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Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study  [PDF]
Simona Holcová, Marie Hladiková
Health (Health) , 2011, DOI: 10.4236/health.2011.31010
Abstract: A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively; p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p < 0.0005) for all secondary parameters as early as day 2/3. Analgesia was the most prominent effect for the patients. Conclusion: The 0.5 % concentration of propolis special extract GH 2002 in a lip balm was found to have the best risk-benefit ratio for the treatment of Herpes labialis.
Foraminiferal assemblages in acid residues from the 'Císa ská rokle' Gorge at Srbsko (the Lower/Middle Devonian boundary interval, Barrandian area) and their paleoenvironmental significance
Holcová K
Bulletin of Geosciences , 2003, DOI: 10.3140/bull.geosci.2003.04.393
Abstract: Thirteen foraminiferal taxa in acid residues were described from the 'Císa ská rokle' Gorge at Srbsko. Foraminifers were recorded only in the nodular T ebotov Limestone and their assemblages are rare and low-diversified. Assemblages dominated by Thurammina diforamens Ireland occur in the lowermost part of the T ebotov Limestone with shale intercalations. Assemblages with Tolypammina div. sp. occur in the lowermost and uppermost part of nodular limestones without shale intercalations. Among Tolypammina div. sp., morphotypes with whole attached tests prevailed, which may indicate higher-energy environment. Similarly to other sections from this time interval, assemblages dominated by Ammodiscus ex gr. incertus Orbigny prevailed in the middle part of the T ebotov Limestone Bimodal size distribution of their tests corresponds probably to megalo- and microspheric forms.
The oxygen and carbon isotopic composition of Langhian foraminiferal tests as a paleoecological proxy in a marginal part of the Carpathian Foredeep (Czech Republic)
Katarína Holcová, Attila Demeny
Geologica Carpathica , 2012, DOI: 10.2478/v10096-012-0010-x
Abstract: Foraminiferal assemblages from three locations of the Moravian part of the Carpathian Foredeep (Kralice, P emyslovice, idlochovice) have been studied in order to determine the paleoenvironmental conditions during the Early Badenian (Middle Miocene). Paleobiological characteristics (plankton/benthos-ratio, relative abundances of warm-water plankton species, five-chambered Globoturborotalita spp., Coccolithus pelagicus and high nutrient markers [benthos], test sizes and ranges of Globigerina sp. and cibicidoids, Benthic Foraminiferal Oxygen Index) were determined along with stable C and O isotope compositions. The stable isotope compositions show large variabilities indicating sample inhomogeneity in well preserved foraminiferal samples, interpreted as a sign of primary environmental variation and postmortem mixing of tests of different populations and sources. Based on the combined interpretation of paleobiological indicators and isotopic compositions, two theoretical models were established to describe the observed paleobiological and stable isotope data, that were used to categorize the locations studied. Several types of near-shore paleoenvironment were distinguished using the theoretical models: (i) bay influenced by seasonal phytodetritus supply from the continent (Kralice); (ii) dynamic shore characterized by variable isotopic compositions probably due to mixing of indigenous, transported and reworked tests (P emyslovice); (iii) shore of alternating normal marine and continentally influenced environments ( idlochovice).
New Middle Miocene Bryozoa from Garbova de Sus (Romania) and their relationship to the sedimentary environment
Kamil Zágor ek, Sorin Filipescu, Katarína Holcová
Geologica Carpathica , 2010, DOI: 10.2478/v10096-010-0031-2
Abstract: The section of Garbova de Sus contains diverse fossil groups and rich bryozoan assemblages, with 77 species altogether. Several taxa have been recognized as very important in the assemblage and two new taxa are described in detail: Poricella garbovensis sp. nov. and Therenia transylvanica sp. nov. Foraminifera and calcareous nannofossil assemblages were used for biostratigraphic and paleoenvironmental interpretations. On the basis of sedimentological features and micropaleontological data, the sequence of paleoenvironments can be subdivided into two intervals indicating slightly different climatic conditions.
Biostratigraphy and paleoecology of the Burdigalian-Serravallian sediments in Wadi Sudr (Gulf of Suez, Egypt): comparison with the Central Paratethys evolution
Ibrahim M. Ied, Katarína Holcová, Ezzat Abd-Elshafy
Geologica Carpathica , 2011, DOI: 10.2478/v10096-011-0019-6
Abstract: Two main Miocene facies were recorded in the Gulf of Suez area: a deep marine and a coastal facies. The analysed sections in the Wadi Sudr area belong to the marine facies. The Lower Miocene (Burdigalian) is represented by coastal, shallow marine sediments, rich in coral, algae, gastropods and large pectinids followed by Langhian open marine sediments and Serravallian lagoonal carbonates. The open marine sediments contain well preserved planktonic and benthic foraminifers and abundant ostracods. The parts of the sections containing foraminifers have been correlated with three planktonic foraminiferal zones (Praeorbulina glomerosa Zone, Orbulina Zone and Globorotalia praemenardii-Globorotalia peripheroronda Zone). Two benthic ecozones were defined (Heterolepa dutemplei-Laevidentalina elegans Zone and Bolivina compressa-Elphidium spp. Zone). Two cycles of sea-level changes can be distinguished and correlated with global sea-level cycles Bur5/Lan1 and Ser1. The first (Langhian) cycle culminated in open marine sublittoral to upper bathyal well aerated sediments. The second (Serravallian) cycle was shallower, littoral suboxic sediments were overlaid by euryhaline carbonates. The studied foraminifera-bearing sediments can be correlated with the lower and Middle Badenian of the Central Paratethys. Though the area of the Gulf of Suez and the Central Paratethys were situated in different climatic zones, and influenced by different tectonic events, the main paleoenvironmental events (sea-level changes, oxygen decrease, salinity changes) are comparable. This correspondence shows that the decisive factors triggering these events were global climatic events.
The invertebrate fauna of the Middle Miocene (Lower Badenian) sediments of Kralice nad Oslavou (Central Paratethys, Moravian part of the Carpathian Foredeep)
Zágor?ek K,Holcová K,Nehyba S,Kroh A
Bulletin of Geosciences , 2009, DOI: 10.3140/bull.geosci.1078
Abstract: An artificial outcrop of Middle Miocene sediments at Kralice nad Oslavou has been studied in detail, all fragments retrieved from the bulk samples were evaluated and described. The most common fossils were bryozoans, foraminifers and echinoderms, but molluscs also occured. Foraminiferal evidence indicates an assignment to the lower part of the Upper Lagenid Zone (Lower Badenian–Langhian, Middle Miocene); the calcareous nannoplankton is characteristic for the zone NN5. In the upper part of the profile, an increased amount of volcanic material can be recognised. Based on an analysis of the faunal composition, the palaeoenvironmental evolution of the section has been investigated. The sediments at the base of the section originate from a deeper marine basin and well oxygenated bottom waters. A first bryozoan event can be recorded in this interval. Above, foraminiferal evidence points to increased depth and decreased oxygen levels, coinciding with an abundance peak of molluscs and asteroids, but disappearance of bryozoans. In the upper half of the section, conditions changed considerably. The faunal content indicates a shallow-marine environment with normal marine salinity and high oxygen levels. Echinoderms and bryozoans exhibit high diversities in this interval. These drastic changes are related here to changes in basin geometry. Increased volcanic activity in the hinterland was documented by volcano-detritic material in the sediment. Neotypes of bryozoans Kionidella moravicensis Procházka, 1893 and Umbonula spinosa (Procházka, 1893) are designated.
Limited Bandwidths and Correlation Ambiguities: Do They Co-Exist in Galileo Receivers  [PDF]
Elena Simona Lohan
Positioning (POS) , 2011, DOI: 10.4236/pos.2011.21002
Abstract: Galileo is the Global Navigation Satellite System that Europe is building and it is planned to be operational in the next 3-5 years. Several Galileo signals use split-spectrum modulations, such as Composite Binary Offset Carrier (CBOC) modulation, which create correlation ambiguities when processed with large or infinite front-end bandwidths (i.e., in wideband receivers). The correlation ambiguities refer to the notches in the correlation shape (i.e., in the envelope of the correlation between incoming signal and reference modulated code) which happen within +/– 1 chip from the main peak. These correlation ambiguities affect adversely the detection probabilities in the code acquisition process and are usually dealt with by using some form of unambiguous processing (e.g., BPSK-like techniques, sideband processing, etc.). In some applications, such as mass-market applications, a narrowband Galileo receiver (i.e., with considerable front-end bandwidth limitation) is likely to be employed. The question addressed in this paper, which has not been answered before, is whether or not this bandwidth limitation can cope inherently with the ambiguities of the correlation function, to which extent, and which the best design options are in the acquisition process (e.g., in terms of time-bin step and ambiguity mitigation mechanisms).
Analysis on Long Precipitation Series in Piedmont (North-West Italy)  [PDF]
Fiorella Acquaotta, Simona Fratianni
American Journal of Climate Change (AJCC) , 2013, DOI: 10.4236/ajcc.2013.21002
Abstract:

This study analyses thirteen daily precipitation series of Piedmont, region of North-West Italy. The meteorological series have been chosen because they were meteorological observatories operating continuously from the beginning of 1900 until 2011. As the first step an historical research over each station has been carried out. In this way, the potential breaks, in the series, either due to changes of locations or instruments, have been determined and the missing values have been recovered. On the precipitation daily series a quality control have been effectuated and by metadata identification it was possible to assess the homogeneity of the meteorological series. In this way we have obtained the complete and correct series on which trends have been computed. In order to better understand the consequences of climate variations on our environment and society, we have calculated the climate indices proposed by “CCL/CLIVAR Working Group on Climate Change Detection” (dry and wet days, rainy days, intensity of precipitation…) over the time. The values of precipitation have also allowed beginning the climatic analysis with the aim at defining the principle local peculiarity in Piedmont.

Numerical Simulations of Fractionated Electrograms and Pathological Cardiac Action Potential
Simona Sanfelici
Computational and Mathematical Methods in Medicine , 2002, DOI: 10.1080/1027366021000041377
Abstract: The aim of this work is twofold. First we focus on the complex phenomenon of electrogram fractionation, due to the presence of discontinuities in the conduction properties of the cardiac tissue in a bidomain model. Numerical simulations of paced activation may help to understand the role of the membrane ionic currents and of the changes in cellular coupling in the formation of conduction blocks and fractionation of the electrogram waveform. In particular, we show that fractionation is independent of INA alterations and that it can be described by the bidomain model of cardiac tissue. Moreover, some deflections in fractionated electrograms may give nonlocal information about the shape of damaged areas, also revealing the presence of inhomogeneities in the intracellular conductivity of the medium at a distance.
Signaling-mediated control of ubiquitin ligases in endocytosis
Simona Polo
BMC Biology , 2012, DOI: 10.1186/1741-7007-10-25
Abstract: Ubiquitination modifies proteins in a variety of ways, the significance of which we only partially comprehend. Ubiquitin can be attached: as an individual moiety to a single or multiple lysine residues of substrate (mono- or multiple monoubiquitination); as chains of ubiquitin moieties that are interlinked through any one of the seven lysine residues of ubiquitin (for example K48- or K63-linked chains); or as branched chains, to name but a few [1]. The cell interprets each of these modifications as a distinct signal. The first described role of ubiquitination as mediating protein degradation through targeting to the proteasome has now been complemented with numerous other functions [2]. For example, the signal encoded by K63-linked chains can mediate functions as diverse as receptor endocytosis [3,4], activation of protein kinases in the NF-κB pathway and the initiation of error-free DNA repair [2].Signal transduction from transmembrane cell surface receptors to nuclear transcription factors is regulated at multiple levels by protein ubiquitination. The covalent attachment of one, or often more, ubiquitin moieties has emerged as the principal mechanism for termination of signaling, by targeting the receptor for endocytosis and, ultimately, degradation in the lysosome [3]. This device controls a vast array of mammalian signaling receptors, such as receptor tyrosine kinases, G-protein coupled receptors (GPCRs), growth hormone receptors, the major histocompatibility complex I, NOTCH, various channels and transporters, and cytokine and interferon receptors [3]. Receptors that are internalized after activation are directed first into the endosomes of the endocytic pathway, and then into multivesicular bodies (MVBs), which undergo a process of maturation that ends with fusion with the lysosome and delivery of the contents for degradation. Ubiquitination of the receptor provides the crucial signal for entering this pathway [3,5-7].Subsequent delivery of membrane receptors
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