaking a course in Mathematics can be worrying for some. Consequently, teachers are faced with disinterested students, who are passive in class, which makes teaching of the subject even more challenging. At times, with non participative students, Mathematics classrooms appear 'solemn'. Through the years, teachers have been experimenting or 'trying out' various approaches/techniques, in their attempt to develop students' interest and motivation. With the advent of information technology tools, teachers have now attempted to adopt more innovative approaches and incorporate ICT tools into Mathematics classrooms as well. One such tool is the graphing calculator (GC), which is adopted in this study. The incorporation of GCs into Malaysian Mathematics classrooms is at its infant stages. The study examined the students' reactions toward the incorporation of GCs into Probability lessons as well as the subject itself. Findings favor the adoption of GC in learning Probability, particularly in terms of calculator usage, quality of output, understanding of Probability concepts, confidence in solving problems, enhanced communication abilities and positive attitudes towards GC. Recommendations made aimed at assisting educators, policy-makers and researchers in enhancing the quality of the teaching and learning of Probability.
Prediction of User Acceptance and Adoption of Smart Phone for Learning with Technology Acceptance Model
Yong-Wee Sek,Siong-Hoe Lau,Kung-Keat Teoh,Check-Yee Law
Journal of Applied Sciences , 2010,
Abstract: This purpose of this study is to examine how the Technology Acceptance Model (TAM) can be used as a practical tool for early user acceptance and adoption of testing mobile communication devices for learning by evaluating the relationships among perceived usefulness, perceived ease of use, attitude towards using, behavioural intentions to use and actual use. In the study, 60 potential users were presented with an introductory demonstration of smart phone for a digital systems course. Following the demonstration, data on user perceptions and attitudes about smart phones were gathered based on this initial exposure. Subjects with prior experience using the smart phones were eliminated from further analysis resulting in a final sample of 40 users. The results indicate that actual use of smart phones for learning is significantly influenced by students intention to use and behavioural intention to use smart phones for learning is largely influenced by users perceived usefulness and attitude towards the smart phone. Students attitude towards the use of the smart phones are influence by the perceived usefulness and perceived ease of use of the smart phones. Implications of these findings for practice and research are examined.
Reuse of nitric acid in the oxidative pretreatment step for preparation of humic acids from low rank coal of Mukah, Sarawak
Fong, Sim Siong;Seng, Lau;Mat, Haslinda Bt;
Journal of the Brazilian Chemical Society , 2007, DOI: 10.1590/S0103-50532007000100004
Abstract: nitric acid is an effective material for production of humic acids. nevertheless, it is an expensive item that renders the process unfavorable industrially. study indicated that there was a possibility to reuse the nitric acid for oxidation however the resulting structures of humic acids was not studied. therefore, the objective of this study was to investigate the chemical and spectroscopic properties of nitrohumic acids prepared with reused nitric acid. the coal sample was oxidized with 5%, 10% and 15% of nitric acid and subjected to extraction for nitrohumic acids. concentration of nitric acid with the most yields was reemployed for another 2 cycles of oxidation. the chemical and spectroscopic properties of nitrohumic acids were evaluated. the results indicated that oxidation process generally improved the acidic functional properties of the nitrohumic acids with 10% nitric acid producing the most promising yield. the nitric acid was reused for extraction and the percentage yield remained good at an average of 78%. structurally, the nitrohumic acids produced with the reused nitric acid demonstrated larger molecular size and fewer acidic functional groups suggesting lesser extent of structure fractionation.
Characterization of the coal derived humic acids from Mukah, Sarawak as soil conditioner
Fong Sim Siong,Seng Lau,Chong Wong Nan,Asing Janice
Journal of the Brazilian Chemical Society , 2006,
Abstract: In Malaysia, abundant coal resources were found in Sarawak and Sabah. The utilization of coal resources, to date, is emphasized on the energy productions. The non-energy utilization as soil conditioner is unexplored. Therefore, this study attempted to characterize the coal humic acids extracted from Mukah coal and to evaluate its properties as soil conditioner. The coal humic acids from the regenerated sample were also assessed. The results revealed that different extractants and concentrations influenced the properties of humic acids. The extraction with KOH at 0.5 mol L-1 produced humic acids with low ash content and high acidic functional groups, which are substantial as soil conditioner. However, the yield was low. Regeneration of coal sample with 10% nitric acids improved the yield to an average of 83.45%. The acidic functional groups of nitrohumic acids were improved with the ash content remained at a low level.
In Vitro Anti-diabetic Activities and Chemical Analysis of Polypeptide-k and Oil Isolated from Seeds of Momordica charantia (Bitter Gourd)
Zuraini Ahmad,Khairul Faizi Zamhuri,Azhar Yaacob,Chiong Hoe Siong,Malarvili Selvarajah,Amin Ismail,Muhammad Nazrul Hakim
Molecules , 2012, DOI: 10.3390/molecules17089631
Abstract: The amino acid and fatty acid composition of polypeptide k and oil isolated from the seeds of Momordica charantia was analysed. The analysis revealed polypeptide k contained 9 out of 11 essential amino acids, among a total of 18 types of amino acids. Glutamic acid, aspartic acid, arginine and glycine were the most abundant (17.08%, 9.71%, 9.50% and 8.90% of total amino acids, respectively). Fatty acid analysis showed unusually high amounts of C18-0 (stearic acid, 62.31% of total fatty acid). C18-1 (oleic acid) and C18-2 (linoleic acid) were the other major fatty acid detected (12.53% and 10.40%, respectively). The oil was devoid of the short fatty acids (C4-0 to C8-0). Polypeptide k and oil were also subjected to in vitro α-glucosidase and α-amylase inhibition assays. Both polypeptide k and seed oil showed potent inhibition of α-glucosidase enzyme (79.18% and 53.55% inhibition, respectively). α-Amylase was inhibited by 35.58% and 38.02%, respectively. Collectively, the in vitro assay strongly suggests that both polypeptide k and seed oil from Momordica charantia are potent potential hypoglycemic agents.
A comparative evaluation on the oxidative approaches for extraction of humic acids from low rank coal of Mukah, Sarawak
Fong, Sim Siong;Seng, Lau;Majri, Norrafidah Bt;Mat, Haslinda Bt;
Journal of the Brazilian Chemical Society , 2007, DOI: 10.1590/S0103-50532007000100003
Abstract: humic acid-based products are well marketed; nevertheless, these products remain unpopular in this region possibly due to the higher selling price resulted from the cost imposed on the imported products. for this reason, it is essential to identify the indigenous source of humic acids as the soil conditioner. abundant of low rank coals are found in mukah and the non-energy application of the source are largely unexplored. preliminary study reported that chemical treatment with nitric acid could potentially increase the essential yield of humic acids from 20% to 85%. nitric acid is an expensive item, which could add on to the cost, hence possibility of employing other oxidative approaches need to be evaluated. in this study, the humic acids were extracted from the low rank coal of mukah with hno3, h2o2 and kmno4 oxidation and were compared in terms of yield, chemical and spectroscopical characteristics. results indicated that h2o2 oxidation involved considerable weight losses upon oxidation render it unfavorable for production of humic acids. potassium permanganate oxidation however was not recommended, as a substantial amount of inorganic compounds was introduced to the products and the essential yield generated was low. nitric acid oxidation remains the choice of the process for extraction of humic acids as the weight losses involved was acceptable; the yield of humic acids obtained was high with characteristics of low ash content and high acidic functional groups.
SDS-PAGE-Based Quantitative Assay for Screening of Kidney Stone Disease
Lau Wai-Hoe, Leong Wing-Seng, Zhari Ismail, Gam Lay-Harn
Biological Procedures Online , 2009, DOI: 10.1007/s12575-009-9007-y
Abstract: Pathogenesis of kidney stone disease involves nucleation, growth, aggregation, and retention of crystals in the kidney. Biochemical tests for urinary electrolytes cannot specifically identify the formation of stone in the kidney. In human, the mechanism against the formation of kidney stone involves macromolecules, i.e., protein and glycosaminoglycan that are polyanionic molecules with substantial amounts of acidic amino acid residues that inhibit crystal aggregation [1]. Tamm Horsfall glycoprotein (THP) is one of the inhibitors to crystalize aggregation in kidney [2,3].Tamm Horsfall glycoprotein is the most abundant urinary protein in healthy individual [4,5]. It is excreted by the thick ascending limb of the loop of Henle [6]. THP is excreted in urine at a rate of ~50 mg/day and can be influenced by many factors including urine volume, diet, and exercise [7]. THP has a molecular weight of ~85 kDa although inclines to form macroaggregates of several million Daltons [8]. THP is heavily glycosylated by N-linked glycans that account for about 30% of its molecular weight [9]. Kidney stone patients excrete THP molecules lacking terminally linked sialic acid that reduces its inhibitory activity against stone formation [10]. Although reduced urinary THP excretion in stone patients had been documented [11-13], quantitative analysis of THP by using electroimmunodiffusion shown no changes in THP excretion levels between stone patients and healthy subjects [14,15]. Other studies by using radioimmunoassay and ELISA shown that THP excretion was inconsistent or reduced in stone patients [17-19] compared to the healthy subjects [16]. In the studies where analysis of THP was carried out by using SDS-PAGE, Yokomizoi et al. [11] showed that THP intensity in stone patients was lower than that of healthy subjects while Pourmand et al. [20] stated there was no significant difference in THP excretion between the two cohorts. In our earlier study, we had reported that THP can be used to
SDS-PAGE-Based Quantitative Assay for Screening of Kidney Stone Disease
Wai-Hoe Lau,Wing-Seng Leong,Ismail Zhari,Lay-Harn Gam
Biological Procedures Online , 2009,
Abstract: Kidney stone disease is a common health problem in industrialised nations. We developed a SDS-PAGE-based method to quantify Tamm Horsfall glycoprotein (THP) for screening of kidney stone disease. Urinary proteins were extracted by using ammonium sulphate precipitation at 0.27 g salt/mL urine. The resulted pellet was dissolved in TSE buffer. Ten microliters of the urinary proteins extract was loaded and separated on 10% SDS-PAGE under reducing condition. THP migrated as single band in SDS-PAGE. The assay reproducibility and repeatability were 4.8% CV and 2.6% CV, respectively. A total of 117 healthy subjects and 58 stone patients were tested using this assay, and a distinct cut-off (P < 0.05) at 5.6 μg/mL THP concentration was used to distinguish stone patients from healthy subjects. The sensitivity and specificity of the method were 92.3% and 83.3%, respectively.
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