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Search Results: 1 - 10 of 401455 matches for " Siddaraju M. Nanjundaiah "
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Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPase/H. pylori Inhibition and Anti-Oxidative Mechanism
Siddaraju M. Nanjundaiah,Harish Nayaka Mysore Annaiah,Shylaja M. Dharmesh
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep060
Abstract: Zinger officinale has been used as a traditional source against gastric disturbances from time immemorial. The ulcer-preventive properties of aqueous extract of ginger rhizome (GRAE) belonging to the family Zingiberaceae is reported in the present study. GRAE at 200?mg?kg?1?b.w. protected up to 86% and 77% for the swim stress-/ethanol stress-induced ulcers with an ulcer index (UI) of 50 ± 4.0/46 ± 4.0, respectively, similar to that of lansoprazole (80%) at 30?mg?kg?1?b.w. Increased H+, K+-ATPase activity and thiobarbituric acid reactive substances (TBARS) were observed in ulcer-induced rats, while GRAE fed rats showed normalized levels and GRAE also normalized depleted/amplified anti-oxidant enzymes in swim stress and ethanol stress-induced animals. Gastric mucin damage was recovered up to 77% and 74% in swim stress and ethanol stress, respectively after GRAE treatment. GRAE also inhibited the growth of H. pylori with MIC of 300 ± 38?μg and also possessed reducing power, free radical scavenging ability with an IC50 of 6.8 ± 0.4?μg?mL?1 gallic acid equivalent (GAE). DNA protection up to 90% at 0.4?μg was also observed. Toxicity studies indicated no lethal effects in rats fed up to 5?g?kg?1?b.w. Compositional analysis favored by determination of the efficacy of individual phenolic acids towards their potential ulcer-preventive ability revealed that between cinnamic (50%) and gallic (46%) phenolic acids, cinnamic acid appear to contribute to better H+, K+-ATPase and Helicobacter pylori inhibitory activity, while gallic acid contributes significantly to anti-oxidant activity. 1. Introduction More and more evidences are being accumulated nowadays regarding the cause of gastric hyperacidity and ulcers. Stress appear to play a major role as indicated by a set of studies which emphasizes that any patient irrespective of the nature of the disease, if admitted to emergency wards in the hospital, invariably ends up with gastric ulcers [1]. Besides this there are characteristic problems such as (i) Zollinger-Ellisson syndrome where there is a high and uncontrolled production of acid; (ii) the use of non-steroidal anti-inflammatory drugs [2] (NSAID) for rheumatoid diseases and (iii) a rod-shaped pathogenic bacteria Helicobacter pylori, normally existing in human stomach are known to cause ulcers [3]. Ulceration may occur either by uncontrolled production of acid or by the side effects of NSAIDs which acts as inhibitors of gastric mucosal defense or by manipulating the mucosal epithelium structure-function causing a defenseless condition and hence ulcers. The concept
Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products
Siddaraju M. Nanjundaiah,Brian Astry,Kamal D. Moudgil
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/518094
Abstract:
Modified Huo-Luo-Xiao-Ling Dan Suppresses Adjuvant Arthritis by Inhibiting Chemokines and Matrix-Degrading Enzymes
Siddaraju M. Nanjundaiah,David Y.-W. Lee,Zhongze Ma,Harry H. S. Fong,Lixing Lao,Brian M. Berman,Kamal D. Moudgil
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/589256
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints that can lead to deformities and disability. The prolonged use of conventionally used drugs is associated with severe adverse reactions. Therefore, safer and less expensive therapeutic products are continually being sought. Huo-Luo-Xiao-Ling dan (HLXL), a traditional Chinese herbal mixture, and its modified versions possess anti-arthritic activity. In this paper, we examined the influence of modified HLXL on two of the key mediators of arthritic inflammation and tissue damage, namely, chemokines and matrix-metalloproteinases (MMPs) in the rat adjuvant-induced arthritis (AA) model of RA. We treated arthritic Lewis rats with HLXL (2.3 g/kg) by daily gavage beginning at the onset of AA. The control rats received the vehicle. At the peak phase of AA, rats were sacrificed and their draining lymph node cells (LNC) and spleen adherent cells (SAC) were tested. The HLXL-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1α, and GRO/KC), MMPs (MMP 2 and 9), as well as cytokines (IL-6 and IL-17) that induce them, compared to the control vehicle-treated rats. Thus, HLXL controls arthritis in part by suppressing the mediators of immune pathology, and it might offer a promising alternative/adjunct treatment for RA.
4-(4-Chlorophenyl)piperidin-4-ol
Grzegorz Dutkiewicz,B. P. Siddaraju,H. S. Yathirajan,M. S. Siddegowda
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810004216
Abstract: In the title compound, C11H14ClNO, the piperidine ring adopts a chair conformation: the hydroxyl substituent and the N-bound H atom occupy the axial positions, while the benzene ring occupies the equatorial position. In the crystal, the molecules are linked into a centrosymmetric tetramer through strong O—H...N and weak N—H...O hydrogen bonds; the N and O atoms act as both donor and acceptor for these interactions. The tetramers are further joined by hydrogen bonds into a layer parallel to (100).
Energy Efficient Routing of Wireless Sensor Networks Using Virtual Backbone and life time Maximization of Nodes
Umesh B.N,G Vasanth,Siddaraju
International Journal of Wireless & Mobile Networks , 2013,
Abstract: Different approaches have been proposed based on routing in WSN (Wireless Sensor Nodes) for EnergyEfficient routing in Multi hop Networks and some localized based on geographical routing schemes havebeen also proposed. The key concept in virtual backbone scheduling is to minimize the energyconsumption and more throughputs. To achieve QOS and fault tolerance of these backbone nodes inMulti hop Networks requires stable links. Hence existing localized routing in virtual backbonescheduling cannot guarantee the energy efficient routes. In this paper we propose an energy efficientrouting for Virtual Back Bone Nodes (VBS) in which it maximizes the node life and turns off it’s radiowhen they are in sleep mode, in order to consume less energy. A concept of Restricted Back BoneNeighborhood Routing is proposed, which assures the efficient routing with minimum energyconsumption of nodes and also implemented the critical transmission radius for Backbone nodes.
Congenital malformation of lamina orbitalis ossis ethmoidalis
Kosuri Kalyan Chakravarthi, Nelluri Venumadhav, KS Siddaraju
Asian Journal of Medical Sciences , 2015, DOI: 10.3126/ajms.v6i2.10534
Abstract: Background: The thinnest portion of the medial wall of the orbit is Lamina orbitalis ossis?ethmoidalis which separates the ethmoidal sinuses from the orbit. Congenital bony?malformation of orbit and anatomical variation of ethmoidal sinuses are important in?terms of the risk of complication development during endoscopic sinus surgery and to?understanding the pathophysiology and spread of sinus disease. Materials and Methods:? Accordingly the present study was designed to fi nd out the congenital malformation of?medial wall of the orbit in relation to lamina orbitalis ossis ethmoidalis. The study was?carried out using 100 dried adult human skulls and twenty six human cadavers irrespective?of sex were obtained from the Department of Anatomy - Mayo Institute of Medical?Sciences-Barabanki, Department of Anatomy - Melaka Manipal Medical College - Manipal?and Department of Anatomy - KMCT Medical College, Manassery - Calicut. Results: In?three skulls (2.380%) we noted unilateral unusual hole at the junction of medial wall and?roof of orbit with dimensions of 2.3 cm long and 1 cm height in two skulls and another?unusual vertical hole at the anterior part of medial wall and roof of orbit with dimensions?of 2 cm height and 1 cm width. We also noted few ethmoidal cells extended in to the?orbital plate and fovea ethmoidalis of the frontal bone. Conclusion: Congenital defective?formation of bony orbit and variable anatomy of paranasal sinuses noted in this study?is may be due to the defective formation of Lamina orbitalis ossis ethmoidalis from the?lateral part of the nasal capsule near the fronto ethmoidal suture such comprehensive?knowledge is necessary to understand the various disorders of this region and to avoid?complications during surgical procedures involving this area. DOI: http://dx.doi.org/10.3126/ajms.v6i2.10534 Asian Journal of Medical Sciences Vol.6(2) 2015 91-94
(2E)-3-(3-Bromo-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one
Grzegorz Dutkiewicz,B. P. Siddaraju,H. S. Yathirajan,B. Narayana
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811012505
Abstract: In the title compound, C16H12BrFO2, the dihedral angle between the aromatic rings is 23.75 (12)° and the dihedral angle between the prop-2-en-1-one fragment and the fluorobenzene ring is 20.9 (2)°. In the crystal, only van der Waals interactions occur.
(2E)-3-(3-Bromo-4-methoxyphenyl)-1-(4-methylphenyl)prop-2-en-1-one
Grzegorz Dutkiewicz,B. P. Siddaraju,H. S. Yathirajan,B. Narayana
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811011482
Abstract: The overall shape of the molecule of the title compound, C17H15BrO2, can be described by the dihedral angles between three planar fragments: 1-bromo-2-methoxyphenyl ring [maximum deviation = 0.003 (2) ], the central prop-2-en-1-one chain [maximum deviation = 0.005 (2) ], and the methylphenyl ring [maximum deviation = 0.004 (2) ]. The terminal planes are twisted by 10.37 (12)°, while the central plane is almost coplanar with the methylphenyl ring [3.30 (13)°], but the dihedral angle with the other phenyl ring is significantly larger [8.76 (16)°]. In the crystal, molecules are linked into chains along [001] by three C—H...O hydrogen bonds. These chains interact with each other by means of weak π–π contacts [centroid–centroid distances = 3.73 (1) and 3.44 (1) ]. An intermolecular C—H...Br interaction also occurs.
2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
Grzegorz Dutkiewicz,B. P. Siddaraju,H. S. Yathirajan,B. Narayana
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810003375
Abstract: In the title compound, C15H10Cl3NO2, an intramolecular N—H...O hydrogen bond forms a six-membered ring and enforces an almost coplanar conformation for the acetamido group, the central benzene ring and the bridging carbonyl C—C(=O)—C group: the dihedral angles between the benzene ring and the acetamide and carbonyl C—C(=O)—C planes are 7.06 (11) and 7.17 (12)°, respectively. The dihedral angle between the two benzene rings is 67.43 (9)°. Because a strong hydrogen-bond donor is involved in the intramolecular interaction, the crystal packing is determined by weak C—H...O and C—H...Cl interactions.
Tramadolium picrate
B. P. Siddaraju,Grzegorz Dutkiewicz,H. S. Yathirajan,Maciej Kubicki
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812004138
Abstract: In the title salt {systematic name: [2-hydroxy-3-(3-methoxyphenyl)cyclohexylmethyl]dimethylazanium 2,4,6-trinitrophenolate}, C16H26NO2+·C6H2N3O7 , the cation is protonated at the N atom. The cyclohexane ring adopts a chair conformation with the hydroxy substituent in an axial position. In the crystal, O—H...O and N—H...O hydrogen bonds link the cations and anions into supramolecular chains along [100].
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