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Search Results: 1 - 10 of 3412 matches for " Simin Lim "
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Proteome-Wide Profiling of the MCF10AT Breast Cancer Progression Model
Lee Yee Choong,Simin Lim,Poh Kuan Chong,Chow Yin Wong,Nilesh Shah,Yoon Pin Lim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011030
Abstract: Mapping the expression changes during breast cancer development should facilitate basic and translational research that will eventually improve our understanding and clinical management of cancer. However, most studies in this area are challenged by genetic and environmental heterogeneities associated with cancer.
Integrin-Linked Kinase Regulates Interphase and Mitotic Microtubule Dynamics
Simin Lim, Eiko Kawamura, Andrew B. Fielding, Mykola Maydan, Shoukat Dedhar
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053702
Abstract: Integrin-linked kinase (ILK) localizes to both focal adhesions and centrosomes in distinct multiprotein complexes. Its dual function as a kinase and scaffolding protein has been well characterized at focal adhesions, where it regulates integrin-mediated cell adhesion, spreading, migration and signaling. At the centrosomes, ILK regulates mitotic spindle organization and centrosome clustering. Our previous study showed various spindle defects after ILK knockdown or inhibition that suggested alteration in microtubule dynamics. Since ILK expression is frequently elevated in many cancer types, we investigated the effects of ILK overexpression on microtubule dynamics. We show here that overexpressing ILK in HeLa cells was associated with a shorter duration of mitosis and decreased sensitivity to paclitaxel, a chemotherapeutic agent that suppresses microtubule dynamics. Measurement of interphase microtubule dynamics revealed that ILK overexpression favored microtubule depolymerization, suggesting that microtubule destabilization could be the mechanism behind the decreased sensitivity to paclitaxel, which is known to stabilize microtubules. Conversely, the use of a small molecule inhibitor selective against ILK, QLT-0267, resulted in suppressed microtubule dynamics, demonstrating a new mechanism of action for this compound. We further show that treatment of HeLa cells with QLT-0267 resulted in higher inter-centromere tension in aligned chromosomes during mitosis, slower microtubule regrowth after cold depolymerization and the presence of a more stable population of spindle microtubules. These results demonstrate that ILK regulates microtubule dynamics in both interphase and mitotic cells.
PET / CT based novel quantitive techniques in measuring disease activity
Simin Dadparvar
Iranian Journal of Nuclear Medicine , 2010,
Abstract: [No abstract available]
PET/CT in lung diseases especially in the SPN and lung cancer
Simin Dadparvar
Iranian Journal of Nuclear Medicine , 2010,
Abstract: [No abstract available]
PET/CT in esophageal cancer and other GI malignancies
Simin Dadparvar
Iranian Journal of Nuclear Medicine , 2010,
Abstract: [No abstract available]
Evolving applications of PET in assessing cardiovascular disease
Simin Dadparvar
Iranian Journal of Nuclear Medicine , 2010,
Abstract: [No abstract available]
The Effect of Inductive Vs. Deductive Instructional Approach in Grammar Learning of ESL Learners
Simin Chalipa
Deccan International Journal of Advanced Research Studies , 2013,
Abstract: Teaching grammar has been a complex issue for centuries. The effectiveness of deductive and inductive approaches, aiming at maximizing the students' opportunity to practice thinking skills, has been investigated in empirical studies. The aim of this study is to investigate whether various rule explication techniques should precede or follow a focus on the use of grammatical forms.The researcher framed this study around the following research questions: 1) Which instructional approach, deductive or guided inductive, will be more effective for EFL learners’ on short-term learning of grammatical structures? 2) Which instructional approach, deductive or guided inductive, will be more effective for EFL learners’ on long-term learning of grammatical structures? In order to investigate the afore-mentioned questions, the sample populations were 40 students. The grammar pretest was administered to participants at the beginning of the semester, prior to the treatment phase, in order to assess the comparability of grammar knowledge between the six sections. The grammar posttest was identical to the grammar pretest. At the end of the semester, 6 weeks after the pretest, the grammar posttest was administered to the participants to measure the long-term learning of the grammatical structures as well as the effectiveness of each presentational approach.To analyze the obtained data, a t-test computation was applied, in which the scores obtained for multiple-choice questions were the dependent measure, the data showed that:1. deductive approach is more effective for EFL learners’ on short-term learning of grammatical structures.2. deductive and guided inductive approach are similar for EFL learners’ on long-term learning of grammatical structures.3. deductive and guided inductive approach are similar for EFL learners’ on short-term learning of grammatical structures.
Equivalent Theory and Retrieval of Effective Metamaterials Parameters
Simin Feng
Physics , 2010,
Abstract: We apply the equivalent theory to orthorhombic anisotropic materials and provide a general unit-cell design criterion for achieving a length-independent retrieval of the effective material parameters from a single layer of unit cells. We introduce a graphical retrieval method and phase unwrapping techniques. The graphical method utilizes the linear regression technique. Our method can reduce the uncertainty of experimental measurements and the ambiguity of phase unwrapping. Moreover, the graphical method can simultaneously determine the bulk values of the six effective material parameters, permittivity and permeability tensors, from a single layer of unit cells.
Graphical retrieval method for orthorhombic anisotropic materials
Simin Feng
Physics , 2010, DOI: 10.1364/OE.18.017009
Abstract: We apply the equivalent theory to orthorhombic anisotropic materials and provide a general unit-cell design criterion for achieving a length-independent retrieval of the effective material parameters from a single layer of unit cells. We introduce a graphical retrieval method and phase unwrapping techniques. The graphical method utilizes the linear regression technique. Our method can reduce the uncertainty of experimental measurements and the ambiguity of phase unwrapping. Moreover, the graphical method can simultaneously determine the bulk values of the six effective material parameters, permittivity and permeability tensors, from a single layer of unit cells.
Dissipation-Induced Super Scattering and Lasing PT-Spaser
Simin Feng
Physics , 2015,
Abstract: Giant transmission and reflection of a finite bandwidth are shown to occur at the same wavelength when the electromagnetic wave is incident on a periodic array of PT-symmetric dimers embedded in a metallic film. Remarkably, we found that this phenomenon vanishes if the metallic substrate is lossless while keeping other parameters unchanged. When the metafilm is adjusted to the vicinity of a spectral singularity, tuning substrate dissipation to a critical value can lead to supper scattering in stark contrast to what would be expected in conventional systems. The PT-synthetic plasmonic metafilm acts as a lasing PT-spaser, a planar source of coherent radiation. The metallic dissipation provides a mean to couple light out of the dark modes of the PT- spaser. Above a critical gain-loss coupling, the metafilm behaves as a meta-gain medium with the meta-gain atoms made from the PT-plasmonic dimers. This phenomenon implies that super radiation is possible from a cavity having gain elements by tuning the cavity dissipation to a critical value.
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