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Search Results: 1 - 10 of 1481 matches for " Simona Spampinato "
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Hyperalgesic activity of kisspeptin in mice
Simona Spampinato, Angela Trabucco, Antonella Biasiotta, Francesca Biagioni, Giorgio Cruccu, Agata Copani, William H Colledge, Maria Sortino, Ferdinando Nicoletti, Santina Chiechio
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-90
Abstract: Immunofluorescent staining in the mouse skin showed the presence of GPR54 receptors in PGP9.5-positive sensory fibers. Intraplantar injection of kisspeptin (1 or 3 nmol/5 μl) induced a small nocifensive response in naive mice, and lowered thermal pain threshold in the hot plate test. Both intraplantar and intrathecal (0.5 or 1 nmol/3 μl) injection of kisspeptin caused hyperalgesia in the first and second phases of the formalin test, whereas the GPR54 antagonist, p234 (0.1 or 1 nmol), caused a robust analgesia. Intraplantar injection of kisspeptin combined with formalin enhanced TRPV1 phosphorylation at Ser800 at the injection site, and increased ERK1/2 phosphorylation in the ipsilateral dorsal horn as compared to naive mice and mice treated with formalin alone.These data demonstrate for the first time that kisspeptin regulates pain sensitivity in rodents and suggest that peripheral GPR54 receptors could be targeted by novel drugs in the treatment of inflammatory pain.Kisspeptin is a 54-amino acid peptide originally discovered for its activity as metastasis-suppressor [1]. It is encoded by the Kiss1 gene as a 145-amino acid precursor protein and cleaved to a 54-amino acid protein as well as into shorter products (kisspeptin-10,-13,-14) known to play a critical role in the neuroendocrine regulation of reproduction [2-5].In the brain, kisspeptin is localized not only in areas involved in gonadotropin secretion, but also in other regions such as the amygdala, hippocampus, and the periacqueductal gray [6,7].Its action is mediated by a 7-TM receptor named GPR54, also known as KISS1R, which is coupled to polyphosphoinositide hydrolysis via a Gq/11 GTP binding protein [2,8].Loss-of-function mutations of GPR54 cause a non-Kallman variant of hypogonadotropic/hypogonadism in humans (i.e. hypogonadotropic/hypogonadism without anosmia) [2,9]. Interestingly, the expression of kisspeptin and GPR54 is not restricted to the hypothalamus. Relatively high levels of kisspeptin and GPR5
Annali di Botanica , 1999,
Abstract: A syntaxonomical revision of the hygrophilous woods occurring in marshy places of the flood-plains from SE Europe is given. This vegetation is included in the Alno-Quercion roboris, alliance of the Populetalia albae, which comprises numerous associations characterized by the dominance of hard-wood trees, such as Quercus robur, Fraxinus oxycarpa, Ulmus minor, Alnus glutinosa, etc. For each association the synonyms, nomenclature type, diagnostic species, ecology, structure and chorology are given.
UAV Thermal Infrared Remote Sensing of an Italian Mud Volcano  [PDF]
Stefania Amici, Matteo Turci, Salvatore Giammanco, Letizia Spampinato, Fabrizio Giulietti
Advances in Remote Sensing (ARS) , 2013, DOI: 10.4236/ars.2013.24038

Extreme environments like active volcanoes exhibit many difficulties in being studied by in situ techniques. For example, during eruptions, summit areas are very hard to be accessed because of logistics problems and/or volcanic hazards. The use of remote sensing techniques in the last 20 years by satellite or airborne platforms has proven their capabilities in mapping and monitoring the evolution of volcanic activity. This approach has become increasingly important, as much interest is actually focused on understanding precursory signals to volcanic eruptions. In this work we verify the use of cutting-edge technology like unmanned flying system thermally equipped for volcanic applications. We present the results of a flight test performed by INGV in collaboration with the University of Bologna (Aerospace Division) by using a multi-rotor aircraft in a hexacopter configuration. The experiment was realized in radio controlled mode to overcome many regulation problems which, especially in Italy, limit the use of this system in autonomous mode. The overall goal was not only qualitative but also quantitative oriented. The system flew above an Italian mud volcano, named Le Salinelle, located on the lower South West flank of Mt. Etna volcano, which was chosen as representative site, providing not only a discrimination between hot and cold areas, but also the corresponding temperature values. The in-flight measurements have been cross-validated with contemporaneous in-situ acquisition of thermal data and from independent measurements of mud/water temperature.

Valutazione ex post della programmazione integrata territoriale in Sicilia
Domenico Spampinato,Giuseppe Timpanaro,Vera Teresa Foti
Aestimum , 2012,
Abstract: -
Limited Bandwidths and Correlation Ambiguities: Do They Co-Exist in Galileo Receivers  [PDF]
Elena Simona Lohan
Positioning (POS) , 2011, DOI: 10.4236/pos.2011.21002
Abstract: Galileo is the Global Navigation Satellite System that Europe is building and it is planned to be operational in the next 3-5 years. Several Galileo signals use split-spectrum modulations, such as Composite Binary Offset Carrier (CBOC) modulation, which create correlation ambiguities when processed with large or infinite front-end bandwidths (i.e., in wideband receivers). The correlation ambiguities refer to the notches in the correlation shape (i.e., in the envelope of the correlation between incoming signal and reference modulated code) which happen within +/– 1 chip from the main peak. These correlation ambiguities affect adversely the detection probabilities in the code acquisition process and are usually dealt with by using some form of unambiguous processing (e.g., BPSK-like techniques, sideband processing, etc.). In some applications, such as mass-market applications, a narrowband Galileo receiver (i.e., with considerable front-end bandwidth limitation) is likely to be employed. The question addressed in this paper, which has not been answered before, is whether or not this bandwidth limitation can cope inherently with the ambiguities of the correlation function, to which extent, and which the best design options are in the acquisition process (e.g., in terms of time-bin step and ambiguity mitigation mechanisms).
Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study  [PDF]
Simona Holcová, Marie Hladiková
Health (Health) , 2011, DOI: 10.4236/health.2011.31010
Abstract: A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively; p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p < 0.0005) for all secondary parameters as early as day 2/3. Analgesia was the most prominent effect for the patients. Conclusion: The 0.5 % concentration of propolis special extract GH 2002 in a lip balm was found to have the best risk-benefit ratio for the treatment of Herpes labialis.
Analysis on Long Precipitation Series in Piedmont (North-West Italy)  [PDF]
Fiorella Acquaotta, Simona Fratianni
American Journal of Climate Change (AJCC) , 2013, DOI: 10.4236/ajcc.2013.21002

This study analyses thirteen daily precipitation series of Piedmont, region of North-West Italy. The meteorological series have been chosen because they were meteorological observatories operating continuously from the beginning of 1900 until 2011. As the first step an historical research over each station has been carried out. In this way, the potential breaks, in the series, either due to changes of locations or instruments, have been determined and the missing values have been recovered. On the precipitation daily series a quality control have been effectuated and by metadata identification it was possible to assess the homogeneity of the meteorological series. In this way we have obtained the complete and correct series on which trends have been computed. In order to better understand the consequences of climate variations on our environment and society, we have calculated the climate indices proposed by “CCL/CLIVAR Working Group on Climate Change Detection” (dry and wet days, rainy days, intensity of precipitation…) over the time. The values of precipitation have also allowed beginning the climatic analysis with the aim at defining the principle local peculiarity in Piedmont.

Diagnosis and Treatment Options for Pulmonary Embolism (PE) in the Acute Care Setting  [PDF]
Simona Campa, Raymund Gantioque
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.82015
Abstract: Thromboembolic diseases continue to be one of the most prevalent medical problems today and can lead to life-threatening conditions, such as pulmonary embolism (PE). Currently, PE diagnosis and treatment are a challenge because of acute onset right ventricular strain with right-sided heart failure, sudden death, pulmonary infarction, and cardiogenic shock, which limit the time for therapeutic success.The aim of this study was to evaluate our perception, knowledge, and concerns regarding PE, discuss the importance of promptly diagnosing PE to provide appropriate treatment options for this life-threatening condition, list the most common clinical manifestations present when PE is suspected, and review the clinical approach to patients with suspected PE in an inpatient setting.In addition, this study reviews the risk stratification of patients with PE and treatment options beyond anticoagulation, compares new treatment options for patients presenting with acute symptomatic PE, and compares aspiration catheters (10 F Pronto .035” and 14 F XL extraction catheter (Vascular Solutions, Minneapolis, MN)) and ultrasound-assisted catheter-directed thrombolysis (USAT) versus systemic thrombolysis.This literature review was limited by the quality and number of studies available regarding new treatment options for patients presenting with acute symptomatic PE. Thus, more studies are needed to prove the validity of newer treatment options being trialed, such as aspiration catheters (10 F Pronto .035” and 14 F XL extraction catheter) and USAT, with the hope that further studies will guide patient management and increase our understanding of next generation aspiration catheters, which may provide novel insights on treating acute symptomatic PE.
Research on Plants for the Understanding of Diseases of Nuclear and Mitochondrial Origin
Claudia P. Spampinato,Diego F. Gomez-Casati
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/836196
Abstract: Different model organisms, such as Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, mouse, cultured human cell lines, among others, were used to study the mechanisms of several human diseases. Since human genes and proteins have been structurally and functionally conserved in plant organisms, the use of plants, especially Arabidopsis thaliana, as a model system to relate molecular defects to clinical disorders has recently increased. Here, we briefly review our current knowledge of human diseases of nuclear and mitochondrial origin and summarize the experimental findings of plant homologs implicated in each process.
Treatises and Ars construendi: Teaching’s Method Theory and Practice of Critical History’s Application Based on Teacher-Student Relationships  [PDF]
Carlos Alberto Cacciavillani, Simona Rinaldi
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.49016
Abstract: The topic of this lecture is the results’ description obtained during many years of teaching. We shall illustrate how students use the same analytical techniques to study two different aspects: 1) Architectural Treatises are first studied separately and then in a comparative way. The purpose of this graphic analysis is to reach a new interpretation of them through the realization of original graphics; 2) The Roman Ars construendi: architectural techniques and buildings’ typologies used by the Romans are investigated in the archaeological sites, where the reading of buildings’ stratification in different historical periods becomes an important teaching tool.
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