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Search Results: 1 - 10 of 422961 matches for " Showmy K.S. "
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Comparative modeling of methylentetrahydrofolate reductase (MTHFR) enzyme and its mutational assessment: in silico approach
Dowlathabad Muralidhara Rao,Anuraj Nayarisseri,Mukesh Yadav,Showmy K.S.
International Journal of Bioinformatics Research , 2010,
Abstract: DNA-synthesis, DNA-repair, and DNA imprinting processes require efficient conversion ofhomocysteine to methionine. This methylation is catalyzed by methylentetrahydrofolate reductase throughreduction of 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate. Normal DNA synthesis isconsidered critical for physiological functions of body. The enzyme is coded by the gene with the symbolMTHFR on chromosome 1 location p36.3 in humans. At least 24 mutations in the MTHFR gene have beenidentified in people with homocystinuria. There is DNA sequence variants (genetic polymorphisms)associated with this gene. Two of the most investigated are C677T (rs1801133) and A1298C (rs1801131)single nucleotide polymorphisms (SNP). Mutations at C677T and A1298C which confer amino acidsubstitution Ala222Val and Glu429Ala respectively with a considerable reduced activity. This polymorphismand mild hyperhomocysteinemia are associated with neural tube defects in offspring, arterial and venousthrombosis, and cardiovascular disease. 677TT individuals are at a decreased risk for certain leukemia andcolon cancer. The MTHFR gene could be one of the factors of overall schizophrenia risk. In silico analysisnow has added important and wide range applications to proteomics from structure modeling to its functionallevels. Several algorithms have been suggested from many authors to bring an accurate modeling at its bestbut ultimately every protein has its own variant features to be treated by the same algorithm. Studies inproteomics through computational techniques need complements between critical requirement for a proteinand features available in an algorithm. Comparative modeling is now bridging the gap between availablesequences and structures modeled with accuracy. Effective refinement techniques made it capable ofdriving models toward native structure. Structure of MTHFR can assist the study of involvement of thisenzyme in the disorders and can provide better level of understanding about structural aspects of it. Wehave modeled wild type and mutated type MTHFR using comparative modeling and structure validation hasgiven appreciable values. This work can further account for the structure based drug design community inthe search of MTHFR inhibitors.
A Study of the Language Learner Strategies Adopted by Nigerian Students
K.S. Ariyo
Pakistan Journal of Social Sciences , 2012, DOI: 10.3923/pjssci.2010.433.436
Abstract: Nigerian students learn and eventually use English as a Second Language (ESL) having acquired at least one of the numerous Nigerian languages as mother tongue (L1). Consequently, learning English in such an ESL environment must take into cognizance some useful strategies that are capable of assisting the English language learner in the Nigerian setting. However, teachers as well as students usually fail to benefit from the numerous opportunities offered by language learner strategies in the course of either language teaching or learning. The written and spoken expressions of Nigerian students in English are generally poor. They obviously need to function adequately well in English since it is the medium of instruction in Nigerian schools. It is on this note that this study aims to attempt a detailed study of the language learner strategies usually adopted in Nigerian schools. It is the position of this study that Nigerian students must be well exposed to all the language learning strategies. They must also be aware that no singular strategy can adequately meet their functional needs.
Enkele opmerkingen met betrekking tot het graf van Herman Boerhaave in de Pieterskerk te Leiden
K.S. Grooss
Tijdschrift voor de Geschiedenis der Geneeskunde, Natuurwetenschappen, Wiskunde en Techniek , 1979,
Abstract:
Cornelis Solingen (1641-1687) en de techniek van het trepaneren
K.S. Grooss
Tijdschrift voor de Geschiedenis der Geneeskunde, Natuurwetenschappen, Wiskunde en Techniek , 1987,
Abstract: C. Solingen and his views on making surgical instruments C. Solingen (1641-1687) may be considered as one of the pioniers in the field of designing a new generation of surgical instruments in the second half of the 17th century. These instruments had a few important properties in common. They were simple and easy to handle, made of a good quality of steel and they lacked the useless curls, characteristic of the 16th and early 17th century surgical instruments. In 1684 Solingen published a book titled Manuale operatien der chirurgie in which he described the instruments he used in various operations. In this book he combined his description with full-size illustrations of his instruments. This gave the reader the opportunity to copy the instruments, use them and test them during the operation. The view of Solingen on form and function of an instrument was based on a long experience at see as a ships-surgeon on several vessels belonging to the Dutch fleet. In this position he had had to work under very difficult circumstances in which one needs instruments, both handy and simple to use. In his own country Solingen's ideas were followed rather quickly, but in France for instance, instrumentmakers kept making instruments with needless ornaments as described by A. Pare and J. Scultetus until far into the 18th century. It was not until the end of the 18th century, that ideas of simplicity, where surgical instruments are concerned, were generally accepted. Solingen bequested his collection of surgical instruments to the university of Leiden and some of them can be identified with the help of the illustrations in his Manuale operatien. They are now in the possession of Museum Boerhaave, Leiden.
B X DE WET ESSAY: THE REFINEMENTS ON THE PARTHENON
K.S. Pendlebury
Akroterion , 2012, DOI: 10.7445/49-0-94
Abstract: The paper judged to be the best student essay submitted to Akroterion by 30 November preceding publication of the volume for that specific year, is published annually as the B X de Wet Essay. The competition, which is sponsored by the Classical Association of South Africa, is open to undergraduate students every year and to Honours students in even-numbered years. A cash prize of R500 is awarded. This essay is named in honour of South African classicist B X de Wet.
Maturity Assessment and Characterisation of Jurassic Crude Oils
K.S. Okiongbo
Research Journal of Environmental and Earth Sciences , 2011,
Abstract: In this study, the thermal maturity of crude oil samples from the Kimmeridge Clay Formation (UK) were assessed and characterised using the following methods: calibration of the oil samples against source rock biomarker dataset of which the maturities are known, use of established empirical relationships between Vitrinite Reflectance Equivalent (VRE) and aromatic molecular ratios, use of phase diagram as a relative maturity indicator and use of GOR as a relative maturity indicator. The results show that the biomarker maturity parameters are only diagnostic of a broad maturity range (VRo ~ 0.65-1.0%), aside, there was no significant increase in the ratios of virtually all parameters (e.g., %29ββ sterane, %29αα sterane, %27Ts, %29Ts) in this maturity range, and in most cases their inversion complicates their application. Vitrinite reflection equivalent (VRE) values derived from the aromatic molecular ratios mainly range from ~0.64-0.89%. These results indicate that virtually all the oils are early mature to mid mature. This assertion is only broadly true as reservoired oils are mixtures of petroleums from source rocks at different levels of maturity. Our dataset also displays poor correlation between GOR and biomarker/aromatic related maturity parameters, indicating the need to (a) carefully consider how these parameters should be used and (b) unravel the effects of petroleum mixing when looking for trends between maturity and bulk composition.
PRELIMINARY EVALUATION OF BINDING PROPERTIES OF RANDIA DUMETORUM FRUIT MUCILAGE.
K.S Bodas*
International Journal of Pharmacy and Technology , 2010,
Abstract: The basic aim of present work was to extract the mucilage from Randia dumetorum fruit by using suitable method and to check its suitability for tablet binder. The mucilage was extracted from fruit powder bymaceration technique using water and then precipitated with alcohol in 1:2 proportion (yield 8-9 % w/w).The physicochemical properties of mucilage like moisture content, solubility, density, viscosity, pH,surface tension, swelling index, water absorption capacity and microbial load were determined. The granules were prepared by Wet Granulation technique using Paracetamol as Model drug and mucilage asbinder in concentrations 1-5 % w/w. Then tablets were punched by keeping pressure constant. The granules and tablets were evaluated as per official procedures. In vitro dissolution profiles of tablets werecarried out in Phosphate Buffer pH 5.8. All parameters were compared with standards like acacia (1-5% w/w) and starch (6, 8, 10%w/w). The evaluation data suggested that tablets prepared with Randiadumetorum fruit mucilage as binder showed good results and comparable dissolution profile as that of standards. Also the results were complied with pharmacopoeial limits. Hence, the mucilage from Randiadumetorum fruit can act as suitable binder for conventional tablets instead of synthetic polymers.
Gypsum karst in the United States.
Johnson K.S.
International Journal of Speleology , 1996,
Abstract: Gypsum is one of the most soluble of common rocks; it is dissolved readily to form caves, sinkholes, disappearing streams, and other karst features that typically are found in limestones and dolomites. The four basic requirements for gypsum karst to develop are: (1) a deposit of gypsum; (2) water, unsaturated with CaSO4 (3) an outlet for escape of dissolving water; and (4) energy to cause water to flow through the system. Gypsum deposits are present in 32 of the 48 conterminous United States, and they underlie about 35-40% of the land area; they are reported in rocks of every geologic system from the Precambrian through the Quaternary. Gypsum karst is known at least locally (and sometimes quite extensively) in almost all areas underlain by gypsum, and commonly extends down to depths of at least 30 m below the land surface. The most widespread and pronounced examples of gypsum karst are in the Permian basin of southwestern United States, but many other areas also are significant. Human activities may also cause, or accelerate, development of gypsum karst.
Interphalangeal Hair Distribution on the Hands and Feet in Relation to Age, Job Type and Gender amongst the Effiks and Ibibios of South Nigeria
K.S. Ordu
Current Research Journal of Biological Sciences , 2013,
Abstract: The aim of this study was to ascertain the influence of differences in age, job type and gender on distribution of interphalangeal hair of the Effiks in comparism to the Ibibios using 500 subjects comprising 250 Efiks and 250 Ibibios aged 18-40 years. With the aid of a hand lens, the pattern and frequency of hair distribution on the proximal, middle and distal phalanges were examined. Proximal phalangeal hair on the hand was absent in 40 (16%) Efiks and 35 (14%) Ibibios while, hair on the toes was absent in 35 (14%) Efiks and 55 (22%) Ibibios. The highest frequency hair distribution on the hands of the Efiks was 28% on finger pattern 2-3-4 of proximal phalanges while the least was found in finger patterns 1-2, 1-2-3-4, 2-3-5, 2-4-5 and 4-5, having 2% each. For the toes, the highest frequency hair distribution was 26% on toe pattern 1-2-3-4 while the least was 2% on toe patterns 1-3-4 and 1-4. The highest frequency hair distribution on the hands of the Ibibios was 30% on finger pattern 2-3-4 on proximal phalanges while the least was 2% in finger patterns 2-3, 3, 3-4-5 and 4-5. For their toes, the highest frequency hair distribution was 22% in toe pattern 1-2-3-4-5 and least frequent in toe patterns 1-2, 2, 2-3 and 3 with 2% each. Middle phalangeal hair was present in only one subject (a male Ibibio) of the entire population. Hair was absent on the distal phalanges. Age was not a factor in the distribution but individual’s sex and job type had effect on hair distribution on the phalanges.
Energy metabolism characteristics in adolescent group with different level of physical activity at rest and functional tests performing
K.S. Rognova
Journal of Asymmetry , 2010,
Abstract:
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