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Search Results: 1 - 10 of 8992 matches for " Silvia Pampana "
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The Emerging Extrahepatic Manifestations of Hepatitis C Virus Infection in Chronic Hepatitis and Mixed Cryoglobulinemia
Poupak Fallahi,Clodoveo Ferri,Silvia Martina Ferrari,Alessandro Pampana
Hepatitis Monthly , 2008,
Abstract: Hepatitis C virus (HCV) is known to be responsible for both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, Sj gren syndrome, and chronic polyarthritis are the most documented rheumatologic extrahepatic manifestations of HCV infection. The most frequent and clinically important extrahepatic endocrine manifestations of chronic HCV infection are thyroid disorders and type 2 diabetes mellitus. From a meta-analysis of the literature, a significant association between HCV infection and thyroid autoimmunity and/or hypothyroidism as well as a high prevalence of thyroid cancer have been reported. The pattern of thyroid disorders observed in HCV infected patients is characterized by the presence of elevated circulating anti-thyroid peroxidase antibodies with increased risk of hypothyroidism. Several clinical epidemiologic studies have reported that HCV infection is a risk factor for type 2 diabetes. The type of diabetes manifested by subjects with chronic HCV infection is not of the classical type 2 diabetes; in fact, HCV-related diabetic patients are leaner than the classical diabetic patients, and have a significantly lower LDL-cholesterol, and both systolic and diastolic blood pressure. Furthermore, patients with mixed cryoglobulinemia (mixed cryoglobulinemia) and chronic HCV infection with type 2 diabetes have more frequently non-organ-specific-autoantibodies than non-diabetic patients with mixed cryoglobulinemia and those with chronic HCV infection. Based on the above-mentioned findings, it has been hypothesized that diabetes in HCV infection may have an immune-mediated pathogenesis. In patients with chronic HCV infection, we found an increased risk of carotid artery plaque and carotid intima-media thickening. These findings suggested a possible role for chronic hepatitis C in the pathogenesis of carotid artery remodelling. Recently, high prevalence rates of anti-HCV antibodies were shown in patients with hypertrophic cardiomyopathy or dilatated cardiomyopathy; association with myocarditis has also been suggested. Many studies have linked the Th1 immune response with HCV infection, autoimmune thyroid disorders and diabetes. These findings suggest that a possible common immunological Th1 pattern could be the pathophysiological basis of the association.
Remobilization of Dry Matter and Nitrogen in Maize as Affected by Hybrid Maturity Class
Silvia Pampana,Laura Ercoli,Alessandro Masoni,Iduna Arduini
Italian Journal of Agronomy , 2007, DOI: 10.4081/ija.2009.39
Abstract: The length of the growing cycle is one of the most important traits determining hybrid adaptability to the environment. The objective of this research was to compare in a field trial the pattern of dry matter and nitrogen accumulation and remobilization of four commercial maize hybrids belonging to FAO maturity group 400, 500, 600 and 700. The duration of the periods emergence-silking and silking-physiological maturity increased with the increase of hybrid maturity class. Silking occurred 6 days later in the latest maturing hybrid than in the earliest one, and physiological maturity 21 days later. Hybrids differed for biomass production at silking and at physiological maturity. At silking, plant dry weight and leaf area increased with hybrid maturity, owing to greater leaves and stalks. The lengthening of the period emergence-silking allowed a greater accumulation of assimilates in the plant, thus increasing the source of remobilization in the following period. The increase of the length of the period silking-maturity from hybrid 400 to hybrid 700 brought to an increase of dry matter accumulation coupled to a reduction of dry matter remobilization. Increases in hybrid maturity class resulted also in an increase of post-silking N uptake and N remobilization from vegetative plant parts. Thus, the longer period silking-maturity was associated with an increased photosynthetic activity of the plant, which hampered the rate of leaf senescence and deterred the mobilization of reserve carbohydrates for grain filling. Conversely, the longer was the hybrid cycle, the greater was the quantity of both N uptake from soil and remobilized N from vegetative plant parts.
Remobilization of Dry Matter and Nitrogen in Maize as Affected by Hybrid Maturity Class
Silvia Pampana,Laura Ercoli,Alessandro Masoni,Iduna Arduini
Italian Journal of Agronomy , 2011, DOI: 10.4081/ija.2009.2.39
Abstract: The length of the growing cycle is one of the most important traits determining hybrid adaptability to the environment. The objective of this research was to compare in a field trial the pattern of dry matter and nitrogen accumulation and remobilization of four commercial maize hybrids belonging to FAO maturity group 400, 500, 600 and 700. The duration of the periods emergence-silking and silking-physiological maturity increased with the increase of hybrid maturity class. Silking occurred 6 days later in the latest maturing hybrid than in the earliest one, and physiological maturity 21 days later. Hybrids differed for biomass production at silking and at physiological maturity. At silking, plant dry weight and leaf area increased with hybrid maturity, owing to greater leaves and stalks. The lengthening of the period emergence-silking allowed a greater accumulation of assimilates in the plant, thus increasing the source of remobilization in the following period. The increase of the length of the period silking-maturity from hybrid 400 to hybrid 700 brought to an increase of dry matter accumulation coupled to a reduction of dry matter remobilization. Increases in hybrid maturity class resulted also in an increase of post-silking N uptake and N remobilization from vegetative plant parts. Thus, the longer period silking-maturity was associated with an increased photosynthetic activity of the plant, which hampered the rate of leaf senescence and deterred the mobilization of reserve carbohydrates for grain filling. Conversely, the longer was the hybrid cycle, the greater was the quantity of both N uptake from soil and remobilized N from vegetative plant parts.
Remobilization of Dry Matter, Nitrogen and Phosphorus in Durum Wheat as Affected by Genotype and Environment
Silvia Pampana,Marco Mariotti,Laura Ercoli,Alessandro Masoni
Italian Journal of Agronomy , 2008, DOI: 10.4081/ija.2007.303
Abstract: Field studies were carried out to determine dry matter (DM), nitrogen (N) and phosphorus (P) assimilation until anthesis and DM, N and P remobilization during grain filling in wheat. Twentyfive durum wheat (Triticum durum L.) varieties were grown in Tuscany at Grosseto and at Arezzo. At Grosseto 76% of DM was assimilated during pre-anthesis while at Arezzo the amount was 81%. At Grosseto 44% and at Arezzo 35% of N was accumulated until anthesis, while 33% of P was stored until anthesis in both localities. Cultivar differences in DM and N remobilization were positively related to pre-anthesis dry matter and N content at anthesis (r > 0.74). Environmental contraints on carbon, N and P availability in the plant are crucial factors in determining grain yield and N and P content in grain, affecting both accumulation and remobilization. In the low rainfall site of Grosseto, most of the grain yield originated from dry matter accumulation, while in the wetter environment of Arezzo remobilization and accumulation contributed equally to grain yield. Conversely, at Grosseto grain N content relied most on remobilization and at Arezzo remobilization and accumulation contributed equally. Finally, at Grosseto and at Arezzo accumulation of P was the main source of grain P content.
Remobilization of Dry Matter, Nitrogen and Phosphorus in Durum Wheat as Affected by Genotype and Environment
Silvia Pampana,Marco Mariotti,Laura Ercoli,Alessandro Masoni
Italian Journal of Agronomy , 2011, DOI: 10.4081/ija.2007.303
Abstract: Field studies were carried out to determine dry matter (DM), nitrogen (N) and phosphorus (P) assimilation until anthesis and DM, N and P remobilization during grain filling in wheat. Twentyfive durum wheat (Triticum durum L.) varieties were grown in Tuscany at Grosseto and at Arezzo. At Grosseto 76% of DM was assimilated during pre-anthesis while at Arezzo the amount was 81%. At Grosseto 44% and at Arezzo 35% of N was accumulated until anthesis, while 33% of P was stored until anthesis in both localities. Cultivar differences in DM and N remobilization were positively related to pre-anthesis dry matter and N content at anthesis (r > 0.74). Environmental contraints on carbon, N and P availability in the plant are crucial factors in determining grain yield and N and P content in grain, affecting both accumulation and remobilization. In the low rainfall site of Grosseto, most of the grain yield originated from dry matter accumulation, while in the wetter environment of Arezzo remobilization and accumulation contributed equally to grain yield. Conversely, at Grosseto grain N content relied most on remobilization and at Arezzo remobilization and accumulation contributed equally. Finally, at Grosseto and at Arezzo accumulation of P was the main source of grain P content.
Safety of Early Carotid Artery Stenting after Systemic Thrombolysis: A Single Center Experience
Fabrizio Sallustio,Giacomo Koch,Alessandro Rocco,Costanza Rossi,Enrico Pampana,Roberto Gandini,Alessandro Meschini,Marina Diomedi,Paolo Stanzione,Silvia Di Legge
Stroke Research and Treatment , 2012, DOI: 10.1155/2012/904575
Abstract: Background. Patients with acute ischemic stroke due to internal carotid artery (ICA) disease are at high risk of early stroke recurrence. A combination of IV thrombolysis and early carotid artery stenting (CAS) may result in more effective secondary stroke prevention. Objective. We tested safety and durability of early CAS following IV thrombolysis in stroke patients with residual stenosis in the symptomatic ICA. Methods. Of consecutive patients treated with IV rtPA, those with residual ICA stenosis ≥70% or <70% with an ulcerated plaque underwent early CAS (>24 hours). The protocol included pre-rtPA MRI and MR angiography, and post-rtPA carotid ultrasound and CT angiography. Stroke severity was assessed by the NIH Stroke Scale (NIHSS). Three- and twelve-month stent patency was assessed by ultrasound. Twelve-month functional outcome was assessed by the modified Rankin Scale (mRS). Results. Of 145 consecutive IV rtPA-treated patients, 6 (4%) underwent early CAS. Median age was 76 (range 67–78) years, median NIHSS at stroke onset was 12 (range 9–16) and 7 (range 7-8) before CAS. Median onset-to-CAS time was 48 (range 30–94) hours. A single self-expandable stent was implanted to cover the entire lesion in all patients. The procedure was uneventful in all patients. After 12 months, all patients had stent patency, and the functional outcome was favourable (mRS ≤ 2) in all but 1 patient experiencing a recurrent stroke for new-onset atrial fibrillation. Conclusion. This small case series of a single centre suggests that early CAS may be considered a safe alternative to CEA after IV rtPA administration in selected patients at high risk of stroke recurrence. 1. Introduction The incidence and management of early recurrent ischemic stroke after intravenous (IV) administration of recombinant tissue plasminogen activator (rtPA) have not been extensively investigated. Among stroke subtypes, patients with stroke due to large-artery atherosclerosis carry the highest risk of stroke recurrence, accounting for 37% of recurrences within 7 days [1]. A combination of IV thrombolysis and early carotid revascularization might result in more effective secondary stroke prevention strategy. However, at least in the first 24 hours after rtPA administration, the risk of intracranial haemorrhage associated with early reperfusion of a recently ischemic brain tissue might be increased [2, 3]. Safety of early carotid endarterectomy (CEA) in patients with residual severe carotid stenosis following IV rtPA administration has been reported in small single-centre case series [4–6].
Percutaneous Angioplasty in Diabetic Patients with Critical Limb Ischemia and Chronic Kidney Disease  [PDF]
Laura Giurato, Roberto Gandini, Marco Meloni, Enrico Pampana, Valeria Ruotolo, Valentina Izzo, Sebastiano Fabiano, Costantino Del Giudice, Luigi Uccioli
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2013, DOI: 10.4236/ojemd.2013.33028
Abstract:

Introduction: Diabetes and Chronic Kidney Disease (CKD) are two strong risk factors for peripheral arterial disease (PAD) and Critical Limb Ischemia (CLI). Further renal insufficiency increases the risk of non healing wounds and major amputation. Primary amputation rates of 22% to 44% have been reported for ischaemic foot lesion in End-Stage Renal Disease (ESRD) patients. In our study we evaluated the outcomes after Percutaneus Transluminal Angioplasty (PTA) in diabetic patient in relation to different CKD classes. Materials and Methods: We studied a group of 456 diabetic patients with PAD complicated by foot lesion who underwent PTA because of a CLI. According to the estimated Glomerular Filtration Rate (eGFR mL/min/1.73 m2) we divided the patients into five CKD groups: group 1 eGFR > 90, group 2 eGFR 90 - 60 (n = 160), group 3 eGFR 60 - 30 (n = 152), group 4 eGFR 30 -15 (n = 34) and group 5 < 15 or in ESRD) (n = 60). The following outcomes were recorded: alive without major amputation, alive with major amputation and death. The follow-up was 16.7 ± 14.3 months. Results: Alive without major amputation, alive with major amputation and death were respectively: for group 1 (77.8%, 11.1%, 11.1%), for group 2 (74.4%, 12.5%, 13.1%), for group 3 (80.3%, 11.2%, 8.5%), for group 4 (82.3%, 8.8%, 8.8%). They were 60%, 18.3%, 21.7% for group 5 significantly different from the other CKD groups (χ2 = 0.0175). Our analysis did not highlight any relationship between eGFR and outcomes and eGFR did not show any significant difference according to the different outcomes, and were respectively 60.2 ± 1.3, 61.8 ± 3.4, 63.8 ± 3.5 (P = ns). Conclusion: The outcomes were similar for groups 1-4 and therefore, according to our data, they seemed not to be influenced by the decline of GFR. Outcomes worse significantly in group 5, but this group included only patients with ESRD in dialysis treatment. Although the outcomes after PTA in group 5 was significantly worse than the other groups, still a 60% limb salvage rate was obtained with PTA also in these very fragile patients. PTA was much less aggressive than by-pass and PTA was the only method used to treat CLI in our patients. This could explain why we recorded similar outcomes in all groups

The practical management of non traumatic cerebral haemorrhage in the acute phase: a call to action
Luca Masotti,Alessandro Pampana,Roberto Cappelli,Daniela Rafanelli
Reviews in Health Care , 2011, DOI: 10.7175/rhc.4921s3-4
Abstract:
Design and characterization of diclofenac diethylamine transdermal patch using silicone and acrylic adhesives combination
Dandigi M Panchaxari, Sowjanya Pampana, Tapas Pal, Bhavana Devabhaktuni, Anil Kumar Aravapalli
DARU Journal of Pharmaceutical Sciences , 2013, DOI: 10.1186/2008-2231-21-6
Abstract: Modified solvent evaporation method was employed for casting of film over Fluoropolymer coated polyester release liner. Initial studies included solubilization of drug in the polymers using solubilizers. The formulations with combination of adhesives were attempted to combine the desirable features of both the adhesives. The effect of the permeation enhancers on the drug permeation were studied using pig ear skin. All the optimized patches were subjected to adhesion, dissolution and stability studies. A 7-day skin irritancy test on albino rabbits and an in vivo anti-inflammatory study on wistar rats by carrageenan induced paw edema method were also performed.The results indicated the high percent drug permeation (% CDP-23.582) and low solubility nature (1%) of Silicone adhesive and high solubility (20%) and low% CDP (10.72%) of acrylic adhesive. The combination of adhesives showed desirable characteristics for DDEA permeation with adequate % CDP and sufficient solubility. Release profiles were found to be dependent on proportion of polymer and type of permeation enhancer. The anti-inflammatory study revealed the sustaining effect and high percentage inhibition of edema of C4/OLA (99.68%). The acute skin irritancy studies advocated the non-irritant nature of the adhesives used.It was concluded that an ideal of combination of adhesives would serve as the best choice, for fabrication of DDEA patches, for sustained effect of DDEA with better enhancement in permeation characteristics and robustness.Drugs can be delivered across the skin to have an effect on the tissues adjacent to the site of application (topical delivery) or to have an effect after distribution through the circulatory system (systemic delivery). While there are many advantages for delivering drugs through the skin the barrier properties of the skin provide a significant challenge. By understanding the mechanisms by which compounds cross the skin it will be possible to devise means for improving drug del
Spontaneous Ureteral Rupture Diagnosis and Treatment
E. Pampana,S. Altobelli,M. Morini,A. Ricci,S. D'Onofrio,G. Simonetti
Case Reports in Radiology , 2013, DOI: 10.1155/2013/851859
Abstract: Rupture of the urinary collecting system associated with perinephric or retroperitoneal extravasation of the urine is an unusual condition and it is commonly associated with renal obstructing disease. Perforation could occur at any level from the calix to the bladder but it is usually seen at the fornices and upper ureter. It may lead to several serious consequences including urinoma, abscess formation, urosepsis, infection, and subsequent irreversible renal impairment. We report a case of a 69-year-old woman who presented at the emergency department of our institution with severe abdominal pain. Due to symptomatology worsening, complete laboratory evaluation was performed and the patient underwent abdominal contrast enhanced computed tomography (CT) evaluation which showed contrast agent extravasation outside the excretory system without any evidence of renal calculi at basal acquisition. It was decided to perform a double-J stent placement which was followed by complete healing of the ureter and its removal was performed 8 weeks later. Diagnosis and therapeutic approaches are discussed. 1. Introduction Obstruction of the genitourinary system is followed by an increase of intraluminal pressure which may lead to rupture of the collecting system and consequently urine extravasation with urinoma formation. Spontaneous rupture of the ureter is rare and can be traumatic or nontraumatic. Calculi represent the most frequent cause of ureteral and pelvis rupture in the nontraumatic group. Urine extravasation may be clinically occult or may lead to symptoms of acute abdomen. We report a rare case of spontaneous ureteric rupture in a patient with a clinical history of recurrent renal colics in the younger age treated with double-J stent placement. We further describe this minimally invasive interventional approach. 2. Case Presentation A 69-year-old woman was admitted to the emergency department of our institution with a severe right-sided flank pain that started 6 hours before, nausea, and history of renal calculi in the younger age. In suspicion of an episode of renal colic, analgesic drugs therapy and complete laboratory evaluation were performed. Her vital signs were as follows: heart ratio: 89 beats per minute and regular; blood pressure: 145/90?mmHg; respiration: 18 per minute; and body temperature: 36,8°C. She had leukocytosis in the blood (9,300/mm3), with 48,2% of neutrophils. Urine analysis showed the presence of leukocytes and erythrocytes. Other values were within the normal limits. The patient reported a previous episode of colic pain 6 weeks before
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