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Design and evaluation of transdermal drug delivery system of gliclazide
Shinde Anilkumar,Shinde Amit,More Harinath
Asian Journal of Pharmaceutics , 2010,
Abstract: Transdermal systems are ideally suited for diseases that demand chronic treatment. Hence, an anti-diabetic agent of both therapeutic and prophylactic usage has been subjected to transdermal investigation. Gliclazide, a second-generation hypoglycemic agent, faces problems like its poor solubility, poor oral bioavailability with large individual variation and extensive metabolism. In the present work, transdermal matrix-type patches were prepared by film casting techniques on mercury using polymers like HPMC, Eudragit RL-100, and chitosan. Also an attempt was made to increase the permeation rate of drug by preparing an inclusion complex with hydroxypropyl β-cyclodextrin (HP β-CD). The possibility of a synergistic effect of chemical penetration enhancers (CPE) (propylene glycol and oleic acid) on the transdermal transport of the drug was also studied. Folding endurance was found to be high in patches containing higher amount of the Eudragit. There was increase in tensile strength with an increase in Eudragit in the polymer blend. In vitro drug release profile indicates that the drug release is sustained with increasing the amount of Eudragit in patches. The patches containing inclusion complex of drug showed higher permeation flux compared with patches containing plain drug. The result of the synergistic effect indicates that the HP β- CD in conjunction with other CPE showed a higher permeation flux.
Post-operative pain relief in children following caudal bupivacaine and buprenorphine--a comparative study.
Anilkumar T,Karpurkar S,Shinde V
Journal of Postgraduate Medicine , 1994,
Abstract: Eighty-five paediatric patients (age range: 6 mths-12yrs) undergoing lower abdominal surgery were studied for post-operative pain relief following either caudal bupivacaine (GpI: n = 43) or buprenorphine (GpII: n = 42). Bupivacaine was administered as 0.5ml/kg body weight of 0.25% solution and buprenorphine as 4 micrograms/ml and volume of 0.5 ml/Kg body weight in normal saline. Post-operatively pain was graded on a 4-point scale and behaviour on a 5-point scale. Any post-operative complications and need for additional analgesia were also noted. Bupivacaine provided good pain relief in the early post-operative hours but buprenorphine provided pain relief lasting for 24 hrs or more post-operatively. Post-operative behaviour of 10 patients receiving buprenorphine was graded as cheerful as compared to 2 from bupivacaine group. Till the end of observation period (i.e. 8 hr post-operatively), majority of patients receiving buprenorphine remained cheerful.
Gastroretentive Drug Delivery System : An Overview
Mr. Shinde Anilkumar J,Dr. More Harinath N.
Pharmaceutical Reviews , 2008,
Abstract: Several approaches have been proposed to retain the dosage forms in the stomach. These methods include bioadhesive system, swelling system and expanding system and floating system.In fact the buoyant dosage unit enhances gastric residence time( GRT) without affecting the intrinsic rate of emptying. Unfortunately floating devices administered in a single unit form ( Hydrodynamically balanced system) HBS are unreliable in prolonging the GRT owing to their ‘ all- or- nothing’ emptying process and, thus they may causes high variability in bioavailibity and local irritation due to large amount of drug delivered at a particular site of the gastrointestinal tract.
DEVELOPMENT AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF LOVASTATIN AS A ANTILIPIDEMIC DRUG
Shinde Anilkumar J,Paithane Manoj B,More Harinath N
International Research Journal of Pharmacy , 2010,
Abstract: In present work was designed to develop suitable transdermal matrix patches of Lovastatin (LS), using hydroxy propyl methyl cellulose (HPMC) and Eudragit RL 100 with Triethyl citrate as a plasticizer. A 32 full factorial design was employed, the amount of HPMC( X1) and Eudragit RL- 100( X2), was used as independent variables. The folding endurance, tensile strength, moisture content, moisture uptake and diffusion of drug were selected as dependent variables. The Casting solvent technique was employed for the preparation of HPMC, ERL-100 film. The dry films were evaluated for Physical appearance, thickness uniformity, moisture content, moisture uptake, tensile strength, flatness and folding endurance. In vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 μ) in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at λ max 254 nm. The experimental results shows that the patch containing HPMC in higher proportion gives increase in the release of drug. It indicates that as the concentration of X2 (Eudragit RL 100) increase, the drug release from the matrix was decrease. The present study has demonstrated the potential of the fabricated matrix film for prolonged release of Lovastatin.
DEVELOPMENT AND IN VITRO EVALUATION OF CHITOSAN GEL FOR WOUND HEALING ACTIVITY
Shinde Anilkumar J.,Khade Kishorkumar M,Kadam Atul R.,More Harinath N
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study aims to evaluate the wound healing activity of gel containing chitosan in rats. Chitosan is reported for wound healing activity, four optimized gel formulations were prepared, out of that CG-4 showed promising physical properties like colour, pH, consistancy, spreadability, extrudability as that of marketed wound healing cream formulations. Topical application of the test formulation CG-4 gel formulation was used for treatment group, which has showed significant wound healing activity in excision wound model. Percentage wound closure, period of complete epithelisation and scar size reduction on complete epithelisation showed P value<0.001 as comparable to marketed formulation (1%w/w). Dead space wound studies also showed significant increase in Hydroxyproline content indicating promotion of collagen formation and ultimately wound healing activity. The present study thus offers a valuable insight into the claimed wound healing potential of the test formulation.
Decreased Expression of Sprouty2 in the Dorsolateral Prefrontal Cortex in Schizophrenia and Bipolar Disorder: A Correlation with BDNF Expression
Anilkumar Pillai
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001784
Abstract: Background Current theories on the pathophysiology of schizophrenia suggest altered brain plasticity such as decreased neural proliferation and migration, delayed myelination, and abnormal synaptic modeling, in the brain of subjects with schizophrenia. Though functional alterations in BDNF, which plays important role in neuroplasticity, are implicated in many abnormalities found in schizophrenia, the regulatory mechanism(s) involved in the abnormal signaling of BDNF in schizophrenia is not clear. The present study investigated whether Sprouty2, a regulator of growth factor signaling, is abnormally expressed in schizophrenia, and is associated with the changes in BDNF mRNA in this disorder. The potential effect of antipsychotic drugs on Sprouty2 expression was tested in adult rats. Methods and Findings Sprouty2 and BDNF gene expression were analyzed in dorsolateral prefrontal cortex samples from the Stanley Array Collection. Quantitative real-time PCR analysis of RNA in 100 individuals (35 with schizophrenia, 31 with bipolar disorder, and 34 psychiatrically normal controls) showed significantly decreased expression of Sprouty2 and BDNF in both schizophrenia and bipolar disorder. Moreover, a significant correlation between these two genes existed in control, schizophrenia and bipolar subjects. Long-term treatment with antipsychotic drugs, haloperidol and olanzapine, showed differential effects on both Sprouty2 and BDNF mRNA and protein levels in the frontal cortex of rats. Conclusion These findings demonstrating decreased expression of Sprouty2 associated with changes in BDNF, suggest the possibility that these decreases are secondary to treatment rather than to factors that are significant in the disease process of either schizophrenia and/or bipolar disorder. Further exploration of Sprouty2-related signal transduction pathways may be helpful to design novel treatment strategies for these disorders.
ASCORBATE EFFECT ON PROTEIN CONTENT DURING NICKEL INTOXICATION IN THE FRESHWATER BIVALVE, LAMELLIDENS CORRIANUS
Pardeshi Anilkumar
Bioscience Discovery , 2012,
Abstract: The effect of L-ascorbic acid on protein content during nickel intoxication of the freshwater bivalve, Lamellidens corrianus has been studied. These bivalves were exposed to chronic (0.3981 ppm) dose of Nickel chloride with and without ascorbic acid. Protein content from gill, gonad, digestive gland, mantle, foot of control and experimental bivalves from different group were estimated after 15 days and 30 days. After 30 days Nickel chloride treated bivalves were allow to recover in normal water with and without ascorbic acid. During recovery protein content was estimated after 5 days and 10 days. Protein content was decreasedless in nickelwith ascorbic acid as compare to exposure to Nickel chloride without ascorbic acid. Bivalves show faster recovery with ascorbic acid as compare to normal water recovery.
Genetic Characteristics of Five Microsatellite Markers Associated with Milk Production Traits in Crossbred Dairy Cattle of Kerala
Naicy Thomas and Anilkumar,K
Veterinary World , 2008,
Abstract: Marker Assisted Selection (MAS), which is the process of using the results of DNA testing to assist in the selection of individuals to become parents of the next generation by combining the genotypes and the expected progeny differences of the bulls. In the present study, all the five markers were highly informative. The highest PIC value was obtained for the microsatellite marker ILSTS096 (0.865), followed by BL41 (0.849), BM4305 (0.846), HUJII77 (0.842) and BM1508 (0.630). The highest direct count heterozygosity was observed for the microsatellite marker ILSTS096 (0.877), followed by BL41 (0.862), BM4305 (0.861), HUJII77 (0.851) and BM1508 (0.683). The highest unbiased heterozygosity of 0.880 was observed for the microsatellite marker ILSTS096, followed by BL41 (0.865), BM4305 (0.864), HUJII77 (0.854) and BM1508 (0.686). [Veterinary World 2008; 1(8.000): 245-247]
Evaluation of Ten Sire Families of Crossbred Dairy Cattle of Kerala Based on Milk Production and Milk Composition Traits
Naicy Thomas and Anilkumar,K.
Veterinary World , 2009,
Abstract: Data on production performance of 200 animals maintained at University Livestock Farm, Kerala Agricultural University, Mannuthy and Cattle Breeding Farm, Thumburmuzhi were used for the study. Among the eight economically important traits [305 day milk yield, fat percentage, protein percentage, SNF(Solids not fat), total solids, peak yield, days to attain peak yield and AFC(Age at first calving)], milk fat percentage and AFC had significant difference among the families. The families of Deva, Bull No.250 and Hakkim showed significantly lower milk fat percentage compared to the other seven families. The AFC of the families of Dipesh, Onkar and Gopal was significantly higher from the other seven sire families. [Vet. World 2009; 2(1.000): 10-12]
Simultaneous HPLC estimation of omeprazole and domperidone from tablets
Sivasubramanian Lakshmi,Anilkumar V
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: The present work describes a simple reverse phase HPLC method for the determination of omeprazole and domperidone from tablet formulations. The determination was carried out on a Hypersil, ODS, C-18 (150x4.6 mm, 5 micron) column using a mobile phase of methanol:0.1 M ammonium acetate (pH 4.9) (60:40). The flow rate and runtime were 1 ml/min and 10 min, respectively. The eluent was monitored at 280 nm. The method was reproducible, with good resolution between omeprazole and domperidone. The detector response was found to be linear in the concentration range of 10-60 μg/ml for omeprazole and 5-30 μg/ml for domperidone.
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