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Southern and Tropical Indian Ocean SST: A Possible Predictor of Winter Monsoon Rainfall over South India  [PDF]
Ravi P. Shukla, Shailendra Rai, Avinash C. Pandey
Atmospheric and Climate Sciences (ACS) , 2013, DOI: 10.4236/acs.2013.34045
Abstract:

The complexities in the relationship between winter monsoon rainfall (WMR) over South India and Sea Surface temperature (SST) variability in the southern and tropical Indian Ocean (STIO) are evaluated statistically. The data of the time period of our study (1950-2003) have been divided exactly in two halves to identify predictors. Correlation analysis is done to see the effect of STIO SST variability on winter monsoon rainfall index (WMRI) for South India with a lead-lag of 8 seasons (two years). The significant positive correlation is found between Southern Indian Ocean (SIO) SST and WMRI in July-August-September season having a lag of one season. The SST of the SIO, Bay of Bengal and North Equatorial Indian Ocean are negatively correlated with WMRI at five, six and seven seasons before the onset of winter monsoon. The maximum positive correlation of 0.61 is found from the region south of 500 S having a lag of one season and the negative correlations of 0.60, 0.53 and 0.57 are found with the SST of the regions SIO, Bay of Bengal and North Equatorial Ocean having lags of five, six and seven seasons respectively and these correlation coefficients have confidence level of 99%. Based on the correlation analysis, we defined Antarctic Circumpolar Current Index A and B (ACCIA (A) & ACCIB (B)), Bay of Bengal index (BOBI (C)) and North Equatorial Index (NEI (D)) by averageing SST for the regions having maximum correlation (positive or negative) with WMRI index. These SST indices are used to predict the WMRI using linear and multivariate linear regression models. In addition, we also attempted to detect a dynamic link for the predictability of WMRI using Nino 3.4 index. The predictive skill of these indices is tested by error analysis and Willmott’s index.

Formulation and in vitro characterization of alginate microspheres loaded with diloxanide furoate for colon- specific drug delivery
Shukla Shailendra,Jain Deepak,Verma Kavita,Verma Sofiya
Asian Journal of Pharmaceutics , 2010,
Abstract: The aim of the research work was to develop cyst-targeted alginates microspheres of diloxanide furoate (DF) for the effective treatment of amoebiasis. Calcium alginates microspheres of DF were prepared using emulsification method using calcium chloride as a cross-linking agent. Alginate is a natural polysaccharide found in brown algae. Alginates are widely used in the food and pharmaceutical industries and have been employed as a matrix for the entrapment of drugs, macromolecules and biological cells. Alginate microspheres produced by the emulsification method using calcium chloride. Formulations were characterized for particle size and shape, surface morphology, entrapment efficiency, and in vitro drug release in simulated gastrointestinal fluids. XRD and differential scanning calorimetery were used to confirm successful entrapment of DF into the alginates microspheres. All the microsphere formulations showed good % drug entrapment (73.82 1.99). Calcium alginate retarded the release of DF at low pH (1.2 and 4.5) and released microspheres slowly at pH 7.4 in the colon without colonic enzymes.
STUDIES ON SYNTHETIC, BIOLOGICAL AND INSECTICIDAL ASPECTS OF SOME DIORGANOTIN (IV) DIAMIDES
SHAILENDRA K. SHUKLA, TIWARI V.K., SUSHMA RANI, RAVI KANT, TEWARI I.C.
International Journal of Agriculture Sciences , 2011,
Abstract: The present manuscript contains a series of new diorganotin (IV) diamides of the type R2SnL2; (R= C6H5, C6F5,C6H4F; L = succinimide and phthalimide), which are synthesized and tested first time for their biological and insecticidalactivity. These compounds show valuable antimicrobial activity against various microbial strains as seen in their inhibitionzone value along with higher to moderate insecticidal activity respectively
STUDIES ON ANTIMICROBIAL AND ANTITUMOR EFFICACY OF SOME NEW DIORGANOTIN (IV) DICARBOXYLATES
SHAILENDRA K. SHUKLA, TIWARI V.K., SUSHMA RANI, TEWARI I.C.
International Journal of Chemical Research , 2011,
Abstract: In this manuscript a series of new diorganotin (IV) dicarboxylates were screened out first time for their bio medicinal activity, like antimicrobial and in-vitro antitumor activity against different pathogenic bacterial and fungal strains along with human breast and mammary cancer cell line. It was found that the compounds show remarkable antitumor efficacy and moderate antimicrobial activity against pathogenic microbial strains.
Micro-Raman and field emission studies of silicon nanowires prepared by metal assisted chemical etching
Vivek Kumar,Shailendra K. Saxena,Vishakha Kaushik,Kapil Saxena,Rajesh Kumar,A. K. Shukla
Physics , 2014, DOI: 10.1039/C4RA11093E
Abstract: Micro-Raman scattering and electron field emission characteristics of silicon nanowires (SiNWs) synthesized by metal assisted chemical etching (MACE) are investigated. Scanning electron microscopy images reveal the growth of well aligned vertical SiNWs. Raman shift and size relation from bond-polarizability model has been used to calculate exact confinement sizes in SiNWs. The Si optical phonon peak for SiNWs showed a downshift and an asymmetric broadening with decreasing diameter of the SiNWs due to quantum confinement of optical phonons. The field emission characteristics of these SiNWs are studied based by carrying out current-voltage measurements followed by a theoretical analysis using Fowler-Nordheim equation. The electron field emission increased with decreasing diameter of SiNWs. Field emission from these SiNWs exhibits significant enhancement in turn-on field and total emission current with decreasing nanowire size. The reported results in the current study indicate that MACE is a simple technique to prepare well-aligned SiNWs with potentials for applications in field emission devices.
Menopausal transition and postmenopausal health problems: a review on its bio-cultural perspectives  [PDF]
Shailendra Kumar Mishra
Health (Health) , 2011, DOI: 10.4236/health.2011.34041
Abstract: This paper documents health problems faced by menopausal and postmenopausal women. These women constitute a sizable proportion of India's population though there exist no health care programmes to cater their specific health needs and health vulnerabilities arose due to menopausal transition. Researchers have generally tried to determine age at menopause and a few have explored psychosomatic problems experienced by them. Abrupt changes in hormone levels among women generally bring out several physical infirmities which have hardly been the interest of research. Studies on menopausal and postmenopausal health problems and their bio-cultural correlates are warranted. Efforts should be made to understand the process of aging among women in relation to menopausal transition. Cross-cultural differences in coping mechanisms to minimise the health problems arose due to menopausal transition are important to study. This review argues provision of culturally appropriate health care programs to facilitate easier menopausal transition and to ensure healthy postmenopausal life for women.
Endobronchial valves: an emerging therapeutic alternative to VATS for the surgical management of advanced emphysema
Shailendra Kapoor
International Journal of General Medicine , 2010, DOI: http://dx.doi.org/10.2147/IJGM.S15644
Abstract: Endobronchial valves: an emerging therapeutic alternative to VATS for the surgical management of advanced emphysema Expert Opinion (2471) Total Article Views Authors: Shailendra Kapoor Published Date December 2010 Volume 2010:3 Pages 393 - 394 DOI: http://dx.doi.org/10.2147/IJGM.S15644 Shailendra Kapoor Family Practitioner, Knoxville, TN, USA I read with great interest the recent article by Lin and Luh on the treatment of patients with bullous emphysema with video-assisted thoracoscopic surgery. The topic is highly interesting. However endobronchial valves have emerged over the past few years as a highly effective and efficient alternative to video-assisted thoracoscopic surgery. Post to: Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter Readers of this article also read: Allied health assistants and what they do: A systematic review of the literature Comparison between the Beck Depression Inventory and psychiatric evaluation of distress in patients on long-term sick leave due to chronic musculoskeletal pain Real-world effectiveness of valsartan on hypertension and total cardiovascular risk: review and implications of a translational research program Does the type of suturing technique used affect astigmatism after deep anterior lamellar keratoplasty in keratoconus patients? Efficacy, safety, and patient acceptability of the Essure procedure Understanding barriers to medication adherence in the hypertensive population by evaluating responses to a telephone survey Berberine hydrochloride: anticancer activity and nanoparticulate delivery system Bactericidal activities of woven cotton and nonwoven polypropylene fabrics coated with hydroxyapatite-binding silver/titanium dioxide ceramic nanocomposite "Earth-plus" Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles Major stroke in a 19-year-old patient with a univentricular heart
CD26: A prognostic marker of other systemic malignancies besides colo-rectal carcinomas
Shailendra Kapoor
World Journal of Clinical Oncology , 2012, DOI: 10.5306/wjco.v3.i8.126
Abstract: I read with great interest the recent article by Cordero et al in a recent issue of your esteemed journal. Interestingly, the past few years have seen the emergence of CD26 as an important diagnostic and prognostic marker for a number of systemic malignancies besides colo-rectal carcinomas. For instance, serum CD26 levels are an important emerging marker of B-cell chronic lymphocytic leukemia (B-CLL). In fact, Molica et al have recently reported shorter time to first treatment in B-CLL which exhibit higher serum CD26 levels and simultaneously demonstrate absence of mutation in IgV (H). Similarly, CD26 serves as a marker of poor prognosis in T cell lymphomas. Simultaneously, a poor response to 2’-deoxycoformycin is seen T cell lymphomas expressing CD26. Similarly, breast carcinomas exhibit decreased CD26 mean fluorescence intensity and a decreased percentage of CD26 positive lymphocytes in comparison to benign breast tumors and healthy individuals.
Beyond pancreatic carcinoma: The close relationship between survivin levels and prognosis in systemic malignancies
Shailendra Kapoor
World Journal of Clinical Oncology , 2012, DOI: 10.5306/wjco.v3.i5.80
Abstract: I read with great interest the recent article by Liu and Wang in a recent issue of your esteemed journal. The article is highly thought provoking. Interestingly, the past few years have seen a number of studies that have established a close relationship between survivin expression and tumor prognosis in systemic malignancies besides pancreatic carcinomas. For instance, a poor prognosis is seen in patients with bladder carcinomas which exhibit survivin over expression. A higher recurrence rate is seen following radio-chemotherapy in bladder carcinomas which exhibit increased survivin expression. Similarly, up regulation of survivin expression is seen in non-small cell lung cancers. In fact, Yamashita et al have shown that when used in combination with p53AIP1, survivin is a powerful prognostic indicator in non-small cell lung carcinomas. Similarly in breast carcinomas, increased survivin expression is more commonly seen in estrogen receptor negative carcinomas and is associated with a poor overall prognosis.
Opioid/naloxone prolonged release combinations for opioid induced constipation
Shailendra Kapoor
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i29.3921
Abstract: I read with great interest the recent article by Chen et al in a recent issue of your esteemed journal. The article is highly thought provoking. One emerging therapeutic alternative for opioid induced constipation is the emergence of opioid/naloxone prolonged release combinations. For instance, naloxone when administered in a 1:2 ratio with oxycodone reverses the inhibitory effect of oxycodone on the gastrointestinal tract. The advantage of oxycodone/naloxone prolonged release (OXN) is that while its anti-nociceptive efficacy is equivalent to that of oxycodone prolonged release (OXC), it significantly decreases the “Bowel Function Index” thereby ameliorating symptoms of opioid induced constipation to a large extent. Schutter et al in a recent study have reported a decrease in the bowel function index from 38.2 to 15.1. Similarly, L wenstein et al in another recent study have reported that following a month of therapy, complete spontaneous bowel movements per week is increased from one in OXC therapy to three in OXN therapy.
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