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Search Results: 1 - 10 of 2984 matches for " Shoichiro; Watanabe "
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Massive Intravascular Hemolysis in a Patient Infected by a Clostridium perfringens
Acta Medica Okayama , 2006,
Abstract: Clostridium perfringens infection is a very rare cause of massive intravascular hemolysis, but it should always be kept in mind, since only early treatment can rescue patients from an otherwise rapidly fatal outcome. We report a case of a 78-year-old diabetic male who was admitted complaining of general fatigue, dark red urine, and vomiting. His blood revealed massive hemolysis. Computer tomography demonstrated huge liver abscess in the right lobe of the liver. About 1 h after admission, he suddenly fell into a critical condition. He died 3 h after admission in spite of intensive care and resuscitation. Clostridium perfringens was detected from the blood taken before death and from liver abscess by biopsy after death. We concluded that this patient died of acute massive intravascular hemolysis in septicemia caused by Clostridium perfringens infection.
First-Principles Study for Evidence of Low Interface Defect Density at Ge/GeO$_2$ Interfaces
Shoichiro Saito,Takuji Hosoi,Heiji Watanabe,Tomoya Ono
Physics , 2009, DOI: 10.1063/1.3168501
Abstract: We present the evidence of the low defect density at Ge/GeO$_2$ interfaces in terms of first-principles total energy calculations. The energy advantages of the atom emission from the Ge/GeO$_2$ interface to release the stress due to the lattice mismatch are compared with those from the Si/SiO$_2$ interface. The energy advantages of the Ge/GeO$_2$ are found to be smaller than those of the Si/SiO$_2$ because of the high flexibility of the bonding networks in GeO$_2$. Thus, the suppression of the Ge-atom emission during the oxidation process leads to the improved electrical properties of the Ge/GeO$_2$ interfaces.
Learning Based Falling Detection Using Multiple Doppler Sensors  [PDF]
Shoichiro Tomii, Tomoaki Ohtsuki
Advances in Internet of Things (AIT) , 2013, DOI: 10.4236/ait.2013.32A005

Automated falling detection is one of the important tasks in this ageing society. Such systems are supposed to have little interference on daily life. Doppler sensors have come to the front as useful devices to detect human activity without using any wearable sensors. The conventional Doppler sensor based falling detection mechanism uses the features of only one sensor. This paper presents falling detection using multiple Doppler sensors. The resulting data from sensors are combined or selected to find out the falling event. The combination method, using three sensors, shows 95.5% accuracy of falling detection. Moreover, this method compensates the drawbacks of mono Doppler sensor which encounters problems when detecting movement orthogonal to irradiation directions.

Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans
Genta Ohno,Kanako Ono,Marina Togo,Yohei Watanabe,Shoichiro Ono,Masatoshi Hagiwara,Hidehito Kuroyanagi
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002991
Abstract: Pre–mRNAs are often processed in complex patterns in tissue-specific manners to produce a variety of protein isoforms from single genes. However, mechanisms orchestrating the processing of the entire transcript are not well understood. Muscle-specific alternative pre–mRNA processing of the unc-60 gene in Caenorhabditis elegans, encoding two tissue-specific isoforms of ADF/cofilin with distinct biochemical properties in regulating actin organization, provides an excellent in vivo model of complex and tissue-specific pre–mRNA processing; it consists of a single first exon and two separate series of downstream exons. Here we visualize the complex muscle-specific processing pattern of the unc-60 pre–mRNA with asymmetric fluorescence reporter minigenes. By disrupting juxtaposed CUAAC repeats and UGUGUG stretch in intron 1A, we demonstrate that these elements are required for retaining intron 1A, as well as for switching the processing patterns of the entire pre–mRNA from non-muscle-type to muscle-type. Mutations in genes encoding muscle-specific RNA–binding proteins ASD-2 and SUP-12 turned the colour of the unc-60 reporter worms. ASD-2 and SUP-12 proteins specifically and cooperatively bind to CUAAC repeats and UGUGUG stretch in intron 1A, respectively, to form a ternary complex in vitro. Immunohistochemical staining and RT–PCR analyses demonstrate that ASD-2 and SUP-12 are also required for switching the processing patterns of the endogenous unc-60 pre-mRNA from UNC-60A to UNC-60B in muscles. Furthermore, systematic analyses of partially spliced RNAs reveal the actual orders of intron removal for distinct mRNA isoforms. Taken together, our results demonstrate that muscle-specific splicing factors ASD-2 and SUP-12 cooperatively promote muscle-specific processing of the unc-60 gene, and provide insight into the mechanisms of complex pre-mRNA processing; combinatorial regulation of a single splice site by two tissue-specific splicing regulators determines the binary fate of the entire transcript.
Smoking, white blood cell counts, and TNF system activity in Japanese male subjects with normal glucose tolerance
Naoya Watanabe, Mitsuo Fukushima, Ataru Taniguchi, Takahide Okumura, Yoshio Nomura, Fusanori Nishimura, Sae Aoyama, Daisuke Yabe, Yoshio Izumi, Ryoichi Ohtsubo, Yoshikatsu Nakai, Shoichiro Nagasaka
Tobacco Induced Diseases , 2011, DOI: 10.1186/1617-9625-9-12
Abstract: One hundred and forty-two Japanese male subjects with normal glucose tolerance were recruited. They were stratified into two groups based on the questionnaire for smoking: one with current smokers (n = 48) and the other with current non-smokers (n = 94). Whereas no significant differences were observed in age, BMI, high molecular weight (HMW) adiponectin, and TNF-α between the two groups, current smokers had significantly higher soluble TNF receptor 1 (sTNF-R1) (1203 ± 30 vs. 1116 ± 21 pg/ml, p = 0.010) and increased WBC counts (7165 ± 242 vs. 5590 ± 163/μl, p < 0.001) and lower HDL cholesterol (55 ± 2 vs. 60 ± 1 mg/dl, p = 0.031) as compared to current non-smokers. Next, we classified 48 current smokers into two subpopulations: one with heavy smoking (Brinkman index ≥ 600) and the other with light smoking (Brinkman index < 600).Whereas no significant difference was observed in age, BMI, HMW adiponectin, WBC counts and TNF-α, sTNF-R1 and sTNF-R2 were significantly higher in heavy smoking group (1307 ± 44 vs. 1099 ± 30 pg/ml, p < 0.001; 2166 ± 86 vs. 827 ± 62 pg/ml, p = 0.005) than in light smoking group, whose sTNF-R1 and sTNF-R2 were similar to non-smokers (sTNF-R1: 1116 ± 15 pg/ml, p = 0.718, sTNF-R2; 1901 ± 32 pg/ml, p = 0.437). In contrast, WBC counts were significantly increased in heavy (7500 ± 324/μl, p < 0.001) or light (6829 ± 352/μl, p = 0.001) smoking group as compared to non-smokers (5590 ± 178/μl). There was no significant difference in WBC counts between heavy and light smoking group (p = 0.158).We can hypothesize that light smoking is associated with an increase in WBC counts, while heavy smoking is responsible for TNF activation in Japanese male subjects with normal glucose tolerance.It is well recognized that smoking is one of the most important factors contributing to the evolution of atherosclerosis and chronic obstructive pulmonary disease in humans [1,2]. It is well established that current smokers are characterized by increased white blood cell
Smoking and adipose tissue inflammation suppress leptin expression in Japanese obese males: potential mechanism of resistance to weight loss among Japanese obese smokers
Shintaro Nagayasu, Shigeki Suzuki, Akiko Yamashita, Ataru Taniguchi, Mitsuo Fukushima, Yoshikatsu Nakai, Kazuko Nin, Naoya Watanabe, Shoichiro Nagasaka, Daisuke Yabe, Fusanori Nishimura
Tobacco Induced Diseases , 2012, DOI: 10.1186/1617-9625-10-3
Abstract: We compared the concentration of inflammatory markers and serum leptin levels among Japanese male subjects. Additionally, leptin and intercellular adhesion molecule (ICAM) -1 gene expression was assessed in adipocytes co-cultured with or without macrophages in the presence or absence of nicotine and/or lipopolysaccharide (LPS).In subjects with BMI below 25 kg/m2, both WBC counts and soluble-ICAM-1 levels are significantly higher in smokers than in non-smokers. However, leptin concentration did not differ according to smoking status. However, in subjects with BMI over 25 kg/m2, smokers exhibited significantly lower serum leptin level as well as higher WBC counts and s-ICAM-1 concentration as compared with non-smokers. Leptin gene expression was markedly suppressed in adipocytes co-cultured with macrophages than in adipocyte culture alone. Furthermore, nicotine further suppressed leptin gene expression. ICAM-1 gene expression was markedly up-regulated in adipocytes co-cultured with macrophages when stimulated with LPS.Adipose tissue inflammation appears to down-regulate leptin expression in adipose tissues. Nicotine further suppresses leptin expression. Thus, both smoking and inflammation may diminish leptin effect in obese subjects. Therefore, obese, but not normal weight, smokers might be more resistant to weight loss than non-smokers.Although there is no doubt that overall serum leptin concentration increases with increased body mass index and body fat content, there also observed large inter-individual differences in circulating leptin concentration even among obese subjects [1]. This may indicate production of leptin protein is regulated by various factors both at genetic and environmental levels. Among environmental factors, smoking appears to be one of such environmental factors, as smoking and its cessation have often been reported to be associated with low body mass index and weight gain [2]. However, previous reports on the effects of smoking on leptin level
Proportional cancer incidence according to selected sites: comparison between residents in the City of S. Paulo, Brazil: Japanese and Brazilian/Portuguese descent
Souza,José Maria Pacheco de; Gotlieb,Sabina Léa Davidson; Costa Júnior,Moacyr Lobo da; Laurenti,Ruy; Mirra,Antonio Pedro; Tsugane,Shoichiro; Watanabe,Shaw;
Revista de Saúde Pública , 1991, DOI: 10.1590/S0034-89101991000300005
Abstract: the percentual distributions of selected sites of cancer cases according to origin, sex and age are compared. data were obtained from the registry of cancer of s. paulo (school of public health of the university of s. paulo, brazil). the reference period for inhabitants of japanese descent was 1969/78 and for those of brazilian descent, the period was 1969/75. standardized proportionate incidence ratios (spir) with approximate 95% confidence intervals (ci) were evaluated using age specific incidence ratios of s. paulo, 1973, as standards. the results agree with findings of previous works on mortality, but show different patterns according to origin. the well known fact that some sub-groups of a population may be different from the overall group is once again brought to the fore. attention should be drawn to the differences detected for stomach, skin and prostate, in males, and for stomach, skin, cervix and uterus in females.
Evaluation of an oral moisture-checking device for screening dry mouth  [PDF]
Yosuke Fukushima, Tetsuya Yoda, Shoichiro Kokabu, Ryuichiro Araki, Tsubasa Murata, Yoshimasa Kitagawa, Ken Omura, Shuji Toya, Kayoko Ito, Saori Funayama, Hiroshi Iwabuchi, Kazuhiro Asano, Yutaka Imai, Akihide Negishi, Satoshi Yokoo, Goichi Matsumoto, Eiro Kubota, Hideki Watanabe, Mikio Kusama, Kojiro Onizawa, Takuya Goto, Seiji Nakamura, Ryuichi Nakazawa, Kiyoshi Harada, Takashi Fujibayashi
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.38073

Objective: This multicenter clinical study was to assess the clinical usability of an oral moisture-checking device in detecting the dry mouth patients and evaluating the optimal measurement site. Materials and Methods: The study group comprised 250 patients with dry mouth and 241 healthy volunteer subjects at 13 medical centers. This device was used to measure the moisture degrees of the lingual mucosa and the buccal mucosa. Subjective oral dryness, objective oral dryness, and saliva flow rates were also compared between the two groups. For statistical analysis, receiver-operating characteristic analysis was performed to calculate the area under the curve (AUC). Results: The moisture degree of the lingual mucosa was significantly lower in the dry mouth group (27.2 ± 4.9) than that in the healthy group (29.5 ± 3.1, AUC = 0.653). When a lingual mucosa moisture degree of 31.0 or higher was defined as normal, less than 27.0 as dry mouth, and 27.0 to less than 31.0 as borderline zone of dry mouth, both the sensitivity and the specificity for the diagnosis of dry mouth were close to 80%. Conclusion: These results suggest that the oral moisture-checking device is a usable screening device for dry mouth.

First-principles electronic-structure calculation of dangling bonds at Si/SiO$_2$ and Ge/GeO$_2$ interfaces
Tomoya Ono,Shoichiro Saito
Physics , 2009,
Abstract: Evidence of the absence of the clear electron spin-resonance signal from Ge dangling bonds (DBs) at Ge/GeO$_2$ interfaces is explored by means of first-principles electronic-structure calculations. Comparing the electronic structures of the DBs at Si/SiO$_2$ and Ge/GeO$_2$ interfaces, we found that the electronic structure of the Ge-DB is markedly different from that of the Si-DB; the Ge-DB states does not position in the energy band gap of the Ge/GeO$_2$ interface while the Si-DB states clearly appears. In addition, the charge density distribution of the Ge-DB state spreads more widely than that of the Si-DB state. These features are explained by considering the metallic properties of the bonding network of the Ge/GeO$_2$ interface and the structural deformation of the Ge bulk at the Ge/GeO$_2$ interface due to the lattice-constant mismatch.
First-Principles Study on Structural Properties of GeO$_2$ and SiO$_2$ under Compression and Expansion Pressure
Shoichiro Saito,Tomoya Ono
Physics , 2010, DOI: 10.1143/JJAP.50.021503
Abstract: The detailed analysis of the structural variations of three GeO$_2$ and SiO$_2$ polymorphs ($\alpha$-quartz, $\alpha$-cristobalite, and rutile) under compression and expansion pressure is reported. First-principles total-energy calculations reveal that the rutile structure is the most stable phase among the phases of GeO$_2$, while SiO$_2$ preferentially forms quartz. GeO$_4$ tetrahedras of quartz and cristobalite GeO$_2$ phases at the equilibrium volume are more significantly distorted than those of SiO$_2$. Moreover, in the case of quartz GeO$_2$ and cristobalite GeO$_2$, all O-Ge-O bond angles vary when the volume of the GeO$_2$ bulk changes from the equilibrium point, which causes further deformation of tetrahedra. In contrast, the tilt angle formed by Si-O-Si in SiO$_2$ markedly changes. This flexibility of the O-Ge-O bonds reduces the stress at the Ge/GeO$_2$ interface due to the lattice-constant mismatch and results in the low defective interface observed in the experiments [Matsubara \textit{et al.}: Appl. Phys. Lett. \textbf{93} (2008) 032104; Hosoi \textit{et al.}: Appl. Phys. Lett. \textbf{94} (2009) 202112].
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