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Search Results: 1 - 10 of 13649 matches for " Shengjie Fan "
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Analysis of Decision Logic in Reporting Behavior from the Perspective of Internet  [PDF]
Shengjie Deng
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.74024
Abstract: The Internet, as one of the most important channels for citizens to obtain and publish information, has an increasing influence on citizens’ whistle-blowing decisions. An in-depth analysis of the impact of the Internet on potential reporters can not only clarify the mechanism of network information on individual decision-making, but also provide a better suggestion for improving China’s network supervision policy. [Method/Process] Based on cost-benefit analysis and Prospect Theory, this research analyzes the impact mechanism of Internet on the ethical judgment, utility evaluation and probability expectation of citizen reporting decision-making process. [Results/Conclusions] The impact of the Internet on reporting decisions mainly includes three stages: the potential whistleblower’s expectation of positive response to netizens strengthens their own cognition of social citizenship, thereby breaking the ethical barriers to loyalty judgments; the anonymous mechanism reduces the potential whistleblower’s estimate of the risk cost; and the rendering effect of online news increases the expectations of potential whistleblowers for the probability of reporting success.
Extract of Wax Gourd Peel Prevents High-Fat Diet-Induced Hyperlipidemia in C57BL/6 Mice via the Inhibition of the PPAR Pathway
Ming Gu,Shengjie Fan,Gaigai Liu,Lu Guo
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/342561
Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPAR and LXR Signaling in High-Fat Diet-Induced C57BL/6 Mouse
Xiaobo Ding,Shengjie Fan,Yan Lu,Yu Zhang
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/678592
Research and Design of UUV Navigation and Control Integrative Simulation System Based on Component  [PDF]
Shengjie Wang, Fengju Kang
Intelligent Information Management (IIM) , 2012, DOI: 10.4236/iim.2012.45027
Abstract: This paper uses the component-based technology and the object oriented simulation technology to analyze the UUV navigation and control integration simulation system. We divide the system into components based on its structure, and describe every component using active diagram. By using the component-based technology, the system described here is easier to extended and be reused. At last, it realizes the whole UUV integrated navigation simulation course using the system to validate the availability.
Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling
Yu Zhang,Shengjie Fan,Na Hu,Ming Gu,Chunxiao Chu,Yiming Li,Xiong Lu,Cheng Huang
PPAR Research , 2012, DOI: 10.1155/2012/374936
Abstract: Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine. However, the components of Rheum palmatum that play the antiobesity role are still uncertain. Here, we tested the weight-reducing effect of two major Rheum palmatum compounds on mouse. We found that rhein (100?mg kg?1?day?1), but not emodin, reduced the fat weight in mouse. Using diet-induced obese (DIO) C57BL/6 mice, we identified that rhein blocked high-fat diet-induced obesity, decreased fat mass and the size of white and brown adipocytes, and lowered serum cholesterol, LDL cholesterol, and fasting blood glucose levels in the mice. To elucidate the underlying mechanisms, we used reporter assay and gene expression analysis and found that rhein inhibited peroxisome proliferator-activated receptor γ (PPARγ) transactivity and the expression of its target genes, suggesting that rhein may act as a PPARγ antagonist. Our data indicate that rhein may be a promising choice for antiobesity therapy. 1. Introduction Obesity is one of the most serious public health problems of the 21st century [1, 2]. It increases the risk of various fetal diseases, particularly coronary artery disease, type II diabetes, hypertension, dyslipidemia, and certain types of cancer [3–5]. At present, there is only one drug, orlistat, approved by the Food and Drug Administration (FDA) for long-term use in the treatment of obesity. Thus, it is urgent to develop a new therapy for the prevention and treatment of obesity [5]. The development of novel antiobesity drugs has been proven difficult because of side-effects and lower efficiency [6–9]. Traditional medicine has various herbs for weight-reducing practice and may be a potential source for novel antiobesity drugs. Rheum palmatum is used most frequently in the weight-reducing formulae of traditional Chinese medicine. Recently, rhein, one of the major components of Rheum palmatum, has been shown to be an inhibitor of 3T3-L1 adipocyte differentiation [10]. Moreover, rhein has been reported to have pharmacological and biochemical effects on the inhibition of liver fibrosis and insulin sensitizing [11–13] and prevent hepatic steatosis through LXR inhibition in a high-fat diet-induced obese mouse model [14]. However, whether rhein plays the antiobesity role in vivo is still uncertain and the underlying mechanisms also need to be elucidated. In the present study, we compared the weight-reducing effect of two major compounds from Rheum palmatum. We found that rhein reduced fat weight in mouse. We also showed that rhein blocked weight
Extracts of Rhizoma Polygonati Odorati Prevent High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice
Ming Gu, Yu Zhang, Shengjie Fan, Xiaobo Ding, Guang Ji, Cheng Huang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081724
Abstract: Polygonatum odoratum (Mill.) Druce belongs to the genus Polygonatum family of plants. In traditional Chinese medicine, the root of Polygonatum odoratum, Rhizoma Polygonati Odorati, is used both for food and medicine to prevent and treat metabolic disorders such as hyperlipidemia, hyperglycemia, obesity and cardiovascular disease. However, there is no solid experimental evidence to support these applications, and the underlying mechanism is also needed to be elucidated. Here, we examined the effect of the extract of Rhizoma Polygonati Odorati (ER) on metabolic disorders in diet-induced C57BL/6 obese mice. In the preventive experiment, the ER blocked body weight gain, and lowered serum total cholesterol (TC), triglyceride (TG) and fasting blood glucose, improved glucose tolerance test (GTT) and insulin tolerance test (ITT), reduced the levels of serum insulin and leptin, and increased serum adiponectin levels in mice fed with a high-fat diet significantly. In the therapeutic study, we induced obesity in the mice and treated the obese mice with ER for two weeks. We found that ER treatments reduced serum TG and fasting blood glucose, and improved glucose tolerance in the mice. Gene expression analysis showed that ER increased the mRNA levels of peroxisome proliferator-activated receptors (PPAR) γ and α and their downstream target genes in mice livers, adipose tissues and HepG2 cells. Our data suggest that ER ameliorates metabolic disorders and enhances the mRNA expression of PPARs in obese C57BL/6 mice induced by high-fat diet.
Extracts of Pomelo Peels Prevent High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice through Activating the PPARα and GLUT4 Pathway
Xiaobo Ding, Lu Guo, Yu Zhang, Shengjie Fan, Ming Gu, Yan Lu, Dong Jiang, Yiming Li, Cheng Huang, Zhiqin Zhou
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077915
Abstract: Objective Metabolic syndrome is a serious health problem in both developed and developing countries. The present study investigated the anti-metabolic disorder effects of different pomelo varieties on obese C57BL/6 mice induced by high-fat (HF) diet. Design The peels of four pomelo varieties were extracted with ethanol and the total phenols and flavonoids content of these extracts were measured. For the animal experiment, the female C57BL/6 mice were fed with a Chow diet or a HF diet alone or supplemented with 1% (w/w) different pomelo peel extracts for 8 weeks. Body weight and food intake were measured every other day. At the end of the treatment, the fasting blood glucose, glucose tolerance and insulin (INS) tolerance test, serum lipid profile and insulin levels, and liver lipid contents were analyzed. The gene expression analysis was performed with a quantitative real-time PCR assay. Result The present study showed that the Citrus grandis liangpinyou (LP) and beibeiyou (BB) extracts were more potent in anti-metabolic disorder effects than the duanshiyou (DS) and wubuyou (WB) extracts. Both LP and BB extracts blocked the body weight gain, lowered fasting blood glucose, serum TC, liver lipid levels, and improved glucose tolerance and insulin resistance, and lowered serum insulin levels in HF diet-fed mice. Compared with the HF group, LP and BB peel extracts increased the mRNA expression of PPARα and its target genes, such as FAS, PGC-1α and PGC-1β, and GLUT4 in the liver and white adipocyte tissue (WAT). Conclusion We found that that pomelo peel extracts could prevent high-fat diet-induced metabolic disorders in C57BL/6 mice through the activation of the PPARα and GLUT4 signaling. Our results indicate that pomelo peels could be used as a dietary therapy and the potential source of drug for metabolic disorders.
Citrange Fruit Extracts Alleviate Obesity-Associated Metabolic Disorder in High-Fat Diet-Induced Obese C57BL/6 Mouse
Yan Lu,Wanpeng Xi,Xiaobo Ding,Shengjie Fan,Yu Zhang,Dong Jiang,Yiming Li,Cheng Huang,Zhiqin Zhou
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141223736
Abstract: Obesity is becoming one of the global epidemics of the 21st century. In this study, the effects of citrange ( Citrus sinensis × Poncirus trifoliata) fruit extracts in high-fat (HF) diet-induced obesity mice were studied. Female C57BL/6 mice were fed respectively a chow diet (control), an HF diet, HF diet supplemented with 1% w/ w citrange peel extract (CPE) or 1% w/ w citrange flesh and seed extract (CFSE) for 8 weeks. Our results showed that both CPE and CFSE regulated the glucose metabolic disorders of obese mice. In CPE and CFSE-treated groups, the body weight gain, blood glucose, serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) levels were significantly ( p < 0.05) reduced relative to those in the HF group. To explore the mechanisms of action of CPE and CFSE on the metabolism of glucose and lipid, related genes’ expressions in liver were assayed. In liver tissue, the expression level of peroxisome proliferator-activated receptor γ ( PPARγ) and its target genes were down-regulated by CPE and CFSE supplementation as revealed by qPCR tests. In addition, both CPE and CFSE decreased the expression level of liver X receptor (LXR) α and β, which are involved in lipid and glucose metabolism. Taken together, these results suggest that CPE and CFSE administration could ameliorate obesity and related metabolic disorders in HF diet-induced obesity mice probably through the inhibition of PPARγ and LXRs gene expressions.
Dust aerosol optical properties over North China
Shengjie Niu,Xiaofeng Xu
Atmospheric Chemistry and Physics Discussions , 2008,
Abstract: Aerosol optical properties were obtained from ground-based sunphotometer data at nine observatories over North China during two periods of 1996–1998 and 2002–2003. The seasonal changes of aerosol optical depth (AOD) at five wavelengths were observed, with the highest value of AOD in spring, while the lowest in winter. Four patterns of AOD diurnal variation were obtained, of which the high value occurred in the morning, noon, evening and no remarkable change, respectively. Together with meteorological records, the characteristics of AOD during dust weather were analyzed, and the results show that it was more detailed and accurate to use AOD to depict the strength change of dust weather than to use surface visibility. Based on measurements by aerodynamic instrument for particle size distribution, a positive correlation between dust particle number concentration and ngstr m turbidity coefficient β, and a negative correlation between aerosol geometric mean diameter (GMD) and wavelength exponent αwere revealed.

ZHANG Guobin,FAN Xiaodong,LIU Yuyang,KONG Jie,WANG Shengjie,

高分子学报 , 2007,
Abstract: 利用γ-甲基丙烯酰氧基丙基三甲基硅氧烷的受控水解反应即A2-B3单体对法来制备超支化聚硅氧烷,并对合成出的聚合物通过FT-IR、1H-NMR和多角度激光光散射技术(MALLS)进行了表征.结果表明,所得聚合物具有超支化结构且分子中含有大量活性官能团,从而可以实现紫外光引发固化.通过等温差示光量热实验(DPC)研究了聚合物结构、引发剂用量、光强度和聚合温度对聚合物光固化行为的影响规律,并得到了其中一种聚合物的光固化动力学参数,光固化反应总级数约为3,表观活化能为16.9kJ/mol.
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