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Search Results: 1 - 10 of 786329 matches for " Silva L.S.M. da "
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Capilaroscopia panoramica periungueal e sua aplica o em doen as reumáticas
Silva L.S.M. da,Lima A.R.A.G.,Pucinelli M.L.C.,Atra E.
Revista da Associa??o Médica Brasileira , 1997,
Abstract:
Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system
Francischi J.N.,Pereira L.S.M.,Castro M.S.
Brazilian Journal of Medical and Biological Research , 1997,
Abstract: Since arthritis induced by Mycobacterium products (adjuvant) in rats is considered to be immunologically driven, the objective of the present study was to determine if the immunosuppressor drug cyclosporin could affect hindpaw edema and joint hyperalgesia simultaneously. Female Holtzman rats (140-170 g) presented hyperalgesia and edema on the 8th and 12th day following adjuvant injection. Daily systemic (oral or intramuscular) administration of cyclosporin (0.5-5.0 mg kg-1 day-1) or dexamethasone (0.01-0.1 mg kg-1 day-1) for 15 days starting on day zero dose-dependently inhibited the hindpaw edema and hyperalgesia in arthritic rats. However, hyperalgesia but not edema could be detected two days after cyclosporin withdrawal. We concluded that a) the continuous presence of cyclosporin is essential to reduce the development of joint hyperalgesia and that b) different mechanisms underlie the appearance of hyperalgesia and edema in this model. The intracerebroventricular (icv) administration of 5-50-fold smaller doses of cyclosporin (1.5-150 μg/day) or dexamethasone (15 μg/day) also reduced the arthritic hindpaw edema and hyperalgesia. Peripheral blood from animals injected with effective systemic cyclosporin doses showed detectable levels of the drug, whereas peripheral blood from those injected with icv cyclosporin did not, as measured by specific RIA. Our results indicate that cyclosporin administered by the central route is as effective as by the systemic route to reduce joint hyperalgesia and hindpaw edema in arthritic rats. The antiarthritic effect induced by low doses of cyclosporin in the central nervous system (CNS) could be explored to avoid its often associated systemic side effects during chronic therapy. However, the mechanism(s) involved in the antiarthritic response to cyclosporin in the CNS remain to be elucidated
Mineral micronutrient density characterization using energy dispersive X-Ray Fluorescence (XRF) analysis in four on-farm Kenyan wild African fruit tree germplasm
L.S.M Akundabweni, R.W Munene, D.M Maina, J.M Mangala
African Journal of Food, Agriculture, Nutrition and Development , 2010,
Abstract: Kenya has over 400 marginalized indigenous fruit species. A majority found in natural habitats are allegedly high in micronutrients that could help mitigate the prevailing micronutrient nutrahealth deficiencies. Amplifying their nutrahealth value more as nutraceutical than wild species, and coupled with local level communitycentred promotion for use and conservation, could stimulate the uncommon opportunities for decentralized and locale-specific community use and conservation. Thus conservation-by-use could enlarge the nutrahealth security basket as well as mitigate loss of the vanishing fruit species. In retrospect, value-adding nutrahealth research is needed to change the un-informed mind. Thus, the objectives of the study were to: (1) tag Mineral-Referred sites (MRS) influencing Fruit Mineral-Density variation (FMDVAR) among Grewa, Rhus, Boabab and Jackfruit accessions; and (2) apply a nutrametric value (grading) test to classifying FMD variation (FMDVAR) within the realm of nutraceutical food, nutrition and health promise. Fruit portions with their tree trunk adjoining soils were collected in 2003/04 from Kanduyi-Chwele- Nalondo (Bungoma) transect; Maseno-Esivalu (Maseno); and Kaseme- Masongaleni (Kibwezi) and subjected to XRF analysis at the Institute of Nuclear Science and Technology in the University of Nairobi. A Clustered-Bar-Graphing test was used to obtain Ca, K, Fe, Zn, Cu, Mn as variation-picking elements which were turned into MRS X-variables upon which fruit species mineral-density variation was determined. Significant (p < 0.05) FMDVAR x MRS and phyto-region x FMDVAR interactions were detected. Rhus spp had the highest Fe-Mn > Grewa spp > Jackfruit > Ficus > Boabab spp depending on locations they were collected from. In that order, Ficus showed the highest iron-manganese but had the lowest Zn-Cu. Jackfruit, with Fe-Mn third in line, had highest Zn-Cu. There was no accession with ‘all-winner’ elements. In density terms some minerals were top while others were variably low. High uptakeability of elements in the tree species such as demonstrated by Rhus may be indicative of their soil-mining (a depletion effect) and/or fruit accumulation (a nutra-health plus) tendency. On the overall, nutrametric valuation (NTV) confirmed that Rhus and Ficus had highest fruit micronutrient variation relative to Jackfruit and Boabab. NTV clusters did not show a one-to-one soil-to-plant element matching between plant and soil mineral content. Plant micronutrient patterns show the potential for exploiting the indigenous trees for development of nutrahealth cropping.
Surtos interespecíficos de dermatomicoses por Microsporum canis e Microsporum gypseum
Costa E.O.,Diniz L.S.M.,Benites N.R.,Coutinho S.D.
Revista de Saúde Pública , 1994,
Abstract: As dermatomicoses dos animais domésticos constituem zoonoses importantes, urna vez que estes mantêm estreito contato com a espécie humana, dada a alta infectividade observada nesses processos. Relata-se a ocorrência de sete surtos de dermatomicoses, um por M. gypseum envolvendo um gato e um indivíduo do sexo feminino e os outros por M. canis envolvendo 20 indivíduos da espécie humana (adultos, jovens e crian as de ambos os sexos), 5 c es, 16 gatos e um macaco gib o (Hylobates lar).
Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats
Yokoro, C.M.;Tatsuo, M.A.K.F.;Pereira, L.S.M.;Alves, D.L.F.;Francischi, J.N.;
Brazilian Journal of Medical and Biological Research , 2003, DOI: 10.1590/S0100-879X2003000100011
Abstract: we compared the intensity and frequency of arthritis in old (8-12 months, n = 12) and juvenile (2 months, n = 10) rats and determined the role played by adrenal glands in this disorder. arthritis was induced by subcutaneous injection of mycobacterium butyricum at the base of the tail of female holtzman rats at day zero. paw edema and hyperalgesia were monitored from day zero to day 21 after induction as signs of arthritis development. some (n = 11) old animals were adrenalectomized bilaterally and treated with dexamethasone or celecoxib immediately following surgery. all bilaterally adrenalectomized old animals became susceptible to arthritis and the onset of disease was shortened from the 10th to the 5th day. hyperalgesia and paw edema responses were less frequent in older animals (50 and 25% compared to control juvenile rats, respectively), although old responder animals showed responses of similar intensity to those of their juvenile counterparts: by the 14th day the data for hyperalgesia were juvenile = 0.8 ± 0.07/old = 0.8 ± 0.09, and for paw edema juvenile = 56.6 ± 6.04/old = 32.24 ± 12.7, reported as d% increase in paw edema. chronic treatment of adrenalectomized old animals with dexamethasone (0.01 or 0.1 mg/kg) but not celecoxib (3 mg/kg), once daily for 21 days by gavage, abolished the effects of adrenalectomy, in particular those related to the hyperalgesia response (old = 0.95 ± 0.03/dexamethasone = 0 ± 0; 14th day), thus suggesting a specific participation of circulating corticosteroids in the modulation of pain in old arthritic rats.
Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats
Yokoro C.M.,Tatsuo M.A.K.F.,Pereira L.S.M.,Alves D.L.F.
Brazilian Journal of Medical and Biological Research , 2003,
Abstract: We compared the intensity and frequency of arthritis in old (8-12 months, N = 12) and juvenile (2 months, N = 10) rats and determined the role played by adrenal glands in this disorder. Arthritis was induced by subcutaneous injection of Mycobacterium butyricum at the base of the tail of female Holtzman rats at day zero. Paw edema and hyperalgesia were monitored from day zero to day 21 after induction as signs of arthritis development. Some (N = 11) old animals were adrenalectomized bilaterally and treated with dexamethasone or celecoxib immediately following surgery. All bilaterally adrenalectomized old animals became susceptible to arthritis and the onset of disease was shortened from the 10th to the 5th day. Hyperalgesia and paw edema responses were less frequent in older animals (50 and 25% compared to control juvenile rats, respectively), although old responder animals showed responses of similar intensity to those of their juvenile counterparts: by the 14th day the data for hyperalgesia were juvenile = 0.8 ± 0.07/old = 0.8 ± 0.09, and for paw edema juvenile = 56.6 ± 6.04/old = 32.24 ± 12.7, reported as delta% increase in paw edema. Chronic treatment of adrenalectomized old animals with dexamethasone (0.01 or 0.1 mg/kg) but not celecoxib (3 mg/kg), once daily for 21 days by gavage, abolished the effects of adrenalectomy, in particular those related to the hyperalgesia response (old = 0.95 ± 0.03/dexamethasone = 0 ± 0; 14th day), thus suggesting a specific participation of circulating corticosteroids in the modulation of pain in old arthritic rats.
Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice
Philip L.S.M. Gordts, Alexander Bartelt, Stefan K. Nilsson, Wim Annaert, Christina Christoffersen, Lars Bo Nielsen, Joerg Heeren, Anton J.M. Roebroek
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038330
Abstract: Objective Determination of the in vivo significance of LDL receptor-related protein 1 (LRP1) dysfunction on lipid metabolism and atherosclerosis development in absence of its main ligand apoE. Methods and Results LRP1 knock-in mice carrying an inactivating mutation in the NPxYxxL motif were crossed with apoE-deficient mice. In the absence of apoE, relative to LRP1 wild-type animals, LRP1 mutated mice showed an increased clearance of postprandial lipids despite a compromised LRP1 endocytosis rate and inefficient insulin-mediated translocation of the receptor to the plasma membrane, likely due to inefficient slow recycling of the mutated receptor. Postprandial lipoprotein improvement was explained by increased hepatic clearance of triglyceride-rich remnant lipoproteins and accompanied by a compensatory 1.6-fold upregulation of LDLR expression in hepatocytes. One year-old apoE-deficient mice having the dysfunctional LRP1 revealed a 3-fold decrease in spontaneous atherosclerosis development and a 2-fold reduction in LDL-cholesterol levels. Conclusion These findings demonstrate that the NPxYxxL motif in LRP1 is important for insulin-mediated translocation and slow perinuclear endosomal recycling. These LRP1 impairments correlated with reduced atherogenesis and cholesterol levels in apoE-deficient mice, likely via compensatory LDLR upregulation.
Muscle strength but not functional capacity is associated with plasma interleukin-6 levels of community-dwelling elderly women
Oliveira, D.M.G.;Narciso, F.M.S.;Santos, M.L.A.S.;Pereira, D.S.;Coelho, F.M.;Dias, J.M.D.;Pereira, L.S.M.;
Brazilian Journal of Medical and Biological Research , 2008, DOI: 10.1590/S0100-879X2008001200017
Abstract: the association of plasma interleukin-6 (il-6) levels, muscle strength and functional capacity was investigated in a cross-sectional study of community-dwelling elderly women from belo horizonte, brazil. elderly people who present controlled chronic diseases with no negative impact on physical, psychosocial and mental functionality are considered to be community-dwelling. psychological and social stress due to unsuccessfully aging can represent a risk for immune system disfunctions. il-6 levels, isokinetic muscle strength of knee flexion/extension, and functional tests to determine time required to rise from a chair and gait velocity were measured in 57 participants (71.21 ± 7.38 years). serum levels of il-6 were measured in duplicate and were performed within one single assay (mouse monoclonal antibody against il-6; high-sensitivity, quantikine?, r & d systems, usa; intra-assay coefficient of variance = 6.9-7.4%; interassay coefficient of variance = 9.6-6.5%; sensitivity = 0.016-0.110 pg/ml; mean = 0.039 pg/ml). muscle strength was assessed with the isokinetic dynamometer biodex system 3 pro?. after the shapiro-wilk normality test was applied, correlations were investigated using spearman and kruskal-wallis tests. post hoc analysis was performed using the dunn test. a significant negative correlation was observed between plasma il-6 levels (1.95 ± 1.77 pg/ml) and muscle strength for knee flexion (70.70 ± 21.14%; r = -0.265; p = 0.047) and extension (271.84 ± 67.85%; r = -0.315; p = 0.017). no significant correlation was observed between il-6 levels and the functional tests (time to rise from a chair = 14.65 ± 2.82 s and gait velocity = 0.95 ± 0.14 m/s). these results suggest that il-6 is associated with reduced muscle strength.
Surtos interespecíficos de dermatomicoses por Microsporum canis e Microsporum gypseum
Costa,E.O.; Diniz,L.S.M.; Benites,N.R.; Coutinho,S.D.; Carvalho,V.M.; Dutra,L.F.; Serra,E.G.;
Revista de Saúde Pública , 1994, DOI: 10.1590/S0034-89101994000500005
Abstract: dermatomycosis in domestic animals are important zoonosis in view of the fact that they maintain close contact with human beings. seven ringworm outbreaks are here described, one of m. gypseum involving a cat and a women and the remainder of m. canis involving 20 human beings (adults, young people and children), 5 dogs, 16 cats and a gibbon-monkey (hylobates lar).
Muscular function and functional mobility of faller and non-faller elderly women with osteoarthritis of the knee
Alencar, M.A.;Arantes, P.M.M.;Dias, J.M.D.;Kirkwood, R.N.;Pereira, L.S.M.;Dias, R.C.;
Brazilian Journal of Medical and Biological Research , 2007, DOI: 10.1590/S0100-879X2006005000058
Abstract: falls are a major concern in the elderly population with chronic joint disease. to compare muscular function and functional mobility among older women with knee osteoarthritis with and without a history of falls, 15 elderly women with a history of falls (74.20 ± 4.46 years) and 15 without a history of falls (71.73 ± 4.73 years) were studied. muscular function, at the angular speed of 60, 120, and 180o/s, was evaluated using the biodex isokinetic dynamometer. the sit-to-stand task was performed using the balance master system and the timed up and go test was used to determine functional mobility. after collection of these data, the history of falls was investigated. a statistically significant difference was detected in the time taken to transfer the center of gravity during the sit-to-stand test (means ± sd; non-fallers: 0.35 ± 0.16 s; fallers: 0.55 ± 0.32 s; p = 0.049, student t-test) and in the timed up and go test (medians; non-fallers: 10.08 s; fallers: 11.59 s; p = 0.038, mann-whitney u-test). the results indicated that elderly osteoarthritic women with a history of falls presented altered functional mobility and needed more time to transfer the center of gravity in the sit-to-stand test. it is important to implement strategies to guarantee a better functional performance of elderly patients to reduce fall risks.
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