Gene Expression Profiling of Human c-Kit Mutant D816V
Journal of Cancer Therapy (JCT)
(PIK3CB, eIF4B, PRKCDBP,
MOAP1) were validated by quantitative polymerase chain reaction. SLA, STAT5B,
MAP3K2 and MAPK14 emerged as important downstream molecular targets of mutant D816V-c-Kit.
Further, by dissecting the signaling pathways, we also demonstrated that the D816V-c-Kit
mediated hematopoietic cell proliferation is dependent on molecular target p38 MAP