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Search Results: 1 - 10 of 7975 matches for " Shoeb Ahmad "
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Chebyshev Approximate Solution to Allocation Problem in Multiple Objective Surveys with Random Costs  [PDF]
Mohammed Faisal khan, Irfan Ali, Qazi Shoeb Ahmad
American Journal of Computational Mathematics (AJCM) , 2011, DOI: 10.4236/ajcm.2011.14029
Abstract: In this paper, we consider an allocation problem in multivariate surveys as a convex programming problem with non-linear objective functions and a single stochastic cost constraint. The stochastic constraint is converted into an equivalent deterministic one by using chance constrained programming. The resulting multi-objective convex programming problem is then solved by Chebyshev approximation technique. A numerical example is presented to illustrate the computational procedure.
Gap Junction Mediated Intercellular Metabolite Transfer in the Cochlea Is Compromised in Connexin30 Null Mice
Qing Chang, Wenxue Tang, Shoeb Ahmad, Binfei Zhou, Xi Lin
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0004088
Abstract: Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-assemble to form gap junctions (GJs) in the cochlea. Mutations in either one of them are the major cause of non-syndromic prelingual deafness in humans. Because the mechanisms of cochlear pathogenesis caused by Cx mutations are unclear, we investigated effects of Cx30 null mutation on GJ-mediated ionic and metabolic coupling in the cochlea of mice. A novel flattened cochlear preparation was used to directly assess intercellular coupling in the sensory epithelium of the cochlea. Double-electrode patch clamp recordings revealed that the absence of Cx30 did not significantly change GJ conductance among the cochlear supporting cells. The preserved electrical coupling is consistent with immunolabeling data showing extensive Cx26 GJs in the cochlea of the mutant mice. In contrast, dye diffusion assays showed that the rate and extent of intercellular transfer of multiple fluorescent dyes (including a non-metabolizable D-glucose analogue, 2-NBDG) among cochlear supporting cells were severely reduced in Cx30 null mice. Since the sensory epithelium in the cochlea is an avascular organ, GJ-facilitated intercellular transfer of nutrient and signaling molecules may play essential roles in cellular homeostasis. To test this possibility, NBDG was used as a tracer to study the contribution of GJs in transporting glucose into the cochlear sensory epithelium when delivered systemically. NBDG uptake in cochlear supporting cells was significantly reduced in Cx30 null mice. The decrease was also observed with GJ blockers or glucose competition, supporting the specificity of our tests. These data indicate that GJs facilitate efficient uptake of glucose in the supporting cells. This study provides the first direct experimental evidence showing that the transfer of metabolically-important molecules in cochlear supporting cells is dependent on the normal function of GJs, thereby suggesting a novel pathogenesis process in the cochlea for Cx-mutation-linked deafness.
Multi-objective convex programming problem arising in multivariate sampling
Mohd Vaseem Ismail, Kaynat Nasser, Qazi Shoeb Ahmad
International Journal of Engineering, Science and Technology , 2010,
Abstract: In this paper, we formulate the multivariate allocation problem as a multi-objective convex programming problem. The objective functions are convex and there is a single linear constraint with some upper and lower bounds. We also consider a two dimensional multivariate problem when the cost is minimized. A numerical example is given to illustrate the solution procedure. International Journal of Engineering, Science and Technology, Vol. 2, No. 6, 2010, pp. 291-296
Mohd. Vaseem Ismail,Kaynat Nasser,Qazi Shoeb Ahmad
Pakistan Journal of Statistics and Operation Research , 2011, DOI: 10.1234/pjsor.v7i1.172
Abstract: In this paper, we consider the problem of minimizing the variances for the various characters with fixed (given) budget. Each convex objective function is first linearised at its minimal point where it meets the linear cost constraint. The resulting multiobjective linear programming problem is then solved by Chebyshev goal programming. A numerical example is given to illustrate the procedure.
Antitermite Activities of C. decidua Extracts and Pure Compounds against Indian White Termite Odontotermes obesus (Isoptera: Odontotermitidae)
Ravi Kant Upadhyay,Gayatri Jaiswal,Shoeb Ahmad,Leena Khanna,Subhash Chand Jain
Psyche , 2012, DOI: 10.1155/2012/820245
Abstract: In the present investigation, we have tested antitermite responses of Capparis decidua stem, root, flower, and fruit extracts and pure compounds to Odontotermes obesus in various bioassays. Crude stem extract has shown very high susceptibility and very low LD50 values, that is, 14.171 μg/mg in worker termites. From stem extract, three pure compounds were isolated in pure form namely, heneicosylhexadecanoate (CDS2), triacontanol (CDS3), and 2-carboxy-1, 1-dimethylpyrrolidine (CDS8) which have shown very low LD50 value in a range of 5.537–10.083 μg/mg. Similarly, one novel compound 6-(1-hydroxy-non-3-enyl)-tetrahydropyran-2-one (CDF1) was isolated from flower extract that has shown an LD50 8.08 μg/gm. Repellent action of compounds was tested in a Y-shaped glass olfactometer in which CDF1 compounds have significantly repelled termites to the opposite arm. Besides this, C. decidua extracts have shown significant reduction (<0.05 and 0.01) in termite infestation in garden saplings when it was coated on cotton tags and employed over tree trunks. Further, C. deciduas stem extract was used for wood seasoning, which gave very good results as test wood sticks have shown significantly (<0.05 and 0.01) very low termite infestation.
Mitochondrial complex-1 in Parkinson′s disease
Khan Shoeb
Neurology India , 2006,
Anticancer agents from medicinal plants
Mohammad Shoeb
Bangladesh Journal of Pharmacology , 2006,
Abstract: Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the treatment of cancer. Several anticancer agents including taxol, vinblas-tine, vincristine, the camptothecin derivatives, topotecan and irinotecan, and etoposide derived from epipodophyllotoxin are in clinical use all over the world. A number of promising agents such as flavopiridol, roscovitine, combretastatin A-4, betulinic acid and silvestrol are in clinical or preclinical development.
Optical and Structural Properties of ZnO Thin Films Fabricated by Sol-Gel Method  [PDF]
Ziaul Raza Khan, Mohd Shoeb Khan, Mohammad Zulfequar, Mohd Shahid Khan
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.25044
Abstract: Highly oriented and transparent ZnO thin films have been fabricated on ultrasonically cleaned quartz substrates by the sol-gel technique. X-ray diffraction, UV-VIS, FTIR, photoluminescence and SEM are used to characterize ZnO thin films. X-ray diffraction study show that all the films prepared in this work have hexagonal wurtzite structure, with lattice constants a = b = 3.260 Å, c = 5.214 Å. The optical band gap energy of the thin films is found to be direct allowed transition ~3.24 eV. The FTIR spectrum of the film has the characteristics ZnO absorption band at 482 cm?1. The photoluminescence spectrum of the samples has an UV emission peak centred at 383 nm with broad band visible emission centred in the range of 500 - 600 nm.
Data-Driven Approaches for Computation in Intelligent Biomedical Devices: A Case Study of EEG Monitoring for Chronic Seizure Detection
Naveen Verma,Kyong Ho Lee,Ali Shoeb
Journal of Low Power Electronics and Applications , 2011, DOI: 10.3390/jlpea1010150
Abstract: Intelligent biomedical devices implies systems that are able to detect specific physiological processes in patients so that particular responses can be generated. This closed-loop capability can have enormous clinical value when we consider the unprecedented modalities that are beginning to emerge for sensing and stimulating patient physiology. Both delivering therapy (e.g., deep-brain stimulation, vagus nerve stimulation, etc.) and treating impairments (e.g., neural prosthesis) requires computational devices that can make clinically relevant inferences, especially using minimally-intrusive patient signals. The key to such devices is algorithms that are based on data-driven signal modeling as well as hardware structures that are specialized to these. This paper discusses the primary application-domain challenges that must be overcome and analyzes the most promising methods for this that are emerging. We then look at how these methods are being incorporated in ultra-low-energy computational platforms and systems. The case study for this is a seizure-detection SoC that includes instrumentation and computation blocks in support of a system that exploits patient-specific modeling to achieve accurate performance for chronic detection. The SoC samples each EEG channel at a rate of 600 Hz and performs processing to derive signal features on every two second epoch, consuming 9 μJ/epoch/channel. Signal feature extraction reduces the data rate by a factor of over 40×, permitting wireless communication from the patient’s head while reducing the total power on the head by 14×.
International Journal of Engineering Science and Technology , 2011,
Abstract: Designing and implementing commercial as well as industrial systems based on Wireless communication has always been a prominent field of interest among many researchers and developers. This paper presents an implementation methodology for a wireless automatic meter reading system (WAMRS) incorporating the widely used GSM network. In many countries GSM network is widely known for its vast coverage area, cost effectiveness and also for its competitive ever growing market.Using GSM as the medium for WAMRS provides a cost-effective, ireless, always-connected, two-way data link between utility company and WAMRS, the WAMRS sends information of utility usage, power quality and outage alarm to utility company, tampering detection to the utility servers. In this paper we suggest a method where we utilize telecommunication systems for automated transmission of data to facilitate bill generation at the server end and also to the customer via SMS, Email.
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