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Search Results: 1 - 10 of 8986 matches for " Silvia Deaglio "
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REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA
Giovanni D'arena,Giovanni Rossi,Barbara Vannata,Silvia Deaglio
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may result in a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosis, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in either cancer and autoimmune disorders.
Active caspase-3 detection to evaluate apoptosis induced by Verbena officinalis essential oil and citral in chronic lymphocytic leukaemia cells
Laura De Martino,Giovanni D' Arena,Maria Marta Minervini,Silvia Deaglio
Revista Brasileira de Farmacognosia , 2011,
Abstract: Verbena officinalis L., Verbenaceae, commonly known as vervain, is a plant widely used in medicine. Despite of its widespread use in different traditional practices, the mechanisms of pharmacological actions of the plant and its volatile oil are still unclear. We evaluated the pro-apoptotic activity of V. officinalis essential oil and of its main component, citral, on lymphocytes collected from ten patients with chronic lymphocytic leukaemia (CLL), a disease in which a faulty apoptotic mechanism is still retained one of the primary pathogenic events, by adding to treated mononuclear cells, annexin-V, propidium iodide, and CD19. Apoptosis was also evaluated using anti-active-caspase-3 monoclonal antibody after permeabilization of the cells. Both V. officinalis essential oil and citral were found able to induce apoptosis in CLL cells and to activate caspase-3, which is considered the way by means they active apoptosis in B neoplastic cells. This data further support evidences that indicate natural compounds as possible lead structure to develop new therapeutic agents for CLL.
Active caspase-3 detection to evaluate apoptosis induced by Verbena officinalis essential oil and citral in chronic lymphocytic leukaemia cells
Martino, Laura De;D' Arena, Giovanni;Minervini, Maria Marta;Deaglio, Silvia;Sinisi, Nicola Pio;Cascavilla, Nicola;Feo, Vincenzo De;
Revista Brasileira de Farmacognosia , 2011, DOI: 10.1590/S0102-695X2011005000082
Abstract: verbena officinalis l., verbenaceae, commonly known as vervain, is a plant widely used in medicine. despite of its widespread use in different traditional practices, the mechanisms of pharmacological actions of the plant and its volatile oil are still unclear. we evaluated the pro-apoptotic activity of v. officinalis essential oil and of its main component, citral, on lymphocytes collected from ten patients with chronic lymphocytic leukaemia (cll), a disease in which a faulty apoptotic mechanism is still retained one of the primary pathogenic events, by adding to treated mononuclear cells, annexin-v, propidium iodide, and cd19. apoptosis was also evaluated using anti-active-caspase-3 monoclonal antibody after permeabilization of the cells. both v. officinalis essential oil and citral were found able to induce apoptosis in cll cells and to activate caspase-3, which is considered the way by means they active apoptosis in b neoplastic cells. this data further support evidences that indicate natural compounds as possible lead structure to develop new therapeutic agents for cll.
Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance
Michele Dal-Bo, Francesco Bertoni, Francesco Forconi, Antonella Zucchetto, Riccardo Bomben, Roberto Marasca, Silvia Deaglio, Luca Laurenti, Dimitar G Efremov, Gianluca Gaidano, Giovanni Del Poeta, Valter Gattei
Journal of Translational Medicine , 2009, DOI: 10.1186/1479-5876-7-76
Abstract: B-cell chronic lymphocytic leukemia (CLL) is a monoclonal expansion of small mature B lymphocytes accumulating in blood, marrow, and lymphoid organs. Despite a remarkable phenotypic homogeneity, CLL is characterized by extremely variable clinical courses with survivals ranging from one to more than 15 years [1]. In this regard, specific chromosomal aberrations (i.e. 17p-, 11q- or +12), as well as the presence of an unmutated (UM) rather than mutated (M) status of immunoglobulin (IG) heavy chain variable (IGHV) genes, or expression levels for ZAP-70, CD38 and CD49d exceeding the value of an established threshold, have been reported to correlate with a poor clinical outcome in CLL [2-8].In the present review, the main factors playing a role in defining the biological features of CLL cells, hence eventually influencing the clinical aggressiveness of the disease, are divided into "intrinsic factors", mainly genomic alterations of CLL cells, and "extrinsic factors", responsible for direct micro-environmental interactions of CLL cells.Under the terms "intrinsic factors" are gathered the major genomic alterations associated with a CLL phenotype. Such alterations can be either primarily responsible for the first step(s) of neoplastic transformation of B cells (primary genetic lesions, e.g. 13q14.3 deletion, see below) or acquired during disease progression, also as a consequence of microenvironmental interactions (i.e. secondary genetic lesions). Telomer lenght too was included in this chapter, although often consequence of environmental factors affecting cell proliferation (see below).It is common notion that, differently from other B-cell lymphoid neoplasms, CLL is characterized by recurrent DNA gains and losses and not by the presence of specific chromosomal translocations. However, using either improved protocols to obtain informative metaphases [9,10] or microarray-based comparative genomic hybridization [11], chromosomal abnormalities can now be detected in over 90% o
The Challenge of UNASUR Member Countries to Replace ICSID Arbitration  [PDF]
Silvia Karina Fiezzoni
Beijing Law Review (BLR) , 2011, DOI: 10.4236/blr.2011.23014
Abstract: In the 2000s, the financial crisis in Argentina and several nationalizations carried out by governments in South America have spawned a large number of claims before International Centre for Settlement of Investment Disputes (ICSID). Latin Americans began to look at ICSID critically, there have been complaints about ICSID's connections with the World Bank; non-commercial interests, such as health or environmental protection, have not received adequate attention in the arbitration cases; a lack of transparency by arbitration panels; and the absence of an appeals process, but only a limited annulment procedure. This situation generates impacts upon the overall due process of ICSID arbitrations and Latin American hostility against ICSID, such the Bolivarian Alliance for the Peoples of our America Peoples'Trade Treaty (ALBA-TCP) Declaration to denounce ICSID Convention and the firm intention of Union of South American Nations (UNASUR) countries to create a regional arbitration centre to replace ICSID arbitration.
On the Relativistic Stars  [PDF]
Silvia Morales, Roberto Aquilano
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.34046
Abstract:

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ??Announcement from Editorial Board

The following article has been retracted due to plagiarism. This paper published in Vol.3 No.4, April 2012, has been removed from this site.


Title: On the Relativistic Stars

Author: Silvia Morales, Roberto Aquilano


It has been brought to our attention that this paper appears exactly as it was published in Astroparticle Physics, vol. 32, 2009, 153. (\"On the nature of relativistic stars\" by Silvia Morales, Alejandra Zorzi, Roberto Aquilano)

Consequently, this paper has been retracted by Journal of Modern Physics.

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?JMP Editorial Board

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?April 30, 2015

Use of Alternative and Complementary Medicine by Old Italians Adults: The Determinant of Choice  [PDF]
Silvia Platania, Giuseppe Santisi
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.37042
Abstract: Complementary and alternative medicine (CAM) is the term for medical products and practices that aren’t part of standard care. Although using complementary and alternative medicines (CAM) is becoming increasingly prevalent in Italy, research in complementary and alternative therapy in older adults is limited. This study investigates the predictors and the determinant of choice of using complementary and alternative medicine (CAM) in older adult consumers [1]-[3]. The sample consisted of 150 Italian older consumers who used alternative medicine in the last year. The older adults interviewed were 52 males (34.7%) and 98 females (65.3%) and the average age was 65.4 (SD = 0.76). The results of this study showed a strong dissatisfaction of respondents with the tra-ditional medical treatments because the alternative’s medicine treatments are considered more invasive.
Phonons near Peierls Structural Transition in Quasi-One-Dimensional Organic Crystals of TTF-TCNQ  [PDF]
Silvia Andronic, Anatolie Casian
Advances in Materials Physics and Chemistry (AMPC) , 2016, DOI: 10.4236/ampc.2016.64010
Abstract: The Peierls structural transition in quasi-one-dimensional organic crystals of TTF-TCNQ is investigated in the frame of a more complete physical model. The two most important electron-phonon interaction mechanisms are taken into account simultaneously. One is similar of that of deformation potential and the other is of polaron type. For simplicity, the 2D crystal model is considered. The renormalized phonon spectrum and the phonon polarization operator are calculated in the random phase approximation for different temperatures. The effects of interchain interaction on renormalized acoustic phonons and on the Peierls critical temperature are analyzed.
Metal-Insulator Transition of Peierls Type in Quasi-One-Dimensional Crystals of TTT2I3  [PDF]
Silvia Andronic, Anatolie Casian
Advances in Materials Physics and Chemistry (AMPC) , 2017, DOI: 10.4236/ampc.2017.75017
Abstract: We investigate the metal-insulator transition in quasi-one-dimensional organic crystals of tetrathiotetracene-iodide, TTT2I3, in the 2D model. A crystal physical model is applied which takes into account two the most important hole-phonon interaction mechanisms. One is similar to that of deformation potential and the other is of polaron type. The scattering on defects is also considered and it is crucial for the explanation of the transition. The phonon polarization operator and the renormalized phonon spectrum are calculated in the random phase approximation for different temperatures applying the method of Green functions. We show that the transition is of Peierls type. The effect of lattice distortion on the dispersion of renormalized acoustic phonons is analyzed.
A general multivariate latent growth model with applications in student careers Data warehouses
Silvia Bianconcini,Silvia Cagnone
Statistics , 2009, DOI: 10.3102/1076998610396886
Abstract: The evaluation of the formative process in the University system has been assuming an ever increasing importance in the European countries. Within this context the analysis of student performance and capabilities plays a fundamental role. In this work we propose a multivariate latent growth model for studying the performances of a cohort of students of the University of Bologna. The model proposed is innovative since it is composed by: (1) multivariate growth models that allow to capture the different dynamics of student performance indicators over time and (2) a factor model that allows to measure the general latent student capability. The flexibility of the model proposed allows its applications in several fields such as socio-economic settings in which personal behaviours are studied by using panel data.
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