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Search Results: 1 - 10 of 13993 matches for " Singh Ratish "
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Clinical Outcome of Percutaneous Endoscopic Lumbar Surgery (PELS) in Treatment of Lumbar Disc Herniation  [PDF]
Mangal P. Hirachan, Zengxin Gao, Yucheng Lin, Ratish Singh
Open Journal of Orthopedics (OJO) , 2017, DOI: 10.4236/ojo.2017.74012
Abstract: Lumbar disc herniation is a spinal problem seen in both young and old people causing pain in the back with pain and numbness in lower extremity leading to disability limiting daily activities. When conservative treatments are ineffective, then it is treated by surgeries, more recently with minimal invasive percutaneous endoscopic lumbar surgery (PELS). One of the mostly accepted PELS by spinal surgeons is percutaneous transforaminal endoscopic lumbar discectomy, which can be performed for any age. The main aim of this review was to evaluate clinical outcome and safety based on the Oswestry Disable Index (ODI), Visual Analog Scale (VAS) and MacNab criteria and complications of PELS surgery and its advantages in clinical basis.
Percutaneous Endoscopic Lumbar Spine Surgery for Lumbar Disc Herniation and Lumbar Spine Stenosis: Emphasizing on Clinical Outcomes of Transforaminal Technique  [PDF]
Singh Ratish, Zeng-Xin Gao, Hirachan Mangal Prasad, Zhang Pei, Dangol Bijendra
Surgical Science (SS) , 2018, DOI: 10.4236/ss.2018.92007
Abstract: Lumbar Disc Herniation and Lumbar Spine Stenosis are the most common spine diseases which are mainly due to age related Spine degeneration. Diagnosis of both Lumbar Disc Herniation and Lumbar Spine Stenosis depends on clinical findings as well as radiological investigations. Treatment of choice of these conditions is on the basis of the patient conditions. Surgical treatment is the option only when the conservative treatment does not improve the patient’s clinical condition. Advancement and improvement of the technology have resulted in the traditional open surgical treatment into minimal invasive surgery. Intervention of the different surgical instruments with expert spinal surgeons had made percutaneous endoscopic lumbar Spine surgery as one of the preferred choices of surgery for treating Lumbar Disc Herniation and Lumbar Spine Stenosis. The concept of percutaneous endoscopic surgery for lumbar region is to provide surgical options without producing iatrogenic morbidity associated with the open surgical procedures. Conventionally, there are different approaches/techniques for Percutaneous Endoscopic Lumbar Spine Surgery, but in this review we are mainly focusing on the Transforaminal Technique. Regarding the Lumbar Disc Herniation treatment with transforaminal approach, a number of articles have been published due to which we mainly focused on those articles which were published after 2009 onwards. While fewer articles related to Lumbar Spine Stenosis treatment with Transforaminal approach were found, we tried to brief out all those articles. On the basis of comparative study of different surgeries done for Lumbar Disc Herniation and Lumbar Spine Stenosis, Percutaneous Transforaminal endoscopic Lumbar Surgery provides a substantial benefit. Transforaminal approach for treating Lumbar Disc Herniation and Lumbar Spine Stenosis is safe and effective. The Percutaneous Transforaminal Endoscopic Lumbar Surgery has advantage as it is performed under local anesthesia with shorter length of hospitalization and early return to normal life. The clinical outcome of the patient that underwent Percutaneous Transforaminal Endoscopic Lumbar Surgery for Lumbar Disc Herniation and Lumbar Spine Stenosis is quite good in regard of its fewer complication and more benefits.
Adjacent Level Vertebral Fractures in Patients Operated with Percutaneous Vertebroplasty  [PDF]
Dangol Bijendra, Xiaotao Wu, Zanli Jiang, Lei Zhu, Maharjan Promish, Singh Ratish
Open Journal of Orthopedics (OJO) , 2018, DOI: 10.4236/ojo.2018.83014
Abstract: Percutaneous vertebroplasty is a minimally invasive procedure that involves filling of a fractured vertebral body with bone cement to relieve pain and to restore the vertebral height. It is a safe and effective treatment and is widely used for treating Osteoporotic Vertebral Compression Fracture. Despite of its beneficial advantages over primary conservative managements, adjacent level vertebral compression fracture remains the challenge for surgeons. Adjacent level vertebral compression fracture following percutaneous vertebroplasty using PMMA cement has been reported as a complication. Numerous risk factors have been reported for the occurrence of new adjacent VCFs after PVP. The multiple level osteoporotic vertebral compression fractures and the increasing age of the patients are directly proportional to the risk of developing new symptomatic adjacent vertebral compression fracture after PVP. Moreover, low BMD and cement leakage are other factors that directly affect the incidence of new symptomatic adjacent vertebral fractures. The aim of this review is to evaluate the adjacent level vertebral compression fracture following percutaneous vertebroplasty on the basis of radiographs, Kaplan-Meier Estimation index and also the factors that lead to adjacent level vertebral compression fractures.
Treatment of Posterior Malleolus Fracture through Posterolateral Approach  [PDF]
Sah Ganesh Kumar, Jun Lu, Singh Ratish, Sinkemani Arjun, Karki Sundar, Jiming Liang
Open Journal of Orthopedics (OJO) , 2019, DOI: 10.4236/ojo.2019.94007
Abstract: Posterior malleolus fractures are quite common and usually result from rotational ankle injuries. For the management of posterior malleolus fractures, more studies are still required, though it is already well-recognized for medial and lateral structure. Therefore, fracture of posterior malleolus is striking subject of study among orthopedic surgeons. Most orthopedic surgeons recommend fixing the posterior malleolus fracture if it is larger than 25% to 33% of the distal articular surface. Further attention is required for the reduction and fixation of fractures involving posterior malleolus. Several approaches and methods for fixation of posterior malleolus have been defined in the literature. Previously, the most common method of fixation of the posterior malleolus is by indirect reduction and antero-posterior screws, it is minimally invasive, the anterior incision does not allow satisfactory visualization of the fragment, so good anatomical reduction is difficult to achieve thorough this approach. Operative management goals to reach a stable ankle with maximal function, decrease the risk of post-traumatic degenerative changes, and diminish the risk of complication. Nowadays, posterolateral approach is gaining the popularity due to adequate visualization and accurate anatomic reduction.
Comparative H2S Sensing Characteristics of Fe2O3: Thin Film vs. Bulk  [PDF]
Vishal Balouria, Ajay Singh, Niranjan Suryakant Ramgir, Anil Krishan Debnath, Aman Mahajan, Ratish Kumar Bedi, Dinesh Kumar Aswal, Shiv Kumar Gupta
Soft Nanoscience Letters (SNL) , 2013, DOI: 10.4236/snl.2013.34A002
Abstract: Comparative investigations of gas sensing characteristics of Fe2O3 in both thin film as well as bulk forms have been performed. Thin film sensors were realized by first depositing Fe films using electron-beam evaporation followed by thermal oxidation. Bulk sensors in the form of pellets were prepared by cold pressing commercial Fe2O3 powder with subsequent sintering. Both thin film and bulk Fe2O3 sensors exhibited a selective and reversible response characteristics towards H2S with maximum response at an operating temperature of 250°C and 200°C, respectively. A negligible response towards other interfering gases was observed. Thin film sensors exhibited an enhanced response in comparison to that of pellets.
Survey of clustering algorithms for MANET
Ratish Agarwal,Dr. Mahesh Motwani
International Journal on Computer Science and Engineering , 2009,
Abstract: Many clustering schemes have been proposed for ad hoc networks. A systematic classification of these clustering schemes enables one to better understand and make improvements. In mobile ad hoc networks, the movement of the network nodes may quickly change the topology resulting in the increase of the overhead message in topology maintenance. Protocols try to keep the number of nodes in a cluster around a pre-defined threshold to facilitate the optimal operation of the medium access control protocol. The clusterhead election is invoked on-demand, and is aimed to reduce the computation and communication costs. A large variety of approaches for ad hoc clustering have been developed by researchers which focus on different performance metrics. This paper presents a survey of different clustering schemes.
Survey of clustering algorithms for MANET
Ratish Agarwal,Dr. Mahesh Motwani
Computer Science , 2009,
Abstract: Many clustering schemes have been proposed for ad hoc networks. A systematic classification of these clustering schemes enables one to better understand and make improvements. In mobile ad hoc networks, the movement of the network nodes may quickly change the topology resulting in the increase of the overhead message in topology maintenance. Protocols try to keep the number of nodes in a cluster around a pre-defined threshold to facilitate the optimal operation of the medium access control protocol. The clusterhead election is invoked on-demand, and is aimed to reduce the computation and communication costs. A large variety of approaches for ad hoc clustering have been developed by researchers which focus on different performance metrics. This paper presents a survey of different clustering schemes.
Reliability and validity of Hindi translation of the migraine disability assessment and headache impact test-6 questionnaires
Juyal Ratish,Verma Rajesh,Garg Ravindra,Shukla Rakesh
Annals of Indian Academy of Neurology , 2010,
Abstract: Objective: The objective of the study was to assess the reliability and validity of the Hindi translation of the Migraine Disability Assessment (MIDAS) and Headache Impact Test-6 (HIT-6) questionnaires. Materials and Methods: The study was conducted on the migraine patients. For test-retest reliability, the respondents filled the MIDAS and HIT-6 questionnaires twice, at an interval of three weeks. For validity, the same population of patients filled the headache diary for three months. After three months they filled the MIDAS and HIT-6 questionnaires again. The patients were subgrouped according to their occupation and level of education. The test-retest reliability and validity were calculated by the Pearson correlation coefficient. Internal consistency was calculated using the Cronbach alpha. Results: A total of 236 migraine patients were screened. Seventy-nine patients fulfilled the inclusion criteria. A total of 69 patients completed the study. The HIT-6 questionnaire was applicable to all the subgroups of patients and had better comprehensibility than the MIDAS. Housewives missed out on the first two questions of the MIDAS and had lower mean MIDAS scores than HIT-6. The test-retest correlation coefficients for the total MIDAS and HIT-6 scores were 0.94 and 0.81, respectively. The correlation coefficients between the total score in the headache diary equivalent and the MIDAS and HIT-6 total score were 0.91 and 0.77, respectively. Cronbach alpha, a measure of internal consistency for the MIDAS questionnaire was > 0.90 at all the compilations. For the HIT-6 questionnaire, it ranged from 0.67 to 0.79. Conclusion: The Hindi versions of MIDAS and HIT-6 questionnaires were reliable and valid, but could not be interchanged. HIT-6 had better comprehensibility.
Macroglossia associated with 271 bp deletion in exon 50 of dystrophin gene
Malhotra Hardeep,Juyal Ratish,Malhotra Kiran,Shukla Rakesh
Annals of Indian Academy of Neurology , 2011,
Abstract: Macroglossia is rare in patients of Duchenne muscular dystrophy (DMD), and its occurrence without any endocrinologic abnormality, seizures or an abnormal karyotype is even rarer. We describe a patient of DMD with isolated macroglossia with 271 bp deletion in exon 50 of the dystrophin gene and speculate a relationship in this regard.
Role of L2 cysteines in papillomavirus infection and neutralization
Ratish Gambhira, Subhashini Jagu, Balasubramanyam Karanam, Patricia M Day, Richard Roden
Virology Journal , 2009, DOI: 10.1186/1743-422x-6-176
Abstract: Papillomavirus infection requires cleavage of minor capsid protein L2 by furin [1]. Mature virions in solution are resistant to furin cleavage and RG-1 binding [2-4]. The binding of virions to cell surfaces, presumably via heparan sulfate proteoglycans [5], promotes furin cleavage of L2, and this can occur on the cell surface. Furin cleavage triggers a conformational change that improves the accessibility of L2 on the capsid surface and its recognition by RG-1 [4]. RG-1 recognizes L2 residues 17-36 [2], and vaccination with this peptide in the appropriate context triggers high titers of neutralizing antibodies and protection against experimental challenge with homologous as well as heterologous virus types [6]. The cross-protective nature of this L2 epitope is consistent with its high degree of sequence conservation among diverse papillomavirus genotypes, and may reflect evolutionary constraints due to critical biological functions within this region [7]. Therefore, we sought to identify L2 residues critical to papillomavirus biology by deletion and alanine scanning mutagenesis within the epitope defined by RG-1. The role of L2 in infection is conserved in diverse papillomavirus types [8], but here we focus upon HPV16 because it is associated with a half of cervical cancer cases and the majority of HPV+vaginal, vulval, penile, anal, and head and neck cancers [9].Sequences of the codon-modified HPV16 L2 gene within the region encoding the RG-1 epitope were deleted to generate the Δ17-30 and Δ23-36 deletion mutants [10]. As controls, two additional deletion mutants Δ353-362 and Δ393-403 were prepared with similarly sized deletions introduced at the C-terminus of HPV16 L2. The four deletion mutants or wild type HPV16 L2 were co-transfected into 293TT cells with an HPV16 L1 expression vector [10] and the SEAP reporter plasmid [11,12]. Three days later the cells were harvested and detergent lysates were treated with benzonase to remove unencapsidated DNA. HPV16 pseudovir
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