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Semi-Quantitative Analysis of Endometrial HOXA10 and BTEB1 Mrna Expressions in the Implantation Window of Patients With Endometriosis and Myoma
Shokrzadeh Sh,Saidijam M,Dehghan A,Esna-Ashari F
Tehran University Medical Journal , 2012,
Abstract: Background: The techniques used in assisted reproductive technologies have progressed considerably, but many embryos do not implant after transfer upon the use of these techniques. One of the causes of infertility is repeated implantation failure due to decreased endometrial receptivity. Furthermore, in clinical conditions such as endometriosis and myoma, implantation decreases after embryo transfer. In this case-control study the expression patterns of HOXA-10 and BTEB1 mRNAs were evaluated at the time of implantation in patients with myoma and endometriosis.Methods : In this study performed in Hamadan University of Medical Sciences during 1389, the cases included 16 patients with endometriosis and myoma (8 in each group) and the control group consisted of 8 fertile women. Endometrial sampling was performed at mid-secretory phase. Later, the expression patterns of HOXA-10 and BTEB1 mRNAs were evaluated using a semi-quantitative RT-PCR method. Results : The optimal PCR cycles determined were 30, 32 and 26 for HOXA10, BTEB1 and β-actin, respectively. Endometrial HOXA-10 and BTEB1 mRNA expression levels (normalized to -actin expression) at the time of implantation were significantly decreased in the endometrium of infertile patients with endometriosis compared with that of healthy fertile controls (P<0.05). A similar pattern was seen in patients with myomas for both HOXA10 and BTEB1 genes, (P<0.05). Conclusion: It seems that lower expression of HOXA-10 and BTEB1 mRNAs in the implantation window of endometrium that increase normally, could account for some aspects of infertility in patients with endometriosis and myoma.
The study of plasma concentration (zinc and copper) and their relation in rheuwatoid arthritis ptarients in comparison to control group
Sh. Ala,M. Shokrzadeh,A. Mohammad Pour shoja,P. Ebrahimi
Journal of Mazandaran University of Medical Sciences , 2008,
Abstract: Background and Purpose: The role of trace elements (Cu, Zn) in chronic inflammatory states has provided interest, as many of them are co-factors in metabolic processes, involving arthricular tissues and immune system function. The purpose of the current study was to evaluate zinc and copper plasma concentration in rheumatoid arthritis (RA) patients, who were referred to the Sari Outpatient Clinics and were compared with control group.Materials and Methods: We studied plasma concentrations of Zn and Cu in 40 patients with RA and compared them with sex and age matched of healthy subjects (N=40). Plasma Cu and Zn concentrations were determined by an analysis of 100 Perkin Elmer model flame atomic absorption spectrometer (FAAS)Results: The plasma Zn concentration in the patient group was statistically lower than control group. The plasma copper was not statistically different in comparison with control group. There was no correlation between Cu and Zn concentration in patient group. In contrast to Cu, there was a significantly positive correlation between Zn and Zn/Cu ratio. However, the decrease of Zn/Cu is more influenced by decreasing the Zn concentration.Conclusion: It appears the decrease of Zn plasma concentration in patients (comparison with control group) is more important than the differences in plasma Cu concentration, but the use of Zn supplement for RA patients needs more investigation.Key words: Zinc, Copper, Rheumatoid arthritis, Plasma concentrationJ Mazand Univ Med Sci 2008; 18(64): 52-59 (Persian)
The Conductivity of Indium Phosphide Irradiated by Fast Electrons  [PDF]
Sh. Sh. Rashidova
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.411183
Abstract:

In this work, studied electrical conductivity(s) and annealing of radiation defects in crystals of n-InP are irradiated by electrons energy of 6 MeV and doses of 1017 el/cm2 (centimeter) and 2 × 1017 el/cm2 (centimeter). It is shown that alongside point defects (in the form of complexes with impurity atoms in crystals of n-InP) also form the complex defects of the type of disordered areas, annealing of which proceeds at T > 300°C that binds accumulating radiation defects.

Therapeutic Results of Transcutaneous Electrical Nerve Stimulation in Post Laminectomy Syndrome
Ahmad Shokrzadeh,Afsoun Seddighi,Amir Saied Seddighi
Global Journal of Health Science , 2010, DOI: 10.5539/gjhs.v2n2137
Abstract: Objectives & Background: Post-laminectomy syndrome specifically refers to pain associated with symptoms not relieved following laminectomy. This entity is a very disabling and hard to manage problem in patients undergoing spinal procedures. Transcutaneous electrical nerve stimulation has been introduced as a non invasive modality for pain control. This study was aimed to determine the effectiveness of TENS in the management of postlaminectomy syndrome. No similar study has been performed in our country yet. Materials and Methods: In this study 35 patients among 85 serial cases with post laminectomy syndrome from 2008-2009 were treated by transcutaneous stimulation. Age, sex, duration and type of symptoms, topographical locations, radiological and the results, for pain control were analyzed. Pain degree determined before stimulation and then 2 hours and 48 hours afterwards using visual analog scale. Results: This study is based on the data from 35 serial patients visited in the senior author's clinic. 60% of the patients were male. The average age of our patients was 49.5 years. The most common location was L4-5 interspace (40%). Average pain score before stimulation was 7 and declined to the mean 5 after 2 hours and to 4 after 48 hours. Conclusions: According to our study the successful results of transcutaneous stimulation occurred in 17.14 % after 2 hours and 22.8 % after 48 hours. In the management of postlaminectomy syndrome the patients need individualized approaches. Further multicentric clinical trials are needed to generalize the results in these patients.
Comparison of Proximal Injections of Local Anesthetics with Distal Injections in Intravenous Block
Ahmad Shokrzadeh,Afsoun Seddighi,Amir Saied Seddighi
Global Journal of Health Science , 2010, DOI: 10.5539/gjhs.v2n2215
Abstract: Background: Perfect pain management is one of the most essential problems in anesthesia. Intravenous block is considered a simple anesthetic method to reduce extremity pain. This study is aimed to determine the effect of proximal injection compared with distal injections to avoid the problems related to be in the vicinity of the surgical field and making use of the larger proximal veins instead of the tiny distal vessels. Methods: In this randomized double blind clinical trial, the patients with traumatic injuries of upper extremities referred to Rajaie Hospital from October 2003 to February 2004 were studied. The cases were divided blindly in to two groups. In one group injections were performed proximally and for the second group distally. Results: This study was based on the data from 100 serial patients. The average time to achieve analgesia was 4.17 + 0.57 minutes for the patients who received distal injections and for the cases that had proximal injection the mean time for analgesia was 5.19 + 0.55. There was no difference in the rate of haematoma formation between the two groups. Conclusions: In intravenous nerve block, the injection of local anesthetic agents in the proximal parts of the limbs is a safe method and is considered as effective as distal injections.
Utilization Pattern of Antibiotics in Different Wards of Specialized Sari Emam University Hospital in Iran
Mohammad Ali Ebrahimzadeh,Mohammad Shokrzadeh,Ahmad Ramezani
Pakistan Journal of Biological Sciences , 2008,
Abstract: The main goal of this study was to compare the utilization of antibiotics in different wards of a university hospital. Consumption of antibacterial drugs rose dramatically during years 2000-2005 in Iran. Data collected during first half of year 2000 and 2005 in Emam University Hospital in city of Sari in Iran, showed use of antibiotics jumped from 95.4 DBDs (Defined Daily Doses per patient`s bed-days) to 124 DBDs. Distribution of different class of anti-microbial showed highest increase in use of vancomycin with 28.4 folds and clindamycin with 4.8 fold. Use of cotrimoxazole, aminoglycosides and tetracyclines remained fairly unchanged during this period. However, during the same period, consumption of penicillin G, aminopenicillins and cloxacillin dropped 10.3, 3.8 and 3 fold, respectively. Among university hospital departments, oncology ward followed by ICU and general surgery consumed the most antibacterial agents in year 2000. In year 2005, ICU ward followed by gynecology, oncology and orthopedic were among the University Hospital Departments with highest consumption of antibiotics. The most highly used antibiotics in year 2000 were cefazolin followed by ampicillin, ceftizoxime and gentamicin. In year 2005, cefazolin, ceftriaoxone, gentamicin and ciprofloxacin were the most prescribed antibiotics. Injectable antibiotics accounted for 51.8 and 79.4% of total DBDs in first half of years 2000 and 2005, respectively. The bulk of prescription (90% of total DBDs) was made up of 13 out of 32 total antibiotic types in 2000 and 11 out of 29 total antibiotics types in 2005. Comparing with similar hospitals in other countries, data presented show a dramatic increase in antibiotics prescribed by physician in Emam University Hospital.
Chronic Toxicity of Menazon and Relation to Oxidative Stress in Red Blood Cells of Rats
A.G. Ebadi,M. Shokrzadeh
Pakistan Journal of Biological Sciences , 2006,
Abstract: The effect of chronic exposure to menazon (Organophosphorus compound) in the production of oxidative stress was assessed in rats. Administration of menazon (50, 100, 500, 1000 ppm) for 2 weeks duration increased catalase (CAT), superoxide dismutase (SOD) activities in red blood cells (RBC). However, acetylcholinesterase (AChE) activity were decreased in these samples. The increase in RBC lipid peroxidation correlated well with the inhibition in RBC AChE activity. Increased activities of CAT and SOD showed significant correlations in RBC samples when different doses of menazon were used. The results of the present study suggest the usefulness of RBC AChE measurement as a good index in the evaluation of menazon-induced oxidative stress affecting blood.
Study of Antioxidative Activity in Four Kinds of Cultivated Rice Grains of Mazandaran Province (Iran)
M. Shokrzadeh,A.G. Ebadi
Pakistan Journal of Biological Sciences , 2006,
Abstract: Antioxidants in rice food are important for human health. However, the level of antioxidative activity of different rice grains (Oriza sativa L.) which is the staple food in Mazandaran province of Iran and is the main agricultural product exported to other countries has not previously been reported. In this preliminary investigation, the antioxidative activity in vitro of the alcoholic extract from four different kinds of rice grains have been determined by ABTS/methemoglobin method compared with Trolox, an vitamin E analog. It was found that the antioxidative activity (TEAC) as μmol per g of dry rice varied from the highest to the lowest as the followings: Tarom rice (20.22), Khazar rice (9.44), Neda rice (8.78) and Sadri rice (1.33), respectively. TEAC is distinguishly the highest in Tarom rice and remarkedly high in Khazar rice. This property may be due to the high contents of rice anthocyanins, vitamin E, tocotrienols and oryzanol. The functional chemistry, nutritional value and health benefits of antioxidants contained in rice grains, rice bran and their products should be intensively studied and characterized for their ingredients and stability. Further development for the value addition of rice as diet supplements and maximum health benefits is needed.
Investigating and Measurement of Residues of Chlorobenzilate (Organochlorine Pesticides) in Four Species of the Most Consumed Fishes in Caspian Sea (Iran)
M. Shokrzadeh,A.G. Ebadi
Pakistan Journal of Nutrition , 2006,
Abstract: In this study samples of four species of the most consumed fishes (Sefid, koli, kilca and kafal fish) were analyzed for concentrations of Chlorobenzilate (organochlorine pesticides). Fish were captured using electric fishing on four sites (Chalous and Babolsar city and Khazar Abad and Miankaleh regions) in Mazandaran provinces of Iran. Quantitative determination of the Chlorobenzilate was performed by gas chromatography electron-capture detection (GC–ECD). Samples contained detectable concentrations of Chlorobenzilate but at concentrations below the maximum residue limit (MRL). No different found between kinds of fishes in each sites about Chlorobenzilate concentrations but there are two groups of sites that were significantly different from one another in terms of Chlorobenzilate concentrations. According to insecticides analyzed in four kinds of fishes the Kafal in the hunting region of Khazar abad had greatest amount of 0.038 PPM. Kilca from Babolsar had the highest amount of Chlorobenzilate, 0.035 PPM (P< 0.05). In the case of Sefid and Koli fishes in regions, significant difference was not seen. It is necessary to mention that no research has so far been done to be a criterion for comparison in this area sites. However, the concentrations of Chlorobenzilate residues in the muscle were found to be lower than the FAO/WHO recommended permissible and should not be public concern among peoples in Mazandaran province.
Antibacterial Effect of Garlic (Allium sativum L.) on Staphylococcus aureus
M. Shokrzadeh,A.G. Ebadi
Pakistan Journal of Biological Sciences , 2006,
Abstract: Garlic (Allium sativum L.) has an important dietary and medicinal role for centuries. It is a large annual plant of the Liliaceae family, which grows in most of Europe and in northern Iran. Iranian garlic is used in traditional medicine for infectious diseases, flu and as an anti-febrile. The present study tested the aqueous extract of garlic in vitro for its antibacterial activity. The extract showed concentration-dependent antibacterial activity against Staphylococcus aureus 8327. This activity was heat resistant, but the activity of freeze-dried extract gradually diminished during a 90 days period. The traditional use of Iranian garlic for infectious diseases and for controlling fever appears to be justified.
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