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A report on the antioxidant activity of the powder of the entire plant of Phyllanthus reticulatus Poir
Maruthappan V,Shree K
International Journal of Green Pharmacy , 2010,
Abstract: In the present study, we determined the antioxidant activity of the entire plant of Phyllanthus reticulatus by performing different in vitro antioxidant assays, including 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) radical scavenging, β-carotene bleaching, superoxide anion radical scavenging, reducing power and metal chelating assay at different concentrations (100, 200 and 400 μg/ml). The entire plant powder of P. reticulatus shows good antioxidant activity of about 90.0% when compared with standard Butylated Hydroxy Toluene (BHT) (85%) at a concentration of 400 μg/ml. Results obtained reveal that methanolic extracts of entire plant of P. reticulatus possess higher antioxidant activity when compared with ethanolic extracts. Thus, this study suggests that P. reticulatus plant can be used as a potent source of natural antioxidants.
Effects of Phyllanthus reticulatus on lipid profile and oxidative stress in hypercholesterolemic albino rats
Maruthappan V,Shree K
Indian Journal of Pharmacology , 2010,
Abstract: Objective: This study was designed to investigate the effect of Phyllanthus reticulatus on lipid profile and oxidative stress in hypercholesterolemic albino rats. Materials and Methods: Hypercholesterolemia was induced in albino rats by administration of atherogenic diet for 2 weeks. Experimental rats were divided into different groups: normal, hypercholesterolemic control and P. reticulatus treated (250 and 500 mg/kg body weight doses for 45 days). After the treatment period of 45 th day triglyceride, VLDL-cholesterol, HDL-cholesterol, total cholesterol (TC), LDL-cholesterol and oxidative stress (protein carbonyl) were assayed and compared with hypercholesterolemic control. Results: The aqueous extract of P. reticulatus (250 mg and 500 mg/kg) produced significant reduction (P < 0.05) in triglyceride, VLDL-cholesterol, total cholesterol (TC), LDL-cholesterol and oxidative stress (protein carbonyl) while increased HDL-cholesterol in atherogenic diet-induced hypercholesterolemic rats at the end of the treatment period (45 days). However, the reduction in the above parameters was comparable with hypercholesterolemic control. Thus, aqueous extract of P. reticulatus is effective in controlling TC, lipid profile and oxidative stress in hypercholesterolemic animals. Conclusion: The results suggest the aqueous extract of P. reticulatus can be utilized for prevention of atherosclerosis in hypercholesterolemic patients.
HYPOLIPIDEMIC ACTIVITY OF HARITAKI (TERMINALIA CHEBULA) IN ATHEROGENIC DIET INDUCED HYPERLIPIDEMIC RATS
V. Maruthappan,K. Sakthi Shree
Journal of Advanced Pharmaceutical Technology & Research , 2010,
Abstract: Haritaki (Terminalia chebula) family Combretaceae is an important plant used traditionally for medicinal purposes. It is component of the classic Ayurvedic combination called “Triphala”. Hyperlipidemia was induced by treated orally with atherogenic diet. In atherogenic diet induced hyperlipidemic model, the rats receiving treatment with Haritaki showed significant reduction in total cholesterol, triglycerides, total protein and elevation of high density lipoprotein cholesterol. Haritaki was found to possess significant hypolipidemic activity. The results also suggest that Haritaki at 1.05 and 2.10 mg/kg b.wt. concentrations are an excellent lipid-lowering agent.
Development and study of the thermal and electrical behaviour of TGDDS epoxy nanocomposites for high-performance applications
K. Shree Meenakshi,E. Pradeep Jaya Sudhan
Applied Nanoscience , 2011, DOI: 10.1007/s13204-011-0015-2
Abstract: The present work focuses on a comparative study of the thermal and electrical behaviour of N,N′-tetraglycidyl diaminodiphenylsulphone (TGDDS) denoted as ‘B’ to find the suitability for its use in high-performance applications. The synthesis of the tetraglycidyl epoxy was done and they were characterized by FT-IR (Fourier transform infrared spectra) and nuclear magnetic resonance spectra (1H-NMR and 13C-NMR). Nanoclay and POSS-amine nanoreinforcements denoted as N1 and N2 were incorporated into the synthesized epoxy resins. Curing was done using diaminodiphenylmethane (DDM) and bis(3-aminophenyl)phenylphosphine oxide (BAPPO) curing agents denoted as X and Y, respectively. The thermal behaviour of the tetraglycidyl resins and their corresponding nanocomposites was studied by thermogravimetric analysis (TGA). The electrical behaviour, namely dielectric strength, comparative tracking index (CTI), volume resistivity, surface resistivity and arc resistance of the nanocomposites were also studied and the interesting results obtained are discussed.
HPLC estimation of berberine in Tinospora cordifolia and Tinospora sinensis
Srinivasan G,Unnikrishnan K,Rema Shree A,Balachandran Indira
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: A high-performance liquid chromatographic method for the estimation of berberine in the stem of Tinospora cordifolia (Willd.) Miers. ex Hook.f. and Thoms. and Tinospora sinensis (Lour.) Merrill is described. The dried stems of T. cordifolia and T. sinensis were defatted with petroleum ether (60-80°). The marc was dried and further extracted with methanol. The concentration of berberine in methanol extract was determined using a C-18 reverse phase column with a mobile phase of acetonitrile:water (10:90 v/v) at a flow rate of 0.6 ml/min and with UV detection at 266 nm. TLC and HPLC comparison of both the species revealed significant variation in the chemical constitution of the two species. This observation becomes important in the context of the use of T. sinensis in place of the genuine drug T. cordifolia .
Preparation and Characterization of Bio Fuel from Industrial Waste
M.N Abinayah Shree,K. Iyappan,C Srinivasakannan
Journal of Sustainable Development , 2009, DOI: 10.5539/jsd.v2n1p71
Abstract: Disposal of biomass becomes often an environmental issue. A novel method has been developed to convert biomass into solid bio-fuel. Experiments were carried out on preparation of solid fuel pellet from industrial biomass wastes. A maximum calorific value of 22,593KJ/kg has been obtained for the bio-fuel prepared in the present investigation and compared with the fossil fuel coal. The bio-fuel pellets were burnt and the emitted green house gases were critically analyzed.
Tolvaptan in the Treatment of Acute Hyponatremia Associated with Acute Kidney Injury
Shilpa Gopinath,Kalyana C. Janga,Sheldon Greenberg,Shree K. Sharma
Case Reports in Nephrology , 2013, DOI: 10.1155/2013/801575
Abstract: Hyponatremia defined as a plasma sodium concentration of less than 135?mmol/L is a very common disorder, occurring in hospitalized patients. Hyponatremia often results from an increase in circulating arginine vasopressin (AVP) levels and/or increased renal sensitivity to AVP, combined with an increased intake of free water. Hyponatremia is subdivided into three groups, depending on clinical history and volume status: hypovolemic, euvolemic, and hypervolemic. Acute symptomatic hyponatremia is usually treated with hypertonic (3%) saline. Syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) and hypervolemic hyponatremia caused by heart failure or cirrhosis are treated with vasopressin antagonists (vaptans) since they increase plasma sodium (Na2+) concentration via their aquaretic effects (augmentation of free-water clearance). The role of tolvaptan in the treatment of acute hyponatremia and conversion of oliguric to nonoliguric phase of acute tubular necrosis has not been previously described. 1. Introduction Acute kidney injury is a frequent complication in critically ill patients and is difficult to manage as it is often accompanied by oliguria or anuria as well as total body fluid overload and edema. Optimal management of volume status as well as normalizing serum sodium levels is essential. Sodium concentration is the major determinant of plasma osmolality; therefore, hyponatremia usually indicates a low plasma osmolality. Low plasma osmolality rather than hyponatremia, per se, is the primary cause of the symptoms of hyponatremia. Hyponatremia not accompanied by hypoosmolality does not cause signs or symptoms and does not require specific treatment [1]. The limitation in the kidney’s ability to excrete water in hyponatremic states is, in most cases, due to the persistent action of antidiuretic hormone (ADH, vasopressin). ADH acts at the distal nephron to decrease the renal excretion of water. The action of ADH is, therefore, to concentrate the urine and, as a result, dilute the serum. Under normal circumstances, ADH release is stimulated primarily by hyperosmolality. However, under conditions of severe intravascular volume depletion or hypotension, ADH may be released even in the presence of serum hypoosmolality [1]. Hyponatremia and impaired urinary dilution can be caused by either a primary or a secondary defect in the regulation of AVP secretion or action. The primary forms are generally referred to as the syndrome of inappropriate antidiuresis (SIADH). When osmotic suppression of antidiuresis is impaired for any reason, retention
Impact of Transceiver Impairments on the Capacity of Dual-Hop Relay Massive MIMO Systems
Anastasios K. Papazafeiropoulos,Shree Krishna Sharma,Symeon Chatzinotas
Mathematics , 2015,
Abstract: Despite the deleterious effect of hardware impairments on communication systems, most prior works have not investigated their impact on widely used relay systems. Most importantly, the application of inexpensive transceivers, being prone to hardware impairments, is the most cost-efficient way for the implementation of massive multiple-input multiple-output (MIMO) systems. Consequently, the direction of this paper is towards the investigation of the impact of hardware impairments on MIMO relay networks with large number of antennas. Specifically, we obtain the general expression for the ergodic capacity of dual-hop (DH) amplify-and-forward (AF) relay systems. Next, given the advantages of the free probability (FP) theory with comparison to other known techniques in the area of large random matrix theory, we pursue a large limit analysis in terms of number of antennas and users by shedding light to the behavior of relay systems inflicted by hardware impairments.
A Novel Approach to Distributed Multi-Class SVM
Aruna Govada,Shree Ranjani,Aditi Viswanathan,S. K. Sahay
Computer Science , 2015, DOI: 10.14738/tmlai.25.562
Abstract: With data sizes constantly expanding, and with classical machine learning algorithms that analyze such data requiring larger and larger amounts of computation time and storage space, the need to distribute computation and memory requirements among several computers has become apparent. Although substantial work has been done in developing distributed binary SVM algorithms and multi-class SVM algorithms individually, the field of multi-class distributed SVMs remains largely unexplored. This research proposes a novel algorithm that implements the Support Vector Machine over a multi-class dataset and is efficient in a distributed environment (here, Hadoop). The idea is to divide the dataset into half recursively and thus compute the optimal Support Vector Machine for this half during the training phase, much like a divide and conquer approach. While testing, this structure has been effectively exploited to significantly reduce the prediction time. Our algorithm has shown better computation time during the prediction phase than the traditional sequential SVM methods (One vs. One, One vs. Rest) and out-performs them as the size of the dataset grows. This approach also classifies the data with higher accuracy than the traditional multi-class algorithms.
Impact of Channel Dynamics, Combined Nonlinearities and ASE Noise on Transmission Performance of all Optical Star WDM Networks  [PDF]
Sridhar Iyer, Shree Prakash Singh
Communications and Network (CN) , 2011, DOI: 10.4236/cn.2011.34028
Abstract: For all optical Wavelength Division Multiplexing (WDM) network based on G.653 fibers, we investigate the quality factor deterioration due to combined nonlinear effects and Amplified spontaneous emission (ASE) noise for system parameters based on ITU-T Recommendation G.692. The investigation: (a) emphasizes on stimulated Raman scattering (SRS) and four wave mixing (FWM) effects which are the dominant nonlinearities known to limit WDM system performance and (b) accounts for beating between nonlinearities and beating between ASE noise and nonlinearities. Using the proposed model, performance of the worst affected channels due to SRS and FWM is compared and the results indicate that the worst affected channel due to SRS performs better and hence must be preferred for reliable and efficient transmission over the worst affected channel due to FWM. Further, the results suggest that to achieve a desired error rate (quality factor); there exists an optimal value of channel spacing for a given number of channels. The proposed theoretical model is also validated through extensive simulations over Rsoft OptSimTM simulator and the two sets of results are found to match, indicating that the proposed model accurately calculates the quality factor of the all optical WDM network.
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