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Design and evaluation of transdermal drug delivery system of gliclazide
Shinde Anilkumar,Shinde Amit,More Harinath
Asian Journal of Pharmaceutics , 2010,
Abstract: Transdermal systems are ideally suited for diseases that demand chronic treatment. Hence, an anti-diabetic agent of both therapeutic and prophylactic usage has been subjected to transdermal investigation. Gliclazide, a second-generation hypoglycemic agent, faces problems like its poor solubility, poor oral bioavailability with large individual variation and extensive metabolism. In the present work, transdermal matrix-type patches were prepared by film casting techniques on mercury using polymers like HPMC, Eudragit RL-100, and chitosan. Also an attempt was made to increase the permeation rate of drug by preparing an inclusion complex with hydroxypropyl β-cyclodextrin (HP β-CD). The possibility of a synergistic effect of chemical penetration enhancers (CPE) (propylene glycol and oleic acid) on the transdermal transport of the drug was also studied. Folding endurance was found to be high in patches containing higher amount of the Eudragit. There was increase in tensile strength with an increase in Eudragit in the polymer blend. In vitro drug release profile indicates that the drug release is sustained with increasing the amount of Eudragit in patches. The patches containing inclusion complex of drug showed higher permeation flux compared with patches containing plain drug. The result of the synergistic effect indicates that the HP β- CD in conjunction with other CPE showed a higher permeation flux.
Phytochemical Composition and Antioxidant Potential of Ruta graveolens L. In Vitro Culture Lines
Renuka Diwan,Amit Shinde,Nutan Malpathak
Journal of Botany , 2012, DOI: 10.1155/2012/685427
Abstract: Ruta graveolens L. is a medicinal plant used in traditional systems of medicine for treatment of psoriasis, vitiligo, leucoderma, and lymphomas with well-known anti-inflammatory and anticancer properties. Therefore antioxidant potential of R. graveolens (in planta and in vitro) was investigated. As antioxidants present in plant extracts are multifunctional, their activity and mechanism depends on the composition and conditions of the test system. Therefore, the total antioxidant capacity was evaluated using assays that detect different antioxidants: free radical scavenging (DPPH and ABTS), transition metal ion reduction (phosphomolybdenum assay), reducing power, and nitric oxide reduction. Content of furanocoumarin-bergapten in the extracts showed good corelation with free radical scavenging, transition metal reduction and reducing power, while total phenolic content showed good corelation with nitric oxide reduction potential. Antioxidant activity of in vitro cultures was significantly higher compared to in vivo plant material. The present study is the first report on comprehensive study of antioxidant activity of R. graveolens and its in vitro cultures. 1. Introduction Free radicals, together with secondarily formed radicals, are known to play an important role in the pathogenesis of many chronic conditions like atherosclerosis, arthritis, diabetes, ischemia, reperfusion injuries, central nervous system injury, and cancer [1, 2]. Hence, the study of antioxidant status during a free radical challenge can be used as an index of protection against the development of these degenerative processes in experimental condition for therapeutic measures. Ruta graveolens is used in homeopathic, ayurvedic, and unani preparations [3] because this herb is so efficacious in various diseases (Ruta derived from Greek “reuo” means to set free). It has been extensively used in treatment of leucoderma, vitiligo, psoriasis, multiple sclerosis, cutaneous lymphomas, rheumatic arthritis and recently reported to possess anti-inflammatory and anticancer activity [4, 5]. Antioxidants in plants are affected by area, climatic conditions, and pest attack [6, 7]; therefore in vitro cultures are being investigated as alternate source of natural antioxidants [8]. For estimation of total antioxidant potential many authors have stressed the need to perform more than one type of antioxidant activity measurement to take into account the various mechanisms of antioxidant action [9]. With this perspective the present study investigates the total antioxidant activity evaluated using DPPH,
UNUSAUAL PRESENTATION OF SUBMANDIBULAR DUCT AND GLAND CALCUI: CASE REPORT
KIRAN J SHINDE,SACHIN SHARMA,AMIT KUMAR SINGH
Otolaryngology Online Journal , 2013,
Abstract: Sialolithiasis is one of the most common pathologies of the submandibular gland; sialoliths account for about 80 percent of all salivary duct calculi.The majority of sialolith occurs in the submandibular gland or its duct and is common cause of acute and chronic infection. Salivary stones larger than 15 mm are classified as giant sialoliths. They are uncommon in the practice of otolaryngology, and their management has always been a therapeutic challenge. This report presents the two unusual and rare cases of large sialolith of the submandibular duct as well as gland measuring 70x11mm and 54x25mm respectively.
Induced High Frequency Shoot Regeneration and Enhanced Isoflavones Production in Psoralea corylifolia
Amit N. Shinde,Nutan Malpathak,Devanand P. Fulzele
Records of Natural Products , 2009,
Abstract: High frequency shoot regeneration and evaluation of product synthesis at various stages in Psoralea corylifolia were investigated. In vitro regenerated shoots were induced from germinated seedling on MS medium supplemented with 2, 4, 8, 20 and 40 μM of thidiazuron and N 6–benzylaminopurine. The results revealed that optimum concentrations of thidiazuron (8 μM) into the medium increased shoot regeneration frequency. Root differentiation was achieved from regenerated shoots on growth regulator free MS medium with frequency of 91.2% and mean number of 4.5 roots per shoot. High concentrations of Indole-3-aceticacid (IAA) into the rooting medium resulted in slow growth. Regenerated shoots and roots enhanced isoflavones production compared to field grown plants. A reverse phase high performance liquid chromatography analysis revealed that in vitro regenerated shoots accumulated 0.85% dry wt of daidzein and 0.06% dry wt of genistein. Maximum daidzein (1.23% dry wt) and genistein (0.38% dry wt) were accumulated by roots which obtained from regenerated shoots, which is 6.3-fold more daidzein and 77-fold more genistein respectively than field grown plants. The regeneration protocol developed successfully in this study showed the possibility for rapid propagation of P. corylifolia and enhanced isoflavones production.
ATTITUDE TOWARDS CHEATING AMONG STUDENTS OF PROFESSIONALAND NON PROFESSIONAL COURSES
SHRAWAN SHINDE
Indian Streams Research Journal , 2012,
Abstract: A study was done to compare the attitude towards cheating of the professional and nonprofessional course students. In this study the sample consisted of 20 professional and 20 nonprofessional course students, studying in DEI and University. For the measurement of Attitude towards Cheating, Attitude towards cheating scale by Sharma was administered on the sample. It consists of 35 statements which are either positive or negative. Responses were to be obtained on five point scale. t-test was used for statistical analysis. The finding of this study showed that the students of professional courses have more positive attitude towards cheating as compared to the students of nonprofessional course. The value of t=16.59** was found to be statistically significant at .01 level between the two group of subjects.
Evaluation of floating press-coated pulsatile release of Aceclofenac tablets. A solution for Rheumatoid athritis
PV Shinde
Asian Journal of Biomedical and Pharmaceutical Sciences , 2013,
Abstract: The objective of this study was to develop and evaluate of a floating press-coated pulsatile drug delivery system intended for treatment of early morning stiffness and symptomatic relief from pain in patients with rheumatoid arthritis with a distinct predetermined lag time of 8 h. Cores containing Aceclofenac as model drug were prepared by direct compression of different Sodium starch glycolate level CT-1 to CT-4) 8 %, 4%, 2% & without disinegrant and Aceclofenac as a model drug by using various proportion of polymers such Hydroxypropyl methylcellulose and Sodium bicarbonate floating layer is prepared. Fifteen formulations were prepared and formulation F15, F18, F22possessed good lag time 8 hr and showed pulsatile drug delivery pattern the tablets In- vitro evaluation tests. Results of this study indicated that by using floating-pulsatile release formulations are suitable to optimize pulsatile drug release formulation of Aceclofenac.
Development of pulsatile release of Aceclofenac tablets with swelling and rupturable layers of ethyl cellulose
Shinde PV.
Asian Journal of Biomedical and Pharmaceutical Sciences , 2013,
Abstract: The objective of this study was to develop and evaluate of Aceclofenactablets with swelling and rupturable layers of ethyl cellulose. A tablet systemconsisting Intended for treatment of early morning stiffness and symptomaticrelief from pain in patients with rheumatoid arthritis with a distinctpredetermined lag time of 6 h. Cores containing Aceclofenac as model drugwere prepared by direct compression of different Sodium starch glycolatelevel CT-1 to CT-4) 8 %, 4%, 2% & without disinegrant and were then coatedsequentially with an inner swelling layer containing a superdisintegrant(croscarmellose sodium) and an outer rupturable layer of ethylcellulose.Seven formulations were prepared and formulation F2 possessed good lagtime 6 hr and showed pulsatile drug delivery pattern the tablets In- vitroevaluation tests. Results of this study indicated that by using ethyl celluloseare suitable to optimize pulsatile drug release formulation of Aceclofenac
A Design of Paraunitary Polyphase Matrices of Rational Filter Banks Based on (P,Q) Shift-Invariant Systems
Sudarshan Shinde
Mathematics , 2010,
Abstract: In this paper we present a method to design paraunitary polyphase matrices of critically sampled rational filter banks. The method is based on (P,Q) shift-invariant systems, and so any kind of rational splitting of the frequency spectrum can be achieved using this method. Ideal (P,Q) shift-invariant system with smallest P and Q that map of a band of input spectrum to the output spectrum are obtained. A new set of filters is obtained that characterize a (P,Q) shift-invariant system. Ideal frequency spectrum of these filters are obtained using ideal $(P,Q)$ shift-invariant systems. Actual paraunitary polyphase matrices are then obtained by minimizing the stopband energies of these filters against the parameters of the paraunitary polyphase matrices.
Two channel paraunitary filter banks based on linear canonical transform
Sudarshan Shinde
Mathematics , 2009,
Abstract: In this paper a two channel paraunitary filter bank is proposed, which is based on linear canonical transform, instead of discrete Fourier transform. Input-output relation for such a filter bank are derived in terms of polyphase matrices and modulation matrices. It is shown that like conventional filter banks, the LCT based paraunitary filter banks need only one filter to be designed and rest of the filters can be obtained from it. It is also shown that LCT based paraunitary filter banks can be designed by using conventional power-symmetric filter design in Fourier domain.
Gnidia glauca flower extract mediated synthesis of gold nanoparticles and evaluation of its chemocatalytic potential
Sougata Ghosh, Sumersing Patil, Mehul Ahire, Rohini Kitture, Deepanjali D Gurav, Amit M Jabgunde, Sangeeta Kale, Karishma Pardesi, Vaishali Shinde, Jayesh Bellare, Dilip D Dhavale, Balu A Chopade
Journal of Nanobiotechnology , 2012, DOI: 10.1186/1477-3155-10-17
Abstract: Synthesis of AuNPs using GGFE was monitored by UV-Vis spectroscopy and was found to be rapid that completed within 20?min. The concentration of chloroauric acid and temperature was optimized to be 0.7?mM and 50°C respectively. Bioreduced nanoparticles varied in morphology from nanotriangles to nanohexagons majority being spherical. AuNPs were characterized employing transmission electron microscopy, high resolution transmission electron microscopy. Confirmation of elemental gold was carried out by elemental mapping in scanning transmission electron microscopic mode, energy dispersive spectroscopy and X-ray diffraction studies. Spherical particles of size ~10?nm were found in majority. However, particles of larger dimensions were in range between 50-150?nm. The bioreduced AuNPs exhibited remarkable catalytic properties in a reduction reaction of 4-nitrophenol to 4-aminophenol by NaBH4 in aqueous phase.The elaborate experimental evidences support that GGFE can provide an environmentally benign rapid route for synthesis of AuNPs that can be applied for various purposes. Biogenic AuNPs synthesized using GGFE exhibited excellent chemocatalytic potential.
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