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Search Results: 1 - 10 of 10063 matches for " Simon Pemberton "
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Deaths in Police Custody: The ‘acceptable’ consequences of a ‘law and order’ society?
Simon Pemberton
Outlines : Critical Practice Studies , 2005,
Abstract: This article seeks to explain the acceptance of the rising numbers of police custody deaths in England and Wales over the last 20 years. It argues that these deaths are a consequence of the transformation in the U.K., from a social democratic to an increasingly neo-liberal mode of social organisation. The article links the characteristics of the authoritarian state, which emerged at this point in time, to the current profile of police custody deaths. Then, by using interview material with those who have investigated these cases, the article seeks to understand the narratives which are mobilised to legitimate these deaths as the ‘acceptable’ consequences of a ‘law and order’ society.
Child Rights and Child Poverty: Can the International Framework of Children's Rights Be Used to Improve Child Survival Rates?
Simon Pemberton ,David Gordon,Shailen Nandy,Christina Pantazis,Peter Townsend
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040307
Dirt, disease and death: control, resistance and change in the post-emancipation Caribbean
Pemberton, Rita;
História, Ciências, Saúde-Manguinhos , 2012, DOI: 10.1590/S0104-59702012000500004
Abstract: this study examines how health facilities and services were used as an agency of worker control in the british caribbean between 1838 and 1860. it argues that planter health strategies were based on flawed assumptions. the resultant policy of deprivation of access to medical services by the labouring population backfired within 16 years of freedom when a cholera epidemic rocked the region. it exposed the poor living conditions of the free villages and generated fear and panic among the local elite who were forced to make policy changes regarding health and sanitation. as a result the first steps towards the establishment of public health services in the british caribbean were stimulated.
Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires
Trevor J Pemberton
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-244
Abstract: PPIase numbers within these fungal repertoires appears associated with genome size and orthology between repertoires was found to be low. Phylogenetic analysis showed the single-domain FKBPs to evolve prior to the multi-domain FKBPs, whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. However, no such commonality was found with the FKBPs. Twelve of the 17 human cyclophilins and both human parvulins, but only one of the 13 human FKBPs, identified orthologues within these fungi. hPar14 orthologues were restricted to the Pezizomycotina fungi, and R. oryzae is unique in the known fungi in possessing an hCyp33 orthologue and a TPR-containing FKBP. The repertoires of Cryptococcus neoformans, Aspergillus fumigatus, and Aspergillus nidulans were found to exhibit the highest orthology to the human repertoire, and Saccharomyces cerevisiae one of the lowest.Given this data, we would hypothesize that: (i) the evolution of the fungal PPIases is driven, at least in part, by the size of the proteome, (ii) evolutionary pressures differ both between the different PPIase families and the different fungi, and (iii) whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more variable roles. Also, the repertoire of Cryptococcus neoformans may represent a better model fungal system within which to study the functions of the PPIases as its genome size and genetic tractability are equal to those of Saccharomyces cerevisiae, whilst its repertoires exhibits greater orthology to that of humans. However, further experimental investigations are required to confirm this.The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is traditio
Self-Access Language Learning in Museums: A Materials Development Project.
Lucy Cooker,Richard Pemberton
Studies in Self-Access Learning Journal , 2010,
Abstract: This paper reports on a project carried out at The University of Nottingham to create and evaluate English for Speakers of Other Languages (ESOL) materials with the aim of exploiting the self-access language learning possibilities that museums offer. A series of thematic resources were produced and trialed with ESOL learners in the Lincolnshire area. Feedback from the learners indicated that museums could have an important role to play in providing flexible language learning opportunities for ESOL students. The authors conclude by suggesting that other public facilities such as libraries, art galleries, botanical gardens and even football stadia could be exploited for this purpose.
Identification and Comparative Analysis of the Peptidyl-Prolyl cis/trans Isomerase Repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe
Trevor J. Pemberton,John E. Kay
Comparative and Functional Genomics , 2005, DOI: 10.1002/cfg.482
Abstract: The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins comprises three member families that are found throughout nature and are present in all the major compartments of the cell. Their numbers appear to be linked to the number of genes in their respective genomes, although we have found the human repertoire to be smaller than expected due to a reduced cyclophilin repertoire. We show here that whilst the members of the cyclophilin family (which are predominantly found in the nucleus and cytoplasm) and the parvulin family (which are predominantly nuclear) are largely conserved between different repertoires, the FKBPs (which are predominantly found in the cytoplasm and endoplasmic reticulum) are not. It therefore appears that the cyclophilins and parvulins have evolved to perform conserved functions, while the FKBPs have evolved to fill ever-changing niches within the constantly evolving organisms. Many orthologous subgroups within the different PPIase families appear to have evolved from a distinct common ancestor, whereas others, such as the mitochondrial cyclophilins, appear to have evolved independently of one another. We have also identified a novel parvulin within Drosophila melanogaster that is unique to the fruit fly, indicating a recent evolutionary emergence. Interestingly, the fission yeast repertoire, which contains no unique cyclophilins and parvulins, shares no PPIases solely with the budding yeast but it does share a majority with the higher eukaryotes in this study, unlike the budding yeast. It therefore appears that, in comparison with Schizosaccharomyces pombe, Saccharomyces cerevisiae is a poor representation of the higher eukaryotes for the study of PPIases.
In Vitro Interactions of Extracellular Histones with LDL Suggest a Potential Pro-Atherogenic Role
Alan D. Pemberton,Jeremy K. Brown
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009884
Abstract: Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are released during acute inflammation, and therefore might interact with circulating lipoproteins in vivo. In view of the associative link between inflammation and cardiovascular disease, the behaviour of histones was investigated using in vitro models of LDL retention and foam cell formation.
An appraisal of ultrasound fetal biometry in the first trimester
Lily K Pemberton, Irina Burd, Eileen Wang
Reports in Medical Imaging , 2010, DOI: http://dx.doi.org/10.2147/RMI.S9119
Abstract: n appraisal of ultrasound fetal biometry in the first trimester Review (6593) Total Article Views Authors: Lily K Pemberton, Irina Burd, Eileen Wang Published Date August 2010 Volume 2010:3 Pages 11 - 15 DOI: http://dx.doi.org/10.2147/RMI.S9119 Lily K Pemberton, Irina Burd, Eileen Wang Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA Abstract: We evaluate the current available literature on first trimester measurement references, how critically these data have been evaluated in subsequent studies, and the generalizability of the standards across different populations. We will then discuss the significance of first trimester dating for genetic screening tests and how growth in the first trimester may predict later pregnancy outcomes, which could lead to future research to modify these outcomes.
Parasitoid Complex of the Gypsy Moth (Lymantria dispar) in the Increase-phase Populations in Korea
Lee, Jang-Hoon,Robert W. Pemberton
Journal of Ecology and Field Biology , 2009,
Abstract: The species composition of the parasitoid complex and the degree of parasitism by each specieswere analyzed for gypsy moth (Lymantria dispar) populations in the increasing phase. Total of 7,826 mid-lateinstar larvae and pupae were collected and reared from two collection sites in Gangwon Province, Korea. Twotachinid flies (Blepharipa schineri and Parasetigena silvestris), and the ichneumonid wasp (Coccygomimusdisparis) were the most abundant parasitoids, in the order of decreasing importance. Other parasitoids occurringincluded Coteisa melanoscelus, Cotesia scheaferi, Glyptapanteles liparidis, Brachymeria lasus, and Exorista spp.The low incidence of the NPVirus is hypothesized to be an important factor in determining degree of parasitismrate by P. silvestris and B. schineri, and their relative dominance in the parasitoid complex.
Restorative justice and victims: Not a self-evident relationship
Pemberton Antony,Winkel Frans W.,Groenhuijsen Mark
Temida , 2006, DOI: 10.2298/tem0601011p
Abstract: The two most prominent developments in criminal justice in the last twenty to thirty years are the rise of restorative justice and the recognition and improvement of the position of the victim. The first part of the paper discusses a theoretical model for victims within restorative justice that the researchers at the InterVICT research institute authors of this paper) are developing at this moment. This model incorporates current knowledge from social psychology and studies surrounding traumatic stress and provides a number of hypotheses that will be subsequently evaluated in practice with participants in restorative justice procedures. On the other hand, international legal protocols for restorative justice also lack a consistent victim-oriented perspective. To this end the European Forum for Victim Services has recently published a statement concerning the position of the victim within mediation. The second part of the paper addresses the central issues in this statement. Taken together the paper moves beyond criticism of restorative justice, as it hopes to redirect theory and implementation of restorative justice toward a stronger victim-orientation.
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