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Perinatal arterial ischemic stroke and multiple thrombo-emboli in a term newborn  [PDF]
Sani Bukari, Abdul Hafeez Siddiqui, Madhvi Rajpurkar, Meera Chitlur
Open Journal of Pediatrics (OJPed) , 2012, DOI: 10.4236/ojped.2012.21012
Abstract: The etiology of perinatal arterial ischemic strokes may be maternal, fetal or both. Venous thrombo-embolism is almost always catheter associated in new-borns. Preliminary guidelines for management of perinatal arterial ischemic strokes exist but are mostly based on adult studies. We report a unique case of perinatal arterial ischemic stroke, lower extremity arterial and inferior vena-caval thrombosis. Our patient was treated with unfractionated heparin for 10 days then switched to low molecular heparin to complete 6 months of therapy. The patient responded well to therapy and shows minimal signs of permanent neurologic deficits after 6 months.
Exact Solutions of a Power Law Fluid Model in Posttreatment Analysis of Wire Coating with Linearly Varying Boundary Temperature  [PDF]
Rehan Ali Shah, Saeed Islam, Abdul Majeed Siddiqui, Tahira Haroon
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.42050
Abstract:

In this paper, analysis of post-treatment of wire coating is presented. Coating material satisfies power law fluid model. Exact solutions for the velocity field, volume flow rate and average velocity are obtained. Moreover, the heat transfer results are presented for different cases of linearly varying on the boundaries. The variations of velocity, volume flow rate, radius of coated wire, shear rate and the force on the total wire are presented graphically and discussed.

Application of He’s Variational Iterative Method for Solving Thin Film Flow Problem Arising in Non-Newtonian Fluid Mechanics  [PDF]
Abdul M. Siddiqui, Ali A. Farooq, Tahira Haroon, Muhammad A. Rana, Bruce S. Babcock
World Journal of Mechanics (WJM) , 2012, DOI: 10.4236/wjm.2012.23016
Abstract: In this paper, He’s variational iteration method is successfully employed to solve a nonlinear boundary value problem arising in the study of thin film flow of a third grade fluid down an inclined plane. For comparison, the same problem is solved by the Adomian decomposition method. The results show that the difference between the two solutions is negligible. The conclusion is that this technique may be considered an alternative and efficient method for finding approximate solutions of both linear and nonlinear boundary value problems. Furthermore, the variational iteration method has an advantage over the decomposition method in that it solves the nonlinear problems without using the Adomian polynomials.
ENVIRONMENTAL RESPONSIVE HYDROGELS: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM
Anish Kumar Gupta,Abdul Wadood Siddiqui
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: Hydrogels are three dimensional crosslinked hydrophilic polymeric networks which has the capability to imbibe water or biological fluids. Environmentally responsive hydrogels have the ability to respond to change in their external environment. They can exhibit dramatic changes in their swelling behaviour, network structure, permeability and mechanical strength in response to change in pH or ionic strength of the surrounding fluid or temperature. Other hydrogels have the ability to respond to applied electric or magnetic field or to change in concentration of glucose. Environmental responsive hydrogels for drug delivery application also requires biocompatibility. The chemical structure of the polymer may also affect the swelling ratio of hydrogels. Hydrogels containing hydrophilic groups swell to a higher degree compared to those containing hydrophobic groups. Swelling of environmentally responsive hydrogels can be affected by changes in the temperature of the swelling media, ionic strength and pH
Evaluation of allelopathic impact of aqueous extract of root and aerial root of Tinospora cordifolia (Willd.) miers on some weed plants
K. M. Abdul RAOOF,M. Badruzzaman SIDDIQUI
Analele Universitatii din Oradea, Fascicula Biologie , 2012,
Abstract: The present laboratory experimental study was conducted to evaluate the allelopathic potential of Tinospora cordifolia (Willd.) Miers on seed germination and seedling growth of weed plants (Chenopodium album L. Chenopodium murale L., Cassia tora L. and Cassia sophera L.). Root and aerial root aqueous extracts of Tinospora at 0.5, 1.0, 2.0 and 4.0% concentrations were applied to determine their effect on seed germination and seedling growth of test plants under laboratory conditions. Germination was observed for 15 days after that the root length and shoot length was measured. Dry weight was measured after oven drying the seedlings. The aqueous extracts from root and aerial root had inhibitory effect on seed germination of test plants. Aqueous extracts from root and aerial root significantly inhibited not only germination and seedling growth but also reduced dry weight of the seedlings. Root length, shoot length of weed species decreased progressively when plants were exposed to increasing concentration (0.5, 1, 2 and 4%). Aqueous extract of aerial root shows the least inhibition. The pH of aqueous extracts of different parts of T. cordifolia does not show any major change when the concentration increases.
Anti-inflammatory and Antihistaminic Study of a Unani Eye Drop Formulation
Latif Abdul, Razique Abdul, R.R. Sukul and Siddiqui Nazish
Ophthalmology and Eye Diseases , 2012, DOI: 10.4137/OED.S3612
Abstract: The Unani eye drop is an ophthalmic formulation prepared for its beneficial effects in the inflammatory and allergic conditions of the eyes. In the present study, the Unani eye drop formulation was prepared and investigated for its anti-inflammatory and antihistaminic activity, using in vivo and in vitro experimental models respectively. The Unani eye drop formulation exhibited significant anti-inflammatory activity in turpentine liniment-induced ocular inflammation in rabbits. The preparation also showed antihistaminic activity in isolated guinea-pig ileum. The anti-inflammatory and antihistaminic activity of eye drop may be due to presence of active ingredients in the formulation. Although there are many drugs in Unani repository which are mentioned in classical books or used in Unani clinical practice effectively in treatment of eye diseases by various Unani physicians. Inspite of the availability of vast literature, there is a dearth of commercial Unani ocular preparations. So, keeping this in mind, the eye drop formulation was prepared and its anti-inflammatory and antihistaminic activity was carried out in animal models. Thus, in view of the importance of alternative anti-inflammatory and anti- allergic drugs, it becomes imperative to bring these indigenous drugs to the front foot and evaluate their activities.
Anti-inflammatory and Antihistaminic Study of a Unani Eye Drop Formulation
Latif Abdul,Razique Abdul,R.R. Sukul,Siddiqui Nazish
Ophthalmology and Eye Diseases , 2010,
Abstract: The Unani eye drop is an ophthalmic formulation prepared for its beneficial effects in the inflammatory and allergic conditions of the eyes. In the present study, the Unani eye drop formulation was prepared and investigated for its anti-inflammatory and antihistaminic activity, using in vivo and in vitro experimental models respectively. The Unani eye drop formulation exhibited significant anti-inflammatory activity in turpentine liniment-induced ocular inflammation in rabbits. The preparation also showed antihistaminic activity in isolated guinea-pig ileum. The anti-inflammatory and antihistaminic activity of eye drop may be due to presence of active ingredients in the formulation. Although there are many drugs in Unani repository which are mentioned in classical books or used in Unani clinical practice effectively in treatment of eye diseases by various Unani physicians. Inspite of the availability of vast literature, there is a dearth of commercial Unani ocular preparations. So, keeping this in mind, the eye drop formulation was prepared and its anti-inflammatory and antihistaminic activity was carried out in animal models. Thus, in view of the importance of alternative anti-inflammatory and anti- allergic drugs, it becomes imperative to bring these indigenous drugs to the front foot and evaluate their activities.
Stability-Indicating HPTLC Method for Determination of Duloxetine Hydrochloride in Bulk Drug and Tablet Formulation
Sheikh Shahnawaz,Abdul Wadood Siddiqui,Mir Tariq Masroor,Vandana Arora
Chromatography Research International , 2011, DOI: 10.4061/2011/404189
Abstract: A simple, accurate, precise, sensitive, selective, and stability-indicating high-performance thin-layer chromatographic method was developed and validated for determination of duloxetine hydrochloride both in bulk drug as well as in tablet formulation. The stationary phase used in our method consisted of HPTLC aluminum plates precoated with silica gel 60F-254, while, chloroform?:?methanol (8?:?2,?v/v) was used as binary mobile phase. These chromatographic conditions eluted the drug effectively, and distinct compact spots were seen, (Rf, retardation factor, value (0.42 ± 0.20). Densitometric determination of duloxetine hydrochloride was carried out in the absorbance mode at a wavelength of 217 nm. The mean value of corelation coefficient; slope and intercept were 0.9962 ± 0.0015, 121.54 ± 0.61, and 987.3 ± 6.17, in the amount range of 600–2000?ng (nanogram) per spot, respectively. Stress testing validation were performed as per the guidelines of International Conference on Harmonization (ICH) and drug was subjected to stress conditions like acid-hydrolysis, alkali-hydrolysis, oxidation, and thermal degradation. As the method effectively separated the active drug from its degradation products, it can be employed as a stability-indicating assay method (SIAM) for identification and quantitative determination of duloxetine HCl in bulk drug and tablet dosage formulation. 1. Introduction Duloxetine hydrochloride designated in IUPAC as (+)-(S)-N-methyl-gamma-(1-naphthyloxy)-2- thiophenepropylamine hydrochloride (Figure 1) is an agent indicated for the treatment of major depressive disorder (MDD), [1]. The years from 1990 through 1999 were termed the “Decade of the Brain” by the Library of Congress and the National Institute of Mental Health. Since that decade, our understanding of depression has grown enormously. It is estimated that Major Depressive Disorder (MDD) affects 18 million people in the United States and 340 million people worldwide. Figure 1: Structure of Duloxetine HCl. It is also indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy [2]. Duloxetine has also been thoroughly experimented to be associated with smoking cessation, and research is going on [3]. A significant reduction in the frequency of incontinence episodes and a resulting improvement in quality of life were found when duloxetine was given to a group of women with stress urinary incontinence. Duloxetine 80?mg, dosed at 40?mg BID, reduced the frequency of episodes by 64% to 100% in half of the women who took the drug, compared with a 41% median
Application of Homotopy Analysis Method to the Unsteady Squeezing Flow of a Second-Grade Fluid between Circular Plates
Mohammad Mehdi Rashidi,Abdul Majid Siddiqui,Mostafa Asadi
Mathematical Problems in Engineering , 2010, DOI: 10.1155/2010/706840
Abstract: We investigated an axisymmetric unsteady two-dimensional flow of nonconducting, incompressible second grade fluid between two circular plates. The similarity transformation is applied to reduce governing partial differential equation (PDE) to a nonlinear ordinary differential equation (ODE) in dimensionless form. The resulting nonlinear boundary value problem is solved using homotopy analysis method and numerical method. The effects of appropriate dimensionless parameters on the velocity profiles are studied. The total resistance to the upper plate has been calculated. 1. Introduction Squeezing flows are induced by externally normal stresses or vertical velocities by means of moving boundary. Squeezing flows have many applications in food industry, especially in chemical engineering. Some practical examples of squeezing flow include polymer processing, compression and injection molding. In addition, the lubrication system can also be modeled by squeezing flows. The study of squeezing flows has its origins in the 19th century and continues to receive considerable attention due to the practical applications in physical and biophysical areas. Stefan [1] published a classical paper on squeezing flow by using lubrication approximation. Such types of flow exist in lubrication when there is squeezing flow between two parallel plates. The tackiness of liquid adhesives also reflects squeeze film effects [2]. The squeeze film geometry has been studied extensively since 1947. Other applications in the biomechanics area relate to squeezing flow between parallel plates and the alternation between contraction and expansion of the blood vessels. In addition, polymer extrusion processes are modeled using squeezing flow of viscous fluids [3]. The squeezing flow between parallel plates when the confining walls have a transverse motion has great importance in hydrodynamic lubrication theory Langlois [4] and Salbu [5] have analyzed isothermal compressible squeeze films neglecting inertial effects. Thorpe [6] presented an explicit solution of the squeeze flow problem taking inertial terms into account. Later, P. S. Gupta and A. S. Gupta [7] showed that the solution given by [6] fails to satisfy the boundary conditions. Gupta solution, however, is restricted only to small Reynolds number. Squeeze film between two plane annuli with fluid inertia effects has been studied by Elkouh [8]. Some numerical solutions of squeezing flow between parallel plates has been conducted by Verma [9] and later by Singh et al. [10]. In addition, Hamza [11] has considered suction and injection
Biochemical Composition in Scylla serrata (Forskal) of Chakaria Sundarban Area, Bangladesh
Mohammad Zafar,Mohammad Ziaul Huda Siddiqui,Mohammed Abdul Hoque
Pakistan Journal of Biological Sciences , 2004,
Abstract: Biochemical composition (protein, fat, ash, moisture and carbohydrate) of male and female of Scylla serrata in Chakaria Sundarban area were studied. One factor ANOVA indicated the significant differences of protein, fat, ash and moisture concentration between male and female of S. serrata. The yearly mean protein content 17.69?2.14% was recorded for male and 19.39?1.29% in female on wet weight basis. The highest protein content in male was recorded during December (20.10%) and for female in February (20.43%) and the lowest protein content for male in May (14.00%) and for female in August (17.20%). The yearly average fat content (0.51 ± 0.12%) was recorded in male and (0.62 ± ?0.13%) was recorded for female S. serrata. The highest fat content was recorded for male in December (0.75%) and lowest in May (0.38%). In the female S. serrata highest fat content 0.78% was recorded in February and lowest (0.44%) during July and August. Correlation analysis showed a positive relation between the protein and fat content of S. serrata (r = 0.864, t = 7.67, df = 22). The highest moisture content was found in male during May (83.50%) and for female in August (79.50%) and the lowest in December (76.5%) for male and female in March (74.98%). In male S. serrata highest ash content was recorded in December (2.22%) and for female during April (2.34%). Highest carbohydrate content was recorded in male during May (0.92%) and in female during September (1.29%). Correlation matrix showed the protein and fat content had positive correlation with pH, Dissolved Oxygen (DO), salinity and as well as water transparency in case of female S. serrata and male indicated a negative relation with recorded DO and salinity of the investigated area.
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