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Search Results: 1 - 10 of 9003 matches for " Silvia Platania "
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Use of Alternative and Complementary Medicine by Old Italians Adults: The Determinant of Choice  [PDF]
Silvia Platania, Giuseppe Santisi
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.37042
Abstract: Complementary and alternative medicine (CAM) is the term for medical products and practices that aren’t part of standard care. Although using complementary and alternative medicines (CAM) is becoming increasingly prevalent in Italy, research in complementary and alternative therapy in older adults is limited. This study investigates the predictors and the determinant of choice of using complementary and alternative medicine (CAM) in older adult consumers [1]-[3]. The sample consisted of 150 Italian older consumers who used alternative medicine in the last year. The older adults interviewed were 52 males (34.7%) and 98 females (65.3%) and the average age was 65.4 (SD = 0.76). The results of this study showed a strong dissatisfaction of respondents with the tra-ditional medical treatments because the alternative’s medicine treatments are considered more invasive.
Pitfalls in neuroendocrine tumor diagnosis
Emilio Bajetta,Marco Platania
Rare Tumors , 2009, DOI: 10.4081/rt.2009.e32
Abstract: Not available
Inflationary Solutions in Quantum Cosmology
Giampiero Esposito,Giovanni Platania
Physics , 1995, DOI: 10.1088/0264-9381/5/7/003
Abstract: We prove that in the Hartle-Hawking approach to quantum cosmology the existence of an inflationary phase is a general property of minisuperspace models given by a closed Friedmann-Robertson-Walker universe containing a massless scalar field with a $\lambda\phi^{n}$ self-interaction. The evolution in time of the cosmic scale factor and of the scalar field in the very early universe is derived, together with the conditions to be satisfied in order to solve the horizon and flatness problems.
Top mass determination, Higgs inflation, and vacuum stability
Vincenzo Branchina,Emanuele Messina,Alessia Platania
Physics , 2014, DOI: 10.1007/JHEP09(2014)182
Abstract: The possibility that new physics beyond the Standard Model (SM) appears only at the Planck scale $M_P$ is often considered. However, it is usually argued that new physics interactions at $M_P$ do not affect the SM stability phase diagram, so the latter is obtained neglecting these terms. According to this diagram, for the current experimental values of the top and Higgs masses, our universe lives in a metastable state (with very long lifetime), near the edge of stability. Contrary to these expectations, however, we show that the stability phase diagram strongly depends on new physics and that, despite claims to the contrary, a more precise determination of the top (as well as of the Higgs) mass will not allow to discriminate between stability, metastability or criticality of the electroweak vacuum. At the same time, we show that the conditions needed for the realization of Higgs inflation scenarios (all obtained neglecting new physics) are too sensitive to the presence of new interactions at $M_P$. Therefore, Higgs inflation scenarios require very severe fine tunings that cast serious doubts on these models.
Parents' attitudes and behaviours towards recommended vaccinations in Sicily, Italy
Maria Coniglio, Marco Platania, Donatella Privitera, Giuseppe Giammanco, Sarina Pignato
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-305
Abstract: Parents of children aged 3-5 years of day-care centres in Sicily were asked to fill out an anonymous questionnaire. Determinants of the attitude towards recommended vaccinations and social influence on the decision-making process were assessed using logistic regression analysis.Of the 1,500 selected parents, 81.0% participated in the study. Prior to the survey, the majority of children (97.6%) received recommended vaccines. Most parents (74.4%) received information about vaccinations from Family Paediatricians, showed a good knowledge about the side effects of the vaccines (73.1%), did not worry about their potential dangerousness (53.0%) and would have accepted their children to be vaccinated even if it was not required for day care (84.1%). The majority (79.9%) were not disposed to follow the advises of the anti-vaccination movements. Parents' background characteristics, sources of information and social influence were not significantly associated with parental acceptance of recommended vaccines for childhood.This study suggests that health information by Family Paediatricians is significantly associated with parental acceptance of recommended vaccinations.Since a long time, Italy has maintained a dual system to administer childhood immunisations, that is a certain number of mandatory vaccinations and a number of recommended vaccinations. At present, mandatory vaccinations are four: inactivated polio (IPV), diphtheria-tetanus (DT), and viral hepatitis B (HBV). Vaccinations against measles, mumps and rubella (MMR), pertussis, varicella, pneumococcal disease and Haemophilus influenzae b (Hib) are nationwide included among recommended immunisations. Until 1995 no organic policy of offer of recommended vaccinations existed. Since that year, a Circular Letter of the Ministry of Health (no. 13, 6 June 1995) established that all the Italian regions should actively offer MMR and acellular pertussis vaccines free of charge. The National Health Plan 1998-2000 set a 95% cove
Homology Modeling of Dopamine D2 and D3 Receptors: Molecular Dynamics Refinement and Docking Evaluation
Chiara Bianca Maria Platania, Salvatore Salomone, Gian Marco Leggio, Filippo Drago, Claudio Bucolo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044316
Abstract: Dopamine (DA) receptors, a class of G-protein coupled receptors (GPCRs), have been targeted for drug development for the treatment of neurological, psychiatric and ocular disorders. The lack of structural information about GPCRs and their ligand complexes has prompted the development of homology models of these proteins aimed at structure-based drug design. Crystal structure of human dopamine D3 (hD3) receptor has been recently solved. Based on the hD3 receptor crystal structure we generated dopamine D2 and D3 receptor models and refined them with molecular dynamics (MD) protocol. Refined structures, obtained from the MD simulations in membrane environment, were subsequently used in molecular docking studies in order to investigate potential sites of interaction. The structure of hD3 and hD2L receptors was differentiated by means of MD simulations and D3 selective ligands were discriminated, in terms of binding energy, by docking calculation. Robust correlation of computed and experimental Ki was obtained for hD3 and hD2L receptor ligands. In conclusion, the present computational approach seems suitable to build and refine structure models of homologous dopamine receptors that may be of value for structure-based drug discovery of selective dopaminergic ligands.
Revasculariza o completa do miocárdio com uso exclusivo de enxertos arteriais
DALLAN Luís Alberto,OLIVEIRA Sérgio Almeida de,LISBOA Luiz A.,PLATANIA Fernando
Revista Brasileira de Cirurgia Cardiovascular , 1998,
Abstract: Os autores apresentam sua experiência com 385 pacientes, no período de 30 meses, que tiveram seu miocárdio revascularizado com o uso exclusivo de enxertos arteriais. Oito deles já haviam sido previamente revascularizados, 114 (29,6%) apresentavam les o coronária unilateral, 118 (30,6%) biarterial e 153 (39,7%) pacientes tinham comprometimento em 3 ou mais artérias coronárias. A artéria torácica interna esquerda foi utilizada preferencialmente para o ramo interventricular anterior. A artéria coronária direita foi usada in situ para a coronária direita e seus ramos, ou como enxerto livre a partir da aorta ou ainda em "Y" artificial a partir da artéria torácica interna esquerda para ramos diagonais e marginais da coronária esquerda, num total de 108 (28,1%) pacientes. Foram também empregadas as artérias: radial em 215 (55,8%) pacientes, gastroepiplóica direita em 24 (6,3%) pacientes e a artéria epigástrica inferior em 4 (1,1%) pacientes. No total foram realizados 809 enxertos arteriais nesse grupo de pacientes, com 839 anastomoses com as artérias coronárias. Nos pacientes com les o coronária triarterial a média de artérias revascularizadas foi de 3,2 por paciente. N o foram observados óbitos intra-operatórios. A mortalidade hospitalar foi de 7 (1,8%) pacientes, dos quais apenas 3 (42,8%) decorrentes de baixo débito cardíaco. Os autores destacam as vantagens do uso preferencial de enxertos arteriais na revasculariza o do miocárdio de grupos selecionados de pacientes, especialmente de faixa etária baixa. Essas conclus es baseiam-se na pequena incidência de morbimortalidade observada, além da reconhecida superioridade dos enxertos arteriais, especialmente da artéria torácica interna, patente a longo prazo e pela possibilidade de sua composi o com os demais enxertos arteriais.
Tratamento cirúrgico da rotura de parede livre do ventrículo esquerdo após infarto agudo do miocárdio
ABREU FILHO Carlos A. C.,DALLAN Luís Alberto O.,LISBOA Luiz Augusto F.,PLATANIA Fernando
Revista Brasileira de Cirurgia Cardiovascular , 2002,
Abstract: CASUíSTICA E METODOS: Entre janeiro de 1983 e maio de 1999, 12.405 pacientes com diagnóstico de infarto agudo do miocárdio (IAM) foram atendidos no InCor. Destes, 127 (1,02%) apresentaram rotura de parede livre do ventrículo esquerdo como complica o do IAM. A rotura miocárdica aguda ocorreu em 98 (77,1%) pacientes e a subaguda em 29 (22,9%). RESULTADOS: Foram operados 5 pacientes na forma aguda, com 80% de mortalidade e 19 na forma subaguda, com 15,8% de mortalidade. A sobrevida pós-operatória abrangendo os dois grupos foi de 70,8%. CONCLUS O: Concluímos que a rotura de parede livre do ventrículo esquerdo é uma grave complica o do IAM, necessitando de atua o imediata. Nas formas agudas, observa-se rápida deteriora o hemodinamica do paciente, muitas vezes sem tempo hábil para tentativa de corre o cirúrgica. As formas subagudas podem ser detectadas e monitorizadas através de exames ecocardiográficos seriados após o IAM. Nestes casos a interven o cirúrgica precoce, muitas vezes sem a necessidade de instala o de circula o extracorpórea, tem contribuído para a sobrevida da maioria dos pacientes.
Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy
Claudio Bucolo,Giuseppina Marrazzo,Chiara Bianca Maria Platania,Filippo Drago,Gian Marco Leggio,Salvatore Salomone
Journal of Diabetes Research , 2013, DOI: 10.1155/2013/432695
Abstract: Diabetic retinopathy is a complex condition where inflammation and oxidative stress represent crucial pathways in the pathogenesis of the disease. Aim of the study was to investigate the effects of a fortified extract of red berries, Ginkgo biloba and white willow bark containing carnosine and -lipoic acid in early retinal and plasma changes of streptozotocin-induced diabetic rats. Diabetes was induced by a single streptozotocin injection in Sprague Dawley rats. Diabetics and nondiabetic (control) rats were treated daily with the fortified extract for the ten days. Retina samples were collected and analyzed for their TNF- and VEGF content. Moreover, plasma oxidative stress was evaluated by thiobarbituric acid reacting substances (TBARS). Increased TNF- and VEGF levels were observed in the retina of diabetic rats. Treatment with the fortified extract significantly lowered retinal cytokine levels and suppressed diabetes-related lipid peroxidation. These data demonstrate that the fortified extract attenuates the degree of retinal inflammation and plasma lipid peroxidation preserving the retina in early diabetic rats. 1. Introduction Diabetic retinopathy, a diabetes-related complication, is the leading cause of blindness and visual impairment in working-age individuals [1]. Diabetic retinopathy is a chronic disease that develops in stages and is rarely detected in the first few years of diabetes. The incidence of the disease increases to 50% by 10 years and to 90% by 25 years of diabetes [1]. Oxidative stress appears to be an important feature of the diabetic complications such as retinopathy. Apart from the well-known increase in lipid peroxide, diabetics have lower concentrations of erythrocyte glutathione and have higher concentrations of dehydroascorbate in their plasma and lower levels of vitamin E in their platelets. Oxidative stress causes a production of chemically reactive molecules, which induce a variety of proinflammatory mediators such as VEGF and TNF-α [2, 3]. The earliest changes detectable in diabetic retinopathy are loss of pericytes, capillary basement membrane thickening, edema, and formation of microaneurysms. These structural and functional changes are followed by microvascular occlusion, neovascularization, and neurodegeneration [4]. Considering that oxidative stress and inflammation represent the key factors in the onset and progression of diabetic retinopathy, antioxidant and anti-inflammatory products are expected to produce significant therapeutic advantages. Current treatments associated with antidiabetic drugs are mostly intended
Sunyaev-Zeldovich Effect from Quasar-driven Blast-waves
P. Platania,C. Burigana,G. De Zotti,E. Lazzaro,M. Bersanelli
Physics , 2002, DOI: 10.1046/j.1365-8711.2002.05907.x
Abstract: Quasar-driven winds are currently the best candidates for accounting for the pre-heating of the intergalactic medium in clusters. Such winds, occurring during early phases of the evolution of spheroidal galaxies, shock-heat the interstellar gas, thus inducing a detectable Sunyaev-Zeldovich effect. We estimate the amplitude and the angular scale of such effect as well as its counts as a function of the comptonization parameter $y$. The contamination due to radio emission by the quasar itself is also discussed. The corresponding mean Compton distortion of the cosmic microwave background spectrum is found to be well below the COBE/FIRAS upper limit.
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