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Search Results: 1 - 10 of 738 matches for " Shoichiro Kawai "
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Choroidal and cutaneous metastasis from gastric adenocarcinoma
Shoichiro Kawai,Tsutomu Nishida,Yoshito Hayashi,Hisao Ezaki
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i9.1485
Abstract: Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions.
Learning Based Falling Detection Using Multiple Doppler Sensors  [PDF]
Shoichiro Tomii, Tomoaki Ohtsuki
Advances in Internet of Things (AIT) , 2013, DOI: 10.4236/ait.2013.32A005

Automated falling detection is one of the important tasks in this ageing society. Such systems are supposed to have little interference on daily life. Doppler sensors have come to the front as useful devices to detect human activity without using any wearable sensors. The conventional Doppler sensor based falling detection mechanism uses the features of only one sensor. This paper presents falling detection using multiple Doppler sensors. The resulting data from sensors are combined or selected to find out the falling event. The combination method, using three sensors, shows 95.5% accuracy of falling detection. Moreover, this method compensates the drawbacks of mono Doppler sensor which encounters problems when detecting movement orthogonal to irradiation directions.

Experiment of Frequency Range Dependent TE10 to TE20 Mode Converter  [PDF]
Yoshihiro Kokubo, Tadashi Kawai
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2016, DOI: 10.4236/jemaa.2016.89017
Abstract: Typical metallic waveguide mode converters convert electromagnetic waves from one mode to another mode for some frequency ranges. However, most electromagnetic waves outside of the specified frequency range are reflected. We report a design for a mode converter which passes the TE10 mode at a low frequency range and efficiently converts the TE10 mode to the TE20 mode at a high frequency range. To gradually shift the mode profile from TE10 to TE20, dielectric rods are placed in a sequence along the waveguide starting near the sidewall and moving to the center of the waveguide with decreasing radius of the rods. This design reduces reflection of electromagnetic waves. Experimental tests demonstrate the efficacy of the design.
A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants  [PDF]
Mariko Kawai, Kiyoshi Ohura
Open Journal of Stomatology (OJST) , 2017, DOI: 10.4236/ojst.2017.711046
Abstract: Dental implant therapy is a highly effective treatment for recovering occlusion after tooth loss. An important factor in the success of dental implants is establishing strong osseointegration. If more epithelial cells migrate to the implant-bone interface than mesenchymal stem cells, effective osseointegration may fail. Therefore, controlling epithelial cell adhesion and motility would be an effective strategy to increase the success rate of osseointegration. Laminin-332 is a major component of the basement membrane and is composed of three chains (α3, β3 and γ2). It is well-known that laminin-332 regulates cellular functions such as adhesion, proliferation, apoptosis and differentiation. These biological functions depend on changes in the structural arrangement of laminin-332 by proteolytic cleavage. It is well-known that cleavage of the α3 chain between its LG domains gives laminin-332 its biological function. In this study, we focused on LG domain cleavage and developed antibodies that target the LG domain cleavage site. We attempted to change the biological function of laminin-332 to control cell adhesion for the purpose of regulating dental implant therapy.
First-principles electronic-structure calculation of dangling bonds at Si/SiO$_2$ and Ge/GeO$_2$ interfaces
Tomoya Ono,Shoichiro Saito
Physics , 2009,
Abstract: Evidence of the absence of the clear electron spin-resonance signal from Ge dangling bonds (DBs) at Ge/GeO$_2$ interfaces is explored by means of first-principles electronic-structure calculations. Comparing the electronic structures of the DBs at Si/SiO$_2$ and Ge/GeO$_2$ interfaces, we found that the electronic structure of the Ge-DB is markedly different from that of the Si-DB; the Ge-DB states does not position in the energy band gap of the Ge/GeO$_2$ interface while the Si-DB states clearly appears. In addition, the charge density distribution of the Ge-DB state spreads more widely than that of the Si-DB state. These features are explained by considering the metallic properties of the bonding network of the Ge/GeO$_2$ interface and the structural deformation of the Ge bulk at the Ge/GeO$_2$ interface due to the lattice-constant mismatch.
First-Principles Study on Structural Properties of GeO$_2$ and SiO$_2$ under Compression and Expansion Pressure
Shoichiro Saito,Tomoya Ono
Physics , 2010, DOI: 10.1143/JJAP.50.021503
Abstract: The detailed analysis of the structural variations of three GeO$_2$ and SiO$_2$ polymorphs ($\alpha$-quartz, $\alpha$-cristobalite, and rutile) under compression and expansion pressure is reported. First-principles total-energy calculations reveal that the rutile structure is the most stable phase among the phases of GeO$_2$, while SiO$_2$ preferentially forms quartz. GeO$_4$ tetrahedras of quartz and cristobalite GeO$_2$ phases at the equilibrium volume are more significantly distorted than those of SiO$_2$. Moreover, in the case of quartz GeO$_2$ and cristobalite GeO$_2$, all O-Ge-O bond angles vary when the volume of the GeO$_2$ bulk changes from the equilibrium point, which causes further deformation of tetrahedra. In contrast, the tilt angle formed by Si-O-Si in SiO$_2$ markedly changes. This flexibility of the O-Ge-O bonds reduces the stress at the Ge/GeO$_2$ interface due to the lattice-constant mismatch and results in the low defective interface observed in the experiments [Matsubara \textit{et al.}: Appl. Phys. Lett. \textbf{93} (2008) 032104; Hosoi \textit{et al.}: Appl. Phys. Lett. \textbf{94} (2009) 202112].
New structural model for GeO2/Ge interface: A first-principles study
Shoichiro Saito,Tomoya Ono
Physics , 2010, DOI: 10.1103/PhysRevB.84.085319
Abstract: First-principles modeling of a GeO2/Ge(001) interface reveals that sixfold GeO2, which is derived from cristobalite and is different from rutile, dramatically reduces the lattice mismatch at the interface and is much more stable than the conventional fourfold interface. Since the grain boundary between fourfold and sixfold GeO2 is unstable, the sixfold GeO2 forms a large grain at the interface. On the contrary, a comparative study with SiO2 demonstrates that SiO2 maintains a fourfold structure. The sixfold GeO2/Ge interface is shown to be a consequence of the ground-state phase of GeO2. In addition, the electronic structure calculation reveals that sixfold GeO2 at the interface shifts the valence band maximum far from the interface toward the conduction band.
Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery  [PDF]
Akito Endo, Shoichiro Asayama
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2019, DOI: 10.4236/jmmce.2019.75016
Abstract: Zinc ions (Zn2+), known to be a novel intracellular second messenger related to various biological functions, have been delivered inside cells. For the intracellular Zn2+ delivery, Zn2+ has been chelated to carboxymethyl poly(1-vinylimidazole) (CM-PVIm) by mixing zinc chloride (ZnCl2) or zinc acetate (Zn(OAc)2) with CM-PVIm. The resulting Zn2+-chelated CM-PVIm, that is, Zn2+/CM-PVIm complex by mixing ZnCl2 exhibited smaller particle size below 10 nm and possessed larger amount of Zn2+ ions, as compared to the Zn2+/CM-PVIm by mixing Zn(OAc)2. The both Zn2+/CM-PVIm complexes exhibited no significant cytotoxicity, leading to intracellular Zn2+ delivery. The Zn2+/CM-PVIm by mixing ZnCl2 delivered larger amount of intracellular Zn2+ ions than that by mixing Zn(OAc)2. These results suggest that the optimal Zn2+/CM-PVIm complex is a useful tool for intracellular Zn2+ delivery to control various biological functions.
In Situ Observation and Measurement of Actin Stress Fiber Deformation in Stretched Osteoblast like Cell  [PDF]
Katsuya Sato, Kenta Nunobiki, Shoichiro Fujisawa, Tasuku Nakahara, Kazuyuki Minami
Advances in Bioscience and Biotechnology (ABB) , 2017, DOI: 10.4236/abb.2017.811031
Abstract: It is believed that mechanical stimuli, such as stretching of the extracellular matrix, are transmitted into cells via focal adhesion complexes and the actin cytoskeleton. Transmission dynamics of strain from the extracellular matrix into intracellular organelles is crucial to clarify the mechanosensing mechanisms of cells. In this study, we observed deformation behavior of actin stress fibers under uniaxial stretch using an originally developed cell-stretching microelectromechanical system (MEMS) device. It was difficult to conduct in situ observation of cells under stretch using conventional cell stretching devices, because motion artifacts such as rigid displacement during stretch application were not negligible. Our novel cell-stretching MEMS device suppressed rigid displacement while stretching, and we succeeded in obtaining time-lapse images of stretched cells. Uniaxial strain with a 10% magnitude and strain rate of 0.5%/sec was applied to cells. Deformation behaviors of the cells and actin stress fibers were recorded using a confocal laser scanning microscope. In time-lapse images of stretched cells, strains along each stress fiber were measured manually. As a result, in cells with a relatively homogeneous stress fiber structure oriented in one direction, distribution of the axial strain on stress fibers generally corresponded to deformation of the stretching sheet on which the cells had adhered. However, in
An improvement in complex Langevin dynamics from a view point of Lefschetz thimbles
Shoichiro Tsutsui,Takahiro M. Doi
Physics , 2015,
Abstract: We develop a way of improving complex Langevin dynamics motivated by a method of Lefschetz thimbles. Observables of an original model is computed by a modified model which consists of a single Lefschetz thimble. We apply our modification method to a one dimensional toy model in which the naive implementation of the complex Langevin dynamics fails to reproduce the exact results. This method can improve complex Langevin dynamics for any models even with a logarithmic term in their actions once a single-thimble structure is achieved.
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