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Poly Trauma in Rural India-Changing Trends
Goyal S,Sancheti K,Shete Kiran
Indian Journal of Orthopaedics , 2006,
Abstract: Background : Poly trauma is a major killer. Team work is essential for better management. Method : Survey was undertaken to collect baseline data in polytrauma patient. Result : Two thousand patients were studied. Cause was fall in 904, vehicular accident in 776 and assault in 320 patients. Conclusion : There should be good prehospital emergency service and quick transport to equipped hospital.
Chitosan and chitosan chlorhydrate based various approaches for enhancement of dissolution rate of carvedilol
Amol S Shete, Adhikrao V Yadav, Srinivasa M Murthy
DARU Journal of Pharmaceutical Sciences , 2012, DOI: 10.1186/2008-2231-20-93
Abstract: The different formulations were prepared by different methods like solvent change approach to prepare hydrosols, solvent evaporation technique to form solid dispersions and cogrind mixtures. The prepared formulations were characterized in terms of saturation solubility, drug content, infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), electron microscopy, in vitro dissolution studies and stability studies.The practical yield in case of hydrosols was ranged from 59.76 to 92.32%. The drug content was found to uniform among the different batches of hydrosols, cogrind mixture and solid dispersions ranged from 98.24 to 99.89%. There was significant improvement in dissolution rate of carvedilol with chitosan chlorhdyrate as compare to chitosan and explanation to this behavior was found in the differences in the wetting, solubilities and swelling capacity of the chitosan and chitosan salts, chitosan chlorhydrate rapidly wet and dissolve upon its incorporation into the dissolution medium, whereas the chitosan base, less water soluble, would take more time to dissolve.This technique is scalable and valuable in manufacturing process in future for enhancement of dissolution of poorly water soluble drugs.The rate of absorption and bioavailability of poorly water soluble drugs is often controlled by the rate of dissolution of the drug in gastrointestinal tract. Many technological methods of enhancing the dissolution characteristics of slightly water soluble drugs have been reported in literature. These include reducing particle size to increase the surface area [1], solublization in surfactant system [2], formation of water soluble complexes [3], use of prodrug, drug derivatization and manipulation of solid state of drug substance to improve drug dissolution i.e. by decreasing drug crystallinity [4] or crystal engineering [5-7]. Chitosan is a linear polycationic copolymer of b [1-4] linked 2-acetamido-2-deoxy-b-D-glucopyranose
PYRAMIDALIMAGEBLENDINGUSING CUDAFRAMEWORK
PRITAM PRAKASH SHETE,VENKAT P. P. K.,S. K. BOSE
International Journal of Engineering Science and Technology , 2011,
Abstract: We propose and implement a pyramidal image blending algorithm using modern programmable graphic processing units. This algorithm is an essential part of an image stitching process for a seamless panoramicmosaic. The CUDA framework is a novel GPU programming framework from NVIDIA. We realize significant acceleration in computations of the pyramidal image blending algorithm by utilizing the CUDA as acomputational resource. Specifically we demonstrate the efficiency of our system by parallelization of the algorithm and optimization of the memory resources of the GPU. We compare the execution time of the CPU as well as various CUDA based implementations. Just parallelization of the algorithm by the CUDA framework provides 20 times speedup, whereas optimizing the GPU memory IO gives more than 30 times speedup.
Syringoma of the Vulva
Tawade Y,Pradhan A,Gharpuray M,Shete S
Indian Journal of Dermatology, Venereology and Leprology , 2000,
Abstract: A 12-year old girl presented with asymptomatic multiple skin-colored grouped papules on the vulva. Histopathology revealed features of syringoma.
Formulation design and optimization of taste-masked mouth-dissolving tablets of Tramadol hydrochloride
Patel K,Shete S,Belgamwar V,Tekade A
Asian Journal of Pharmaceutics , 2010,
Abstract: The aim of the present study was to mask the extremely bitter taste of Tramadol HCL, an opioid analgesic, and to formulate a tablet which can rapidly disintegrate in saliva (rapidly disintegrating tablet). The crucial aspect in the formulation of mouth-dissolving tablets is to mask the bitter taste and to minimize the disintegration time. Taste masking was done using sweetening agent and D-mannitol and taste-masked pellets were prepared by extrusion spheronization technique. Prepared pellets were tested for drug content, taste evaluation in oral cavity and molecular property. Pellet shows significant taste masking, confirmed by in vitro taste evaluation; therefore, it was selected for further study. Pellets were evaluated for density, angle of repose, Carr′s index, Hausner′s ratio and sphericity while tablets were evaluated for disintegration and in vitro dissolution. A 3 2 full factorial design and statistical models were applied to optimize the effect of two factors, i.e. superdisintegrant sodium starch glycolate and taste-masking agent (D-mannitol). In this study, response surface methodology was used for designing of the experiment, generation of mathematical models and optimization study. Taste evaluation of pellets in human volunteers revealed considerable taste masking with a degree of bitterness below threshold value (2.0) within 10 s, whereas Tramadol HCl was rated intensely bitter with a score of +4 for 10 s. The size of the pellets varied from 0.895 to 1.423 mm for different batch and found to be a spherical. Disintegration time of different formulations varied from 30 to 60 s. It was observed that the responses, i.e. disintegration time and sphericity were affected by both the factors. The statistical models were validated and can be successfully used to prepare optimized taste-masked mouth-dissolving tablets of Tramadol HCl with adequate disintegration and shape.
Formulation and Evaluation of Hydrotropic Solublization Based Suspensions of Griseofulvin
A. S. Shete,,A. V. Yadav,A.P. Dabke,S. S. Sakhare
International Journal of Pharma Sciences and Research , 2010,
Abstract: Purpose: Hydrotropes increases the solubility of organics in water. Objective of present investigation was to enhance the solubility of griseofulvin using the technique of hydrotropic solubilization technique and convert them into suitable oral liquid dosage form (suspension) useful for enhancement of bioavailability. Methods: 0.5M, 1M, 2M of the hydrotropes (tri sodium citrate, urea, sodium acetate, sodium benzoate and sodium salicylates) were used to study the saturation solubility. Solubility was found to be greater with sodium benzoate. Suspensions were prepared by using sodium benzoate solution, greseofulvin, xanthan gum, acacia, sodium alginate as a aqueous phase, dispersed phase and suspending agents respectively. Prepared suspensions were characterized for appearance of phases, density, particle size of dispersed Phase, pourability, sedimentationvolume and invitro drug release. Results: All formulations of sodium benzoate suspension were uniformly distributed, density in the range of 1.020 to 1.050gm/ml, particle size of the dispersed phase was 10μm to 20μm, suspensions were easily pourable from the bottle and sedimentation volume in the rage of 0.5-1. More than 70% drug release was obtained at the end of the 45 minutes. Conclusions: Hydrotropic solublization technique for preparation of suspensions of poor water soluble drugs will gave stability to the formulation and helps in enhancement of bioavailability of greseofulvin.
Probiotics In Pharmaceuticals
Vaishali V. Potnis,Dr. Suniti S. Gore,Mr. Milind M. Shete,Mr. Madhav A. Shetkar
Pharmaceutical Reviews , 2006,
Abstract: The ready availability of antibiotics in the 1950s resultedin their widespread use as therapeutic agents and growth stimulants for farmanimals. Since that time there has been growing concern that the use of antibioticsas growth promoters was resulting in the development of resistant populationsof bacteria, which made subsequent use of antibiotics for therapy difficult.Although they are effective in curing the disease for which they are prescribed,the effect on the indigenous gut flora may persist even after cessation ofthe treatment.The concern aboutundesired side effects of use of antibiotics as therapeutic agents produceda climate in which both consumer and manufacturer are looking for alternatives.Probiotics are being considered as effective alternative.
Solid Tumors: Facts, Challenges and Solutions
Gavhane Y. N.,Shete A. S,Bhagat A. K.,,Shinde V. R.
International Journal of Pharma Sciences and Research , 2011,
Abstract: In 2005, 7.6 million people died of cancer out of 58 million deaths worldwide. Based on projections, cancer deaths will continue to rise with an estimated 9 million people dying from cancer in 2015, and 11.4 million dying in 2030. The increasing trend of cancer incidence has forced the humanity to work more on the cancer prevention and treatments. It is important for the public health professionals to understand the dynamics and kinetics of tumor incidence for future strategies. Over here we have reviewed solid tumor modeling, their detail classification, treatment strategies available along with their merits and demerits. To overcome these limitations, design focus for future studies is suggested.
Optimization of Water Circulation Period for the Culture of Goldfish with Spinach in Aquaponic System
A. P. Shete,A. K. Verma,R. S. Tandel,Chandra Prakash
Journal of Agricultural Science , 2013, DOI: 10.5539/jas.v5n4p26
Abstract: Experiment with varied water circulation periods having 4, 8, 12, and 24 hrs/day as T1, T2, T3 and T4, respectively in aquaponics, evaluated against a control (without aquaponics) revealed higher fish and plant growth in T3 and T4. The mean growth of fish varied significantly among treatments showing higher growth in T4 and control followed by T3, T2 and T1. Survival rate was 100% in all the treatments as well as control. Percentage weight gain, SGR (% day-1) also showed the similar trend as that of growth showing T4 as better treatment immediately followed by T3 then T2 and T1. The system maintained favourable water quality throughout the experiment. The growth in T3 and T4 did not vary significantly and was higher than the T1, T2 and control. Also percentage length gain at the end of the trial was maximum in T3 and T4. The Chl (a+b) content in the control was higher than all the treatments whereas, T4 showed the maximum concentration among treatments followed by T3, T2 and then T1. Comparison of all the growth attributes and water quality parameters indicated that water circulation can be reduced to 12 hrs/day for economically effective aquaponics and can be considered as optimum water circulation period for goldfish production in aquaponic system.
Testing Hardy-Weinberg Proportions in a Frequency-Matched Case-Control Genetic Association Study
Jian Wang, Sanjay Shete
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027642
Abstract: In case-control genetic association studies, cases are subjects with the disease and controls are subjects without the disease. At the time of case-control data collection, information about secondary phenotypes is also collected. In addition to studies of primary diseases, there has been some interest in studying genetic variants associated with secondary phenotypes. In genetic association studies, the deviation from Hardy-Weinberg proportion (HWP) of each genetic marker is assessed as an initial quality check to identify questionable genotypes. Generally, HWP tests are performed based on the controls for the primary disease or secondary phenotype. However, when the disease or phenotype of interest is common, the controls do not represent the general population. Therefore, using only controls for testing HWP can result in a highly inflated type I error rate for the disease- and/or phenotype-associated variants. Recently, two approaches, the likelihood ratio test (LRT) approach and the mixture HWP (mHWP) exact test were proposed for testing HWP in samples from case-control studies. Here, we show that these two approaches result in inflated type I error rates and could lead to the removal from further analysis of potential causal genetic variants associated with the primary disease and/or secondary phenotype when the study of primary disease is frequency-matched on the secondary phenotype. Therefore, we proposed alternative approaches, which extend the LRT and mHWP approaches, for assessing HWP that account for frequency matching. The goal was to maintain more (possible causative) single-nucleotide polymorphisms in the sample for further analysis. Our simulation results showed that both extended approaches could control type I error probabilities. We also applied the proposed approaches to test HWP for SNPs from a genome-wide association study of lung cancer that was frequency-matched on smoking status and found that the proposed approaches can keep more genetic variants for association studies.
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