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Search Results: 1 - 10 of 42948 matches for " Shoei-Sheng Lee "
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Metabolomic Analysis of Complex Chinese Remedies: Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid
Dong-Ming Tsai,Jaw-Jou Kang,Shoei-Sheng Lee,San-Yuan Wang
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/263757
Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway
Shih-Chin Wang,Sai-Wen Tang,Sio-Hong Lam,Chung-Chieh Wang,Yu-Huei Liu,Hsuan-Yuan Lin,Shoei-Sheng Lee,Jung-Yaw Lin
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/409823
Abstract: Renal cell carcinoma (RCC) cells are characterized by strong drug resistance and high metastatic incidence. In this study, the effects of ten kinds of Chinese herbs on RCC cell migration and proliferation were examined. Aqueous extract of Paeonia suffruticosa (PS-A) exerted strong inhibitory effects on cancer cell migration, mobility, and invasion. The results of mouse xenograft experiments showed that the treatment of PS-A significantly suppressed tumor growth and pulmonary metastasis. We further found that PS-A markedly decreased expression of VEGF receptor-3 (VEGFR-3) and phosphorylation of FAK in RCC cells. Moreover, the activation of Rac-1, a modulator of cytoskeletal dynamics, was remarkably reduced by PS-A. Additionally, PS-A suppressed polymerization of actin filament as demonstrated by confocal microscopy analysis and decreased the ratio of F-actin to G-actin in RCC cells, suggesting that PS-A inhibits RCC cell migration through modulating VEGFR-3/FAK/Rac-1 pathway to disrupt actin filament polymerization. In conclusion, this research elucidates the effects and molecular mechanism for antimigration of PS-A on RCC cells and suggests PS-A to be a therapeutic or adjuvant strategy for the patients with aggressive RCC.
Real-time PCR Machine System Modeling and a Systematic Approach for the Robust Design of a Real-time PCR-on-a-Chip System
Da-Sheng Lee
Sensors , 2010, DOI: 10.3390/s100100697
Abstract: Chip-based DNA quantification systems are widespread, and used in many point-of-care applications. However, instruments for such applications may not be maintained or calibrated regularly. Since machine reliability is a key issue for normal operation, this study presents a system model of the real-time Polymerase Chain Reaction (PCR) machine to analyze the instrument design through numerical experiments. Based on model analysis, a systematic approach was developed to lower the variation of DNA quantification and achieve a robust design for a real-time PCR-on-a-chip system. Accelerated lift testing was adopted to evaluate the reliability of the chip prototype. According to the life test plan, this proposed real-time PCR-on-a-chip system was simulated to work continuously for over three years with similar reproducibility in DNA quantification. This not only shows the robustness of the lab-on-a-chip system, but also verifies the effectiveness of our systematic method for achieving a robust design.
A Study of the Form of Organizations: Toward an Integrative Framework of Population Ecology and Institutionalism
Sheng-Hsien Lee
International Journal of Business and Management , 2012, DOI: 10.5539/ijbm.v7n10p108
Abstract: Does the form of organizations tend to show diversity or homogeneity? This paper begins with two contrasting questions: ‘Why are there many organizational forms?’ and ‘Why are organizations similar?’ Population ecology and institutional theory represent different lenses through which theorists use for interpreting these organizational phenomena. Each paradigm offers compelling concepts and arguments for supporting their own perspectives even though they seem to lead to contradictory results. This conceptual paper is an attempt to clarify the fundamental divergence of ecological and institutional approaches and proposes an integrated perspective for future empirical studies.
Association of Lower Extremity Arterial Calcification with Amputation and Mortality in Patients with Symptomatic Peripheral Artery Disease
Chi-Lun Huang, I-Hui Wu, Yen-Wen Wu, Juey-Jen Hwang, Shoei-Shen Wang, Wen-Jone Chen, Wen-Jeng Lee, Wei-Shiung Yang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090201
Abstract: Objective The clinical implication of the coronary artery calcium score (CS) is well demonstrated. However, little is known about the association between lower extremity arterial calcification and clinical outcomes. Methods and Results Eighty-two patients with symptomatic peripheral artery disease (age 61.0±12.4 years) were followed for 21±11 months. CSs, ranging from the common iliac artery bifurcation to the ankle area, were analyzed through noncontrast multidetector computed tomography images retrospectively. The primary endpoints of this study were amputation and mortality. Old age, diabetes, hyperlipidemia, and end-stage renal disease were associated with higher CSs. Patients with more advanced Fontaine stages also tended to have significantly higher CSs (p = 0.03). During the follow-up period (21±11 months), 29 (35%) patients underwent amputation, and 24 (29%) patients died. Among the patients who underwent amputation, there were no significant differences in CSs between the amputated legs and the non-amputated legs. In the Cox proportional hazard model with CS divided into quartiles, patients with CS in the highest quartile had a 2.88-fold (95% confidence interval [CI] 1.18–12.72, p = 0.03) and a 5.16-fold (95% CI 1.13–21.61, p = 0.04) higher risk for amputation and all-cause mortality, respectively, than those with CS in the lowest quartile. These predictive effects remained after conventional risk factor adjustment. Conclusion Lower extremity arterial CSs are associated with disease severity and outcomes, including amputation and all-cause mortality, in patients with symptomatic peripheral artery disease. However, the independent predictive value needs further investigation in large scale, prospective studies.
Epigenetic Effects of Environmental Chemicals Bisphenol A and Phthalates
Sher Singh,Steven Shoei-Lung Li
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms130810143
Abstract: The epigenetic effects on DNA methylation, histone modification, and expression of non-coding RNAs (including microRNAs) of environmental chemicals such as bisphenol A (BPA) and phthalates have expanded our understanding of the etiology of human complex diseases such as cancers and diabetes. Multiple lines of evidence from in vitro and in vivo models have established that epigenetic modifications caused by in utero exposure to environmental toxicants can induce alterations in gene expression that may persist throughout life. Epigenetics is an important mechanism in the ability of environmental chemicals to influence health and disease, and BPA and phthalates are epigenetically toxic. The epigenetic effect of BPA was clearly demonstrated in viable yellow mice by decreasing CpG methylation upstream of the Agouti gene, and the hypomethylating effect of BPA was prevented by maternal dietary supplementation with a methyl donor like folic acid or the phytoestrogen genistein. Histone H3 was found to be trimethylated at lysine 27 by BPA effect on EZH2 in a human breast cancer cell line and mice. BPA exposure of human placental cell lines has been shown to alter microRNA expression levels, and specifically, miR-146a was strongly induced by BPA treatment. In human breast cancer MCF7 cells, treatment with the phthalate BBP led to demethylation of estrogen receptor (ESR1) promoter-associated CpG islands, indicating that altered ESR1 mRNA expression by BBP is due to aberrant DNA methylation. Maternal exposure to phthalate DEHP was also shown to increase DNA methylation and expression levels of DNA methyltransferases in mouse testis. Further, some epigenetic effects of BPA and phthalates in female rats were found to be transgenerational. Finally, the available new technologies for global analysis of epigenetic alterations will provide insight into the extent and patterns of alterations between human normal and diseased tissues. In vitro models such as human embryonic stem cells may be extremely useful in bettering the understanding of epigenetic effects on human development, health and disease, because the formation of embryoid bodies in vitro is very similar to the early stage of embryogenesis.
Energy Saving Effects of Wireless Sensor Networks: A Case Study of Convenience Stores in Taiwan
Chih-Sheng Chen,Da-Sheng Lee
Sensors , 2011, DOI: 10.3390/s110202013
Abstract: Wireless sensor network (WSN) technology has been successfully applied to energy saving applications in many places, and plays a significant role in achieving power conservation. However, previous studies do not discuss WSN costs and cost-recovery. The application of WSNs is currently limited to research and laboratory experiments, and not mass industrial production, largely because business owners are unfamiliar with the possible favorable return and cost-recovery on WSN investments. Therefore, this paper focuses on the cost-recovery of WSNs and how to reduce air conditioning energy consumption in convenience stores. The WSN used in this study provides feedback to the gateway and adopts the predicted mean vote (PMV) and computational fluid dynamics (CFD) methods to allow customers to shop in a comfortable yet energy-saving environment. Four convenience stores in Taipei have used the proposed WSN since 2008. In 2008, the experiment was initially designed to optimize air-conditioning for energy saving, but additions to the set-up continued beyond 2008, adding the thermal comfort and crowds peak, off-peak features in 2009 to achieve human-friendly energy savings. Comparison with 2007 data, under the same comfort conditions, shows that the power savings increased by 40% (2008) and 53% (2009), respectively. The cost of the WSN equipment was 500 US dollars. Experimental results, including three years of analysis and calculations, show that the marginal energy conservation benefit of the four convenience stores achieved energy savings of up to 53%, recovering all costs in approximately 5 months. The convenience store group participating in this study was satisfied with the efficiency of energy conservation because of the short cost-recovery period.
Innovative Design of an Automatic Car-Door Opening System
Hsin Sheng Lee,Long Chang Hsieh
Lecture Notes in Engineering and Computer Science , 2009,
A New Look at an Old Tool-the Cumulative Spectral Power of Fast-Fourier Transform Analysis
Sheng-Chiang Lee,Randall D. Peters
Physics , 2009,
Abstract: As an old and widely used tool, it is still possible to find new insights and applications from Fast Fourier Transform (FFT)-based analyses. The FFT is frequently used to generate the Power Spectral Density (PSD) function, by squaring the spectral components that have been corrected for influence from the instrument that generated the data. Although better than a raw-data spectrum, by removing influence of the instrument transfer function, the PSD is still of limited value for time varying signals with noise, due to the very nature of the Fourier transform. The authors present here another way to treat the FFT data, namely the Cumulative Spectral Power (CSP), as a promising means to overcome some of these limitations. As will be seen from the examples provided, the CSP holds promise in a variety of different fields.
Flat histogram simulation of lattice polymer systems
Lik Wee Lee,Jian-Sheng Wang
Physics , 2001, DOI: 10.1103/PhysRevE.64.056112
Abstract: We demonstrate the use of a new algorithm called the Flat Histogram sampling algorithm for the simulation of lattice polymer systems. Thermodynamics properties, such as average energy or entropy and other physical quantities such as end-to-end distance or radius of gyration can be easily calculated using this method. Ground-state energy can also be determined. We also explore the accuracy and limitations of this method. Key words: Monte Carlo algorithms, flat histogram sampling, HP model, lattice polymer systems
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