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Search Results: 1 - 10 of 600 matches for " Shingo Hatakeyama "
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Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer
Tatsuo Kido,Shingo Hatakeyama,Chikara Ohyama,Yun-Fai Chris Lau
Genes , 2010, DOI: 10.3390/genes1020283
Abstract: TSPY is a Y-encoded gene that is expressed in normal testicular germ cells and various cancer types including germ cell tumor, melanoma, hepatocellular carcinoma, and prostate cancer. Currently, the correlation between TSPY expression and oncogenic development has not been established, particularly in somatic cancers. To establish such correlation, we analyzed the expression of TSPY, in reference to its interactive oncoprotein, EEF1A, tumor biomarker, AMACR, and normal basal cell biomarker, p63, in 41 cases of clinical prostate cancers (CPCa), 17 cases of latent prostate cancers (LPCa), and 19 cases of non-cancerous prostate (control) by immunohistochemistry. Our results show that TSPY was detected more frequently (78%) in the clinical prostate cancer specimens than those of latent prostate cancer (47%) and control (50%). In the latent cancer group, the levels of TSPY expression could be correlated with increasing Gleason grades. TSPY expression was detected in seven out of nine high-grade latent cancer samples (Gleason 7 and more). The expression of the TSPY binding partner EEF1A was detectable in all prostate specimens, but the levels were higher in cancer cells in clinical and latent prostate cancer specimens than normal prostatic cells. These observations suggest that expressions of TSPY and its binding partner EEF1A are associated with the development and progression of prostate cancer.
Gene Expression Changes in Venous Segment of Overflow Arteriovenous Fistula
Yasuhiro Hashimoto,Akiko Okamoto,Hisao Saitoh,Shingo Hatakeyama,Takahiro Yoneyama,Takuya Koie,Chikara Ohyama
International Journal of Nephrology , 2013, DOI: 10.1155/2013/980923
Abstract: Aim. The objective of this study was to characterize coordinated molecular changes in the structure and composition of the walls of venous segments of arteriovenous (AV) fistulas evoked by overflow. Methods. Venous tissue samples were collected from 6 hemodialysis patients with AV fistulas exposed to overflow and from the normal cephalic veins of 4 other hemodialysis patients. Total RNA was extracted from the venous tissue samples, and gene expression between the 2 groups was compared using Whole Human Genome DNA microarray 44?K. Microarray data were analyzed by GeneSpring GX software and Ingenuity Pathway Analysis. Results. The cDNA microarray analysis identified 397 upregulated genes and 456 downregulated genes. Gene ontology analysis with GeneSpring GX software revealed that biological developmental processes and glycosaminoglycan binding were the most upregulated. In addition, most upregulation occurred extracellularly. In the pathway analysis, the TGF beta signaling pathway, cytokines and inflammatory response pathway, hypertrophy model, and the myometrial relaxation and contraction pathway were significantly upregulated compared with the control cephalic vein. Conclusion. Combining microarray results and pathway information available via the Internet provided biological insight into the structure and composition of the venous wall of overflow AV fistulas. 1. Introduction Arteriovenous (AV) fistulas are very useful for determining optimal blood flow for dialysis, but AV fistulas exposed to overflow are thought to increase cardiac output and cause high-output cardiac failure [1, 2]. Measurement of blood flow via an internal shunt was first developed by Krivitski et al., and the monitoring of blood flow via a shunt has since become widespread [3]. We use this technique to monitor the blood flow of AV fistulas at our hospital and correct overflow AV fistulas with surgery. It is thought that the outflow vein of overflow AV fistulas bears a heavy load: as the vein is exposed to increased arterial flow, the wall dilates, triggering a vascular remodeling process. However, the molecular mechanisms by which the outflow vein is remodeled into a mature fistula remain unclear. By investigating venous remodeling in overflow AV fistulas, candidate genes important to the remodeling process can be discovered and their functional significance investigated. Thus, the identification of relevant genes involved in this process should provide insight into AV fistula maturation. In this study, we performed a cDNA microarray analysis and compared segments of the venous
Predicting Driver Behavior Using Field Experiment Data and Driving Simulator Experiment Data: Assessing Impact of Elimination of Stop Regulation at Railway Crossings
Toshihisa Sato,Motoyuki Akamatsu,Toru Shibata,Shingo Matsumoto,Naoki Hatakeyama,Kazunori Hayama
International Journal of Vehicular Technology , 2013, DOI: 10.1155/2013/912860
Abstract: We investigated the impact of deregulating the presence of stop signs at railway crossings on car driver behavior. We estimated the probability that a driver would stop inside the crossing, thereby obstructing the tracks, when a lead vehicle suddenly stopped after the crossing and a stop regulation was eliminated. We proposed a new assessment method of the driving behavior as follows: first, collecting driving behavior data in a driving simulator and in a real road environment; then, predicting the probability based on the collected data. In the simulator experiment, we measured the distances between a lead vehicle and the driver’s vehicle and the driver’s response time to the deceleration of the leading vehicle when entering the railway crossing. We investigated the influence of the presence of two leading vehicles on the driver’s vehicle movements. The deceleration data were recorded in the field experiments. Slower driving speed led to a higher probability of stopping inside the railway crossing. The probability was higher when the vehicle in front of the leading vehicle did not slow down than when both the lead vehicle and the vehicle in front of it slowed down. Finally, advantages of our new assessment method were discussed. 1. Introduction Driving simulators have been used to evaluate driver behaviors and the influences of advanced driver assistance systems on the driving behaviors. The simulators are an essential tool in automotive human factors research. Advantages of using the driving simulator are a safety (no traffic accidents during the driving experiments), an easy collection of the driver behavior data, and a precise reproduction of road traffic environments within and between the drivers. The driving simulator has contributed to collecting driving behavior data under situations with potential risks for a traffic accident (e.g., situations where pedestrians or bicycles suddenly rush out in front of the driver’s vehicle). The data collection and an assessment of the driver behavior when avoiding the incidents have led to developing advanced driver assistance systems and warning systems for reducing these accidents. However, the experiments under the risky conditions using the simulators have mainly two disadvantages: (1) a driving simulator cannot fully reproduce the driver behavior on a real road, and (2) once a driver experiences a target situation, he/she becomes cautious about similar situations and the behavior data under the same target situation and/or the other risky situations with different traffic conditions will never be
Surgical Treatment of a Giant Liposarcoma in a Japanese Man
Yasuhiro Hashimoto,Shingo Hatakeyama,Tokushi Tachiwada,Takahiro Yoneyama,Takuya Koie,Noritaka Kamimura,Takeshi Yanagisawa,Kenichi Hakamada,Chikara Ohyama
Advances in Urology , 2010, DOI: 10.1155/2010/943073
Abstract: We report a case of a rapidly progressing giant retroperitoneal liposarcoma weighing 22?kg in a 41-year-old Japanese man, successfully treated with surgical excision. To our knowledge, this is the largest liposarcoma in the Japanese population reported in the literature. 1. Introduction Liposarcoma is a common soft tissue sarcoma which occurs in adults [1, 2]. Its common sites of occurrence are the extremities, retroperitoneum, and inguinal region [3]. Although liposarcomas can often grow into large tumors, resected tumors weighing over 20?kg are extremely rare and considered to be “giant liposarcomas.” Here, we report our experience of a giant retroperitoneal liposarcoma, presumably the largest reported from Japan; it weighed 22?kg and caused abdominal swelling, marked leg edema, and cough due to the pressure it exerted on the patient’s diaphragm. 2. Case Presentation A 41-year-old Japanese man became aware of abdominal swelling in December 2008 but did not seek a medical opinion until he developed marked leg edema, a 30?kg weight gain, and cough. He was hospitalized the same day after a retroperitoneal tumor was detected by computed tomography (CT). After hospitalization, the patient was diagnosed with a liposarcoma by CT-guided needle biopsy. The patient was emergently transferred to our hospital due to worsening respiratory status. On admission his body surface area was 2.18?m2. A CT scan detected a 43 × 37 × 31?cm tumor in the right retroperitoneum, with the right kidney significantly displaced to the left and anterior side (Figure 1). Whole-body CT scan detected no metastasis. His condition was diagnosed as respiratory failure due to elevation of the diaphragm as a consequence of the rapid growth of the tumor (Figure 2). Figure 1: Computerized tomography detected a 43 × 37 × 31-cm tumor in the right retroperitoneum, and the right kidney was deflected greatly to the left ventral side (white arrow). Figure 2: Chest X-ray showed that elevation of the diaphragm due to rapid growth of retroperitoneal tumor and cardiac enlargement. We concluded that surgical resection was the only option for saving the patient’s life, so we performed a tumorectomy 3 weeks later through a midline incision. The operation took 3 hours and 20 minutes, and the estimated blood loss was 3990?mL requiring 800?mL blood transfusion. During surgery, the tumor and right kidney were completely resected. Pathological examination showed that the resected mass weighed 22?kg and was 45 × 40 × 30?cm in size (Figure 3). Grossly, the tumor was well encapsulated and transverse sectioning
Clearance and Safety of the Radiocontrast Medium Iopamidol in Peritoneal Dialysis Patients
Shingo Hatakeyama,Akihiko Abe,Takehiro Suzuki,Yasuhiro Hashimoto,Takuya Koie,Tomihisa Funyu,Shigeru Satoh,Tomonori Habuchi,Chikara Ohyama,Shigeki Matsuo
International Journal of Nephrology , 2011, DOI: 10.4061/2011/657051
Abstract: Although the characteristics and safety of radiocontrast media in peritoneal dialysis (PD) patients are not yet well defined, their use in PD patients is considered generally safe. In this study, we evaluated clearance and adverse events of iopamidol in PD patients. We measured the iopamidol concentration in the plasma, dialysate, and urine of 11 patients. Iopamidol clearance from patient plasma was delayed with a half-life of 33.3?h, and the elimination ratio was 83.6% for 96?h. We retrospectively investigated adverse events occurring in a total of 50 stable PD patients who underwent a total of 64 angiographic computed tomography (CT) scans. In 64 angiographic CT scans, two cases of adverse events were observed. Our results suggest that iopamidol can be eliminated by regular PD and careful observation for adverse events are necessary for the safe use of radiocontrast media. 1. Introduction With the increased incidence of chronic renal failure, radiocontrast studies are important for diagnosis and treatment. Therefore, the use of iodinated radiocontrast media in computed tomography (CT) and angiography is often required in these patients [1–3]. The European Society for Urogenital Radiology guidelines, which were published in 1999, did not recommend hemodialysis (HD) after the use of iodinated radiocontrast media in continuous ambulatory peritoneal dialysis (CAPD) patients [4–6]. However, a few studies have addressed the peritoneal clearance and safety of iodinated radiocontrast media in CAPD patients [7–9]. Peritoneal dialysis (PD) is effective for removing iodinated radiocontrast media from the body, but it takes longer time than HD. The accumulation or delayed elimination of iodinated radiocontrast media may cause adverse events in chronic dialysis patients with anuria or cardiovascular dysfunction. Several reports have demonstrated acute adverse events such as heat sensations, acute urticaria, and iododerma, and delayed reactions such as vasculitis, skin disorders, submandibular swelling, and sialoadenitis even with the use of low osmolar nonionic contrast media [2, 7, 10–13]. However, not much is known about the adverse events caused by delayed elimination. In this study, we evaluated the clearance of iopamidol, a low osmolar nonionic iodinated radiocontrast media, and the incidence of adverse events associated with its use in CAPD patients. 2. Subjects and Methods Between 2002 and 2009, 50 patients who had undergone a total of 64 angiographic CT scans while receiving CAPD at the Akita City Hospital and the Oyokyo Kidney Research Institute were
Relevance in Real-Time Interpretation of Utterances  [PDF]
Shingo Tokimoto
Open Journal of Modern Linguistics (OJML) , 2015, DOI: 10.4236/ojml.2015.56044
Abstract: This article proposes a new evaluation of relevance in the context of relevance theory (RT). Although RT has made substantial contributions to communication science, there are few studies that employ an experimental setting to examine RT in the real-time interpretation of utterances because the evaluation of relevance has remained inadequate for experimental examination. In the original RT, relevance is evaluated based on cognitive effects and processing costs, which are mutually dependent—although conceptually distinct—in the real-time interpretation of utterances. In fact, the mutual dependence of cognitive effects and processing costs is the primary reason why RT is difficult to investigate experimentally. This article proposes cognitive effects as a sigmoid function of processing costs and relevance as the ratio of cognitive effects to the processing costs required. This new evaluation of relevance is shown to have favorable theoretical consequences regarding both the convergence of the computation of utterance interpretation and the disambiguation of potentially ambiguous utterances. Furthermore, this new evaluation of relevance enhances the possibilities of examining RT experimentally.
Why Island Constraint Is Weaker in Japanese than in English: A Processing Perspective  [PDF]
Shingo Tokimoto
Open Journal of Modern Linguistics (OJML) , 2019, DOI: 10.4236/ojml.2019.92012
Abstract: The constraints on discontinuous dependency in a sentence have been discussed as “island constraint”. Island phenomenon can be observed in many languages; however, while the island effect is quite noticeable in English, it seems obscure in Japanese. This study thus experimentally evaluates the strength of island effect in Japanese complex sentences quantitatively and demonstrates that the island effect in Japanese is weaker than that in English. Furthermore, we attempt to attribute the difference in the strength of the island effect in these two languages to their processing characteristics; that is, the syntactic relationship between two discontinuous elements in English must be computed at the head of an island, with one of the two elements unreceived, while the syntactic computation at the head of an island in Japanese is performed with both elements received. We assume that the processing of discontinuous dependency is thus more costly in English than in Japanese, and that the strong island effect in English reflects the relative difficulty of the syntactic computation. We obtained evidence for our hypothesis from an experiment asking participants to make grammatical judgments on Japanese sentences in which we manipulated their word-order in three ways. We suggest that part of the apparent syntactic phenomenon can be attributed to processing factors.
A Case of Malignant Pheochromocytoma Detected during Fertility Treatment
Kazuhisa Hagiwara,Itsuto Hamano,Ayumu Kusaka,Hiromi Murasawa,Noriko Tokui,Kengo Imanishi,Akiko Okamoto,Hayato Yamamoto,Atsushi Imai,Shingo Hatakeyama,Takahiro Yoneyama,Yasuhiro Hashimoto,Takuya Koie,Chikara Ohyama
Case Reports in Urology , 2014, DOI: 10.1155/2014/646743
Abstract: We report a case of malignant pheochromocytoma in a 35-year-old Japanese woman during fertility treatment, successfully treated with surgical excision. The patient recovered without any postoperative problems, and plasma catecholamine levels normalized. At present, 18 months after the operation, there are no signs of relapse. 1. Introduction Although the incidence of malignant tumors during fertility treatment with ovulation-inducing drugs has been described in several reports, many authors state that in the short-term, ovulation-induction treatment may not be a risk factor for ovarian cancer. Herein we describe a case of malignant pheochromocytoma detected during fertility treatment. 2. Case Report We evaluated a 35-year-old woman with no medical or family history of endocrine disease. She underwent surgical removal of the benign breast tumor at the age of 22 and underwent a surgical procedure for a uterine myoma at the age of 32. She started visiting the Department of Obstetrics and Gynecology at our hospital for fertility treatment in 2009 (31 years of age). In January 2012, a tumor of 10?cm diameter was identified on the inferior side of the right hepatic lobe via abdominal ultrasound screening. Malignant pheochromocytoma was diagnosed using imaging (CT, MRI) and endocrine testing, and consequently the patient was referred to our department for a surgical procedure. The subjective symptoms were as follows: no headache, no pallor of the face, no palpitations, and a sudden rise in temperature. There was no hypertension. The patients’ characteristics recorded at the time of hospital admission were as follows: height 149.8?cm, weight 57.6?kg, BMI 25.7, blood pressure 110/65, heart rate 75?bpm, and body temperature 36.4°C. The abdominal tumor was not palpable. Biochemical examination of blood showed fractionated plasma catecholamine levels as follows: adrenaline <5?ng/mL (0–100), noradrenaline 809?ng/mL (100–450), and dopamine 8?ng/mL (0–20); thus, only the noradrenaline level was elevated. Fractionated urinary catecholamines were as follows: adrenaline 10?μg/day (1.5–4.3), noradrenaline 568?μg/day (3.4–26.9), and dopamine 685?μg/day (365–961); only the noradrenaline level was elevated. Diagnostic imaging by means of abdominal CT revealed a tumor 11 × 10?cm in size on the inferior side of the liver, which displaced the right kidney (Figure 1). Swelling was also observed in the lymph nodes around the inferior vena cava. MRI revealed an adrenal tumor exhibiting low signal intensity on T1-weighted imaging and high signal intensity on T2-weighted imaging. At
High Et Jet Production
Kenichi Hatakeyama
Physics , 2009,
Abstract: A review is presented on studies of high $E_T$ jet production and production of photon, $W$ and $Z$ associated with jets from the HERA and Tevatron experiments. Such studies have been used to examine the Standard Model (SM) in the area of the strong interaction, Quantum Chromodynamics, at highest energies currently attainable in collider experiments, to extract values of the coupling of the strong interaction, to determine the parton distribution functions in the proton, and to provide constraints on SM processes that constitute background to the Higgs boson and new physics searches. Some of them are also directly sensitive to the presence of physics beyond the SM. Future prospects for results from the LHC experiments are discussed.
Velocity-selective sublevel resonance of atoms with an array of current-carrying wires
Atsushi Hatakeyama
Physics , 2008, DOI: 10.1007/s00340-008-3102-7
Abstract: Resonance transitions between the Zeeman sublevels of optically-polarized Rb atoms traveling through a spatially periodic magnetic field are investigated in a radio-frequency (rf) range of sub-MHz. The atomic motion induces the resonance when the Zeeman splitting is equal to the frequency at which the moving atoms feel the magnetic field oscillating. Additional temporal oscillation of the spatially periodic field splits a motion-induced resonance peak into two by an amount of this oscillation frequency. At higher oscillation frequencies, it is more suitable to consider that the resonance is mainly driven by the temporal field oscillation, with its velocity-dependence or Doppler shift caused by the atomic motion through the periodic field. A theoretical description of motion-induced resonance is also given, with emphasis on the translational energy change associated with the internal transition.
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